Welcome to Sugiyama Lab

We are interested in the chemical biology of nucleic acids.Using the tools of organic chemistry, molecukar biookogy and physical chemistry, we explore the chemical priciples underlying the recognition, reactivity and structure of nucleic acids. awe certainly believe that our group is one of the most active laboratories in the world. Please visit our Research and Pubikication sections to learn more about our scientific activities. Also, you can see our lab members and staff profiles to learn more about us!



  • Mimicking Membrane-Related Biological Events by DNA Origami Nanotechnology Suzuki, Y.; Endo, M.; Sugiyama, H.ACS. Nano. In Press.
  • Small Molecule Binding to G-hairpin and Griplex: A New Insight in Anticancer Drug Design Targeting G-rich Regions Rajendran, A.; Endo, M.; Hidaka, K.; Teulade-Fichou, M.; Mergny, J, L.; Sugiyama, H.
  • Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primat Model Igarashi, J.; Fukuda, N.; Inoue, T.; Nakai, S.; Saito, K.; Fujiwara, K.; Matsuda, H.; Ueno, T.; Matsumoto, Y.; Watanabe, T.; Nagase, H.; Bando, T.; Sugiyama, H.; Itoh, T.; Soma, M.PLOS. ONE. In Press.
  • Integrating Epigenetic Modulators Into NanoScript for Enhances Chondrogenesis of Stem Cells Patel, S.; Pongkulapa, T.; Yin, P.; Pandian, G, N.; Rathnam, C.; Bando, T.; Vaijayanthi, T.; Sugiyama, H.; Lee, K, B. J. Am. Chem. Soc. In Press.
  • Self-assembling DNA Dendrimer for Effective Delivery of Immunostimulatory CpG DNA to Immune Cells Mohri, K.; Kusuki, Eri.; Ohtsuki, S.; Takahashi, N.; Endo, M.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Biomacromolecules. In Press.
  • 京都大学 物質−細胞統合システム拠点
  • 分子科学的アプローチによる遺伝子発現の制御と機構の解明
  • 京都大学理学研究科・理学部


〒 606-8502
Department of Chemistry,
Graduate School of Science Kyoto University
Kitashirakawa-Oiwakecho, Sakyo-Ku, kyoto, Japan

TEL +81-75-753-4002
FAX +81-75-753-3670