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Department of Chemistry, Graduate School of Science, Kyoto University
 

Mikiko SODEOKA (Professor)

Field of Expertise:
Synthetic Organic Chemistry,
Chemical Biology,
Organometallic Chemistry,
Medicinal Chemistry
Research Interests:
  1. Development of new and efficient reactions and methodologies for the synthesis of bioactive molecules.
  2. Design and synthesis of novel intracellular signal transduction modulators.
  3. Cell biology research using bioactive molecules and chemical methodologies.
Recent Papers:
  1. E. Iwasa, Y. Hamashima, S. Fujishiro, E. Higuchi, A. Ito, M. Yoshida, and M. Sodeoka, “Total Synthesis of (+)-Chaetocin and its Analogs: Their Histone Methyltransferase G9a Inhibitory Activity”, J. Am. Chem. Soc. 132, 4078-4079 (2010).
  2. A. Nakamura, S. Lectard, D. Hashizume, Y. Hamashima, and M. Sodeoka, “Diastereo- and Enantioselective Conjugate Addition of α-Ketoesters to Nitroalkenes Catalyzed by Chiral Ni(OAc)2 Complex under Mild Conditions”, J. Am. Chem. Soc. 132, 4036-4037 (2010).
  3. M. Sodeoka and K. Dodo, “Development of Selective Inhibitors of Necrosis”, Chemical Record, 10, 308-314 (2010).
  4. M. Ohkubo, G. Hirai, and M. Sodeoka, “Synthesis of DFGH-ring System of Type B Physalins: A Characteristic Highly Oxygen-functionalized and Cage-shaped Molecule”, Angew. Chem. Int. Ed. 48, 3862-3866 (2009).
  5. N. Umebayashi, Y. Hamashima, D. Hashizume, and M. Sodeoka, “Catalytic Enantioselective Aldol-type Reaction of β-Keto Esters with O,O-Acetals”, Angew. Chem. Int. Ed. 47, 4196-4199 (2008).
  6. G. Hirai, T. Watanabe, K. Yamaguchi, T. Miyagi, M. Sodeoka, “Stereo-controlled and Convergent Entry to CF2-Sialosides: Synthesis of CF2-linked Ganglioside GM4”, J. Am. Chem. Soc. 129, 15420-15421 (2007).
  7. T. Suzuki, Y. Hamashima, and M. Sodeoka, “Asymmetric Fluorination of α-Arylacetic Acid Derivatives Using a Novel Catalytic System Consisting of NiCl2-BINAP/R3SiOTf/2,6-Lutidine”, Angew. Chem. Int. Ed. 46, 5435-5439 (2007).
  8. N. Sasamoto, C. Dubs, Y. Hamashima, and M. Sodeoka, “Pd(II)-Catalyzed Asymmetric Addition Reaction of Malonates to Dihydroisoquinolines”, J. Am. Chem. Soc. 12, 14010-14011 (2006).
  9. T. Suzuki, H. Takano, Y. Shimura, and M. Sodeoka, “Catalytic Enantioselective Fluorination of Oxindoles. Y. Hamashima”, J. Am. Chem. Soc. 127, 10164-10165 (2005).
  10. Y. Baba, N. Hirukawa, N. Tanohira, and M. Sodeoka, “Structure-Based Design of Highly Selective Catalytic Site-Directed Inhibitor of Ser/Thr Protein Phosphatase 2B (Calcineurin)”, J. Am. Chem. Soc., 125, 9740-9749 (2003).
Contact Information:
RIKEN Advanced Science Institute, Synthetic Organic Chemistry Laboratory,
2-1 Hirosawa, Wako, Saitama 351-0198
E-mail: sodeoka + @riken.jp
Link:
生物活性分子科学分科紹介 (internal link)
RIKEN Advanced Science Institute, Synthetic Organic Chemistry Laboratory
RIKEN Advanced Science Institute, Molecular Ligand Synthesis Research Team

This page was last modified on 05 April 2018.
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