
Welcome to Chemical Biology Lab
We are interested in the chemical biology of nucleic acids. Using the tools of organic chemistry, molecular biology and physical chemistry, we explore the chemical principles underlying the recognition, reactivity and structure of nucleic acids.
We certainly believe
that our group is one of the most active laboratories in the world. Please visit our Research
and Publication sections to learn more about our scientific activities. Also, you can see our
lab menbers and staff profiles to learn more about us!

2022.3
杉山 弘教授が最終講義を行いました。
https://ocw.kyoto-u.ac.jp/course/1072/2021.12
日高拓也さんの井上研究奨励賞の受賞が決まりました。
http://kuchem.kyoto-u.ac.jp/chembio/news.html2021.10
平島 眞吾さん(D2)が第43回日本光医学・光生物学会で口頭発表を行い奨励賞を受賞しました。
http://kuchem.kyoto-u.ac.jp/chembio/news.html2021.09
がん免疫療法の効果を高めるポリアミドを開発しました。
https://www.icems.kyoto-u.ac.jp/news/4468/2021.09
ミトコンドリアの変異DNAを減らす化合物を開発しました。
https://www.icems.kyoto-u.ac.jp/news/44212021.04
掲示板を更新しました。“Web of Science Top 10% Papers”
http://kuchem.kyoto-u.ac.jp/chembio/news.html-
2021.02
平島 眞吾さん(D1)が第4回A3若手研究者ミーティングで発表しA3北京大会へ選抜されました。
http://asianprobe.jp/news/the-fourth-a3-young-scientist-meeting/ -
2020.11
453. A Near-Infrared Fluorogenic Pyrrole-Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres
Tsubono, Y.; Kawamoto, Y.; Hidaka, T.; Pandian, G.; Hashiya, K.; Bando, T.; Sugiyama, H.
J. Am. Chem. Soc. 2020, 142, 17356-17363.
の内容が紹介されました。
https://www.icems.kyoto-u.ac.jp/en/news/5646 -
2020.10
436. DNA Nanostructures as a Tool for Targeted Antimicrobial Delivery
Mela, I.; Vallejo-Raminez, P. P.; Makarchuk, S.; Christie, G.; Bailey D.; Henderson, R. M.; Sugiyama, H, Endo, M.; Kaminski, C. F.
Angew Chem. 2020, 59, 12698-12702.
の内容がYoutubeの記事になりました。 -
2020.07
朴 先生(助教)が旭硝子財団からの研究助成金を受けました。
“生物化学、DNAとアミノ酸を融合した機能性バイオハイプリッド分子の開発と応用"
- 505. Chlorambucil-conjugated PI-polyamides (Chb-M’), a Transcription Inhibitor of RUNX Family, Has an Anti-tumor Activity Against SHH-type Medulloblastoma with p53 Mutation
Matsui, Y.; Mineharu, Y.; Noguchi, Y.; Yamamoto-Hattori, E.; Kubota, H.; Hirata, M.; Miyamoto, S.; Sugiyama, H.; Kamikubo, Y.
BBRC, in press - 504. A Box-shaped Ribozyme Octamer Formed by Face-to-face Dimerization of a Pair of Square-shaped Ribozyme Tetramers
Islam, M. D.; Hidaka, K.; Suzuki, Y.; Sugiyama, H,; Endo, M.; Matsumura, S.; Ikawa, Y.
J. Biosci. Bioeng., in press - 503. N-terminal Cationic Modification of Linear Pyrrole-Imidazole Polyamide Improves its Binding
Hatanaka, J.; Hirose, Y.; Hashiya, K.; Bando, B.; Sugiyama, H.
ChemBioChem, in press - 502. Characterization of 2-Fluoro-2’-deoxyadenosine in Duplex, G-quadruplex and I-motif
Hirashima, S.; Sugiyama, H.; Park, S.
ChemBioChem, in press - 501. An Informatics Approach to Distinguish RNA Modifications in Nanopore Direct RNA Sequencing
Ramasamy, S.; Mishra, S.; Sharma, S.; Parimalam, S. S.; Thangavel, V.; Fujita, Y.; Kovi, B.; Sugiyama, H.; Pandian, G. N.
Genomics, in press - 500. Targeting Chemoresistance in Xp11.2 Translocation Renal Cell Carcinoma using a Novel Polyamide-chlorambucil Conjugate.
Funasaki, S.; Mehanna, S.; Ma, W.; Nishizawa, H.; Kamikubo, Y.; Sugiyama, H.; Ikeda, S.; Motoshima, T.; Hasumi, H.; Linehan, W. M.; Schmit, L.S.; Ricketts, C.; Suda, T.; Oike, Y. Kamba, T.; Baba, M.
Cancer Science, in press - 499. Harnessing DNA as a Designable Scaffold for Asymmetric Catalysis: Recent Advances and Future Perspectives
Yum, J. H.; Sugiyama, H.; Park, S.
Chemical Record, 2022, 22, e202100333. - 498. Inhibition of GLI-mediated Transcription by Cyclic Pyrrole-Imidazole Polyamide in Cancer Stem Cells.
Sahayasheela, V. J.; Yu, Z.; Hirose, Y.; Pandian, G. N.; Bando, T.; Sugiyama, H.
Bull. Chem. Soc. J., in press - 497. Tumor Accumulation of PIP-based KRAS Inhibitor KR12 Evaluated by the Use of a Simple, Versatile Chicken Egg Tumor Model.
Higashi, Y.; Ikeda, S.; Matsumoto, K.; Satoh, S.; Komatsu, A.; Sugiyama, H.; Tamanoi, F.
Cancers, in press - 496. A Hexameric Ribozyme Nanostructure Formed by Double-Decker Assembly of a Pair of Triangular Ribozyme Trimers
Yu, K.; Hidaka, K.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y.
ChemBioChem., 2022, 23, e202100573. - 495. Photo-Cross-Linking between BrU and Pyrene Residues in an RNA/DNA Hybrid
Tashiro, R.; Yum, J. H.; Park, S.; Sugiyama, H.
ChemBioChem., 2022, 23, e202100626. - 494. Single Base-Modification Reports and Locates Z-DNA Conformation on a Z-B-Chimera Formed by Topological Constraint
Liu, M.; Cui, Y.; Zhang, Y.; An, R.; Li, L.; Park, S.; Sugiyama, H.; Liang, X.
Bull. Chem. Soc. J., 2022, 95, 433-439. - 493. Dissection of Nanoconfinement and Proximity Effects on the Binding Events in DNA Origami Nanocavity.
Jonchhe, S.; Pandey, S.; Beneze, C.; Emura, T.; Sugiyama, H.; Endo, M.; Mao, H.
Nucleic Acids Res., 2022, 50, 697-703. - 492. Enhanced Immunostimulatory Activity of Covalent DNA Dendrons
Kawamoto, Y.; Liu, W.; Yum, J. H.; Park, S.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.
ChemBioChem., 2022, 23, e202100583. - 491. RUNX1 Transactivates BCR-ABL1 Expression in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
Masuda, T.; Maeda, S.; Shimada, S. ; Sakuramoto, N.; Morita, K.; Koyama, A.; Suzuki, K.; Mitsuda, Y.; Matsuo, H.; Kubota, H.; Kato, I.; Tanaka, K.; Takita, J.; Hirata, M.; Karaoke, T.; Nakahata, T.; Adachi, S.; Hirai, H.; Mizuta, S.; Naka, K.; Imai, Y.; Kimura, S.; Sugiyama, H.; Kamikubo, Y.
Cancer Science, 2022, 113, 529-539. - 490. Photoswitchable Single-Stranded DNA-Peptide Coacervate Formation as a Dynamic System for Reaction Control
Wee, W. A.; Sugiyama, H.; Park, S.
iScience, in press - 489. Strong and Specific Recognition of CAG/CTG Repeat DNA (5’-dWGCWGCW-3’) by a Cyclic Pyrrole–Imidazole Polyamide
Hirose, Y.; Ohno, T.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H.
ChemBioChem., 2022, 23, e202100533 (1-5). - 488. Biomimetic DNA Nanotechnology to Understand and Control Cellular Responses
Sethi, S.; Sugiyama, H.; Endo, M.
ChemBioChem., 2022, 23, e202100446. - 487. Single-Molecule Visualization of B-Z Transition in DNA Origami using High-Speed AFM
Endo, M; Sugiyama H.
Z-DNA Methods and Protocols. Methods in Molecular Biology K. Kim and V. Subramani Ed., in press - 486. Photoreaction of DNA Containing 5-Halouracil and its Products
Tashiro, R.; Sugiyama, H.
Photochemistry and Photobiology, 2022, 98, 532-545. - 485. Targeted Epigenetic Induction of Mitochondrial Biogenesis Enhances Antitumor Immunity in Mouse Model
Matinee M.; Pandian, G. N.; Sugiyama, H.
Cell Chem. Biol., 2022, 29, 463-475. - 484. Targeted Elimination of Mutated Mitochondrial DNA by a Multi-functional Conjugate Capable of Sequence-specific Adenine Alkylation
Hidaka, T.; Hashiya, K.; Bando, T.; Pandian, G. N.; Sugiyama, H.
Cell Chem. Biol., 2022, 29, 1-6. - 483. Telomere-Specific Chromatin Capture using a Pyrrole–Imidazole Polyamide Probe for the Identification of Proteins and Non-Coding RNAs.
Ide, S.; Sasaki, A.; Kawamoto, Y.; Bando, T.; Sugiyama, H.; Maeshima, K.
Epigenetics & Chromatin, 2021, 14, 46. - 482. Photo-controllable Phase Transition of Arylazopyrazole-conjugated Oligonucleotides
Hidaka,T.; Wee, W. A.; Yum, J. H.; Sugiyama, H.; Park, S.
Bioconjugate Chem., 2021, 32, 2129-2133. - 481. Characterization of a Conformation-restricted Amyloid β Peptide and Immunoreactivity of its Antibody in Human AD Brain
Kageyama, Y.; Irie, Y.; Matsushima, Y.; Segawa, T.; Bellier, J.-P.; Hidaka, K.; Sugiyama, H.; Kaneda, D.; Hashizume, Y.; Akatsu, H.; Miki, K.; Kita, A.; Walker, D. ; Irie, K.; Tooyama, I.
ACS Chemical Neuroscience, 2021, 12, 3418-3432. - 480. Integrated Analysis of Immune-related Gene Subtype and Immune Index for Immunotherapy in Clear Cell Renal Cell Carcinoma
Bai, D.; Chen, S.; Feng, H.; Yin, A.; Lu, J.; Ma, Y.; Sugiyama, H.
Pathol. Res. Pract., in press - 479. Genomic Analysis Uncovers Prognostic and Immunogenic Characteristics of Ferroptosis for Clear Cell Renal Cell Carcinoma
Bai, D.; Feng, H.; Yang, J.; Yin, A.; Lin, X.; Qian, A.; Sugiyama, H.
Mol. Ther. Nucleic Acids, in press - 478. A Novel Method for Locating Nucleosomes by Exploiting 5-Bromouracil, Pyrene-Modified Histone, and Photoirradiation
Hashiya, F., Sugiyama, H.
Photomedicine and Photobiology, 2021, 42, 13-16. - 477. Flexible Assembly of Engineered Tetrahymena Ribozymes Forming Polygonal RNA Nanostructures with Catalytic Ability
Mori, Y.; Oi, H.; Suzuki, Y.; Hidaka, K.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y.
ChemBioChem.,2021, 22, 2168-2176. - 476. Short Intrinsically Disordered Polypeptide-Oligonucleotide Conjugates for Programmed Self-assembly of Nanospheres with Temperature-dependent Size Controllability
Wang, B.; Pan, R.; Zhu, W.; Xu, Y.; Tian, Y.; Endo, M.; Sugiyama, H.; Yang, Y.; Qian, X.
Soft Matter, 2021, 17, 1184-11886. - 475. Tropylium Derivatives as New Entrants that Sence G-quadruplex Structures
Hori, D.; Yum, J. H.; Sugiyama, H.; Park, S.
Bull. Chem. Soc. J., 2021, DOI: 10.1246/bcsj.20210123. - 474. Impact of Reactive Oxygen Species and G-Quadruplexes in Telomeres and Mitochondri
Malinee, M.; Sugiyama, H
Creative Complex Systems, Springer Book, Nishimura, K.; Murase, M.; Yoshimura, K. ed. Creative Complex Systems, 2021, 249-274.
- 473. RUNX Inhibitor Suppresses Graft-versus-host Disease through Targeting RUNX-NFATC2 Axi
Kubota, H.; Masuda, T.; Noura, M.; Furuichi, K.; Matsuo, H.; Hirata, M.; Kataoka, T.; Hiramatsu, H.; Yasumi, T.; Nakahata, T.; Imai, Y.; Takita, J.; Adachi, S.; Sugiyama, H.; Kamikubo, Y.
eJHaem., 2021, DOI: 10.1002/jha2.230. - 472. Discovery of Pyrrole-imidazole Polyamides as PD-L1 Expression Inhibitors and Their Anticancer Activity via Immune and Nonimmune Pathways
Wang, M.; Ma, X.; Zhou, K.; Mao, H.; Liu, J.; Xiong, X.; Zhao, X.; Narva, S.; Tanaka, Y.; Wu, Y.; Guo, C.; Sugiyama, H.; Zhang, W.
J. Med. Chem., 2021, 64, 6021-6036. - 471. Non-invasive Regulation of Cellular Morphology Using a Photoswitchable Mechanical DNA Polyme
Sethi, S.; Hidaka, K.; Sugiyama, H.; Endo, M.
Angew. Chem. Int. Ed., 2021, 60, 20342-20349. - 470. Construction of an Optically Controllable CRISPR-Cas9 System using a DNA Origami Nanostructure
Abe, K.; Sugiyama, H.; Endo, M.
Chem. Commun., 2021, 57, 5594-5596. - 469. Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs
Hidaka, T.; Sugiyama, H.; Pandian, G. N.
Methods Mol. Biol., 2021, 2275, 217-225. - 468. Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin
Yum, J. H.; Ishizuka, T.; Fukumoto, K.; Hori, D.; Bao, H. L.; Xu, Y.; Sugiyama, H.; Park, S.
ACS Biomater. Sci. Eng., 2021, 1338-1343.
- 467. Landscape of Immune Cell Infiltration in Clear Cell Renal Cell Carcinoma to Aid Immunotherapy
Bai, D.; Feng, H.; Yang, J.; Yin, A.; Qian, A.; Sugiyama, H.
Cancer Science, 2021, 112, 2126-2139.
- 466. HBD1 Protein with a Tandem Repeat of Two HMG Box Domains is a DNA Clip to Organize Chloroplast Nucleoids in Chlamydomonas Reinhardtii
Takusagawa, M.; Kobayashi, Y.; Fukao, Y.; Hidaka, K.; Endo, M.; Sugiyama, H.; Yamaji, T.; Kato, Y.; Miyakawa, I.; Misumi, O.; Shikanai, T.; Nishimura, Y.
Proc. Natl. Acad. Sci. USA., 2021, 118, , 118 (20) e2021053118. - 465. An RNA Triangle with Six Ribozyme Units can Promote a Trans-splicing Reaction through Trimerization of Unit Ribozyme Dimers
Akagi, J.; Yamada, T.; Hidaka, K.; Fujita, Y.; Saito, H.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y.
Applied Sciences, 2021, 11, 2583. - 464. Synthesis and Application of a 19F-labeled Fluorescent Nucleoside as a Dual-mode Probe for i-Motif DNAs
Wee, W. A.; Yum, J. H.; Hirashima, S.; Sugiyama, H.; Park, S.
RSC Chem. Biol. in press - 463. Nanoscopic Observation of a DNA Crystal Surface and Its Dynamic Formation
and Degradation Using Atomic Force Microscopy
Eki, H.; Abe, K.; Sugiyama, H.; Endo, M.
Chem. Commun. 2021, 57, 1651-1654. - 462. Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment
Maeda, R.; Bando, T.; Sugiyama, H.
ChemBioChem in press - 461. Chemical Approaches to the Development of Artificial Transcription Factors Based on Pyrrole-Imidazole Polyamides
Hidaka, T.; Sugiyama, H.
Chemical Record in press - 460. Designing Biomimicking Synthetic Transcription Factors for Therapeutic Gene Modulation
Pandian, G. N.; Sugiyama, H.
Cell-Inspired Materials and Engineering, Springer Book, 2021, 135-161. - 459. CGG Repeat RNA G-quadruplexes Interact with FMRpolyG to Cause Neuronal Dysfunction in Fragile X-related Tremor/ataxia Syndrome
Asamitsu, S.; Yabuki, Y.; Ikenoshita, S.; Kawakubo, K.; Kawasaki, M.; Usuki, S.; Nakayama, Y.; Adachi, K.; Kugoh, H.; Ishii, K.; Matsuura, T.; Nanba, E.; Sugiyama, H.; Fukunaga, K.; Shioda, N.
Science Advances 2021, 7, eabd9440. - 458. Combined Use of Chemically Modified Nucleobases and Nanostructured DNA for Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide
Araie, Y.; Ohtsuki, S.; Park, S.; Nagaoka, M.; Umemura, K.; Sugiyama, H.; Kusamori, K.; Takahashi, Y.; Takakura, Y.; Nishikawa, M.
Bioorg. Med. Chem. 2021, 29, 115864. - 457. Evaluation of the DNA Alkylation Properties of a Chlorambucil-Conjugated Cyclic Pyrrole–Imidazole Polyamide
Hirose, Y.; Hashiya, K.; Bando, T.; Sugiyama, H.
Chem. Eur. J. 2021, 27, 2782-2788. - 456. Photocontrolled DNA Origami Assembly using Two Photoswitches
Mishra, S.; Park, S.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M.
Chem. Eur. J. 2021, 27, 778-784. - 455. Nucleosomes and Epigenetics from a Chemical Perspective
Feng, Y.; Endo, M.; Sugiyama, H.
ChemBioChem. 2021, 22, 595-612.
- 454. Targeted Epigenetic Modulation using a DNA-based Histone Deacetylase Inhibitor Enhances Cardiomyogenesis in Mouse Embryonic Stem Cells
Lee, J. A.; An, J.; Taniguchi, J.; Kashiwazaki, G.; Pandian, G. P.; Parveen, N.; Kang, T. M.; Sugiyama, H.; Kim K. K.
J. Cell. Phys. 2021, 236, 3946-3962. - 453. Suppression of Malignant Rhabdoid Tumors through Chb-M’-mediated RUNX1 Inhibition
Daifu, T.; Mikami, M.; Hiramatsu, H.; Iwai, A.; Umeda, K.; Noura, M.; Kubota, H.; Matsuda, T.; Furuichi, K.; Takasaki, S.; Noguchi, Y.; Morita, K.; Bando, T.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Kuwahara, Y.; Iehara, T.; Hosoi, H.; Takita, J.; Sugiyama, H.; Adachi, S.; Kamikubo, Y.
Pediatric Blood & Cancer 2020, DOI: 10.1002/pbc.28789. - 452. A Near-Infrared Fluorogenic Pyrrole-Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres
Tsubono, Y.; Kawamoto, Y.; Hidaka, T.; Pandian, G.; Hashiya, K.; Bando, T.; Sugiyama, H.
J. Am. Chem. Soc. 2020, 142, 17356-17363. - 451. Differentially Expressed Goes on the Growth of Mouse Leydig Cells Treated with Standardized Eurycoma Longifolia Extract
Ahmed, N. A. K; Lim, S. K.; Pandian, G. N.; Sugiyama, H.; Lee, C. Y.; Khoo, B. Y.; Chan, K. L.
Molecular Medicine Reports 2020, DOI: 10.3892/mmr.2020.11485. - 450. Construction of a FRET System in a Double-Stranded DNA Using Fluorescent Thymidine and Cytidine Analogs
Hirashima, S.; Sugiyama, H.; Park, S.
J. Phys. Chem. B 2020, 124, 8794-8800. - 449. Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of Tri-arginine Vector
Hidaka, T.; Tsubono, Y.; Hashiya, K.; Bando, T.; Pandian, G. N.; Sugiyama, H.
Chem. Commun. 2020, 56, 12371-12374.
- 448. Modular Quadruplex-Duplex Hybrids as Biomolecular Scaffolds for Asymmetric Michael Addition Reactions
Yum, J. H.; Sugiyama, H.; Park, S.
Org. Biomol. Chem. 2020, 18, 6812-6817.
- 447. Direct Observation of Dynamic Interactions between Orientation-Controlled Nucleosomes in a DNA Origami Frame
Feng, Y.; Hashiya, F.; Hidaka, K.; Sugiyama, H.; Endo, M.
Chem. Eur. J. 2020, 26, 15282-15289. - 446. Design, Synthesis and Anti-Cancer Activity of Pyrrole-Imidazole Polyamides through Target-Downregulation of c-Kit Gene Expression
Zhang, M.; Liang, J.; Jiang, S-K.; Xu, L.; Wu, Y-L.; Awadasseid, A.; Zhao, X-Y.; Xiong, X-Q.; Sugiyama, H.; Zhang, W.
Eur. J. Med. Chem. 2020, 207, 112704. - 445. DNA Alkylation of the RUNX-binding Sequence by CBI-PI Polyamides Conjugates
Maeda, R.; Ito, S.; Hashiya, K.; Bando, T.; Sugiyama, H.
Chem. Eur. J. 2020, 26, 14639-14644. - 444. DNA Density-dependent Uptake of DNA Origami-based Two-or Three-dimensional Nanostructures by Immune Cells
Maezawa, T.; Ohtsuki, S.; Hidaka, K.; Sugiyama, H.; Endo, Takahashi, Y.; Takakura, Y.; Nishikawa, M.
Nanoscale 2020, 12, 14818-14824. - 443. Development of Antibody-Oligonucleotide Complexes for targeting Exosomal microRNA
Yamayoshi, A.; Oyama, S.; Kishimoto, Y.; Konishi, R.; Yamamoto, T.; Kobori, A.; Harada, H.; Ashihara, E.; Sugiyama, H.; Murakami, A.
Pharmaceutics 2020, 12, 545. - 442. Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles
Nobeyama, T.; Shigyou, K.; Nakatsuji, H.; Sugiyama, H.; Komura, N.; Ando, H.; Hamada, T.; Murakami, T.
Langmuir 2020, 36, 7741-7746. - 441. Dynamic Stabilization of DNA Assembly by Using Pyrrole-Imidazole Polyamide
Ang, Y. S.; Bando, T.; Sugiyama, H.; Yung, L. Y. L.
ChemBioChem. 2020, 21, 2912-2915. - 440. X-ray Crystal Structure of a Cyclic-PIP–DNA Complex in the Reverse-binding Orientation
Abe, K.; Hirose, Y.; Eki, H.; Takeda, K.; Bando, T.; Endo, M.; Sugiyama, H.
J. Am. Chem. Soc. 2020, 142, 10544-10549. - 439. A Photocaged DNA Nanocapsule for Delivery and Manipulation in Cells
Feng, Y.; Tohgasaki, T.; Shitomi, Y.; Sugiyama, H. Endo, M.
Methods in Enzymology 2020, 641, 329-342. - 438. Duplex DNA is Weakened in Nanoconfinement
Jonchhe, S.; Pandey, S.; Karna, D.; Pokhrel, P.; Cui, Y.; Mishra, S.; Sugiyama, H.; Endo, M.; Mao, H.
J. Am. Chem. Soc. 2020, 142, 10042-10049. - 437. Catalytic RNA Nano-objects Formed by Self-assembly of Group I Ribozyme Dimers Serving as Unit Structures
Kiyooka, R.; Akagi, J.; Sugiyama, H.; Endo, M. Matsumura, S.; Ikawa, Y.
J. Bioscience & Bioengineering 2020, 130, 253-259. - 436. DNA Nanostructures as a Tool for Targeted Antimicrobial Delivery
Mela, I.; Vallejo-Raminez, P. P.; Makarchuk, S.; Christie, G.; Bailey D.; Henderson, R. M.; Sugiyama, H, Endo, M.; Kaminski, C. F.
Angew Chem. 2020, 59, 12698-12702. - 435. Telomeric Quadruplexes as Therapeutic Target
Asamitsu, S.; Shioda, N.; Sugiyama, H. Stephen Needle (eds.)
Quadruplex nucleic acids as targets for medicinal chemistry, Part 2 Quadruplex Targets in human and other organisms.
Elsevier 2020, 54, 77-99. - 434. Histidine-conjugated DNA as a Biomolecular Depot for Metal Ions
Park, S.; Matsui, H.; Fukumoto, K.; Yum, J. H.; Sugiyama, H.
RSC Advances 2020, 10, 9717-9722. - 433. Direct Observation and Analysis of TET-mediated Oxidation Processes in a DNA Origami Nanochip
Xing, X.; Sato, S., Wong, N-K.; Hidaka, K.; S.; Sugiyama, H.; Endo, M.
Nucleic Acids Research 2020, 48, 4041-4051. - 432. N1-Methylpseudouridine Substitution Enhances the Performance of Synthetic mRNA Switches in Cells
Parr, C.; Wada, S.; Kotake, K.; Kameda, S.; Matsuura, S.; Sakashita, S.; Park, S.; Sugiyama, H.; Kuang, Y.; Saito, H.
Nucleic Acids Research 2020, 48, e35. - 431. A Synthetic Transcription Factor Pair Mimic for Precise Recruitment of an Epigenetic Modifier to the Targeted DNA Locus
Yu, Z.; Ai, M; Samanta, S. K.; Hashiya, F.; Taniguchi, J.; Asamitsu, S.; Ikeda, S.; Hashiya, K.; Bando, T.; Pandian, G. N.; Isaacs, L.; Sugiyama, H.
Chem. Comm. 2020, 56, 2296-2299. - 430. Targeted Suppression of Metastasis Regulatory Transcription Factor SOX2 in Various Cancer Cell Lines using a Sequence-specific Designer Pyrrole-imidazole Polyamide
Malinee, M.; Kumar, A.; Hidaka, T.; Hirose, M.; Hasegawa, K.; Namasivayam, P. G.; Sugiyama, H.
Bioorg. Med. Chem. 2020, 28, 115248. - 429. Advances in DNA Origami-Cell Interfaces
Mishra, S.; Feng, Y.; Endo, M.; Sugiyama, H.
ChemBioChem. 2020, 21, 33-44. - 428. Sequence-specific PI Polyamides Make It Possible to Regulate DNA Structure and Function
Bando, T.; Sugiyama, H.
Bull. Chem. Soc. J. 2020, 93, 205-215.
〒 606-8502
Department of Chemistry,
Graduate School of Science Kyoto University
Kitashirakawa-Oiwakecho, Sakyo-Ku, kyoto, Japan
TEL +81-75-753-4002
FAX +81-75-753-3670