Welcome to Sugiyama Lab
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2018.03.20
杉山 弘先生が第７０回日本化学会賞受賞しました。
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2018.02.09
第4回生体分子科学シンポジウムを開催しました。
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2017.10
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2017.7
朴先生が第10回資生堂(Shiseido)女性研究者サイエンスグラントを受賞しました。
http://www.nikkei.com/article/DGXLASDZ07HFZ_X00C17A7000000
“生物化学、DNAのらせん構造に基づく金属酵素の開発と不斉合成への反応（DNAの二重らせん構造に基づくバイオハイブリッド触媒を開発し、 それを利用して有用な化合物を合成します）"
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2017.3
河本 佑介さん(D2)が日本化学会第97春季年会で口頭発表を行い、学生講演賞を受賞しました。
“Visualization of human telomeres with pyrrole-imidazole polyamides targeting human telomeric repeats” -
2017.1
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2017.1
岡村和泉さん（M2）の論文がChemistry Letters誌のEditor's Choiceに選定されました。
http://www.journal.csj.jp/doi/abs/10.1246/cl.161024 -
2016.12
日高拓也さん(M1)が第39回日本分子生物学会年会でポスター発表を行い、優秀ポスター賞を受賞しました。
"ミトコンドリアDNAを標的とした配列選択的DNA結合能を有する機能性分子の開発" -
2016.11
河本佑介さん(D2)がProf. Hanbin Mao (Kent State University, USA)の研究室を訪問しました。
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2016.8
Anandhakumar Chandran さん(PD)が Puthiya Thalaimurai Tamizhan award 2016 science 部門を受賞しました。
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2016.6
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2016.3
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2016.3
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2016.3
- 391. Environment-dependent Self-assembly of DNA Origami Lattices on Phase-separated Lipid Membranes
Sato, Y.; Endo, M.; Morita, M.; Takinoue, M.; Sugiyama, H.; Murata, S.; Nomura, S.; Suzuki, Y.
Adv. Mater. Interfaces in press - 390. RUNX1 Positively Regulates the ErbB2/HER2 Signaling Pathway through Modulating SOS1 Expression in Gastric Cancer Cells
Mitsuda, Y.; Morita, K.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Obara, M.; Hirata, M.; Kataoka, R. T.; Muto, M.; Kaneda, Y.; Nakahata, T.; Liu, P. P.; Adachi, S.; Sugiyama, H.; Kamikubo, Y.
Scientific Reports in press - 389. Complexing DNA Origami Frameworks through Sequential Self-assembly Based on Directed Docking
Suzuki, Y.; Sugiyama, H.; Endo, M.
Angew. Chem. Int. Ed. in press - 388. A Synthetic DNA-binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
Wei, Y.; Pandian, G.; Yu, Z.; Zou, T.; Li, Y.; Darokar, J.; Hashiya, K.; Bando, T.; Sugiyama, H.
ACS Omega 2018, 3, 3608-3616. - 387. Pip-HoGu: an Artificial Assembly with Cooperative DNA Recognition
Capable of Mimicking Transcription Factor Pairs
Yu, Z.; Guo, C.; Wei, Y.; Hashiya, K.; Bando, T.; Sugiyama, H.
J. Am. Chem. Soc. 2018, 140, 2426-2429. - 386. Triggering Nucleic Acid Nanostructure Assembly by Conditional Kissing Interactions
Azema, L.; Bonnet-Salomon, S.; Endo, M.; Takeuchi, Y.; Durand, G.; Emura, T.; Hidaka, K.; Dausse, E.; Sugiyama, H.; Toulme, JJ.
Nucleic Acids Res. 2018, 46, 1052-1058. - 385. Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-binding Components to a G-quadruplex and its Proximal Duplex
Asamitsu, S.; Obata, S.; Phan, A. T.; Hashiya, K.; Bando, T.; Sugiyama, H.
Chem. Eur. J. 2018, 24, 4428-4435. - 384. Sequence-specific DNA Binding Pyrrole-Imidazole Polyamides and Their
Applications
Kawamoto, Y.; Bando, T.; Sugiyama, H.
Bioorg. Med. Chem. 2018, 26, 1393-1411. - 383. RUNX Transcription Factors Potentially Control E-Selectin Expressions in the Bone Marrow Vascular Niche of Mice
Morita, K.; Tokushige, C.; Maeda, S.; Kiyose, H.; Noura, M.; Iwai, A.; Yamada, M.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Adachi, S.; Sugiyama, H.; Kamikubo, Y.
Blood Advances 2018, 5, 509-515. - 382. Targeting G-quadruplex DNA as Cognitive Function Therapy for ATR-X Syndrome
Shioda, N.; Yabuki, Y.; Yamaguchi, K.; Onozato, M.; Li, Y.; Kurosawa, K.; Tanabe, H.; Okamoto, N.; Era, T.; Sugiyama, H.; Wada, T.; Fukunaga, K.
Nature Medicine in press.
- 381. DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels
Kurokawa, T.; Kiyonaka, S.; Nakata, E.; Endo, M.; Koyama, S.; Mori, E.; Tran, N. H.; Dinh, H.; Suzuki, Y.; Hidaka, K.; Kawata, M.; Sato, C.; Sugiyama, H.; Morii, T.; Mori, Y.
Angew. Chem. 2018, 57, 2586-2591.
- 380. Investigating Nucleosome Accessibility for MNase, FeII Peplomycin, and Duocarmycin B2 by Using Capillary Electrophoresis
Zou, T.; Kizaki, S.; Sugiyama, H.
ChemBioChem. 2018, 19, 664-668.
- 379. G-Quadruplex Induction by the Hairpin Pyrrole-Imidazole Polyamide
Dimer
Obata, S.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H.
Biochem 2018, 57, 498-502.
- 378. UVA Irradiation of BrU-Substituted DNA in The Presence of Hoechst 33258
Saha, A.; Kizaki, S.; Han, J. H.; Yu, Z.; Sugiyama, H.
Bioorg. Med. Chem. 2018, 26, 37-40.
- 377. Evaluation of Alkylating Pyrrole-Imidazole Polyamide Conjugates by
a Novel Method for High-Throughput Sequencer
Kashiwaszaki, G.; Maeda, R.; Kawase, T.; Hashiya, K.; Bando, T.; Sugiyama, H.
Bioorg. Med. Chem. 2018, 26, 1-7. - 376. Autonomous Feedback Loop of RUNX1-p53-CBFB in Acute Myeloid Leukemia
Cells
Morita, K.; Noura, M.; Tokushige, C.; Maeda, S.; Kiyose, H.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Yoshida, K.; Ozaki, T.; Matsuo, H.; Ogawa, S.; Liu, P. P.; Nakahata, T.; Sugiyama, H.; Adachi, S.; Kamikubo, Y.
Sci. Reports 2017, 7, 16604. - 375. Single-Molecule Observation of The Photo Regulated Conformational
Dynamics of DNA Origami Nanoscissors
Willner, E.; Kamada, Y.; Suzuki, Y.; Emura, T.; Hidaka, K.; Dietz, H.; Sugiyama, H.; Endo, M.
Angew. Chem. Int. Ed. 2017, 56, 15324-15328.
- 374. A Combination of Visible-Light Photoredox and Metal Catalysis for
the Mannich-Type Reaction of N-Aryl Glycine Esters
Okamura, I.; Park, S.;Han, J.;Notsu, S.;Sugiyama, H.
Chem. Lett. 2017, 46, 1597-1600. - 373. Effective Anti-mRNA Oligonucleotides Show High Releasing Rate of MicroRNA from RNA-Inducing Silencing Complex (RISC)
Ariyoshi, J.; Matsuyama, Y.; Kobori, A.; Murakami, A; Sugiyama, H.; Yamayoshi, A.
Nucleic Acid Ther. 2017, 27, 303-308. - 372. A Synthetic DNA-binding Inhibitor of SOX2 Guides Human Induced Pluripotent Stem Cells to Differentiate into Cardiac Mesoderm
Taniguchi, J.; Pandian, G.; Hidaka, T.; Hashiya, K.; Bando, T.; Kim, K. K.; Sugiyama, H.
Nucleic Acids Res. 2017, 45, 9219-9228. - 371. Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately-attenuated RUNX1 expressions
Morita, K.; Maeda, S.; Suzuki, K.; Kiyose, H.; Taniguchi, J.; Liu, P.P.; Sugiyama, H.; Adachi, S.; Kamikubo, Y. , Blood Adv. 2017, 1, 1440-1451. - 370. Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate
Shibata, T.; Fujita, Y.; Ohno, H.; Suzuki, Y.; Hayashi, K.; Komatsu, K.; Kawasaki, S.; Hidaka, K.; Yonehara, S.; Sugiyama, H.; Endo, M.; Saito, H., Nature Comm. 2017, 8, 540. - 369. Antiproliferative and Apoptotic Activities of Sequence-Specific Histone Acetyltransferase Inhibitors
Yu, Z.; Taniguchi, J.; Wei, Y.; Pandian, G.N.; Hashiya, K.; Bando, T.; Sugiyama, H. , Eur. J. Med. Chem. 2017, 138, 320-327 - 368. Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression
Hidaka, T.; Pandian, G.; Taniguchi, J.; Nobeyama, T.; Hashiya, K.; Bando, T.; Sugiyama, H. , J. Am. Chem. Soc. 2017, 139, 8444-8447. - 367. Copper-containing DNA-Silica Mineral Complexes for the Asymmetric Diels-Alder Reaction
Sakashita, S.; Park, S.; Sugiyama, H. Chemistry Letters. 2017, doi:10.1246/cl.170411. - 366. Holliday junction resolvases mediate chloroplast nucleoid segregation
Kobayashi, Y.; Misumi, O.; Odahara, M.; Ishibashi, K.; Hirono, M.; Hidaka, K.; Endo, M.; Sugiyama, H.; Iwasaki, H.; Kuroiwa, T.; Shikanai, T.; Nishimura, Y. Science. 2017, 356, 631-634.
- 365. Development of a Vivid FRET System Based on a Highly Emissive dG-dC Analogue Pair
Han, J.; Yamamoto, S.; Park, S.; Sugiyama, H. Chem. Eur. J. 2017, 23, 7607-7613.
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第38回
日本光医学・光生物学会 -
Department of Chemistry, Graduate School of Science, Kyoto University -
Institute for Integrated Cell-Material Sciences, Kyoto University -
AMED
戦略的イノベーション創出推進プログラム -
JSPS 基盤S
Control and elucidation of gene expression at a molecular level
〒 606-8502
Department of Chemistry,
Graduate School of Science Kyoto University
Kitashirakawa-Oiwakecho, Sakyo-Ku, kyoto, Japan
TEL +81-75-753-4002
FAX +81-75-753-3670