Welcome to Sugiyama Lab

We are interested in the chemical biology of nucleic acids. Using the tools of organic chemistry, molecular biology and physical chemistry, we explore the chemical principles underlying the recognition, reactivity and structure of nucleic acids. We certainly believe that our group is one of the most active laboratories in the world. Please visit our Research and Publication sections to learn more about our scientific activities. Also, you can see our lab members and staff profiles to learn more about us!

Welcome to Sugiyama Lab

publications

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  • 316. Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulator Nucleic Acids to Immune Cells Ohtsuki, S.; Matsuzaki, N.; Mohri, K.; Endo, M.; Emura, T.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Ishiyama, K.; Kadowaki, N.; Takakura, Y.; Nishikawa, M. Nucleic Acid Therapeutics. In Press.
  • 315. Linking Two DNA Duplexes with a Rigid Linker for DNA Nanotechnology Tashiro, R.; Iwamoto, M.; Morinaga, H.; Emura, T.; Hidaka, K.; Endo, M.; Sugiyama, H. Nucleic Acids Res. In Press.
  • 314. Folding RNA-Protein Complex into Designed Nanostructures. Shibata, T.; Suzuki, Y.; Sugiyama, H.; Endo, M; Saito, H. Methods in Molecular Biology. 2015, 1316, 169-179.
  • 313. Single-Molecule Visualization of the Zn2+ Dependent DNAzyme Functions. Endo, M.; Takeuchi, Y.; Suzuki, Y.; Emura, T; Hidaka, K; Wang, F; Willner, I; Sugiyama, H. Angew. Chem. Int. Ed. In Press.
  • 312. Detection of UV-induced Cyclobutane Primidine Dimers by Near-infared Spectroscopy and Aquaphotomics. Goto, N.; Bazar, G.; Kovacs, Z.; Kunusada, M.; Morita, H.; Kizaki, .S; Sugiyam, H.; Tesenkova, R.; Nishigori, C. Sci. Rep. In Press.
  • 311. Studying RNAP-promoter Interactions Using Atomic Force Microscopy. Suzuki, Y.; Endo, M.; Sugiyama, H. Methods. In Press.
  • 310. A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network. Han, L.; Pandian, G, N.; Chandran, A.; Sato, S.; Taniguchi, J.; Kashiwazaki, G.; Sawatani, Y.; Hashiya, K.; Bando, T.; Xu, Y.; Qian, X,; Sugiyama, H. Angew. Chem. Int. Ed. In Press.
  • 309. A Synthetic Transcriptional Activator of Genes Associated with Retina in Human Dermal Fibroblasts. Syed, J.; Chandran, A.; Pandian, G, N.; Taniguchi, J.; Sato, S.; Hashiya, K.; Kashiwazaki, G.; Bando, T.; Sugiyama, H. ChemBioChem. In Press.