2 0 0 8

Carbometalation and hydroallylation reactions

Shirakawa, E.; Hayashi, T. Denshi Kyoyakukei Yuki Zairyo no Sosei - Kino Kaihatsu - Oyo 2008, 25

Palladium-Catalyzed Asymmetric Decarboxylative Lactamization of γ -Methylidene-δ -valerolactones with Isocyanates: Conversion of Racemic Lactones to Enantioenriched Lactams.  

Shintani, R.; Park, S.; Shirozu, F.; Murakami, M.; Hayashi, T. J. Am. Chem. Soc. 2008, 130, 16174.

DOI: 10.1021/ja807662b

Rhodium-Catalyzed Asymmetric Addition of Terminal Alkynes to Diarylphosphinylallenes

Nishimura, T.; Guo, X.-X.; Hayashi, T. Chem. Asian J. 2008, 3, 1505.

Simple Chiral Diene Ligands Provide High Enantioselectivities in Transition-Metal-Catalyzed Conjugate Addition Reactions

Okamoto, K.; Hayashi, T.; Rawal, V. H. Org. Lett. 2008, 10, 4387

Chiral Tetrafluorobenzobarrelenes as Highly Efficient Ligands for the Rhodium-catalyzed Asymmetric 1,4-Addition of Arylboronic Acids

Nishimura, T.; Makoto Nagaosa, M.; Hayashi, T. Chem. Lett. 2008, 37, 860.

Platinum-catalyzed 1,4-Addition of Arylboronic Acids to β-Substituted α,β-Unsaturated Ketones

Hayashi, T.; Sasaki, K. Chem. Lett. 2008, 37, 842.

C2-Symmetric Tetrafluorobenzobarrelenes as Highly Efficient Ligands for the Iridium-Catalyzed Asymmetric Annulation of 1,3-Dienes with 2-Formylphenylboron Reagents

Nishimura, T.; Yasuhara, Y.;Nagaosa, M.; Hayashi, T. Tetrahedron: Asymmetry 2008, 19, 1778.

Rhodium-Catalyzed Asymmetric Ring-Opening Alkynylation of Azabenzonorbornadienes

Nishimura, T.; Tsurumaki, E.; Kawamoto, T.; Guo, X. -X.; Hayashi, T. Org. Lett.  2008,  10,  4057.

Ruthenium-Catalyzed 1,4-Addition of Organoboronic Acids to α, β -Unsaturated Ketones

Shintani, R.; Hayashi, T. Chem. Lett.  2008,  37,  724.

Cobalt-catalyzed coupling of alkenyl triflates with aryl and alkenyl Grignard reagents

Shirakawa, E.; Imazaki, Y.; Hayashi, T. Chem. Lett.  2008,  37,  654.

γ-Methylidene-δ-valerolactones as a Coupling Partner for Cycloaddition: Palladium-Catalyzed [4+3] Cycloaddition with Nitrones

Shintani, R.; Murakami, M.; Hayashi, T. Pure and Applied Chemistry  2008,  80,  1135.

Rhodium-Catalyzed Addition of Organo[2-(hydroxymethyl)phenyl]dimethylsilanes to Arenesulfonylimines.
Nakao, Y.; Takeda, M.; Chen, J.; Hiyama, T.; Ichikawa, Y.; Shintani, R.; Hayashi, T.  Chem. Lett. 2008, 37, 290.

Fe-Cu Cooperative Catalysis in the Isomerization of Alkyl Grignard Reagents.
Shirakawa, E.; Ikeda, D.; Yamaguchi, S.; Hayashi, T.  Chem. Commun. 2008, 1214.

Rhodium-Catalyzed Rearrangement of Aryl Bis(alkynyl) Carbinols to 3-Alkynyl-1-indanones.
Shintani, R.; Takatsu, K.; Kato, T.; Nishimura, T.; Hayashi, T.  Angew. Chem. Int. Ed. 2008, 47, 1447.

Rhodium-Catalyzed Kinetic Resolution of Tertiary Homoallyl Alcohols via Stereoselective Carbon-Carbon Bond Cleavage.
Shintani, R.; Takatsu, K.; Hayashi, T.  Org. Lett. 2008, 10, 1191.

Platinum-Catalyzed Generation of Silylenes from Hydrodisilanes and Their Addition to α,β-Unsaturated Ketones.
Okamoto, K.; Hayashi, T.  Chem. Lett. 2008, 37, 108.

Rhodium/Chiral Diene-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Arylmethylene Cyanoacetates.
Sörgel, S.; Tokunaga, N.; Sasaki, K.; Okamoto, K.; Hayashi, T.  Org. Lett. 2008, 10, 589.

Steric Tuning of Silylacetylenes and Chiral Phosphine Ligands for Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of Enones.
Nisimura, T.; Guo, X.-X.; Uchiyama, N.; Katoh, T.; Hayashi, T.  J. Am. Chem. Soc. 2008, 130, 1576.

2 0 0 7

Unprecedented Formation of μ-Vinylidene Complexes from Phospharuthenocene and Acyl Chloride via Activation of the C=O Double Bond

Ogasawara, M.; Sakamoto, T.; Ito, A.; Ge, Y.; Nakajima, K.; Takahashi, T.; Hayashi, T. Organometallics 2007, 26, 6698.

Rhodium-Catalyzed Hydroalkynylation of Internal Alkynes with Silylacetylenes: an Alkynylrhodium(I) Intermediate Generated from the Hydroxorhodium(I) Complex [Rh(OH)(binap)]2
Nishimura, T.; Guo, X.-X.; Ohnishi, K.; Hayashi, T.  Adv. Synth. Catal. 2007, 349, 2669.

Preparation of Arylzinc Reagents and Their Use in the Rhodium-Catalyzed Asymmetric 1,4-Addition for the Synthesis of 2-Aryl-4-piperidones.
Shintani, R.; Hayashi, T.  Nature Protocols 2007¸ 2, 2903.

Palladium-Catalyzed Synthesis of Spiro[2.4]heptanes: Ligand-Dependent Position Control in the Nucleophilic Attack to a π-Allylpalladium Intermediate.
Shintani, R.; Park, S.; Hayashi, T.  J. Am. Chem. Soc. 2007, 129, 14866.

Platinum-Catalyzed Addition of Dimethylsilylene to β-Methyl α,β-Unsaturated Ketones: γ- Silylation Forming 1-Oxa-2-silacyclohex-5-enes.
Okamoto, K.; Hayashi, T.  Org. Lett. 2007, 9, 5067.

Cobalt-Catalyzed Cross-Coupling of Alkenyl Grignard Reagents with Alkenyl Triflates.
Shirakawa, E.; Sato, T.; Imazaki, Y.; Kimura, T.; Hayashi, T.  Chem. Commun. 2007, 4513.

Rhodium-Catalyzed Asymmetric Rearrangement of Alkynyl Alkenyl Carbinols: Synthetic Equivalent to Asymmetric Conjugate Alkynylation of Enones.
Nishimura, T.; Katoh, T.; Takatsu, K.; Shintani, R.; Hayashi, T.  J. Am. Chem. Soc. 2007, 129, 14158.

A Cationic Rhodium-Chiral Diene Complex as a High-Performance Catalyst for the Intramolecular Asymmetric [4 + 2] Cycloaddition of Alkyne-1,3-dienes
Shintani, R.; Sannohe, Y.; Tsuji, T.; Hayashi, T.  Angew. Chem., Int. Ed. 2007, 46, 7277.

Catalytic Asymmetric Synthesis of Allylsilanes through Rhodium/Chiral Diene-Catalyzed 1,4-Addition of Alkenyl[2-(hydroxymethyl)phenyl]dimethylsilanes.
Shintani, R.; Ichikawa, Y.; Hayashi, T.; Chen, J.; Nakao, Y.; Hiyama, T.  Org. Lett. 2007, 9, 4643.

γ-Methylidene-δ-valerolactones as a Coupling Partner for Cycloaddition: Palladium-Catalyzed [4 + 3] Cycloaddition with Nitrones
Shintani, R.; Murakami, M.; Hayashi, T.  J. Am. Chem. Soc.  2007, 129, 12356.

Palladium-Catalyzed Asymmetric [3 + 3] Cycloaddition of Trimethylenemethane Derivatives With Nitrones
Shintani, R.; Park, S.; Duan, W.-L.; Hayashi, T.  Angew. Chem., Int. Ed. 2007, 46, 5901.

Asymmetric Construction of Chiral C-N Axes Through Rhodium-Catalyzed 1,4-Addition
Duan, W.-L.; Imazaki, Y.; Shintani, R.; Hayashi, T.  Tetrahedron 2007, 63, 8529.

Organo[2-(hydroxymethyl)phenyl]dimethylsilanes as Mild and Reproducible Agents for Rhodium-Catalyzed 1,4-Addition Reactions
Nakao, Y.; Chen, J.; Imanaka, H.; Hiyama, T.; Ichikawa, Y.; Duan, W.-L.; Shintani, R.; Hayashi, T.  J. Am. Chem. Soc.  2007, 129, 9137.

Rhodium-Catalyzed Aryl Transfer from Trisubstituted Aryl Methanols to α,β-Unsaturated Carbonyl Compounds
Nishimura, T.; Katoh, T.; Hayashi, T.  Angew. Chem., Int. Ed. 2007, 46, 4937.

Rhodium-Catalyzed Asymmetric Synthesis of 3,3-Disubstituted 1-Indanones
Shintani, R.; Takatsu, K.; Hayashi, T.  Angew. Chem., Int. Ed. 2007, 46, 3735.

Iridium-Catalyzed [3 + 2] Annulation of 1,3-Dienes with ortho-Carbonylated Phenylboronic Acids. A Catalytic Process Involving Regioselective 1,2-Addition
Nishimura, T.; Yasuhara, Y.; Hayashi, T.  J. Am. Chem. Soc.  2007, 129, 7506.

Palladium-Catalyzed Conjugate Reduction of Enones into α,β-Dideuterioketones with Hexamethyldisilane and Deuterium Oxide
Otsuka, H.; Shirakawa, E.; Hayashi, T.  Chem. Commun. 2007, 1819.

Iron-Catalyzed Arylmagnesiation of Aryl(alkyl)acetylenes in the Presence of an N-Heterocyclic Carbene Ligand
Yamagami, T.; Shintani, R.; Shirakawa, E.; Hayashi, T.  Org. Lett. 2007, 9, 1045.

Asymmetric 1,4-Addition of Organoboron Reagents to Quinone Monoketals Catalyzed by a Chiral Diene/Rhodium Complex: A New Synthetic Route to Enantioenriched 2-Aryltetralones
Tokunaga, N.; Hayashi, T.  Adv. Synth. Catal. 2007, 349, 513.

Chiral Phosphine-olefin Ligands in the Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions
Duan W.-L.; Iwamura H.; Shintani R.; Hayashi T.  J. Am. Chem. Soc. 2007, 129, 2130.

Rhodium-catalyzed Asymmetric Cyclodimerization of Oxa- and Azabicyclic Alkenes
Nishimura T.; Kawamoto T.; Sasaki K.; Tsurumaki E.; Hayashi T.   J. Am. Chem. Soc. 2007, 129, 1492.

2 0 0 6

Kinetic Studies Prove High Catalytic Activity of a Diene-rhodium Complex in 1,4-Addition of Phenylboronic Acid to α,β-Unsaturated Ketones
Kina, A.; Yasuhara, Y.; Nishimura, T.; Iwamura, H.; Hayashi, T.  Chem. Asian J. 2006, 1, 707.

Expanding the C2-Symmetric Bicyclo[2.2.1]hepta-2,5-diene Ligand Family: Concise Synthesis and Catalytic Activity in Rhodium-Catalyzed Asymmetric Addition
Berthon-Gelloz, G.; Hayashi, T.  J. Org. Chem. 2006, 71, 8957.

Highly Selective 1,6-Addition of Arylboronic Acids to α,β,γ,δ-Unsaturated Carbonyl Compounds Catalyzed by an Iridium Complex
Nishimura, T.; Yasuhara, Yuichi; Hayashi, T.  Angew. Chem., Int. Ed. 2006, 45, 5164.

Nickel-Catalyzed Conjugate Addition of Arylboron Reagents to α,β-Unsaturated Carbonyl Compounds with the Aid of a Catalytic Amount of an Alkyne
Shirakawa, E.; Yasuhara, Y.; Hayashi, T.  Chem. Let. 2006, 35, 768.

Synthesis of 2,5-Bis(binaphthyl)phospholes and Phosphametallocene Derivatives and Their Application in Palladium-Catalyzed Asymmetric Hydrosilylation
Ogasawara, M.; Ito, A.; Yoshida, K.; Hayashi, T.  Organometallics 2006, 25, 2715.

Highly Enantioselective 1,4-Addition of Arylzinc Reagents to 3-Arylpropenals Catalyzed by a Rhodium-BINAP Complex in the Presence of Chlorotrimethylsilane
Tokunaga, N.; Hayashi, T.  Tetrahedron: Asymmetry 2006, 17, 607.

Asymmetric Catalysis
Chan, A. S. C.; Hayashi, T.  Tetrahedron: Asymmetry 2006, 17, 479.

Palladium-Catalyzed Silylation of Alcohols with Hexamethyldisilane
Shirakawa, E.; Hironaka, K.; Otsuka, H.; Hayashi, T.  Chem. Commun. 2006, 37, 3927.

Rhodium-Catalyzed Isomerization of Unactivated Alkynes to 1,3-Dienes
Shintani, R.; Duan, W.-L.; Park, S.; Hayashi, T.  Chem. Commun. 2006, 37, 3646.

Rhodium-Catalyzed Multicomponent-Coupling Reactions Involving a Carborhodation-Cross-Coupling Sequence
Shintani, R.; Yamagami, T.; Hayashi, T.  Org. Lett. 2006, 8, 4799.

Rhodium-Catalyzed Asymmetric Addition of Aryl- and Alkenylboronic Acids to Isatins
Shintani R.; Inoue M.; Hayashi T.  Angew. Chem., Int. Ed. 2006, 45, 3353.

Palladium-Catalyzed [3 + 3] Cycloaddition of Trimethylenemethane with Azomethine Imines
Shintani, R.; Hayashi, T.  J. Am. Chem. Soc. 2006, 128, 6330.

Rhodium-Catalyzed Asymmetric Construction of Quaternary Carbon Stereocenters: Ligand-Dependent Regiocontrol in the 1,4-Addition to Substituted Maleimides
Shintani, R.; Duan, W.-L.; Hayashi, T.  J. Am. Chem. Soc. 2006, 128, 5628.

A Kinetic Study on Rh/Binap-Catalyzed 1,4-Addition of Phenylboronic Acid to Enones: Negative Nonlinear Effect Caused by Predominant Homochiral Dimer Contribution
Kina A.; Iwamura H.; Hayashi T.  J. Am. Chem. Soc. 2006, 128, 3904.

Rhodium-Catalyzed Asymmetric Synthesis of Indanones: Development of a New "Axially Chiral" Bisphosphine Ligand
Shintani, R.; Yashio, K.; Nakamura, T.; Okamoto, K.; Shimada, T.; Hayashi, T.  J. Am. Chem. Soc. 2006, 128, 2772.

Asymmetric Addition of Dimethylzinc to N-Tosylarylimines Catalyzed by a Rhodium-Diene Complex toward the Synthesis of Chiral 1-Arylethylamines
Nishimura, T.; Yasuhara, Y.; Hayashi T.  Org. Lett. 2006, 8, 979.

Rhodium-Catalyzed Asymmetric Hydroarylation of Diphenylphosphinylallenes with Arylboronic Acids
Nishimura, T.; Hirabayashi, S; Yasuhara, Y.; Hayashi, T.  J. Am. Chem. Soc. 2006, 128, 2556.

High Performance of a Chiral Diene-Rhodium Catalyst for the Asymmetric 1,4-Addition of Arylboroxines to α,β-Unsaturated Ketones
Chen, F.-X.; Kina, A.; Hayashi, T.  Org. Lett. 2006, 8, 341.

2 0 0 5

Asymmetric 1,4-Addition of Arylboronic Acids to α,β-Unsaturated Aldehydes Catalyzed by a Chiral Diene-Rhodium Complex
Hayashi, T.; Tokunaga, N.; Okamoto, K.; Shintani, R.  Chem. Lett. 2005, 34, 1480.

1,2-Dideuterioalkenes with Hexamethyldisilane and Deuterium Oxide in the Presence of a Palladium Catalyst
Shirakawa, E.; Otsuka, H.; Hayashi, T.  Chem. Commun. 2005, 47, 5885.

Enantiomerically Pure Rhodium Complexes Bearing 1,5-Diphenyl-1,5-cyclooctadiene as a Chiral Diene Ligand. Their Use as Catalysts for Asymmetric 1,4-Addition of Phenylzinc Chloride
Kina, A.; Ueyama, K.; Hayashi, T.  Org. Lett. 2005, 7, 5889.

Arylmagnesiation of Alkynes Catalyzed Cooperatively by Iron and Copper Complexes
Shirakawa, E.; Yamagami, T.; Kimura, T.; Yamaguchi, S.; Hayashi, T.  J. Am. Chem. Soc. 2005, 127, 17164.

Chiral Diene Ligands for Catalytic Asymmetric Reactions
Hayashi, T.  Shokubai 2005, 47, 533.

Palladium/Chiral Phosphine-Olefin Complexes: X-ray Crystallographic Analysis and the Use in Catalytic Asymmetric Allylic Alkylation
Shintani, R.; Duan, W.-L.; Okamoto, K.; Hayashi, T.  Tetrahedron: Asymmetry 2005, 16, 3400.

Asymmetric Synthesis of 2-Aryl-2,3-dihydro-4-quinolones by Rhodium-Catalyzed 1,4-Addition of Arylzinc Reagents in the Presence of Chlorotrimethylsilane
Shintani, R.; Yamagami, T.; Kimura, T.; Hayashi, T. Org. Lett. 2005, 7, 5317.

Rhodium-Catalyzed Synthesis of Indenols by Regioselective Coupling of Alkynes with Ortho-carbonylated Arylboronic Acids
Shintani, R.; Okamoto, K.; Hayashi, T.  Chem. Lett. 2005, 34, 1294.

Carbon-Carbon Bond-Forming Enantioselective Synthesis of Chiral Organosilicon Compounds by Rhodium/Chiral Diene-Catalyzed Asymmetric 1,4-Addition Reaction
Shintani, R.; Okamoto, K.; Hayashi, T.  Org. Lett. 2005, 7, 4757.

Silver-Catalyzed Alkyl-Alkyl Homo-Coupling of Grignard Reagents
Nagano, T.; Hayashi, T.  Chem. Lett. 2005, 34, 1152.

Chiral Phosphine-Olefin Bidentate Ligands in Asymmetric Catalysis: Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl Boronic Acids to Maleimides
Shintani, R.; Duan, W.-L.; Nagano, T.; Okada, A.; Hayashi, T.  Angew. Chem., Int. Ed. 2005, 44, 4611.

Rhodium-Catalyzed Asymmetric 1,6-Addition of Aryl Zinc Reagents to Dienones
Hayashi, T.; Yamamoto, S.; Tokunaga, N.  Angew. Chem., Int. Ed. 2005, 44, 4224.

Highly Chemo- and Enantioselective Arylative Cyclization of Alkyne-Tethered Electron-Deficient Olefins Catalyzed by Rhodium Complexes with Chiral Dienes
Shintani, R.; Tsurusaki, A.; Okamoto, K.; Hayashi, T.  Angew. Chem., Int. Ed. 2005, 44, 3909.

Rhodium/Diene-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to α,β-Unsaturated Weinreb Amides
Shintani, R.; Kimura, T.; Hayashi, T.  Chem. Commun. 2005, 25, 3213.

A New Route to Methyl (R,E)-(-)-Tetradeca-2,4,5-trienoate (Pheromone of Acanthoscelides obtectus) Utilizing a Palladium-Catalyzed Asymmetric Allene Formation Reaction
Ogasawara, M.; Nagano, T.; Hayashi, T.  J. Org. Chem. 2005, 70, 5764.

Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Coumarins: Asymmetric Synthesis of (R)-Tolterodine
Chen, G.; Tokunaga, N.; Hayashi, T.  Org. Lett. 2005, 7, 2285.

C2-Symmetric Bicyclo[3.3.1]nona-2,6-diene and Bicyclo[3.3.2]deca-2,6-diene: New Chiral Diene Ligands Based on the 1,5-Cyclooctadiene Framework
Otomaru, Y.; Kina, A.; Shintani, R.; Hayashi, T.  Tetrahedron: Asymmetry 2005, 16(9), 1673.

Rhodium(I)-Catalyzed Asymmetric Addition of Organometallic Reagents to Electron-Deficient Olefins
Yoshida, K.; Hayashi, T.  Modern Rhodium-Catalyzed Organic Reactions 2005, 55-77.

1,4-Addition of Allyl and Alkenyl Metal Reagents Using Rhodium Catalyst
Yoshida, K.; Hayashi, T.  Gendai Kagaku Zokan 2005, 43(Saishin Yuki Gosei Kagaku, 2005),136-147.

Rhodium-Catalyzed Addition of Arylzinc Reagents to Aryl Alkynyl Ketones: Synthesis of β,β-Disubstituted Indanones
Shintani, R.; Hayashi, T.  Org. Lett. 2005, 7, 2071.

Preparation of C2-Symmetric Bicyclo[2.2.2]octa-2,5-diene Ligands and Their Use for Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids
Otomaru, Y; Okamoto, K.; Shintani, R.; Hayashi, T.  J. Org. Chem. 2005, 70, 2503.

Preparation of Optically Active Compounds and Chiral Diene Transition Metal Complexes for It
Hayashi, T.  Tokkyo Koho 2005, 44.

Rhodium-Catalyzed Isomerization of α-Arylpropargyl Alcohols to Indanones: Involvement of an Unexpected Reaction Cascade
Shintani, R.; Okamoto, K.; Hayashi, T.  J. Am. Chem. Soc. 2005, 127, 2872.

Iron-Catalyzed Oxidative Homo-Coupling of Aryl Grignard Reagents
Nagano, T.; Hayashi, T.  Org. Lett. 2005, 7, 491.

C2-Symmetric Bicyclo[3.3.1]nonadiene as a Chiral Ligand for Rhodium-Catalyzed Asymmetric Arylation of N-(4-Nitrobenzenesulfonyl)arylimines
Otomaru, Y.; Tokunaga, N.; Shintani, R.; Hayashi, T.  Org. Lett. 2005, 7, 307.

Catalytic Asymmetric Arylative Cyclization of Alkynals: Phosphine-Free Rhodium/Diene Complexes as Efficient Catalysts
Shintani, R.; Okamoto, K.; Otomaru, Y.; Ueyama, Kazuhito; Hayashi, T.  J. Am. Chem. Soc. 2005, 127, 54.

2 0 0 4

Transition Metal-Catalyzed Synthesis of Allenes
Ogasawara, M.; Hayashi, T.  Modern Allene Chemistry 2004, 93.

Asymmetric Synthesis of Diarylmethyl Amines by Rhodium-Catalyzed Asymmetric Addition of Aryl Titanium Reagents to Imines
Hayashi, T.; Kawai, M.; Tokunaga, N.  Angew. Chem., Int. Ed. 2004, 43, 6125.

A New Approach to Axially Chiral Bipyridine N,N'-Dioxides Bearing Aromatic Substituents and Their Use for Catalytic Asymmetric Allylation of Aldehydes with Allyl(trichloro)silane
Kina, A.; Shimada, T.; Hayashi, T.  Adv. Synth. Catal. 2004, 346, 1169.

C2-Symmetric Bicyclo[2.2.2]octadienes as Chiral Ligands: Their High Performance in Rhodium-Catalyzed Asymmetric Arylation of N-Tosylarylimines
Tokunaga, N.; Otomaru, Y.; Okamoto, K.; Ueyama, K.; Shintani, R.; Hayashi, T.  J. Am. Chem. Soc. 2004, 126, 13584.

Preparation of an Amphiphilic Resin-Supported BINAP Ligand and Its Use for Rhodium-Catalyzed Asymmetric 1,4-Addition of Phenylboronic Acid in Water
Otomaru, Y.; Senda, T.; Hayashi, T.  Org. Lett. 2004, 6, 3357.

Rhodium-Catalyzed Asymmetric 1,4-Addition of Alkenylsilanes Generated by Hydrosilylation of Alkynes: A One-Pot Procedure Where a Rhodium/(S)-Binap Complex Catalyzes the Two Successive Reactions
Otomaru, Y.; Hayashi, T.  Tetrahedron: Asymmetry 2004, 15, 2647.

Chiral Norbornadienes as Efficient Ligands for the Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Fumaric and Maleic Compounds
Shintani, R.; Ueyama, K.; Yamada, I.; Hayashi, T.  Org. Lett. 2004, 6, 3425.

Bonding of organic Groups to Inorganic Solids
Inagaki, S; Hayashi, T.; Shimada, T.  Jpn. Kokai Tokkyo Koho (2004), 28 pp.

Immobilization of Chiral Phosphine Ligands on Silica Gel by Means of the Allylsilane Method and Their Use for Catalytic Asymmetric Reactions
Aoki, K.; Shimada, T.; Hayashi, T.  Tetrahedron: Asymmetry 2004, 15, 1771.

A New Entry of Nucleophiles in Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions: Addition of organozinc Reagents for the Synthesis of 2-Aryl-4-piperidones
Shintani, R.; Tokunaga, N.; Doi, H.; Hayashi, T.  J. Am. Chem. Soc. 2004, 126, 6240.

Palladium-Catalyzed Heck and Carbonylation Reactions of a Dinaphthaleneiodonium Salt Forming Functionalized 2-Iodo-1,1'-binaphthyls
Kina, A.; Miki, H.; Cho, Y.-H.; Hayashi, T.  Adv. Synth. Catal. 2004, 346, 1728.

Asymmetric Synthesis of Axially Chiral Biaryls by Nickel-Catalyzed Grignard Cross-Coupling of Dibenzothiophenes
Cho, Y.-H.; Kina, A.; Shimada, T.; Hayashi, T.  J. Org. Chem. 2004, 69, 3811.

Mechanistic Studies on the Catalytic Cycle of Rhodium-Catalyzed Asymmetric 1,4-Addition of aryltitanate Reagents to α,β-Unsaturated Ketones
Tokunaga, N.; Yoshida, K.; Hayashi, T.  Proceedings of the National Academy of Sciences of the United States of America 2004, 101, 5445.

Regioselective Preparation of β-Substituted Silyl Enolates and Ketones via Titanium Enolates from α,β-Unsaturated Ketones
Hayashi, T. Jpn. Kokai Tokkyo Koho  2004, 16 pp.

Asymmetrical Solid Catalyst Having optically Active binaphthyl Derivative Ligand
Inagaki, S.; Hayashi, T.; Shimada, T. Jpn. Kokai Tokkyo Koho 2004, 18 pp.

Optically active Metallocenes as Asymmetric Polymerization Catalysts, Their Optically Active Ligands, and Manufacture of the Ligands
Hayashi, T. Jpn. Kokai Tokkyo Koho 2004, 19 pp.

Iron-Catalyzed Grignard Cross-Coupling with Alkyl Halides Possessing β-Hydrogens
Nagano, T.; Hayashi, T.  Org. Lett. 2004, 6, 1297.

Rhodium-Catalyzed Asymmetric Addition of Aryl- and Alkenylboron Reagents to Electron Deficient Olefins 

Hayashi, T. Pure Appl. Chem. 2004, 76, 465-475.

Deuterium-Labeling Studies Establishing Stereochemistry at the Oxypalladation Step in Wacker-Type Oxidative Cyclization of an o-Allylphenol
Hayashi, T.; Yamasaki, K.; Mimura, M.; Uozumi, Y.  J. Am. Chem. Soc. 2004, 126, 3036.

Palladium-Catalyzed Asymmetric Allylic Alkylation with an Indenide
Hayashi, T.; Suzuka, T.; Okada, A.; Kawatsura, M.  Tetrahedron: Asymmetry 2004, 15, 545.

Rhodium-Catalyzed Asymmetric Addition of Organo-boron and -titanium Reagents to Electron-deficient Olefins
Hayashi, T.  Bull. Chem. Soc. Jpn. 2004, 77, 13.

Rhodium-Catalyzed Asymmetric 1,6-Addition of Aryltitanates to Enynones Giving Axially Chiral Allenes
Hayashi, T.; Tokunaga, N.; Inoue, K.  Org. Lett. 2004, 6, 305.

2 0 0 3

A Chiral Chelating Diene as a New Type of Chiral Ligand for Transition Metal Catalysts: Its Preparation and Use for the Rhodium-Catalyzed Asymmetric 1,4-Addition
Hayashi, T.; Ueyama, K.; Tokunaga, N.; Yoshida, K.  J. Am. Chem. Soc. 2003, 125, 11508.

Rhodium-Catalyzed Asymmetric 1,4-Addition and Its Related Asymmetric Reactions
Hayashi, T.; Yamasaki, K. Chem. Rev. 2003, 103, 2829.

Bipyridyl-Based Diphosphine as an Efficient Ligand in the Rhodium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Ketones 

Shi, Q.; Xu, L.; Li, X.; Jia, X.; Wang, R.; Au-Yeung, T. T.-L.; Chan, A. S. C.; Hayashi, T.; Cao, R.; Hong, M. Tetrahedron Lett. 2003, 44, 6505-6508.

A New Synthetic Route to Enantiomerically Pure Axially Chiral 2,2'-Bipyridine N,N'-Dioxides. Highly Efficient Catalysts for Asymmetric Allylation of Aldehydes with Allyl(trichloro)silanes
Shimada, T.; Kina, A.; Hayashi, T.  J. Org. Chem. 2003, 68, 6329.

Induction of Atropisomeric Chirality on Heavily Substituted Phosphametallocenes
Ogasawara, M.; Yoshida, K.; Hayashi, T.  Organometallics 2003, 22, 1783.

Rhodium-Catalyzed Asymmetric 1,4-Addition of 3-thiopheneboronic Acid to α,β-Unsaturated Carbonyl Compounds
Yoshida, K.; Hayashi, T.  Heterocycles 2003, 59, 605.

High Enantioselectivity in Rhodium-Catalyzed Allylic Alkylation of 1-Substituted 2-Propenyl Acetates
Hayashi, T.; Okada, A.; Suzuka, T.; Kawatsura, M.  Org. Lett. 2003, 5, 1713.

Functionalization on Silica Gel with Allylsilanes. A New Method of Covalent Attachment of Organic Functional Groups on Silica Gel
Shimada, T.; Aoki, K.; Shinoda, Y.; Nakamura, T.; Tokunaga, N.; Inagaki, S.; Hayashi, T.  J. Am. Chem. Soc. 2003, 125, 4688.

Palladium-Catalyzed Asymmetric Allylic Substitution with a Cyclopentadienide: Asymmetric Synthesis of Metallocenes
Suzuka, T.; Kawatsura, M.; Okada, A.; Hayashi, T.  Tetrahedron: Asymmetry 2003, 14, 511.

A New cine-Substitution of Alkenyl Sulfones with Aryltitanium Reagents Catalyzed by Rhodium: Mechanistic Studies and Catalytic Asymmetric Synthesis of Allylarenes
Yoshida, K.; Hayashi, T.  J. Am. Chem. Soc. 2003, 125, 2872.

Synthesis of 1,1'-Diphospha[4]ferrocenophanes by Molybdenum-Catalyzed Ring-Closing Metathesis
Ogasawara, M.; Nagano, T.; Hayashi, T.  Organometallics 2003, 22, 1174.

Generation of Chiral Boron Enolates by Rhodium-Catalyzed Asymmetric 1,4-Addition of 9-Aryl-9-borabicyclo[3.3.1]nonanes (B-Ar-9BBN) to α,β-Unsaturated Ketones
Yoshida, K.; Ogasawara, M.; Hayashi, T.  J. Org. Chem. 2003, 68, 1901.

Palladium-Catalyzed Asymmetric Synthesis of Axially Chiral (Allenylmethyl)silanes and Chirality Transfer to Stereogenic Carbon Centers in SE' Reactions
Ogasawara, M.; Ueyama, K.; Nagano, T.; Mizuhata, Y; Hayashi, T.  Org. Lett. 2003, 5, 217.

2 0 0 2

Preparation of New Ferrocenylmonophosphine Ligands Containing Two Planar Chiral Ferrocenyl Moieties and Their Use for Palladium-Catalyzed Asymmetric Hydrosilylation of 1,3-Dienes
Han, J. W.; Tokunaga, N.; Hayashi, T.  Helv. Chim. Acta 2002, 85, 3848.

Nickel-Catalyzed Asymmetric Grignard Cross-Coupling of Dinaphthothiophene Giving Axially Chiral 1,1'-Binaphthyls
Shimada, T.; Cho, Y.-H.; Hayashi, T.  J. Am. Chem. Soc. 2002, 124, 13396.

Effects of Bidentate Phosphine Ligands on syn-anti Isomerization in π-Allylpalladium Complexes
Ogasawara, M.; Takizawa, K.; Hayashi, T.  Organometallics 2002, 21, 4853.

Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryltitanium Reagents Generating Chiral Titanium Enolates: Isolation as Silyl Enol Ethers
Hayashi, T.; Tokunaga, N.; Yoshida, K.; Han, J. W.  J. Am. Chem. Soc. 2002, 124, 12102.

Palladium- or Nickel-Catalyzed Cross-Coupling of Organotitanium Reagents with Aryl Triflates and Halides
Han, J. W.;Tokunaga, N.; Hayashi, T. Synlett 2002, 871.

A New Type of Catalytic Tandem 1,4-Addition-Aldol Reaction Which Proceeds through an (Oxa-π-allyl)rhodium Intermediate
Yoshida, K.; Ogasawara, M.; Hayashi, T.  J. Am. Chem. Soc. 2002, 124, 10984.

Metathesis Route to Bridged Metallocenes
Ogasawara, M.; Nagano, T.; Hayashi, T.  J. Am. Chem. Soc.  2002, 124, 9068.

A Novel Axially Chrial 2,2'-Bipyridine N,N'-Dioxide. Its Preparation and Use for Asymmetric Allylation of Aldehydes with Allyl(trichloro)silane as a Highly Efficient Catalyst
Shimada, T.; Kina, A.; Ikeda, S.; Hayashi, T.  Org. Lett. 2002, 4, 2799.

Synthesis and Characterization of 1,1'-Diphospharuthenocenes
Ogasawara, M.; Nagano, T.; Yoshida, K.; Hayashi, T.  Organometallics 2002, 21, 3062.

Catalytic Asymmetric Cross-coupling
Hayashi, T.  J. Organomet. Chem. 2002, 653, 41.

Asymmetric Synthesis of Metallocenes through Enantioselective Addition of Organolithium Reagents to 6-(Dimethylamino)fulvene
Suzuka, T.; Ogasawara, M.; Hayashi, T.  J. Org. Chem. 2002, 67, 3355.

Catalytic Cycle of Rhodium-Catalyzed Asymmetric 1,4-Addition of Organoboronic Acids. Arylrhodium, Oxa-π-allylrhodium, and Hydroxorhodium Intermediates
Hayashi, T.; Takahashi, M.; Takaya, Y.; Ogasawara, M.  J. Am. Chem. Soc. 2002, 124, 5052.

Enhanced Catalytic Activity in Asymmetric Hydrosilylation of 1,3-Dienes with a Soluble Palladium Catalyst
Han, J. W.; Hayashi, T.  Tetrahedron: Asymmetry 2002, 1, 325.

Asymmetric Synthesis of 1-Aryl-1,2-ethanediols from Arylacetylenes by Palladium-Catalyzed Asymmetric Hydrosilylation as a Key Step
Shimada, T.; Mukaide, K.; Shinohara, A.; Han, J. W.; Hayashi, T.  J. Am. Chem. Soc. 2002, 124, 1584.

(R)-3-Phenylcyclohexanone

Hayashi, T.; Takahashi, M.; Takaya, Y.; Ogasawara, M. Org. Synth. 2002, 79, 84-92. 

(R)-2-Diphenylphosphino-2'-methoxy-1,1'-binaphthyl

Uozumi, Y.; Kawatsura, M.; Hayashi, T. Org. Synth. 2002, 78, 1-13.

2 0 0 1

Rhodium-Catalyzed Asymmetric 1,4-Addition of Organoboronic Acids and Their Derivatives to Electron Deficient Olefins
Hayashi, T. Synlett 2001, 879.

Preparation of Enantiomerically Pure 2'-Substituted 2-Diphenylphosphino-1,1'-binaphthyls by Reductive Cleavage of Carbon-Phosphorus Bond in a Borane Complex of 2-Diphenylphosphino-2'-diphenylphosphinyl-1,1'-binaphthyl
Shimada, T.; Kurushima, H.; Cho, Y.-H.; Hayashi, T.  J. Org. Chem. 2001, 66, 8854.

Palladium-Catalyzed Asymmetric Hydrosilylation of 4-Substituted 1-Buten-3-ynes. Catalytic Asymmetric Synthesis of Axially Chiral Allenylsilanes
Han, J. W.; Tokunaga, N.; Hayashi, T.  J. Am. Chem. Soc. 2001, 123, 12915.

Rhodium-Catalyzed Asymmetric 1,4-Addition of Organoboron Reagents to 5,6-Dihydro-2(1H)-pyridinones. Asymmetric Synthesis of 4-Aryl-2-piperidinones
Senda, T.; Ogasawara, M.; Hayashi, T.  J. Org. Chem. 2001, 66, 6852.

Rhodium-Catalyzed Hydroarylation of Alkynes with Arylboronic Acids. 1,4-Shift of Rhodium from 2-Aryl-1-alkenylrhodium to 2-Alkenylarylrhodium Intermediate
Hayashi, T.; Inoue, K.; Taniguchi, N.; Ogasawara, M.  J. Am. Chem. Soc. 2001, 123, 9918.

Preparation of a New MOP Ligand Containing a Long-Chain Alkyl Group and Its Use for Palladium-Catalyzed Asymmetric Hydrosilylation of Cyclic 1,3-Dienes
Han, J. W.; Hayashi, T.  Chem. Lett. 2001, 976.

A Novel Chiral Phosphino-Phosphaferrocene: Its Coordination Behavior and Application to Palladium-Catalyzed Asymmetric Allylic Alkylation
Ogasawara, M.; Yoshida, K.; Hayashi, T.  Organometallics 2001, 20, 3913.

Chloroprene as a Source of Fine Chemicals: Palladium-Catalyzed Synthesis of Terminal Allenes
Ogasawara, M.; Ikeda, H.; Nagano, T.; Hayashi, T.  Org. Lett. 2001, 3, 2615.

Modification of Chiral Monodentate Phosphine Ligands (MOP) for Palladium-Catalyzed Asymmetric Hydrosilylation of Cyclic 1,3-Dienes
Hayashi, T.; Han, J. W.; Takeda, A.; Tang, J.; Nohmi, K.; Mukaide, K.; Tsuji, H.; Uozumi, Y.  Adv. Synth. Catal. 2001, 343, 279.

Rhodium-Catalyzed Asymmetric Arylation of α,β-Unsaturated Imines with Arylstannanes. Catalytic Asymmetric Synthesis of Allylic Amines
Hayashi, T.; Ishigedani, M.  Tetrahedron 2001, 57, 2589.

Palladium-Catalyzed Asymmetric Synthesis of Axially Chiral Allenes: A Synergistic Effect of Dibenzalacetone on High Enantioselectivity
Ogasawara, M.; Ikeda, H.; Nagano, T.; Hayashi, T.  J. Am. Chem. Soc. 2001, 123, 2089.

Synthesis and Characterization of a Novel Chiral Phosphole and Its Derivatives
Ogasawara, M.; Yoshida, K.; Hayashi, T.  Organometallics 2001, 20, 1014.

Asymmetric Hydrosilylation of Styrenes Catalyzed by Palladium-MOP Complexes: Ligand Modification and Mechanistic Studies
Hayashi, T.; Hirate, S.; Kitayama, K.; Tsuji, H.; Torii, A.; Uozumi, Y.  J. Org. Chem. 2001, 66, 1441.

2 0 0 0

Chiral Monodentate Phosphine Ligand MOP for Transition-Metal-Catalyzed Asymmetric Reactions
Hayashi, T.  Acc. Chem. Res. 2000, 33, 354.

Rhodium-Catalyzed Asymmetric Conjugate Addition of Organoboronic Acids to Nitroalkenes
Hayashi, T.; Senda, M.; Ogasawara, M.  J. Am. Chem. Soc. 2000, 122, 10716.

Modification of Chiral Monodentate Phosphine (MOP) Ligands for Palladium-catalyzed Asymmetric Hydrosilylation of Styrenes
Hayashi, T.; Hirate, S.; Kitayama, K.; Tsuji, H.; Torii, A.; Uozumi, Y.  Chem. Lett. 2000, 1272.

Asymmetric 1,4-Addition of Phenylboronic Acid to 2-Cyclohexenone Catalyzed by Rh(I)/binap Complexes
Takaya, Y.; Ogasawara, M.; Hayashi, T.  Chirality 2000, 12, 469.

Palladium-Catalyzed Synthesis of Butatrienes
Ogasawara, M.; Ikeda, H.; Ohtsuki, K.; Hayashi, T.  Chem. Lett. 2000, 776.

2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl: New EntR.f Bidentate Triarylphosphine Ligand to Transition Metal-Catalyzed Reactions
Ogasawara, M.; Yoshida, K.; Hayashi, T.  Organometallics 2000, 19, 1567.

π-Allylpalladium-Mediated Catalytic Synthesis of Functionalized Allenes
Ogasawara, M.; Ikeda, H.; Hayashi, T.  Angew. Chem., Int. Ed. 2000, 39, 1042

Palladium-Catalyzed Asymmetric Reduction of Racemic Allylic Esters with Formic Acid: Effects of Phosphine Ligands on Isomerization of π-Allylpalladium Intermediates and Enantioselectivity
Kawatsura, M.; Uozumi, Y.; Ogasawara, M.; Hayashi, T.  Tetrahedron 2000, 56, 2247.

Rhodium-Catalyzed Asymmetric Arylation of Imines with Organostannanes. Asymmetric Synthesis of Diarylmethylamines
Hayashi, T.; Ishigedani, M.  J. Am. Chem. Soc. 2000, 122, 976.

Novel Palladium Chiral Phosphino-Oxazoline Complexes: Crystal Structure Studies and Application to Asymmetric Heck Reaction
Ogasawara, M.; Yoshida, K.; Hayashi, T.  Heterocycles 2000, 52, 195.

1 9 9 9

Reactions of Bis(silyl)palladium(II) Complexes with Allyl Halides. Synthesis of Mono(silyl)palladium(II) Halides and X-ray Structure of trans-PdCl(SiF2Ph)(PMe2Ph)2
Ozawa, F.; Sugawara, M.; Hasebe, K.; Hayashi, T.  Inorg. Chimica Acta. 1999, 296, 19.

Rhodium-Catalyzed Asymmetric 1,4-Addition to 1-Alkenylphosphonates
Hayashi, T.; Senda, T.; Takaya, Y.; Ogasawara, M.  J. Am. Chem. Soc. 1999, 121, 11591.

Allylic Substitution in Water Catalyzed by Amphiphilic Resin-Supported Palladium-Phosphine Complexes
Danjo, H.; Tanaka, D.; Hayashi, T.; Uozumi, M.  Tetrahedron 1999, 55, 14341.

Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboron Reagents to α,β-Unsaturated Esters
Takaya, Y.; Senda, T.; Kurushima, H.; Ogasawara, M.; Hayashi, T.  Tetrahedron: Asymmetry 1999, 10, 4047.

Palladium-Catalyzed Enantioselective Carbonylative Cyclization of Aryl and Alkenyl Triflates with Carbon Monoxide
Hayashi, T.; Tang, J.; Kato, K.  Org. Lett. 1999, 1, 1487.

Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboron Compounds Generated in situ from Aryl Bromides
Takaya, Y.; Ogasawara, M.; Hayashi, T.  Tetrahedron Lett. 1999, 40, 6957.

Cross-Coupling of Aryl Halides and Allyl Acetates with Arylboron Reagents in Water Using an Amphiphilic Resin-Supported Palladium Catalyst
Uozumi, Y.; Danjo, H.; Hayashi, T.  J. Org. Chem. 1999, 64, 3384.

Design and Preparation of 3,3'-Disubstituted 2,2'-Bis(oxazolyl)-1,1'-binaphthyls (boxax): New Chiral Bis(oxazoline)Ligands for Catalytic Asymmetric Wacker-Type Cyclization
Uozumi, Y.; Kyota, H.; Kato, K.; Ogasawara, M.; Hayashi, T.  J. Org. Chem. 1999, 64, 1620.

Enantioposition-Selective Arylation of Biaryl Ditriflates by Palladium-Catalyzed Asymmetric Grignard Cross-Coupling
Kamikawa, T.; Hayashi, T.  Tetrahedron 1999, 55, 3455.

Catalytic Asymmetric Reactions via π-Allylpalladium Complexes Coordinated with Chiral Monophosphine Ligands

Hayashi, T. J. Organomet. Chem. 1999, 576, 195-202.

1 9 9 8

Dichloro[(2-dimethylamino)propyldiphenylphosphine]palladium(II) (PdCl2(alaphos)): An Efficient Catalyst for Cross-Coupling of Aryl Triflates with Alkynyl Grignard Reagents
Kamikawa, T.; Hayashi, T.  J. Org. Chem. 1998, 63, 8922.

Rhodium-Catalyzed Asymmetric 1,4-Addition of 2-Alkenyl-1,3,2-benzodioxaboroles to α,β-Unsaturated Ketones
Takaya, Y.; Ogasawara, M.; Hayashi, T.  Tetrahedron Lett. 1998, 39, 8479.

Palladium-Catalyzed Asymmetric Allylic Substitution in Aqueous Media Using Amphiphilic Resin-Supported MOP Ligands
Uozumi, Y.; Danjo, H.; Hayashi, T.  Tetrahedron Lett. 1998, 39, 8303.

Cyclization of o-Allylstyrene via Hydrosilylation: Mechanistic Aspects of Hydrosilylation of Styrenes Catalyzed by Palladium-Phosphine Complexes
Uozumi, Y.; Tsuji, H.; Hayashi, T.  J. Org. Chem. 1998, 63, 6137.

Cationic Palladium-boxax Complexes for Catalytic Asymmetric Wacker-Type Cyclization
Uozumi, Y.; Kato, K.; Hayashi, T.  J. Org. Chem. 1998, 63, 5071.

Synthesis and Application of Novel Chiral Phosphino-Oxazoline Ligands with 1,1'-Binaphthyl Skeleton
Ogasawara, M.; Yoshida, K.; Kamei, H.; Kato, K.; Uozumi, Y.; Hayashi, T.  Tetrahedron Asymmetry 1998, 9, 1779.

Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl- and Alkenylboronic Acids to Enones
Takaya, Y.; Ogasawara, M.; Hayashi, T.; Sakai, M.; Miyaura, N.  J. Am. Chem. Soc. 1998, 120, 5579.

Asymmetric Aza-Claisen Rearrangement of Allyl Imidates Catalyzed by Homochiral Cationic Palladium(II) Complexes
Uozumi, Y.; Kato, K.; Hayashi, T.  Tetrahedron Asymmetry 1998, 9, 1065.

Retention of RegiochemistR.f Allylic Esters in Palladium-Catalyzed Allylic Alkylation in the Presence of a MOP Ligand
Hayashi, T.; Kawatsura, M.; Uozumi, Y.  J. Am. Chem. Soc. 1998, 120, 1681.

Regiocontrol in Palladium-Catalysed Allylic Alkylation by Addition of Lithium Iodide
Kawatsura, M.; Uozumi, Y.; Hayashi, T.  Chem. Commun. 1998, 217.

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