Welcome to Chemical Biology Lab

We are interested in the chemical biology of nucleic acids. Using the tools of organic chemistry, molecular biology and physical chemistry, we explore the chemical principles underlying the recognition, reactivity and structure of nucleic acids. We certainly believe
that our group is one of the most active laboratories in the world. Please visit our Research
and Publication sections to learn more about our scientific activities. Also, you can see our
lab menbers and staff profiles to learn more about us!





  • 509. RUNX-targeted “Gene Switch Technology” Regulates Glioblastoma
    Hattori, E. Y.; Arakawa, Y.; Mineharu, Y.; Mikami, M.; Terada, Y.; Matsui, Y.; Masuda, T.; Kubota, H.; Hidemasa Matsuo, H.; Masahiro Hirata, M.; Kataoka, T. R.; Nakahata, T.; Ikeda, S.; Sugiyama, H.; Souichi Adachi, S.; Miyamoto, S.; Kamikubo, Y.
    Communication Biology, in press
  • 508. Artificial Intelligence in Microbial Natural Product Drug Discovery: Current and Emerging Role
    Sahayasheela, V. J.; Lankadasari, M. B.; Dan, V. M.; Dastager, S. G.; Pandian, G. N.; Sugiyama, H.
    Natural Product Reports, in press
  • 507. DNA-Based Daisy Chain Rotaxane Nanocomposite Hydrogels as Dual-Programmable Dynamic Scaffolds for Stem Cell Adhesion
    Yao, S.; Chang, Y.; Zhai, Z.; Sugiyama, H.; Endo, M.; Zhu, W.; Xu, Y.; Yang, Y.; Qian, X.
    ACS Appl. Mater. Interfaces, 2022, 14, 20739-20748
  • 506. RUNX1-Survivin Axis as a Novel Therapeutic Target for Malignant Rhabdoid Tumor
    Mikami, M.; Masuda, T.; Kanatani, T.; Noura, M.; Umeda, K.; Hiramatsu, H.; Kubota, H.; Daifu, T.; Iwai, A.; Hattori, E.; Furuichi, K.; Takasaki, S.; Tanaka, S.; Matsui, Y.; Matsuo, H.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Kuwahara, Y.; Iehara, T.; Hosoi, H.; Takita, J.; Sugiyama, H.; Adachi, S.; Kamikubo, Y.
    BBRC, in press
  • 505. Chlorambucil-conjugated PI-polyamides (Chb-M’), a Transcription Inhibitor of RUNX Family, Has an Anti-tumor Activity Against SHH-type Medulloblastoma with p53 Mutation
    Matsui, Y.; Mineharu, Y.; Noguchi, Y.; Yamamoto-Hattori, E.; Kubota, H.; Hirata, M.; Miyamoto, S.; Sugiyama, H.; Kamikubo, Y.
    Molecules and Cells, in press
  • 504. A Box-shaped Ribozyme Octamer Formed by Face-to-face Dimerization of a Pair of Square-shaped Ribozyme Tetramers
    Islam, M. D.; Hidaka, K.; Suzuki, Y.; Sugiyama, H,; Endo, M.; Matsumura, S.; Ikawa, Y.
    J. Biosci. Bioeng., in press
  • 503. N-terminal Cationic Modification of Linear Pyrrole-Imidazole Polyamide Improves its Binding
    Hatanaka, J.; Hirose, Y.; Hashiya, K.; Bando, B.; Sugiyama, H.
    ChemBioChem, in press
  • 502. Characterization of 2-Fluoro-2’-deoxyadenosine in Duplex, G-quadruplex and I-motif
    Hirashima, S.; Sugiyama, H.; Park, S.
    ChemBioChem, in press
  • 501. An Informatics Approach to Distinguish RNA Modifications in Nanopore Direct RNA Sequencing
    Ramasamy, S.; Mishra, S.; Sharma, S.; Parimalam, S. S.; Thangavel, V.; Fujita, Y.; Kovi, B.; Sugiyama, H.; Pandian, G. N.
    Genomics, in press
  • 500. Targeting Chemoresistance in Xp11.2 Translocation Renal Cell Carcinoma using a Novel Polyamide-chlorambucil Conjugate.
    Funasaki, S.; Mehanna, S.; Ma, W.; Nishizawa, H.; Kamikubo, Y.; Sugiyama, H.; Ikeda, S.; Motoshima, T.; Hasumi, H.; Linehan, W. M.; Schmit, L.S.; Ricketts, C.; Suda, T.; Oike, Y. Kamba, T.; Baba, M.
    Cancer Science, in press
  • 499. Harnessing DNA as a Designable Scaffold for Asymmetric Catalysis: Recent Advances and Future Perspectives
    Yum, J. H.; Sugiyama, H.; Park, S.
    Chemical Record, 2022, 22, e202100333.
  • 498. Inhibition of GLI-mediated Transcription by Cyclic Pyrrole-Imidazole Polyamide in Cancer Stem Cells.
    Sahayasheela, V. J.; Yu, Z.; Hirose, Y.; Pandian, G. N.; Bando, T.; Sugiyama, H.
    Bull. Chem. Soc. J., in press
  • 497. Tumor Accumulation of PIP-based KRAS Inhibitor KR12 Evaluated by the Use of a Simple, Versatile Chicken Egg Tumor Model.
    Higashi, Y.; Ikeda, S.; Matsumoto, K.; Satoh, S.; Komatsu, A.; Sugiyama, H.; Tamanoi, F.
    Cancers, in press
  • 496. A Hexameric Ribozyme Nanostructure Formed by Double-Decker Assembly of a Pair of Triangular Ribozyme Trimers
    Yu, K.; Hidaka, K.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y.
    ChemBioChem., 2022, 23, e202100573.
  • 495. Photo-Cross-Linking between BrU and Pyrene Residues in an RNA/DNA Hybrid
    Tashiro, R.; Yum, J. H.; Park, S.; Sugiyama, H.
    ChemBioChem., 2022, 23, e202100626.
  • 494. Single Base-Modification Reports and Locates Z-DNA Conformation on a Z-B-Chimera Formed by Topological Constraint
    Liu, M.; Cui, Y.; Zhang, Y.; An, R.; Li, L.; Park, S.; Sugiyama, H.; Liang, X.
    Bull. Chem. Soc. J., 2022, 95, 433-439.
  • 493. Dissection of Nanoconfinement and Proximity Effects on the Binding Events in DNA Origami Nanocavity.
    Jonchhe, S.; Pandey, S.; Beneze, C.; Emura, T.; Sugiyama, H.; Endo, M.; Mao, H.
    Nucleic Acids Res., 2022, 50, 697-703.
  • 492. Enhanced Immunostimulatory Activity of Covalent DNA Dendrons
    Kawamoto, Y.; Liu, W.; Yum, J. H.; Park, S.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.
    ChemBioChem., 2022, 23, e202100583.
  • 491. RUNX1 Transactivates BCR-ABL1 Expression in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
    Masuda, T.; Maeda, S.; Shimada, S. ; Sakuramoto, N.; Morita, K.; Koyama, A.; Suzuki, K.; Mitsuda, Y.; Matsuo, H.; Kubota, H.; Kato, I.; Tanaka, K.; Takita, J.; Hirata, M.; Karaoke, T.; Nakahata, T.; Adachi, S.; Hirai, H.; Mizuta, S.; Naka, K.; Imai, Y.; Kimura, S.; Sugiyama, H.; Kamikubo, Y.
    Cancer Science, 2022, 113, 529-539.
  • 490. Photoswitchable Single-Stranded DNA-Peptide Coacervate Formation as a Dynamic System for Reaction Control
    Wee, W. A.; Sugiyama, H.; Park, S.
    iScience, in press
  • 489. Strong and Specific Recognition of CAG/CTG Repeat DNA (5’-dWGCWGCW-3’) by a Cyclic Pyrrole–Imidazole Polyamide
    Hirose, Y.; Ohno, T.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H.
    ChemBioChem., 2022, 23, e202100533 (1-5).
  • 488. Biomimetic DNA Nanotechnology to Understand and Control Cellular Responses
    Sethi, S.; Sugiyama, H.; Endo, M.
    ChemBioChem., 2022, 23, e202100446.
  • 487. Single-Molecule Visualization of B-Z Transition in DNA Origami using High-Speed AFM
    Endo, M; Sugiyama H.
    Z-DNA Methods and Protocols. Methods in Molecular Biology K. Kim and V. Subramani Ed., in press
  • 486. Photoreaction of DNA Containing 5-Halouracil and its Products
    Tashiro, R.; Sugiyama, H.
    Photochemistry and Photobiology, 2022, 98, 532-545.
  • 485. Targeted Epigenetic Induction of Mitochondrial Biogenesis Enhances Antitumor Immunity in Mouse Model
    Matinee M.; Pandian, G. N.; Sugiyama, H.
    Cell Chem. Biol., 2022, 29, 463-475.
  • 484. Targeted Elimination of Mutated Mitochondrial DNA by a Multi-functional Conjugate Capable of Sequence-specific Adenine Alkylation
    Hidaka, T.; Hashiya, K.; Bando, T.; Pandian, G. N.; Sugiyama, H.
    Cell Chem. Biol., 2022, 29, 1-6.
  • 483. Telomere-Specific Chromatin Capture using a Pyrrole–Imidazole Polyamide Probe for the Identification of Proteins and Non-Coding RNAs.
    Ide, S.; Sasaki, A.; Kawamoto, Y.; Bando, T.; Sugiyama, H.; Maeshima, K.
    Epigenetics & Chromatin, 2021, 14, 46.
  • 482. Photo-controllable Phase Transition of Arylazopyrazole-conjugated Oligonucleotides
    Hidaka,T.; Wee, W. A.; Yum, J. H.; Sugiyama, H.; Park, S.
    Bioconjugate Chem., 2021, 32, 2129-2133.
  • 481. Characterization of a Conformation-restricted Amyloid β Peptide and Immunoreactivity of its Antibody in Human AD Brain
    Kageyama, Y.; Irie, Y.; Matsushima, Y.; Segawa, T.; Bellier, J.-P.; Hidaka, K.; Sugiyama, H.; Kaneda, D.; Hashizume, Y.; Akatsu, H.; Miki, K.; Kita, A.; Walker, D. ; Irie, K.; Tooyama, I.
    ACS Chemical Neuroscience, 2021, 12, 3418-3432.
  • 480. Integrated Analysis of Immune-related Gene Subtype and Immune Index for Immunotherapy in Clear Cell Renal Cell Carcinoma
    Bai, D.; Chen, S.; Feng, H.; Yin, A.; Lu, J.; Ma, Y.; Sugiyama, H.
    Pathol. Res. Pract., in press
  • 479. Genomic Analysis Uncovers Prognostic and Immunogenic Characteristics of Ferroptosis for Clear Cell Renal Cell Carcinoma
    Bai, D.; Feng, H.; Yang, J.; Yin, A.; Lin, X.; Qian, A.; Sugiyama, H.
    Mol. Ther. Nucleic Acids, in press
  • 478. A Novel Method for Locating Nucleosomes by Exploiting 5-Bromouracil, Pyrene-Modified Histone, and Photoirradiation
    Hashiya, F., Sugiyama, H.
    Photomedicine and Photobiology, 2021, 42, 13-16.
  • 477. Flexible Assembly of Engineered Tetrahymena Ribozymes Forming Polygonal RNA Nanostructures with Catalytic Ability
    Mori, Y.; Oi, H.; Suzuki, Y.; Hidaka, K.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y.
    ChemBioChem.,2021, 22, 2168-2176.
  • 476. Short Intrinsically Disordered Polypeptide-Oligonucleotide Conjugates for Programmed Self-assembly of Nanospheres with Temperature-dependent Size Controllability
    Wang, B.; Pan, R.; Zhu, W.; Xu, Y.; Tian, Y.; Endo, M.; Sugiyama, H.; Yang, Y.; Qian, X.
    Soft Matter, 2021, 17, 1184-11886.
  • 475. Tropylium Derivatives as New Entrants that Sence G-quadruplex Structures
    Hori, D.; Yum, J. H.; Sugiyama, H.; Park, S.
    Bull. Chem. Soc. J., 2021, DOI: 10.1246/bcsj.20210123.
  • 474. Impact of Reactive Oxygen Species and G-Quadruplexes in Telomeres and Mitochondri
    Malinee, M.; Sugiyama, H
    Creative Complex Systems, Springer Book, Nishimura, K.; Murase, M.; Yoshimura, K. ed. Creative Complex Systems, 2021, 249-274.
  • 473. RUNX Inhibitor Suppresses Graft-versus-host Disease through Targeting RUNX-NFATC2 Axi
    Kubota, H.; Masuda, T.; Noura, M.; Furuichi, K.; Matsuo, H.; Hirata, M.; Kataoka, T.; Hiramatsu, H.; Yasumi, T.; Nakahata, T.; Imai, Y.; Takita, J.; Adachi, S.; Sugiyama, H.; Kamikubo, Y.
    eJHaem., 2021, DOI: 10.1002/jha2.230.
  • 472. Discovery of Pyrrole-imidazole Polyamides as PD-L1 Expression Inhibitors and Their Anticancer Activity via Immune and Nonimmune Pathways
    Wang, M.; Ma, X.; Zhou, K.; Mao, H.; Liu, J.; Xiong, X.; Zhao, X.; Narva, S.; Tanaka, Y.; Wu, Y.; Guo, C.; Sugiyama, H.; Zhang, W.
    J. Med. Chem., 2021, 64, 6021-6036.
  • 471. Non-invasive Regulation of Cellular Morphology Using a Photoswitchable Mechanical DNA Polyme
    Sethi, S.; Hidaka, K.; Sugiyama, H.; Endo, M.
    Angew. Chem. Int. Ed., 2021, 60, 20342-20349.
  • 470. Construction of an Optically Controllable CRISPR-Cas9 System using a DNA Origami Nanostructure
    Abe, K.; Sugiyama, H.; Endo, M.
    Chem. Commun., 2021, 57, 5594-5596.
  • 469. Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs
    Hidaka, T.; Sugiyama, H.; Pandian, G. N.
    Methods Mol. Biol., 2021, 2275, 217-225.
  • 468. Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin
    Yum, J. H.; Ishizuka, T.; Fukumoto, K.; Hori, D.; Bao, H. L.; Xu, Y.; Sugiyama, H.; Park, S.
    ACS Biomater. Sci. Eng., 2021, 1338-1343.
  • 467. Landscape of Immune Cell Infiltration in Clear Cell Renal Cell Carcinoma to Aid Immunotherapy
    Bai, D.; Feng, H.; Yang, J.; Yin, A.; Qian, A.; Sugiyama, H.
    Cancer Science, 2021, 112, 2126-2139.
  • 466. HBD1 Protein with a Tandem Repeat of Two HMG Box Domains is a DNA Clip to Organize Chloroplast Nucleoids in Chlamydomonas Reinhardtii
    Takusagawa, M.; Kobayashi, Y.; Fukao, Y.; Hidaka, K.; Endo, M.; Sugiyama, H.; Yamaji, T.; Kato, Y.; Miyakawa, I.; Misumi, O.; Shikanai, T.; Nishimura, Y.
    Proc. Natl. Acad. Sci. USA., 2021, 118, , 118 (20) e2021053118.
  • 465. An RNA Triangle with Six Ribozyme Units can Promote a Trans-splicing Reaction through Trimerization of Unit Ribozyme Dimers
    Akagi, J.; Yamada, T.; Hidaka, K.; Fujita, Y.; Saito, H.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y.
    Applied Sciences, 2021, 11, 2583.
  • 464. Synthesis and Application of a 19F-labeled Fluorescent Nucleoside as a Dual-mode Probe for i-Motif DNAs
    Wee, W. A.; Yum, J. H.; Hirashima, S.; Sugiyama, H.; Park, S.
    RSC Chem. Biol. in press
  • 463. Nanoscopic Observation of a DNA Crystal Surface and Its Dynamic Formation and Degradation Using Atomic Force Microscopy
    Eki, H.; Abe, K.; Sugiyama, H.; Endo, M.
    Chem. Commun. 2021, 57, 1651-1654.
  • 462. Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment
    Maeda, R.; Bando, T.; Sugiyama, H.
    ChemBioChem in press
  • 461. Chemical Approaches to the Development of Artificial Transcription Factors Based on Pyrrole-Imidazole Polyamides
    Hidaka, T.; Sugiyama, H.
    Chemical Record in press
  • 460. Designing Biomimicking Synthetic Transcription Factors for Therapeutic Gene Modulation
    Pandian, G. N.; Sugiyama, H.
    Cell-Inspired Materials and Engineering, Springer Book, 2021, 135-161.
  • 459. CGG Repeat RNA G-quadruplexes Interact with FMRpolyG to Cause Neuronal Dysfunction in Fragile X-related Tremor/ataxia Syndrome
    Asamitsu, S.; Yabuki, Y.; Ikenoshita, S.; Kawakubo, K.; Kawasaki, M.; Usuki, S.; Nakayama, Y.; Adachi, K.; Kugoh, H.; Ishii, K.; Matsuura, T.; Nanba, E.; Sugiyama, H.; Fukunaga, K.; Shioda, N.
    Science Advances 2021, 7, eabd9440.
  • 458. Combined Use of Chemically Modified Nucleobases and Nanostructured DNA for Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide
    Araie, Y.; Ohtsuki, S.; Park, S.; Nagaoka, M.; Umemura, K.; Sugiyama, H.; Kusamori, K.; Takahashi, Y.; Takakura, Y.; Nishikawa, M.
    Bioorg. Med. Chem. 2021, 29, 115864.
  • 457. Evaluation of the DNA Alkylation Properties of a Chlorambucil-Conjugated Cyclic Pyrrole–Imidazole Polyamide
    Hirose, Y.; Hashiya, K.; Bando, T.; Sugiyama, H.
    Chem. Eur. J. 2021, 27, 2782-2788.
  • 456. Photocontrolled DNA Origami Assembly using Two Photoswitches
    Mishra, S.; Park, S.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M.
    Chem. Eur. J. 2021, 27, 778-784.
  • 455. Nucleosomes and Epigenetics from a Chemical Perspective
    Feng, Y.; Endo, M.; Sugiyama, H.
    ChemBioChem. 2021, 22, 595-612.
  • 454. Targeted Epigenetic Modulation using a DNA-based Histone Deacetylase Inhibitor Enhances Cardiomyogenesis in Mouse Embryonic Stem Cells
    Lee, J. A.; An, J.; Taniguchi, J.; Kashiwazaki, G.; Pandian, G. P.; Parveen, N.; Kang, T. M.; Sugiyama, H.; Kim K. K.
    J. Cell. Phys. 2021, 236, 3946-3962.
  • 453. Suppression of Malignant Rhabdoid Tumors through Chb-M’-mediated RUNX1 Inhibition
    Daifu, T.; Mikami, M.; Hiramatsu, H.; Iwai, A.; Umeda, K.; Noura, M.; Kubota, H.; Matsuda, T.; Furuichi, K.; Takasaki, S.; Noguchi, Y.; Morita, K.; Bando, T.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Kuwahara, Y.; Iehara, T.; Hosoi, H.; Takita, J.; Sugiyama, H.; Adachi, S.; Kamikubo, Y.
    Pediatric Blood & Cancer 2020, DOI: 10.1002/pbc.28789.
  • 452. A Near-Infrared Fluorogenic Pyrrole-Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres
    Tsubono, Y.; Kawamoto, Y.; Hidaka, T.; Pandian, G.; Hashiya, K.; Bando, T.; Sugiyama, H.
    J. Am. Chem. Soc. 2020, 142, 17356-17363.
  • 451. Differentially Expressed Goes on the Growth of Mouse Leydig Cells Treated with Standardized Eurycoma Longifolia Extract
    Ahmed, N. A. K; Lim, S. K.; Pandian, G. N.; Sugiyama, H.; Lee, C. Y.; Khoo, B. Y.; Chan, K. L.
    Molecular Medicine Reports 2020, DOI: 10.3892/mmr.2020.11485.
  • 450. Construction of a FRET System in a Double-Stranded DNA Using Fluorescent Thymidine and Cytidine Analogs
    Hirashima, S.; Sugiyama, H.; Park, S.
    J. Phys. Chem. B 2020, 124, 8794-8800.
  • 449. Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of Tri-arginine Vector
    Hidaka, T.; Tsubono, Y.; Hashiya, K.; Bando, T.; Pandian, G. N.; Sugiyama, H.
    Chem. Commun. 2020, 56, 12371-12374.
  • 448. Modular Quadruplex-Duplex Hybrids as Biomolecular Scaffolds for Asymmetric Michael Addition Reactions
    Yum, J. H.; Sugiyama, H.; Park, S.
    Org. Biomol. Chem. 2020, 18, 6812-6817.
  • 447. Direct Observation of Dynamic Interactions between Orientation-Controlled Nucleosomes in a DNA Origami Frame
    Feng, Y.; Hashiya, F.; Hidaka, K.; Sugiyama, H.; Endo, M.
    Chem. Eur. J. 2020, 26, 15282-15289.
  • 446. Design, Synthesis and Anti-Cancer Activity of Pyrrole-Imidazole Polyamides through Target-Downregulation of c-Kit Gene Expression
    Zhang, M.; Liang, J.; Jiang, S-K.; Xu, L.; Wu, Y-L.; Awadasseid, A.; Zhao, X-Y.; Xiong, X-Q.; Sugiyama, H.; Zhang, W.
    Eur. J. Med. Chem. 2020, 207, 112704.
  • 445. DNA Alkylation of the RUNX-binding Sequence by CBI-PI Polyamides Conjugates
    Maeda, R.; Ito, S.; Hashiya, K.; Bando, T.; Sugiyama, H.
    Chem. Eur. J. 2020, 26, 14639-14644.
  • 444. DNA Density-dependent Uptake of DNA Origami-based Two-or Three-dimensional Nanostructures by Immune Cells
    Maezawa, T.; Ohtsuki, S.; Hidaka, K.; Sugiyama, H.; Endo, Takahashi, Y.; Takakura, Y.; Nishikawa, M.
    Nanoscale 2020, 12, 14818-14824.
  • 443. Development of Antibody-Oligonucleotide Complexes for targeting Exosomal microRNA
    Yamayoshi, A.; Oyama, S.; Kishimoto, Y.; Konishi, R.; Yamamoto, T.; Kobori, A.; Harada, H.; Ashihara, E.; Sugiyama, H.; Murakami, A.
    Pharmaceutics 2020, 12, 545.
  • 442. Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles
    Nobeyama, T.; Shigyou, K.; Nakatsuji, H.; Sugiyama, H.; Komura, N.; Ando, H.; Hamada, T.; Murakami, T.
    Langmuir 2020, 36, 7741-7746.
  • 441. Dynamic Stabilization of DNA Assembly by Using Pyrrole-Imidazole Polyamide
    Ang, Y. S.; Bando, T.; Sugiyama, H.; Yung, L. Y. L.
    ChemBioChem. 2020, 21, 2912-2915.
  • 440. X-ray Crystal Structure of a Cyclic-PIP–DNA Complex in the Reverse-binding Orientation
    Abe, K.; Hirose, Y.; Eki, H.; Takeda, K.; Bando, T.; Endo, M.; Sugiyama, H.
    J. Am. Chem. Soc. 2020, 142, 10544-10549.
  • 439. A Photocaged DNA Nanocapsule for Delivery and Manipulation in Cells
    Feng, Y.; Tohgasaki, T.; Shitomi, Y.; Sugiyama, H. Endo, M.
    Methods in Enzymology 2020, 641, 329-342.
  • 438. Duplex DNA is Weakened in Nanoconfinement
    Jonchhe, S.; Pandey, S.; Karna, D.; Pokhrel, P.; Cui, Y.; Mishra, S.; Sugiyama, H.; Endo, M.; Mao, H.
    J. Am. Chem. Soc. 2020, 142, 10042-10049.
  • 437. Catalytic RNA Nano-objects Formed by Self-assembly of Group I Ribozyme Dimers Serving as Unit Structures
    Kiyooka, R.; Akagi, J.; Sugiyama, H.; Endo, M. Matsumura, S.; Ikawa, Y.
    J. Bioscience & Bioengineering 2020, 130, 253-259.
  • 436. DNA Nanostructures as a Tool for Targeted Antimicrobial Delivery
    Mela, I.; Vallejo-Raminez, P. P.; Makarchuk, S.; Christie, G.; Bailey D.; Henderson, R. M.; Sugiyama, H, Endo, M.; Kaminski, C. F.
    Angew Chem. 2020, 59, 12698-12702.
  • 435. Telomeric Quadruplexes as Therapeutic Target
    Asamitsu, S.; Shioda, N.; Sugiyama, H. Stephen Needle (eds.)
    Quadruplex nucleic acids as targets for medicinal chemistry, Part 2 Quadruplex Targets in human and other organisms.
    Elsevier 2020, 54, 77-99.
  • 434. Histidine-conjugated DNA as a Biomolecular Depot for Metal Ions
    Park, S.; Matsui, H.; Fukumoto, K.; Yum, J. H.; Sugiyama, H.
    RSC Advances 2020, 10, 9717-9722.
  • 433. Direct Observation and Analysis of TET-mediated Oxidation Processes in a DNA Origami Nanochip
    Xing, X.; Sato, S., Wong, N-K.; Hidaka, K.; S.; Sugiyama, H.; Endo, M.
    Nucleic Acids Research 2020, 48, 4041-4051.
  • 432. N1-Methylpseudouridine Substitution Enhances the Performance of Synthetic mRNA Switches in Cells
    Parr, C.; Wada, S.; Kotake, K.; Kameda, S.; Matsuura, S.; Sakashita, S.; Park, S.; Sugiyama, H.; Kuang, Y.; Saito, H.
    Nucleic Acids Research 2020, 48, e35.
  • 431. A Synthetic Transcription Factor Pair Mimic for Precise Recruitment of an Epigenetic Modifier to the Targeted DNA Locus
    Yu, Z.; Ai, M; Samanta, S. K.; Hashiya, F.; Taniguchi, J.; Asamitsu, S.; Ikeda, S.; Hashiya, K.; Bando, T.; Pandian, G. N.; Isaacs, L.; Sugiyama, H.
    Chem. Comm. 2020, 56, 2296-2299.
  • 430. Targeted Suppression of Metastasis Regulatory Transcription Factor SOX2 in Various Cancer Cell Lines using a Sequence-specific Designer Pyrrole-imidazole Polyamide
    Malinee, M.; Kumar, A.; Hidaka, T.; Hirose, M.; Hasegawa, K.; Namasivayam, P. G.; Sugiyama, H.
    Bioorg. Med. Chem. 2020, 28, 115248.
  • 429. Advances in DNA Origami-Cell Interfaces
    Mishra, S.; Feng, Y.; Endo, M.; Sugiyama, H.
    ChemBioChem. 2020, 21, 33-44.
  • 428. Sequence-specific PI Polyamides Make It Possible to Regulate DNA Structure and Function
    Bando, T.; Sugiyama, H.
    Bull. Chem. Soc. J. 2020, 93, 205-215.


〒 606-8502
Department of Chemistry,
Graduate School of Science Kyoto University
Kitashirakawa-Oiwakecho, Sakyo-Ku, kyoto, Japan

TEL +81-75-753-4002
FAX +81-75-753-3670