京都大学理学研究科化学専攻杉山研究室（生物化学　Chemical Biology）

Welcome to Sugiyama Lab

2018.10

化学のフロンティアのレポート用資料はこちらになります。
日本語で作成しても大丈夫です。
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2018-2019

生体分子機能論の講義資料はこちらになります。
10.15
10.22
10.29
11.5
11.12
11.19
12.10
12.17
1.7
1.21
2018.11
第45回国際核酸化学シンポジウムを開催します。
Paper Application (発表申込)2018.08.24 (金)までです。
2018.07.20
杉山弘教授が第40回日本光医学・光生物学会　学会賞を受賞しました。
2018.07.06
朴先生が第10回資生堂(Shiseido)女性研究者サイエンスグラントの受賞者代表として招待公演をしました。

http://www.shiseidogroup.jp/rd/doctor/grants/science/
2018.03.20
杉山弘教授が第７０回日本化学会賞受賞しました。
2018.02.09
第4回生体分子科学シンポジウムを開催しました。
2017.7

朴先生が第10回資生堂(Shiseido)女性研究者サイエンスグラントを受賞しました。
“生物化学、DNAのらせん構造に基づく金属酵素の開発と不斉合成への反応（DNAの二重らせん構造に基づくバイオハイブリッド触媒を開発し、それを利用して有用な化合物を合成します）"
http://www.nikkei.com/article/DGXLASDZ07HFZ_X00C17A7000000
2017.3

河本佑介さん(D2)が日本化学会第97春季年会で口頭発表を行い、学生講演賞を受賞しました。
“Visualization of human telomeres with pyrrole-imidazole polyamides targeting human telomeric repeats”
2017.1

杉山先生の御還暦をお祝いして、リーガロイヤルホテル京都にて還暦お祝いの会を開催しました。
2017.1

岡村和泉さん（M2）の論文がChemistry Letters誌のEditor's Choiceに選定されました。
http://www.journal.csj.jp/doi/abs/10.1246/cl.161024
2016.12

日高拓也さん(M1)が第39回日本分子生物学会年会でポスター発表を行い、優秀ポスター賞を受賞しました。
"ミトコンドリアDNAを標的とした配列選択的DNA結合能を有する機能性分子の開発"
2016.11

河本佑介さん(D2)がProf. Hanbin Mao (Kent State University, USA)の研究室を訪問しました。
2016.8

Anandhakumar Chandran さん(PD)が Puthiya Thalaimurai Tamizhan award 2016 science 部門を受賞しました。
2016.6

河本佑介さん(D2)と谷口純一(D2)さんがGordon Research Conference -Bioorganic Chemistry- (Andover, USA)でポスター発表を行いました。
2016.3

柏﨑玄伍さん(PD)が日本化学会第96春季年会で口頭発表を行い、学術講演賞を受賞しました。"Comparison of DNA-Binding Selectivities of PI Polyamides with Different Designs by a Next-Generation Sequencer"
2016.3

延山知弘さん(M1)が新学術領域「分子ロボティクス」領域会議において、若手ディスカッション賞を受賞しました。
2016.3

木崎誠一朗さん(D2)がProf. Thomas Carell (Ludwig Maximilian University of Munich, Germany), Prof. Marie-Paule Teulade-Fichou (Curie Institute, France), Prof. Andreas Marx (University of Konstanz, Germany), Prof. Shana Sturla (ETH Zurich, Switzerland)の研究室を訪問しました。

416. Direct Observation and Analysis of the Dynamics of the Photoresponsive Transcription Factor GAL4
Raghavan, G.; Hidaka, K.; Sugiyama, H.; Endo, M.
Angew. Chem. in press
415. A Photocaged DNA Nanocapsule for Controlled Unlocking and Opening inside the Cell
Tohgasaki, T.; Shitomi, Y. Feng, Y.; Honna, S.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M.
Bioconjugate Chem. in press
414. Submolecular Dissection Reveals Strong and Specific Binding of Polyamide-Pyridostatin Conjugates to Human Telomere Interface
Mandal, S.; Kawamoto, Y.; Yue, Z.; Hashiya, K.; Cui Y.; Bando, T.; Sugiyama, H.; Mao, H.
Nucleic Acids Res. in press
413. Modular DNA-based Hybrid Catalysts as a Toolbox for Enantioselective Hydration of α,β-Unsaturated Ketones
Yum, J. H.; Park, S.; Hiraga, R.; Okamura, I.; Notsu, S.; Sugiyama, H.
Org. and Biomol. Chem. 2019, 17, 2548-2553.
412. Therapeutic Gene Regulation using Pyrrole-Imidazole Polyamides
Yu, Z.; Pandian, G. N.; Hidaka, T.; Sugiyama, H.
Adv. Drug Deliv. Rev. in press
411. Recent Progress of Specific G-quadruplex-Preferred Ligands Toward Cancer Therapy
Asamitsu, S.; Obata, S.; Yu, Z.; Bando, T.; Sugiyama, H.
Molecules 2019, 24, 429.
410. Molecular Characteristics of DNA-Alkylating PI Polyamides Targeting RUNX Transcription Factors
Maeda, R.; Sato, S.; Ohno, T.; Kashiwazaki, G.; Obata, S.; Hashiya, K.; Bando, T.; Sugiyama, H.
J. Am. Chem. Soc. 2019, 141, 4257-4263.
409. Chemical and Photobiological Study of the Structures and Functions of DNA
Sugiyama, H.
Photomedicine and Photobiology in press
408. Direct Observation of the Double-Stranded DNA Formation through Metal Ion-Mediated Base Pairing in the Nanoscale Structure
Xing, X.; Feng, Y.; Yu, Z.; Hidaka, K.; Liu F.; Ono, A.; Sugiyama, H.; Endo, M.
Chem. E. J. 2019, 25, 1446-1450.
407. Electron Injection from Mitochondrial Transcription Factor A to DNA Associated with Thymine Dimer Photo Repair
Hashiya, F.; Ito, S.; Sugiyama, H.
Bioorg. Med. Chem. 2019, 27, 278-284.
406. Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-quadruplex
Jonchhe, S.; Chimire, C.; Cui, Y.; Park, S.; Iida, K.; Nagasawa, K.; Sugiyama, H.; Mao, H.
Angew. Chem. Int. Ed. 2019, 58, 877-881.
405. Nanochannel-confined TAMRA-polypyrrole Stained DNA Stretching by Varying the Ionic Strength from Micromolar to Millimolar Concentrations
Jo, K.; Lee, S.; Lee, Y.; Kim, Y.; Wang, C.; Park, J.; Jung, G. Y.; Chen, Y. L.; Chang, R.; Ikeda, S.; Sugiyama, H.
Polymers 2019, 11, 15.
404. Ligand Design to Acquire Specificity to Intended G-quadruplex Structure
Asamitsu, S.; Bando, T.; Sugiyama, H.
Chem. Eur. J. 2019, 25, 417-430.
403. Chemical Control System of Epigenetics
Vaijayanthi, T.; Pandian G. N.; Sugiyama, H.
Chemical Records 2018, 18, 1833-1853.
402. Approach to the Investigation of Nucleosome Structure by Using the Highly Emissive Nucleobase thdG-tC FRET Pair
Han, J. H.; Park, S.; Hashiya, F.; Sugiyama, H.
Chem. Eur. J. 2018, 24, 17091-17095.
401. Sequence Preference and Structural Heterogeneity of BZ junctions
Kim, D.; Hur, J.; Han, J. H.; Ha, S. C.; Shin, D.; Lee, S.; Park, S.; Sugiyama, H.; Kim, K. K.
Nucleic Acids Research 2018, 46, 10504-10513
400. Direct Observation of Dynamic Movement of DNA Molecules in DNA Origami Imaged using High-speed AFM
Endo, M.; Sugiyama, H.
Springer Protocols. Methods in Molecular Biology 1814, Nanoscale Imaging, Lyubchenko Y. L. ed., Chapter 13 213-224.
399. Direct Observation of H3-H4 Octasome by High-Speed AFM
Zou, T.; Hashiya, F.; Wei, Y.; Yu, Z.; Ganesh, N. P.; Sugiyama, H.
Chem. Eur. J. 2018, 24, 15998-16002.
398. Decreased Water Activity in Nanoconfinement Contributes to the Folding of G-quadruplex and i-Motif Structures
Jonchhe, S.; Pander, S.; Emura, T.; Hidaka, K.; Hossain, M. A.; Shrestha, P.; Sugiyama, H. Endo, M.; Mao, H.
PNAS 2018, 115, 9539-9544.
397. Colloidal Stability of Lipid/Protein-Coated Nanomaterials in Salt and Sucrose Solutions
Nobeyama, T.; Mori, M.: Shigyou, K.; Takata, K.; Pandian, G. N.; Sugiyama, H.; Murakami T.
ChemistrySelect 2018, 3, 8325-8331.
396. DNA Origami Nanomachines
Endo, M.; Sugiyama, H.
Molecules 2018, 23, E1766.
395. Orthogonal γPNA Dimerization Domains Empower DNA Binders with Cooperativity and Versatility Mimicking that of Transcription Factor Pairs
Yu, Z.; Hsieh, W-C.; Asamitsu, S.; Hashiya, K.; Bando, T.; Ly, H. D.; Sugiyama, H.
Chem. Eur. J. 2018, 24, 14183-14188.
394. Construction of Integrated Gene Logic-chip
Masubuchi, T.; Endo, M.; Iizuka, R.; Iguchi, A.; Yoron, D. H.; Sekiguchi, T.; Qi, H.; Iinuma, R.; Miyazono, Y.; Shoji, S.; Funatsu, T.; Sugiyama, H.; Harada, Y.; Ueda, T.; Tadakuma, H.
Nature Nanotechnology 2018, 13, 933-940.
393. TAMRA-Polypyrrole for A/T Sequence Visualization on DNA Molecules
Lee, S.; Kawamoto, Y.; Thangavel, V.; Park, J.; Bae, J.; Kim-Ha, J.; Sugiyama, H.; Jo, K.
Nucleic Acids Research 2018, 46, e108.
392. Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones
Taniguchi, J.; Feng, Y.; Pandian, G.; Hashiya, F.; Hidaka, T.; Hashiya, K.; Park, S.; Bando, T.; Ito, S.; Sugiyama, H.
J. Am. Chem. Soc. 2018, 140, 7108-7115.
391. Environment-dependent Self-assembly of DNA Origami Lattices on Phase-separated Lipid Membranes
Sato, Y.; Endo, M.; Morita, M.; Takinoue, M.; Sugiyama, H.; Murata, S.; Nomura, S.; Suzuki, Y.
Adv. Mater. Interfaces 2018, 1800437.
390. RUNX1 Positively Regulates the ErbB2/HER2 Signaling Pathway through Modulating SOS1 Expression in Gastric Cancer Cells
Mitsuda, Y.; Morita, K.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Obara, M.; Hirata, M.; Kataoka, R. T.; Muto, M.; Kaneda, Y.; Nakahata, T.; Liu, P. P.; Adachi, S.; Sugiyama, H.; Kamikubo, Y.
Scientific Reports 2018, 8, 6423.
389. Complexing DNA Origami Frameworks through Sequential Self-assembly Based on Directed Docking
Suzuki, Y.; Sugiyama, H.; Endo, M.
Angew.Chem. 2018, 130, 7179-7183.
388. A Synthetic DNA-binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
Wei, Y.; Pandian, G.; Yu, Z.; Zou, T.; Li, Y.; Darokar, J.; Hashiya, K.; Bando, T.; Sugiyama, H.
ACS Omega 2018, 3, 3608-3616.
387. Pip-HoGu: an Artificial Assembly with Cooperative DNA Recognition Capable of Mimicking Transcription Factor Pairs
Yu, Z.; Guo, C.; Wei, Y.; Hashiya, K.; Bando, T.; Sugiyama, H.
J. Am. Chem. Soc. 2018, 140, 2426-2429.
386. Triggering Nucleic Acid Nanostructure Assembly by Conditional Kissing Interactions
Azema, L.; Bonnet-Salomon, S.; Endo, M.; Takeuchi, Y.; Durand, G.; Emura, T.; Hidaka, K.; Dausse, E.; Sugiyama, H.; Toulme, JJ.
Nucleic Acids Res. 2018, 46, 1052-1058.
385. Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-binding Components to a G-quadruplex and its Proximal Duplex
Asamitsu, S.; Obata, S.; Phan, A. T.; Hashiya, K.; Bando, T.; Sugiyama, H.
Chem. Eur. J. 2018, 24, 4428-4435.
384. Sequence-specific DNA Binding Pyrrole-Imidazole Polyamides and Their Applications
Kawamoto, Y.; Bando, T.; Sugiyama, H.
Bioorg. Med. Chem. 2018, 26, 1393-1411.
383. RUNX Transcription Factors Potentially Control E-Selectin Expressions in the Bone Marrow Vascular Niche of Mice
Morita, K.; Tokushige, C.; Maeda, S.; Kiyose, H.; Noura, M.; Iwai, A.; Yamada, M.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Adachi, S.; Sugiyama, H.; Kamikubo, Y.
Blood Advances 2018, 5, 509-515.
382. Targeting G-quadruplex DNA as Cognitive Function Therapy for ATR-X Syndrome
Shioda, N.; Yabuki, Y.; Yamaguchi, K.; Onozato, M.; Li, Y.; Kurosawa, K.; Tanabe, H.; Okamoto, N.; Era, T.; Sugiyama, H.; Wada, T.; Fukunaga, K.
Nature Medicine 2018, 24, 802-813.
381. DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels
Kurokawa, T.; Kiyonaka, S.; Nakata, E.; Endo, M.; Koyama, S.; Mori, E.; Tran, N. H.; Dinh, H.; Suzuki, Y.; Hidaka, K.; Kawata, M.; Sato, C.; Sugiyama, H.; Morii, T.; Mori, Y.
Angew. Chem. 2018, 57, 2586-2591.
380. Investigating Nucleosome Accessibility for MNase, Fe^II Peplomycin, and Duocarmycin B₂ by Using Capillary Electrophoresis
Zou, T.; Kizaki, S.; Sugiyama, H.
ChemBioChem. 2018, 19, 664-668.
379. G-Quadruplex Induction by the Hairpin Pyrrole-Imidazole Polyamide Dimer
Obata, S.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H.
Biochem 2018, 57, 498-502.
378. UVA Irradiation of ^BrU-Substituted DNA in The Presence of Hoechst 33258
Saha, A.; Kizaki, S.; Han, J. H.; Yu, Z.; Sugiyama, H.
Bioorg. Med. Chem. 2018, 26, 37-40.
377. Evaluation of Alkylating Pyrrole-Imidazole Polyamide Conjugates by a Novel Method for High-Throughput Sequencer
Kashiwaszaki, G.; Maeda, R.; Kawase, T.; Hashiya, K.; Bando, T.; Sugiyama, H.
Bioorg. Med. Chem. 2018, 26, 1-7.
376. Autonomous Feedback Loop of RUNX1-p53-CBFB in Acute Myeloid Leukemia Cells
Morita, K.; Noura, M.; Tokushige, C.; Maeda, S.; Kiyose, H.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Yoshida, K.; Ozaki, T.; Matsuo, H.; Ogawa, S.; Liu, P. P.; Nakahata, T.; Sugiyama, H.; Adachi, S.; Kamikubo, Y.
Sci. Reports 2017, 7, 16604.
375. Single-Molecule Observation of The Photo Regulated Conformational Dynamics of DNA Origami Nanoscissors
Willner, E.; Kamada, Y.; Suzuki, Y.; Emura, T.; Hidaka, K.; Dietz, H.; Sugiyama, H.; Endo, M.
Angew. Chem. Int. Ed. 2017, 56, 15324-15328.
374. A Combination of Visible-Light Photoredox and Metal Catalysis for the Mannich-Type Reaction of N-Aryl Glycine Esters
Okamura, I.; Park, S.;Han, J.;Notsu, S.;Sugiyama, H.
Chem. Lett. 2017, 46, 1597-1600.
373. Effective Anti-mRNA Oligonucleotides Show High Releasing Rate of MicroRNA from RNA-Inducing Silencing Complex (RISC)
Ariyoshi, J.; Matsuyama, Y.; Kobori, A.; Murakami, A; Sugiyama, H.; Yamayoshi, A.
Nucleic Acid Ther. 2017, 27, 303-308.
372. A Synthetic DNA-binding Inhibitor of SOX2 Guides Human Induced Pluripotent Stem Cells to Differentiate into Cardiac Mesoderm
Taniguchi, J.; Pandian, G.; Hidaka, T.; Hashiya, K.; Bando, T.; Kim, K. K.; Sugiyama, H.
Nucleic Acids Res. 2017, 45, 9219-9228.
371. Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately-attenuated RUNX1 expressions
Morita, K.; Maeda, S.; Suzuki, K.; Kiyose, H.; Taniguchi, J.; Liu, P.P.; Sugiyama, H.; Adachi, S.; Kamikubo, Y. , Blood Adv. 2017, 1, 1440-1451.
370. Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate
Shibata, T.; Fujita, Y.; Ohno, H.; Suzuki, Y.; Hayashi, K.; Komatsu, K.; Kawasaki, S.; Hidaka, K.; Yonehara, S.; Sugiyama, H.; Endo, M.; Saito, H., Nature Comm. 2017, 8, 540.
369. Antiproliferative and Apoptotic Activities of Sequence-Specific Histone Acetyltransferase Inhibitors
Yu, Z.; Taniguchi, J.; Wei, Y.; Pandian, G.N.; Hashiya, K.; Bando, T.; Sugiyama, H. , Eur. J. Med. Chem. 2017, 138, 320-327
368. Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression
Hidaka, T.; Pandian, G.; Taniguchi, J.; Nobeyama, T.; Hashiya, K.; Bando, T.; Sugiyama, H. , J. Am. Chem. Soc. 2017, 139, 8444-8447.
367. Copper-containing DNA-Silica Mineral Complexes for the Asymmetric Diels-Alder Reaction
Sakashita, S.; Park, S.; Sugiyama, H. Chemistry Letters. 2017, doi:10.1246/cl.170411.
366. Holliday junction resolvases mediate chloroplast nucleoid segregation
Kobayashi, Y.; Misumi, O.; Odahara, M.; Ishibashi, K.; Hirono, M.; Hidaka, K.; Endo, M.; Sugiyama, H.; Iwasaki, H.; Kuroiwa, T.; Shikanai, T.; Nishimura, Y. Science. 2017, 356, 631-634.
365. Development of a Vivid FRET System Based on a Highly Emissive dG-dC Analogue Pair
Han, J.; Yamamoto, S.; Park, S.; Sugiyama, H. Chem. Eur. J. 2017, 23, 7607-7613.