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1. Singlet-Oxygen Reactions of 1,4-Cyclohexadiene. A Synthetic Approach to the Benzene-1,4-Endoperoxide. Saito, I.; Tamoto, K.; Katsumura, A.; Sugiyama, H.; Matsuura, T. Chemistry Letters, 1978, 127-130.
2. Photochemical Reaction of 8-Azaxantine with Nucleophiles. Saito, I.; Ito, S.; Sugiyama, H.; Akita, M.; Matsuura, T. Tetrahedron Lett., 1979, 42, 4065-4066.
3. Electroreductive Hydrocoupling of Activated Olefines with Ketones or Aldehydes. Shono, T.; Ohmidzu, H.; Kawakami, S.; Sugiyama, H. Tetrahedron Lett., 1980, 21, 5029-5032.
4. Organic Chemical Approach to Photo-Cross-Links of Nucleic Acids to Proteins. T. Matsuura, T.; Saito, I.; Ito, S.; Sugiyama, H.; Shinmura, T. Pure Appl. Chem., 1980, 52, 2705-2715. (Review)
5. A Novel Photoreaction of Thymidine with Lysine. Photoinduced Migration of Thymine from DNA to Lysine. Saito, I.; Sugiyama, H.; Ito, S.; Furukawa, N.; Matsuura, T. J. Am. Chem. Soc., 1981, 103, 1598-1600.
6. Photochemical Ring Opening of Thymidine and Thymine in the Presence of Primary Amines. Saito, I.; Sugiyama, H.; Furukawa, N.; Matsuura, T. Tetrahedron Lett., 1981, 34, 3265-3268.
7. Photoreaction of Thymidine with Alkylamines. Application to Selective Removal of Thymine from DNA. Saito, I.; Sugiyama, H.; Matsuura, T. J. Am. Chem. Soc., 1983, 105, 956-962.
8. Isolation and Characterization of a Thymine-Lysine Adduct in UV-Irradiated Nuclei. The Role of Thymine-Lysine Photoreaction in Photo-Cross-Linking of Proteins to DNA. Saito, I.; Sugiyama, H.; Matsuura, T. J. Am. Chem. Soc., 1983, 105, 6989-6991.
9. Photochemical Reactions of Nucleic Acids and Their Constituents of Photobiological Relevance. Saito, I.; Sugiyama, H.; Matsuura, T. Photochem. Photobiol., 1983, 38, 735-743.
10. A New Procedure for Determinig Thymine Residues in DNA Sequencing. Photoinduced Cleavage of DNA Fragments in the Presence of Spermine. Saito, I.; Sugiyama, H.; Matsuura, T.; Ueda, K.; Komano, T. Nucleic Acids Res., 1984, 12, 2879-2885.
11. Photochemical Reaction between Tryptophan and Thymine. Saito, I.; Sugiyama, H.; Matsuura, T.; Fukuyama, N.; Katsube, Y. Tetrahedron Lett., 1984, 25, 3243-3246.
12. Photochemical Hydrogen-Deuterium Exchange Reaction of Tryptophan. The Role in Nonradiative Decay of Singlet Tryptophan. Saito, I.; Sugiyama, H.; Yamamoto, A.; Muramatsu, S.; Matsuura, T. J. Am. Chem. Soc., 1984, 106, 4286-4287.
13. Specific Labelling of Biologically Important Indoles. Saito, I.; Nakagawa, H.; Sugiyama, H.; Muramatsu, S.; Matsuura, T. Photomedicine and Photobiology, 1984, 6, 55-56.
14. Stacking Interaction between Tryptophan and Uracil in a Synthetic Model Compound. Saito, I.; Sugiyama, H.; Matsuura, T.; Fukuyama, K. Tetrahedron Lett., 1985, 26, 4467-4470.
15. Regio-Controlled Hydrogen-Deuterium Exchange of Biologically Important Indoles under UV Irradiation. Saito, I.; Muramatsu, S.; Sugiyama, H.; Yamamoto, A.; Matsuura, T. Tetrahedron Lett., 1985, 26, 5891-5894.
16. Analysis of Products Formed during Bleomycin-Mediated DNA Degradation. Murugesan, N.; Xu, C.; Ehrenfeld, G. M.; Sugiyama, H.; Kilkuskie, R. E.; Rodriguets, L. O.; Chang, L-H.; Hecht, S. M. Biochemistry, 1985, 24, 5735-5744.
17. Structure of the Alkali-Labile Product Formed during Iron(II)-Bleomycin-Mediated DNA Strand Scission. Sugiyama, H.; Xu, C.; Murugesan, N.; Hecht, S. M. J. Am. Chem. Soc., 1985, 107, 4104-4105.
18. DNA Strand Scission by Bleomycin Group Antibiotics. Sugiyama, H.; Ehrenfeld, G. M.; Shipley, J. B.; Kilkuskie, R. E.; Chang, L-H.; Hecht, S. M. J. Nat. Prod., 1985, 48, 869-877.
19. An Efficient, Site-Specific DNA Target for Bleomycin. Sugiyama, H.; Kilkuskie, R. E.; Hecht, S. M.; van der Marel, G. A.; van Boom, J. H. J. Am. Chem. Soc., 1985, 108, 7765-7767.
20. DNA Strand Scission by Bleomycin: Catalytic Cleavage and Strand Selectivity. Sugiyama, H.; Kilkuskie, R. E.; Chang, L-H.; Ma, L-T.; Hecht, S. M.; van der Marel G. A.; van Boom, J. H. J. Am. Chem. Soc., 1986, 108, 3852-3854.
21. Copper-Dependent Cleavage of DNA by Bleomycin. Ehrenfeld, G. M.; Shiply, J. B.; Heimbrook, D. C.; Sugiyama, H.; Long, E. C.; van Boom, J. H.; van der Marel, G. A.; Oppenheimer, N. J.; Hecht, S. M. Biochemistry, 1987, 26, 931-942.
22. Excited-State Behavior of Tryptamine and Related Indoles. Remarkably Efficient Intramolecular Proton-Induced Quenching. Shizuka, H.; Serizawa, M.; Kobayashi, H.; Kameta, K.; Sugiyama, H.; Matsuura, T.; Saito, I. J. Am. Chem. Soc., 1988, 110, 1726-1732.
23. Chemistry of the Alkali-Labile Lesion Formed by Iron(II) Bleomycin and d(CGCTTTAAAGCG). Sugiyama, H.; Xu, C.; Murugesan, N.; Hecht, S. M.; van der Marel, G. A.; van Boom, J. H. Biochemistry, 1988, 27, 58-67.
24. Photoinduced DNA Strand Scission by Cobalt Bleomycin Green Complex. Saito, I.; Morii, T.; Sugiyama, H.; Matsuura, T.; Meares, C. F.; Hecht, S. M. J. Am. Chem. Soc., 1989, 111, 2307-2308.
25. Chemistry of Neocarzinostatin-Mediated Degradation of d(GCATGC). Mechanism of Spontaneous Thymine Release. Kawabata, H.; Takeshita, H.; Fujiwara, T.; Sugiyama, H.; Matsuura, T.; Saito, I. Tetrahedron Lett., 1989, 30, 4263-4266.
26. A Novel Ribose C-4' Hydroxylation Pathway in Neocarzinostatin-Mediated Degradation of Oligonulceotides. Saito, I.; Kawabata, H.; Fujiwara, T.; Sugiyama, H.; Matsuura, T. J. Am. Chem. Soc., 1989, 111, 8302-8303.
27. Synthetic Cobalt Bleomycin Models as a Photochemical DNA Cleaver. Saito, I.; Morii, T.; Obayashi, T.; Sera, T.; Sugiyama, H.; Matsuura, T. J. Chem. Soc., Chem. Commun., 1989, 6, 360-361.
28. Metallo-Bleomycin-Mediated Degradation of Deoxytetranucleotides. Unusual C-4' Hydroxylation at Terminal Cytidine. Sugiyama, H.; Tashiro, T.; Dannoue, Y.; Miwa, T.; Matsuura, T.; Saito, I. Tetrahedron Lett., 1989, 30, 7213-7216.
29. Oxidative Strand Scission of DNA. Matsuura, T.; Saito, I.; Sugiyama, H.; Morii, T.; Kawabata, H. Pure Appl. Chem., 1989, 61, 473-476. (Review)
30. Specific Detection of C-4' Hydroxylated Abasic Sites Generated by Bleomycin and Neocarzinostatin in DNA. Sugiyama, H.; Kawabata, H.; Fujiwara, T.; Dannoue,Y.; Matsuura, T. J. Am. Chem. Soc., 1990, 112, 5253-5257.
31. Highly Sequence Selective Photoreaction of 5-Bromouracil-Containing Deoxyhexanucleotides. Sugiyama, H.; Tsutsumi, Y.; Saito, I. J. Am. Chem. Soc., 1990, 112, 6720-6721.
32. Covalent Alkylation of DNA with Duocarmycin A. Identification of Abasic Site Structure. Sugiyama, H.; Hosoda, M.; Saito, I.; Asai, A.; Saito, H. Tetrahedron Lett., 1990, 31, 7179-7200.
33. Bleomycin-Mediated Degradation of Aristeromycin-Containing DNA. Novel Dehydrogenation Activity of Iron(II)-Bleomycin. Sugiyama, H.; Sera, T.; Dannoue, Y.; Saito, I. J. Am. Chem. Soc., 1991, 113, 2290-2295.
34. Bis-Hydroperoxy Naphthaldiimide as "Photo-Fenton Reagent": Sequence-Specific Photocheavage of DNA. Matsugo, S.; Kawanishi, S.; Yamamoto, K.; Sugiyama, H.; Matsuura, T.; Saito, I. Ang. Chem. Int. Ed. Engl., 1991, 30, 1351-1353.
35. DNA Cleavage Reaction of Antitumour Antibiotic, Kapurimycin A3, with Deoxytetranucleotide d(CGCG)2. Chan, K. L.; Sugiyama, H.; Saito, I. Tetrahedron Lett., 1991, 32, 7719-7722.
36. A Novel Cyclization Pathway in Activation of Neocarzinostatin Chromophore by Thiol under Physiological Conditions. Sugiyama, H.; Yamashita, K.; Saito, I.; Nishi, M. Tetrahedron Lett., 1992, 33, 515-518.
37. Chemistry of Neocarzinostatin-Mediated Cleavage of Oligonucleotides. Competitive Ribose C5' and C4' Hydroxylation. Sugiyama, H.; Fujiwara, T.; Kawabata, H.; Saito, I.; Hirayama, N.; Yoda, N. J. Am. Chem. Soc., 1992, 114, 5573-5578.
38. 6α-Hydroxyeurycomalactone, A Quassinoid from Eurycoma Longifolia. Chan, K. L.; Iitaka, Y.; Noguchi, H.; Sugiyama, H.; Saito, I.; Sankawa, U. Phytochemistry, 1992, 31, 4295-4298.
39. Concerted DNA Recognition and Novel Site-Specific Alkylation by Duocarmycin A with Distamycin A. Yamamoto, K.; Sugiyama, H.; Kawanishi, S. Biochemistry, 1993, 32, 1059-1066.
40. A Novel Guanine N3 Alkylation by Antitumor Antibiotic Duocarmycin A. Sugiyama, H.; Ohmori, K.; Chan, K. L.; Hosoda, M.;Asai, A.; Saito, H.; Saito, I. Tetrahedron Lett., 1993, 34, 2179-2182.
41. Photoinduced Deoxyribose C2' Oxidation in DNA. Alkali-Dependent Cleavage of Erythrose-Containing Sites via a Retroaldol Reaction. Sugiyama, H.; Tsutsumi, Y.; Fujimoto, K.; Saito, I. J. Am. Chem. Soc., 1993, 115, 4443-4448.
42. Apoprotein-Assisted Unusual Cyclization of Neocarzinostatin Chromophore. Sugiyama, H.; Yamshita, K.; Fujiwara, T.; Saito, I. Tetrahedron, 1994, 50, 1311-1325.
43. Chemistry of Thermal Degradation of Abasic Sites in DNA. Mechanistic Investigation on Thermal DNA Strand Cleavage of Alkylated DNA. Sugiyama, H.; Fujiwara, T.; Ura, A.; Tashiro, T.; Yamamoto, K.; Kawanishi, S.; Saito, I. Chem. Res. Toxicology, 1994, 7, 673-683.
44. Oligonucleotides Containing a Radical Trap: The Trapping of Deoxyribose C4' Radical in Bleomycin-Mediated Reactions. Sugiyama, H.; Ohmori, K.; Saito, I. J. Am. Chem. Soc., 1994, 116, 10326-10327.
45. Activation of Neocarzionstatin-Chromophore by 4-Hydroxythiophenol: Intermolecular Radical Trapping of Biradical Intermediate. Sugiyama, H.; Fujimoto, K.; Saito, I. Tetrahendron Lett., 1994, 35, 8825-8828.
46. Stereospecific 1,2-Hydride Shift in Ribonolactone Formation in the Photoreaction of 2'-Iododeoxyuridine. Sugiyama, H.; Fujimoto, K.; Saito, I. J. Am. Chem. Soc., 1995, 117, 2945-2946.
47. Photoinduced DNA Cleavage via Electron Transfer: Demonstration that Guanine Residues Loacated 5' to Guanine Are the Most Electron-Donating Sites. Saito, I.; Takayama, M.; Sugiyama, H.; Nakatani, K.; Tsuchida, A.; Yamamoto, M. J. Am. Chem. Soc., 1995, 117, 6406-6407.
48. NMR Characterization of Guanine and DNA Site Alkylated by Kapurimycin A3, An Antitumour Antibiotic from Streptomyces sp. Chan, K. L.; Sugiyama, H.; Saito, I.; Hara, M. Phytochemistry, 1995, 40, 1373-1374.
49. Evidence for Intrastrand C2' Hydrogen Abstraction in Photoirradiation of 5-Halouracil-Containing Oligonucleotides by Using Stereospecifically C2'-Deuterated Deoxyadenosine. Sugiyama, H.; Fujimoto, K.; Saito, I.; Kawashima, E.; Sekine, T.; Ishido, Y. Tetrahedron Lett., 1996, 37, 1805-1808.
50. Synthesis, Structure and Thermodynamic Properties of 8-Methylguanine-Containing Oligonucleotides: Z-DNA under Physiological Salt Conditions. Sugiyama, H.; Kawai, K.; Matsunaga, A.; Fujimoto, K.; Saito, I.; Robinson, H.; Wang, A. H.-J. Nucleic Acids Res., 1996, 24, 1272-1278.
51. Theoretical Studies of GG-Specific Photocleavage of DNA via Electron Transfer: Significant Lowering of Ionization Potential and 5'-Localization of HOMO of Stacked GG Bases in B-Form DNA. Sugiyama, H.; Saito, I. J. Am. Chem. Soc., 1996, 118, 7063-7068.
52. Catalytic Activities of Hammerhead Ribozymes with a Triterpenoid Linker Instead of Stem/Loop II. Sugiyama, H.; Hatano, K.; Saito, I.; Amontov, S.; Taira, K. FEBS Letters., 1996, 392, 215-219.
53. Remarkably Stable Parallel-Stranded Oligonucleotides Containing 5-Methylisocytosine and Isoguanine. Sugiyama, H.; Ikeda, S.; Saito, I. J. Am. Chem. Soc., 1996, 118, 9994-9995.
54. Distamycin A Modulates the Sequence Specificity of DNA Alkylation by Duocarmycin A. Sugiyama, H.; Lian, C.; Isomura, M.; Saito, I.; Wang, A. H.-J. Proc. Natl. Acad. Sci. USA., 1996, 93, 14405-14410.
55. New Synthetic Method of 5-Formyluracil-Containing Oligodeoxynucleotides and Their Melting Behavior. Sugiyama, H.; Matsuda, S.; Kino, K.; Zhang, Q.-M.; Yonei, S.; Saito, I. Tetrahedron Lett., 1996, 37, 9067-9070.
56. Structures of Cobalt(III)-Pepleomycin and Cobalt(III)-Deglycopepleomycin (green forms) Determined by NMR Studies. Caceres-Cortes, J.; Sugiyama, H.; Ikudome, K.; Saito, I.; Wang, A. H.-J. Eur. J. Biochem., 1997, 244, 818-828.
57. Interactions of Deglycosylated Cobalt (III)-Pepleomycin (Green Form) with DNA Based on NMR Structural Studies. Caceres-Cortes, J.; Sugiyama, H.; Ikudome, K.; Saito, I.; Wang, A. H.-J. Biochemistry, 1997, 36, 9995-10005.
58. Preferential C1' Hydrogen Abstraction by a Uracilyl Radical in a DNA-RNA Hybrid. Sugiyama, H.; Fujimoto, K.; Saito, I. Tetrahedron Lett., 1997, 38, 8057-8060.
59. Replication of DNA Templates Containing 5-Formyluracil, a Major Oxidative Lesion of Thymine in DNA. Zhang, Q.-M.; Sugiyama, H.; Matsuda, S.; Saito, I. Nucleic Acids Res., 1997, 25, 3969-3973.
60. Design of Photochemical DNA-Cleaving Molecules via Electron Transfer. Saito, I.; Takayama, M.; Sugiyama, H.; Nakamura. T. J. Photochem. Phobiol. A: Chemistry, 1997, 106, 141-144.
61. Sequence Dependent Photoreduction of 5-Bromouracil-Containing Oligonucleotides via Electron Transfer. Fujimoto, K.; Sugiyama, H.; Saito, I. Tetrahedron Lett., 1998, 39, 2137-2140.
62. Stabilization of Hoogsteen Base Pairing by Introduction of NH2 Group at the C8 Position of Adenine. Kawai, K.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 1998, 39, 5221-5224.
63. Structural Studies of a Stable Paralle-Stranded DNA Duplex Incorporating Isoguanine:Cytosine and Isocytosine:Guanine Basepairs by Nuclear Magnetic Resonance Spectroscopy. Yang, X.-L.; Sugiyama, H.; Ikeda, S.; Saito, I.; Wang, A. H.-J. Biophys. J., 1998, 75, 1163-1171.
64. Facile Synthesis of Puromycin-Tethered Oligonucleotides at the 3'-End. Ikeda, S.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 1998, 39, 5975-5978.
65. Product Analysis of GG-Specific Photooxidation of DNA via Electron Transfer: 2-Aminoimidazolone as a Major Guanine Oxidation Product. Kino, K.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 1998, 120, 7373-7374.
66. Mapping of the Hot Spots for DNA Damage by One-Electron Oxidation: Efficacy of GG Doublets and GGG Triplets as a Trap in Long-Range Hole Migration. Saito, I.; Nakamura, T.; Nakatani, K.; Yoshioka, Y.; Yamaguchi, K.; Sugiyama, H. J. Am. Chem. Soc., 1998, 120, 12686-12687.
67. Conformation-Dependent Photochemistry of 5-Halouracil-Containing DNA: Stereospecific 2’α-Hydroxylation of Deoxyribose in Z-form DNA. Kawai, K.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 1999, 121, 1391-1392.
68. Highly Efficient DNA Interstrand Crosslinking Induced by an Antitumor Antibiotic, Carzinophilin. Fujiwara, T.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 1999, 40, 315-318.
69. Sequence-Specific DNA Alkylation by Hybrid Molecules between Segment A of Duocarmycin A and Pyrrole/Imidazole Diamide. Tao, Z.-F.; Fujiwara, T.; Saito, I.; Sugiyama, H. Angew. Chem. Int. Ed., 1999, 38, 650-653.
70. Replication in vitro and Cleavage by Restriction Endonuclease of 5-Formyluracil- and 5-Hydroxymethyluracil-Containing Oligonucleotides. Zhang, Q-M.; Sugiyama, H.; Miyabe, I.; Matuda, S.; Kino, K.; Saito, I.; Yonei, S. Int. J. Radiat. Biol., 1999, 75, 59-65.
71. Rational Design of Sequence-Specific DNA Alkylating Agents Based on Duocarmycin A and Pyrrole-Imidazole Hairpin Polyamides. Tao, Z.-F.; Fujiwara, T.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 1999, 121, 4961-4967.
72. Intrastrand 2'β Hydrogen Abstraction of 5-Adjacent Deoxyguanosine by Deoxyuridin-5-yl in Z-form DNA. Kawai, K.; Saito, I.; Kawashima, E.; Ishido, Y.; Sugiyama, H. Tetrahedron Lett., 1999, 40, 2589-2592.
73. Photochemical Halogen-Exchange Reaction of 5-Iodouracil-Containing Oligonucleotides. Kawai, K.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 1999, 40, 5721-5724.
74. Modulation of Sequence Specificity of Duocarmycin-Dependent DNA Alkylation by Pyrrole-Imidazole Triamides. Fujiwara, T.; Tao, Z.-F.; Ozeki, Y.; Saito, I.; Wang, A. H.-J.; Lee, M.; Sugiyama, H. J. Am. Chem. Soc., 1999, 121, 7706-7707.
75. Substrate Recognition by Escherichia coli MutY using Substrate Analogs. Chepanoske, C. L.; Porello, S. L.; Fujiwara, T.; Sugiyama, H.; David, S. S. Nucleic Acids Res., 1999, 27, 3197-3204.
76. Imidazole-imidazole Pair as a Minor Groove Recognition Motif for T:G Mismatched Base Pairs. Yang, X.-L.; Hubbard IV, R. B.; Lee, M.; Tao, Z.-F.; Sugiyama, H.; Wang, H.-J. Nucleic Acids Res., 1999, 27, 4183-4190.
77. State Transtitions by Molecules. Sakamoto, K.; Kiga, D.; Ken, K.; Gouzu. H.; Yokoyama, S.; Ikeda, S.; Sugiyama, H.; Hagiya, M. Biosystems, 1999, 52, 81-91.
78. Highly Cooperative DNA Dialkylation by the Homodimer of Imidazole-Pyrrole Diamide-CPI Conjugate with Vinyl Linker. Tao, Z.-F.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 2000, 122, 1602-1608.
79. Enhanced Cytotoxicity in a Z-Photoisomer of a Benzopyrane Derivative of Propolis. Hirota, M.; Matsuno, T.; Fujiwara, T.; Sugiyama, H.; Mineshita, S. J. Nat. Prod., 2000, 63, 366-370.
80. Metallo-Bleomycin Cleaves Parallel-Stranded DNA Similarly to B-DNA. Ikeda, S.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 2000, 41, 3919-3922.
81. Mechanism of DNA Strand Scission Induced by (1,10-Phenanthroline) Copper Complex: Major Direct DNA Cleavage Is Not through 1', 2'-Dehydronucleotide Intermediate nor β-Elimination of Forming Ribonolactone. Oyoshi, T.; Sugiyama, H. J. Am. Chem. Soc., 2000, 122, 6313-6314.
82. Identification of Repair Enzymes for 5-Formyluracil in DNA: Nth, Nei and MutM Proteins of Escherichia coli. Zhang, Q.-M.; Miyabe, I.; Matsumoto, Y.; Kino, K.; Sugiyama, H.; Yonei, S. J. Biol. Chem., 2000, 275, 35471-35477.
83. Amplification of Pepleomycin-Mediated DNA Cleavage and Apoptosis by Unfused Aromatic Cations. Kawanishi, S.; Oikawa, S.; Kawanishi, M.; Sugiyama, H.; Saito, I.; Stredowski, L.; Wilson, W. D. Biochemistry, 2000, 39, 13210-13215.
84. Mutagenic Effects of 5-Formyluracil on a Plasmid Vector during Replication in Escherichia coli. Miyabe, I.; Zhang, Q.-M.; Kino, K.; Sugiyama, H.; Yonei, S. Int. J. Radiat. Biol., 2001, 77, 53-58.
85. Amplification of Bleomycin-Induced DNA Cleavage at Cytosine Residues 3' to GGG Sequences by Pyrrole Triamide. Hiraku,Y.; Oikawa, K.; Sugiyama, H.; Saito, I.; Kawanishi, S. Biochemical Pharmacology, 2001, 61, 351-356.
86. Possible Cause of G･C->C･G Transversion Mutation by Guanine Oxidation Product, Imidazolone. Kino, K.; Sugiyama, H. Chem. & Biol., 2001, 8, 369-378.
87. Sequence-Specific DNA Interstrand Cross-Linking by Imidazole-Pyrrole CPI Conjugate. Bando, T.; Iida, H.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 2001, 123, 5158-5159.
88. Design, Synthesis, DNA Binding, and Biological Evaluation of Water-Soluble Hybrid Molecules Containing Two Pyrazole Analogues of the Alkylating Cyclopropylpyrroloindole (CPI) Subunit of the Antitumor Agent CC-1065 and Polypyrrole Minor Groove Binders. Baraldi, G.; Balbone, G.; Pabani, M. G.; Spalluto, G.; Clercq, E.; Balzarini, J.; Bando, T.; Sugiyama, H.; Romagnoli, R. J. Med. Chem., 2001, 44, 2536-2543.
89. Synthesis of 6-(2-Thienyl)Purine Nucleoside Derivatives That Form Unnatural Base Pairs with Pyridin-2-one Nucleosides. Fujiwara, T.; Kimoto, M.; Sugiyama, H.; Hirao, I.; Yokoyama, S. Bioorg. Med. Chem. Lett., 2001, 11, 2221-2223.
90. Photoreactivity of 5-Iodouracil-Containing DNA-Sso7d Complex in Solution: Protein-Induced DNA Kink Causes Intrastrand Hydrogen Abstraction from 5-Methyl of Thymine at the 5' Side. Oyoshi, T.; Wang, A. H.-J.; Sugiyama, H. J. Am. Chem. Soc., 2002, 124, 2086-2087.
91. Identification of 5-Formyluracil DNA Glycosylase Activity of Human hNTH1 Protein. Miyabe, I.; Zhang, Q.-M.; Kino, K.; Sugiyama, H.; Kakao, M.; Yasui , A.; Yonei, S. Nucleic Acids Res., 2002, 30, 3443-3448.
92. Characterization of 2-Hydroxyadenine DNA Glycosylase Activity of Escherichia coli MutY Protein. Hashiguchi, K.; Zhang, Q. M.; Sugiyama, H.; Ikeda, S.; Yonei, S. Int. J. Radiat. Biol., 2002, 78, 585-592.
93. Sequence-Specific Protection of Plasmid DNA from Restriction Endonuclease Hydrolysis by Pyrrole-Imidazole-Cyclopropapyrroloindole Conjugates. Fujimoto, K.; Iida, H.; Bando, T.; Tao, Z.-F.; Sugiyama, H. Nucleic Acids Res., 2002, 30, 3748-3753.
94. Molecular Design of a Pyrrole-Imidazole Hairpin Polyamides for Effective DNA Alkylation. Bando, T.; Narita, A.; Saito, I.; Sugiyama, H. Chem. Eur. J., 2002, 8, 4781-4790.
95. The Conformational Study of Two Carbocyclic Nucleosides: Why Carbocyclic Nucleic Acids (CarNAs) Form more Stable Duplexes with RNA than DNA Does. Xu, Y.; Kino, K.; Sugiyama, H. J. Biol. Struct. Dyn., 2002, 20, 437-446.
96. Deglyco-Peplomycin Metal Complexes on DNA Fibers: A Role of the Sugar Moiety for the Stability and the Orientation on the Complexes. Iiyama,T.; Chikira, M.; Oyoshi, T.; Sugiyama, H. J. Bioinorg. Chem., 2003, 8, 135-140.
97. Efficient C2'α-Hydroxylation of Deoxyribose in Protein-Induced Z-Form DNA. Oyoshi, T.; Kawai, K.; Sugiyama H. J. Am. Chem. Soc., 2003, 125, 1526-1531.
98. Identification of High Excision Capacity for 5-Hydroxymethyluracil Mispaired with Guanine in DNA of Eschericha coli MutM, Nei and Nth DNA Glydosylases. Hori, M.; Yonei, S.; Sugiyama, H.; Kino, K; Yamamoto, K.; Zhang, Q. M. Nucleic Acids Res., 2003, 31, 1191-1196.
99. Highly Efficient Sequence-Specific DNA Interstrand Cross-linking by Pyrrole/Imidazole CPI Conjugates. Bando, T.; Narita, A.; Sugiyama, H. J. Am. Chem. Soc., 2003, 125, 3471-3485.
100. Inhibition of Transcription at a Coding Sequence by Alkylating Polyamide. Oyoshi, T.; Kawakami, W.; Narita, A.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2003, 125, 4752-4753.
101. Specific Alkylation of Human Telomere Repeats by Hairpin Pyrrole-Imidazole Polyamide. Takahashi R,; Bando T,; Sugiyama H. Bioorg. Med. Chem., 2003, 11, 2503-2509.
102. Sequence Specificity, Reactivity, and Antitumor Activity of DNA-Alkylating Pyrrole-Imidazole Diamides. Bando, T.; Iida, T.; Tao, Z.-F.; Narita, A.; Fukuda, N.; Yamori, T.; Sugiyama, H. Chem. Biol., 2003, 10, 751-758.
103. 8-Methylguanosine: A Powerful Z-DNA Stabilizer. Xu, Y.; Ikeda, R.; Sugiyama, H. J. Am. Chem. Soc., 2003, 125, 13519-13524.
104. A Nanothermometer Based on the Different π-Stacking of B- and Z-DNA. Tashiro, R.; Sugiyama, H. Angew. Chem. Int. Ed., 2003, 42, 6018-6020.
105. Unique Charge Transfer Properties of the Four-Base π-Stacks in Z-DNA. Tashiro, R.; Sugiyama, H. J. Am. Chem. Soc., 2003, 125, 15282-15283.
106. Biology of N-Methylpyrrole-N-Methylimidazole Hairpin Polyamide. Murthy, M.S.R.C.; Sugiyama, H. Biol. Pharm. Bull., 2004, 27, 468-474. (Review)
107. Nucleotide Excision Repair of 5-Formyluracil in Vitro Is Enhanced by the Presence of Mismatched Bases. Kino, K.; Shimizu, Y.; Sugasawa, K.; Sugiyama, H.; Hanaoka, F. Biochemistry, 2004, 43, 2682-2687.
108. C-H to N Substitution Dramatically Alters the Sequence-Specific DNA Alkylation, Cytotoxicity, and Expression of Human Cancer Cell Lines. Bando, T.; Narita, A.; Iwai, A.; Kihara, K.; Sugiyama, H. J. Am. Chem. Soc., 2004, 126, 3406-3407.
109. Sequence-Specific Gene Silencing in Mammalian Cells by Alkylating Pyrrole-Imidazole Polyamides. Shinohara, K.; Narita, A.; Oyoshi, T.; Bando, T.; Teraoka, H.; Sugiyama, H. J. Am. Chem. Soc., 2004 , 126, 5113-5118.
110. Highly Efficient Photochemical 2'-Deoxyribonolactone Formation at the Diagonal Loop of a 5-Iodouracil-Containing Antiparallel G-Quartet. Xu, Y.; Sugiyama, H. J. Am. Chem. Soc., 2004, 126, 6274-6279.
111. (P)-Helicene Displays Chiral Selection in Binding to Z-DNA. Xu, Y.; Zhang Y. X.; Sugiyama, H. ; Umano, T.; Osuga, H.; Tanaka, K. J. Am. Chem. Soc., 2004, 126, 6566-6567.
112. Enantioselective DNA Alkylation by a Pyrrole-Imidazole S-CBI Conjugate. Bando, T.; Narita, A.; Asada, K.; Ayame, H.; Sugiyama, H. J. Am. Chem. Soc., 2004, 126, 8948-8955.
113. Binding of Distamycin A to UV-Damaged DNA. Inase, A.; Kodama, T.S.; Sharif, J.; Xu, Y.; Ayame, H.; Sugiyama, H.; Iwai S. J. Am. Chem. Soc., 2004, 126, 11017-11023.
114. DNA Glycosylase Activities for Thymine Residues Oxidized in the Methyl Group are Functions of the hNEIL1 and hHTH1 Enzymes in Human Cells. Zhang, Q.-M.; Yonekura, S.; Takao, M.; Yasui, A.; Sugiyama, H.; Yonei, S. DNA Repair, 2005, 4, 71-79.
115. Efficient Generation of 2'-Deoxyuridin-5-yl at 5'-(G/C)AAXUXU-3' (X=Br, I) Sequences in Duplex DNA under UV Irradiation. Watanabe, T.; Bando, T.; Xu, Y.; Tashiro, R.; Sugiyama, H. J. Am. Chem. Soc., 2005, 127, 44-45.
116. Biomolecule-Based Switching Devices that Respond Inversely to Thermal Stimuli. Tashiro, R.; Sugiyama, H. J. Am. Chem. Soc., 2005, 127, 2094-2097.
117. 5-Exo versus 6-Endo Cyclization of Nucleoside 2-Sila-5-hexenyl Radicals: Reaction of 6-(Bromomethyl)dimethylsilyl 1', 2'-Unsaturated Uridines. Ogamino, J.; Mizunuma, H.; Kumamoto, H.; Takeda, S.; Haraguchi, K.; Nakamura, K. T.; Sugiyama, H.; Tanaka, H. J. Org. Chem., 2005, 70, 1684-1690.
118. UVR-Induced G-C to C-G Transversions from Oxidative DNA Damage. Kino, K.; Sugiyama, H. Mutat. Res., 2005, 571, 33-42.
119. Synthetic Pyrrole-Imidazole Polyamide Inhibits Expression of the Human Transforming Growth Factor-β1 Gene. Lai, Y.-M.; Fukuda, N.; Ueno, T.; Kishioka, H.; Matsuda, H.; Saito, S.; Matsumoto, K.; Ayame, H.; Bando, T.; Sugiyama, H.; Mugishima, H.; Kim, S.-J. J. Pharmacol. Exp. Ther., 2005, 315, 571-575.
120. Specific Adenine Alkylation by Pyrrole-Imidazole CBI Conjugates. Bando, T.; Narita, A.; Sasaki, S.; Sugiyama, H. J. Am. Chem. Soc., 2005, 127, 13890-13895.
121. Development of Gene Silencing Pyrrole-Imidazole Polyamide Targeting the TGF-β1 Promoter for Treatment of Progressive Renal Diseases. Matsuda, H.; Fukuda, N.; Ueno, T.; Tahira, Y.; Ayame, H.; Zhang, W.; Bando, T.; Sugiyama, H.; Saito, S.; Matsumoto, K.; Mugishima, H.; Serie, K. J. Am. Soc. Nephrol., 2006, 17, 422-432.
122. Photochemical Approach to Probing Different DNA Structures. Xu, Y.; Sugiyama, H. Angew. Chem. Int. Ed., 2006, 45, 1354-1362.
123. Antitumor Activity of Sequence-Specific Alkylating Agents: Pyrolle-Imidazole CBI Conjugates with Indole Linker. Shinohara, K.; Bando, T.; Sasaki, S.; Sakakibara, Y.; Minoshima, M.; Sugiyama, H. Cancer Sci., 2006, 97, 219-225.
124. Efficient DNA Alkylation by a Pyrrole-Imidazole CBI Conjugate with an Indole Lnker: Sequence-Specific Alkylation with Nine-Base-Pair Recognition. Bando, T.; Sasaki, S.; Minoshima, M.; Dohno, C.; Shinohara, K.; Narita, A.; Sugiyama, H. Bioconjug. Chem., 2006, 17, 715-720.
125. Formation of the G-quadruplex and I-motif Structures in Retinoblastoma Susceptibility Genes (Rb). Xu, Y.; Sugiyama, H. Nucleic Acids Res., 2006, 34, 949-954.
126. Alkylation of Template Strand of Coding Region Causes Effective Gene Silencing. Shinohara, K.; Sasaki, S.; Minoshima, M.; Bando, T.; Sugiyama, H. Nucleic Acids Res., 2006, 34, 1189-1195.
127. The New Models of the Human Telomere d[AGGG(TTAGGG)3] in K+ Solution. Xu, Y.; Noguchi, Y.; Sugiyama, H. Bioorg. Med. Chem., 2006, 14, 5584-5591.
128. Suppression of VEGF Transcription in Renal Cell Carcinoma Cells by Pyrrole-Imidazole Hairpin Polyamides Targeting the Hypoxia Responsive Element. Kageyama, Y.; Sugiyama, H.; Ayame, H.; Iwai, A.; Fujii, Y.; Huang, L. E.; Kizaka-Kondoh, S.; Hiraoka, M.; Kihara, K. Acta. Oncol., 2006, 45, 317-324.
129. Discrimination of Hairpin Polyamides with an α-Substituted-γ-Aminobutyric Acid as a 5'-TG-3' Reader in DNA Minor Groove. Zhang, W.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2006, 128, 8766-8776.
130. Synthesis and Biological Properties of Sequence-Specific DNA-Alkylating Pyrrole-Imidazole Polyamides. Bando, T.; Sugiyama, H. Acc. Chem. Res., 2006, 39, 935-944. (Review)
131. Sequence-Specific Alkylation of Double-Strand Human Telomere Repeat Sequence by Pyrrole-Imidazole Polyamides with Indole Linkers. Sasaki, S.; Bando, T.; Minoshima, M.; Shimizu, T.; Shinohara, K.; Takaoka, T.; Sugiyama, H. J. Am. Chem. Soc., 2006, 128, 12162-12168.
132. Photoreactivation of DNA by an Archaeal Nucleoprotein Sso7d. Tashiro, R.; Wang A. H. -J.; Sugiyama, H. Proc. Natl. Acad. Sci. USA., 2006, 103, 16655-16659.
133. Base Pair Recognition of the Stereochemically α-Substituted γ-Turn of Pyrrole/Imidazole Hairpin Polyamides. Zhang, W.; Minoshima, M.; Sugiyama, H. J. Am. Chem. Soc., 2006, 128, 14905-14912.
134. I-motif and Quadruplex-Based Device that can Control a Protein Release or Bind Release Small Molecule to Influence Biological Processes. Xu, Y.; Hirao, Y.; Nishimura, Y.; Sugiyama, H. Bioorg. Med. Chem., 2007, 15, 1275-1279.
135. Photochemical Determination of Different DNA Structures. Xu, Y.; Tashiro, Ryu.; Sugiyama, H. Nat. Protoc., 2007, 2, 78-87.
136. Chemical Biology that Controls DNA Structure and Function: Lessons in Organic Chemistry from Nature. Sugiyama, H. Bull. Chem. Soc. Jpn., 2007, 80, 823-841. (Review)
137. User-friendly Synthesis and Photoirradiation of a Flavin-Linked Oligomer. Kino, K.; Miyazawa, H.; Sugiyama, H. Genes and Environment, 2007, 29, 23-28.
138. Distamycin A Enhances the Cytotoxicity of Duocarmycin A and Suppresses Duocarmycin A-induced Apoptosis in Human Lung Carcinoma Cells. Hirota, M.; Fujiwara, T.; Mineshita, S.; Sugiyama, H.; Teraoka H. Int. J. Biochem. Cell. Biol., 2007, 39, 988-996.
139. DNA Alkylation by Pyrrole-Imidazole seco-CBI Conjugates with an Indole Linker: Sequence-Specific DNA Alkylation with 10-Base-Pair Recognition through Hetelodimer Formation. Minoshima, M.; Bando, T.; Sasaki, S.; Shinohara, K.; Shimizu, T.; Fujimoto, J.; Sugiyama, H. J. Am. Chem. Soc., 2007, 129, 5384-5390.
140. Efficient and Erroneous Incorporation of Oxidized DNA Precursors by Human DNA Polymerase η. Shimizu, M.; Gruz, P.; Kamiya, H.; Masutani, C.; Xu, Y.; Usui, Y.; Sugiyama, H.; Harashima, H.; Hanaoka, F.; Nohmi, T. Biochemistry, 2007, 46, 5515-5522.
141. Photoreaction at 5'-(G/C)AABrUT-3' Sequence in Duplex DNA: Efficient Generation of Uracil-5-yl Radical by Charge Transfer. Watanabe, T.; Tashiro, R.; Sugiyama, H. J. Am. Chem. Soc., 2007, 129, 8163-8168.
142. Structure of a Human Telomeric DNA Sequence Stabilized by 8-Bromoguanosines Substitutions, as Determined by NMR in a K+ Solution. Matsugami, A.; Xu, Y.; Noguchi, Y.; Sugiyama, H.; Katahira, M. FEBS J., 2007, 274, 3545-3556.
143. Detection of CAG Repeat DNA Sequences by Pyrene-Functionalized Pyrrole-Imidazole Polyamides. Bando, T.; Fujimoto, J.; Minoshima, M.; Shinohara, K.; Sasaki, S.; Kashiwazaki, G.; Mizumura, M.; Sugiyama, H. Bioorg. Med. Chem., 2007, 15, 6937-6942.
144. Recombinant Schizosaccharomyces pombe Nth1 Protein Exhibits DNA Glycosylase Activities for 8-oxo-7,8-dihydroguanine and Thymine Residues Oxidized in the Methyl Group. Yonekura, S.; Nakamura, N.; Doi, T.; Sugiyama, H.; Yamamoto, K.; Yonei, S.; Zhang, Q.-M. J. Radiat. Res., 2007, 48, 417-424.
145. Meeting Review: First International Meeting on Quadruplex DNA. Wilson, W. D.; Sugiyama, H. ACS Chem. Biol., 2007, 2 , 589-594.
146. Optimization and Validation of a High-Performance Liquid Chromatographic Method with UV Detection for the Determination of Pyrrole-Imidazole Polyamides in Rat Plasma. Fukasawa, A.; Nagashima, T.; Aoyama, T.; Fukuda, N.; Matusda, H.; Ueno, T.; Sugiyama, H.; Nagase, H.; Matsumono, Y. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2007, 859, 272-275.
147. The Androgen Receptor as Putative Therapeutic Target in Hormonone-Refractory Prostate Cancer. Kageyama, Y.; Hyochi, N.; Kihara, K.; Sugiyama, H. Recent Pat. Anticancer Drug Discov., 2007, 2, 203-211.
148. Sequence-Specific Alkylation by Y-Shaped and Tandem Hairpin Pyrrole-Imidazole Polyamides. Sasaki, S.; Bando, T.; Minoshima, M.; Shinohara, K.; Sugiyama, H. Chem. Eur. J., 2008, 18, 864-870.
149. Photoreaction of Iodouracil in DNA duplex; C-I bond is Cleaved via Two Different Pathways "Homolysis and Heterolysis". Tashiro, R.; Nakamura, K.; Sugiyama, H. Tetrahedron Lett., 2008, 49, 428-431.
150. Requirement of β-Alanine Components in Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Conjugates with Seven-Base Pair Recognition. Bando, T.; Minoshima, M.; Kashiwazaki, G.; Shinohara, K.; Sasaki, S.; Fujimoto, J.; Ohtsuki, A.; Murakami, M.; Nakazono, S.; Sugiyama, H. Bioorg. Med. Chem., 2008, 16, 2286-2291.
151. Pyrrole-Imidazole Hairpin Polyamides with High Affinity at 5'-CGCG-3' DNA Sequence; Influence of Cytosine Methylation on Binding. Minoshima, M.; Bando, T.; Sasaki, S.; Fujimoto, J.; Sugiyama, H. Nucleic Acids Res., 2008, 36, 2889-2894.
152. Detection of Triplet Repeat Sequences in the Double-Stranded DNA using Pyrene-Functionalized Pyrrole-Imidazole Polyamides with Rigid Linkers. Fujimoto, J.; Bando, T.; Minoshima, M.; Uchida, S.; Iwasaki, M.; Shinohara, K.; Sugiyama, H. Bioorg. Med. Chem., 2008, 16, 5899-5907.
153. Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Attenuates Restenosis of the Artery after Injury. Yao, E-H; Fukuda, N.; Ueno,T.; Matsuda, M.; Matsumoto, M.; Nagase, H.; Matsumoto, Y.; Takasaka, A.; Serie, K.; Sugiyama, H.; Sawamura, T. Hypertension, 2008, 52, 86-92.
154. G-Quadruplex Structures of Human Telomere DNA examined by Single Molecule FRET and BrG-Substitution. Okamoto, K.; Sannohe, Y.; Mashimo, T.; Sugiyama, H.; and Terazima, M. Bioorg. Med. Chem., 2008, 16, 6873-6879.
155. Development of Pyrrole-Imidazole Polyamide for Specific Regulation of Human Aurora Kinase-A and -B Gene Expression. Takahashi, T.; Asami, Y.; Kitamura, E.; Suzuki, T.; Wang, X.; Igarashi, J.; Morohashi, A.; Shinojima, Y.; Kanou, H.; Saito, K.; Takasu, T.; Nagase, H.; Harada, Y.; Kuroda, K.; Watanabe, T.; Kumamoto, S.; Aoyama, T.; Matsumoto, Y.; Bando, T.; Sugiyama, H.; Yoshida-Noro, C.; Fukuda, N.; Hayashi N. Chem. Biol., 2008, 15, 829-841.
156. Perylene-Conjugated Pyrrole Polyamide as a Sequence-Specific Fluorescent Probe. Fujimoto, J.; Bando, T.; Minoshima, M.; Kashiwazaki, G.; Nishijima, S.; Shinohara, K.; Sugiyama, H. Bioorg. Med. Chem., 2008, 16, 9741-9744.
157. Stable Lariat Formation Based on a G-Quadruplex Scaffold. Xu, Y.; Sato, H.; Sannohe, Y.; Shinohara, K.; Sugiyama, H. J. Am. Chem. Soc., 2008, 130, 16470-16471.
158. A Pyrrole-Imidazole Polyamide Targeting Transforming Growth Factor-β1 Inhibits Restenosis and Preserves Endothelialization in the Injured Artery. Yao, E-H.; Fukuda, N.; Ueno, T.; Matsuda, H.; Nagase, N.; Matsumoto, Y.; Sugiyama, H.; Matsumoto, K. Cardiovasc. Res., 2009, 81, 797-804.
159. Cooperative Alkylation of Double-Strand Human Telomere Repeat Sequences by PI Polyamides with 11-Base-Pair Recognition Based on a Heterotrimeric Design. Kashiwazaki, G.; Bando, T.; Shinohara, K.; Minoshima, M.; Nishijima, S.; Sugiyama, H. Bioorg. Med. Chem., 2009, 17, 1393-1397.
160. The Orientation of the Ends of G-Quadruplex Structures Investigated using End-Extended Oligonucleotides. Sannohe, Y.; Sato, K.; Matsugami, A.; Shinohara, K.; Mashimo, T.; Katahira, M.; Sugiyama, H. Bioorg. Med. Chem., 2009, 17, 1870-1875.
161. Pharmacokinetic Modeling and Prediction of Plasma Pyrrole-Imidazole Polyamide Concentration in Rats using Simultaneous Urinary and Biliary Excretion Data. Nagashima, T.; Aoyama, T.; Yokoe, T.; Fukasawa, A.; Fukuda, N.; Ueno, T.; Sugiyama, H.; Nagase, H. Bio. Pharm. Bull., 2009, 32, 921-927.
162. Pharmacokinetics of Pyrrole-Imidazole Polyamides after Intravenous Administration in Rat. Fukasawa, A.; Aoyama, T.; Nagashima, T.; Fukuda, N.; Ueno, T.; Sugiyama, H.; Nagase, H.; Matsumoto, H. Biopharm. Drug Dispos., 2009, 30, 81-89.
163. KsgA, a 16S rRNA Adenine Methyltransferase, Has a Novel DNA Glycosylase/AP lyase Activity to Prevent Mutations in Escherichia coli. Zhang-Akiyama, Q. M.; Morinaga, H.; Kikuchi, M.; Yonekura, S.; Sugiyama, H.; Yamamoto, K.; Yonei, S.; Nucleic Acids Res., 2009, 37, 2116-2125.
164. A Novel Gene Silencer, Pyrrole-Imidazole Polyamide Targeting Human Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Gene Improves Endothelial Cell Function. Ueno, T.; Fukuda, N.; Tsunemi, A.; Yao, E. H.; Matsuda, H.; Tahira, K.; Matsumoto, T.; Matsumoto, Y.; Nagase, H.; Sugiyama, H.; Sawamura, T. J. Hypertens., 2009, 27, 508-516.
165. Determination of Pyrrole-Imidazole Polyamide in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Nagashima, T.; Aoyama, T.; Fukasawa, A.; Watabe, S.; Fukuda, N.; Ueno, T.; Sugiyama, H.; Nagase, H.; Matsumoto, Y. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2009, 877, 1070-1076.
166. Purification and Characterization of Caenorhabditis Elegans NTH, a Homolog of Human Endonuclease III: Essential Role of N-Terminal Region. Morinaga, H.; Yonekura, S.; Nakamura, N.; Yonei, S.; Zhang-Akiyama, Q. M. DNA Repair, 2009, 8, 844-851.
167. Development of a Molecule-Recognized Promoter DNA Sequence for Inhibition of HER2 Expression. Suzuki, T.; Asami, Y.; Takahashi, T.; Wang, X.; Watanabe, T.; Bando, T.; Sugiyama, H.; Fukuda, N.; Nagase, H. J. Antibiot., 2009, 62, 339-341.
168. Chemical Approaches to DNA Nanotechnology. Endo, M.; Sugiyama, H. ChemBioChem, 2009, 10, 2420-2443. (Review)
169. Synthesis and Properties of PI Polyamide-SAHA Conjugate. Ohtsuki, A.; Kimura, M. T.; Minoshima, M.; Suzuki, T.; Ikeda, M.; Bando, T.; Nagase, H.; Shinohara, K.; Sugiyama, H. Tetrahedron Lett., 2009, 50, 7288-7292.
170. Eukaryotic DNA Polymerases α, β and ε Incorporate Guanine Opposite 2,2,4-Triamino-5(2H) -oxazolone. Kino, K.; Sugasawa, K.; Mizuno, T.; Bando, T.; Sugiyama, H.; Akita, M.; Miyazawa, H.; Hanaoka, F. ChemBioChem, 2009, 10, 2613-2616.
171. DNA Prism Structures Constructed by Folding of Multiple Rectangular Arms. Endo, M.; Hidaka, K.; Kato, T.; Namba, K.; Sugiyama, H. J. Am. Chem. Soc., 2009, 131, 15570-15571.
172. Design of a G-quadruplex Topology through Glycosidic Bond Angles. Webba da Silva, M.; Trajkovsiki, M.; Sannohe, Y.; Ma'ami Hessari, N.; Sugiyama, H.; Plavec, J. Angew. Chem. Int. Ed., 2009, 48, 9167-9170.
173. Potent Activity Against K562 Cells by Polyamide-seco-CBI Conjugates Targeting Histone H4 Genes. Minoshima, M.; Chou, J. C.; Lefebvre, S.; Bando, T.; Shinohara, K.; Gottesfeld, J. M.; Sugiyama, H. Bioorg. Med. Chem., 2010, 18, 168-174.
174. Cell Permeability of Py-Im-Polyamide-Fluorescein Conjugates: Influence of Molecular Size and Py/Im Content. Nishijima, S.; Shinohara, K.; Bando,T.; Minoshima, M.; Kashiwazaki, G.; Sugiyama, H. Bioorg. Med. Chem., 2010, 18, 978-983.
175. Comparative Analysis of DNA Alkylation by Conjugates between Pyrrole-Imidazole Hairpin Polyamides and Chlorambucil or seco-CBI. Minoshima, M.; Bando, T.; Shinohara, K.; Kashiwazaki, K.; Nishijima, S.; Sugiyama, H. Bioorg. Med. Chem., 2010, 18, 1236-1243.
176. Anticancer Activities of Alkylating Pyrrole-Imidazole Polyamides with Specific Sequence Recognition. Shinohara, K.; Bando, T.; Sugiyama, H. Anticancer Drugs, 2010, 21, 228-242. (Review)
177. Regulation of DNA Methylation using Different Tensions of Double Strands Constructed in a Defined DNA Nanostructure. Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132 , 1592-1597.
178. A Chiral Wedge Molecule Inhibits Telomerase Activity. Shinohara, K.; Sannohe, Y.; Kaieda, S.; Tanaka, K.; Osuga, H.; Xu, Y.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132, 3778-3782.
179. Overview of Formation of G-Quadruplex Structures. Sannohe, Y.; Sugiyama, H. Curr. Protoc. Nucleic Acid Chem., 2010, 17.2.1-17.2.17. (Review)
180. DNA-Based Hybrid Catalysts for Asymmertic Organic Synthesis. Park, S.; Sugiyama, H. Angew. Chem. Int. Ed., 2010, 49, 3870-3878. (Review)
181. Inhibition of MMP-9 Transcription and Suppression of Tumor Metastasis by Pyrrole-Imidazole Polyamide. Wang, X.; Nagase, H.; Watanabe, T.; Nobusue, H.; Suzuki, T.; Kimura, M.; Mishra, R.; Shinojima, Y.; Kawashima, H.; Takagi, K.; Igarashi, J.; Takayama, T.; Fukuda, N.; Sugiyama, H. Cancer Sci., 2010, 101, 759-766.
182. Alkylation of a Human Telomere Sequence by Heterotrimeric Chlorambucil PI Polyamide Conjugates. Kashiwazaki, G.; Bando, T.; Shinohara, K.; Minoshima, M.; Kumamoto, H.; Nishijima, S.; Sugiyama, H. Bioorg. Med. Chem., 2010, 18, 2887-2893.
183. Programmed-Assembly System Using DNA Jigsaw Pieces. Endo, M.; Sugita, T.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. Chem. Eur. J., 2010, 16, 5362-5368.
184. Synthesis of Bicyclic Enediynes That Possess a Photosensitive Triggering Device and Exhibit strong DNA Cleaving Activity. Tanaka, H.; Tanaka, Y.; Minoshima, M.; Yamaguchi, S.; Takahashi, H.; Fuse, S.; Doi, T.; Kusumi, T.; Kawauchi, S.; Sugiyama, H.; Takahashi, T. Chem. Commum., 2010, 46, 5942-5944.
185. Folding Pathways of Human Telomeric Type-1 and Type-2 G-Quadruplex Structures. Mashimo, T.; Yagi, H.; Sannohe, Y.; Rajendran, A.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132, 14910-14918.
186. The Distance between Donor and Acceptor Affects the Proportion of C1' and C2' Oxidation Products of DNA in a BrU-containing Excess Electron Transfer System. Tashiro, R.; Ohtsuki, A.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132, 14361-14363.
187. Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine. Hori, M.; Yonekura, S.I.; Nohmi, T.; Gruz, P.; Sugiyama, H.;Yonei, S.; Zhang Akiyama, Q. M. J. Nucleic Acids, 2010, 807579-807588.
188. Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure. Sannohe, Y.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132, 16311-16313.
189. A Versatile DNA Nanochip for Direct Analysis of DNA Base-Excision Repair. Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. Angew. Chem. Int. Ed., 2010, 49, 9412-9416.
190. Transcriptional Inhibition of Progressive Renal Disease by the Gene Silencing Pyrrole-Imidazole polyamide Targeted to the TGF-β1Promoter. Matsuda, H.; Fukuda, N.; Ueno, T.; Katakawa, M.; Wang, X.; Watanabe, T.; Matsui, S.; Aoyama, T.; Saito, K.; Bando, T.; Matsumoto, Y.; Nagase, H.; Matsumoto, K.; Sugiyama, H. Kidney Int., 2011, 79, 46-56.
191. Programmed Two-Dimensional Self-Assembly of Multiple sDNA Origami Jigsaw Pieces. Rajendran, A.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. ACS Nano, 2011, 5, 665-671.
192. Direct AFM Observation of an Opening Event of a DNA Cuboid Constructed via a Prism Structure. Endo, M.; Hidaka, K.; Sugiyama, H. Org. Biomol. Chem., 2011, 9, 2075-2077.
193. Photo Controllable Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Polyamide seco-CBI Conjugate. Park, S.; Bando, T.; Shinohara, K.; Sugiyama, H. Biocojugate Chem., 2011, 22, 120-124.
194. Two-Dimensional DNA Origami Assemblies Using a Four-Way Connector. Endo, M.; Sugita, T.; Rajendran, A.; Katsuda, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2011, 47, 3213-3215.
195. Direct Observation of Stepwise Movement of a Synthetic Molecular Transporter. Wickham, S. F. J.; Endo, M.; Katsuda, Y.; Hidaka, K.; Bath, J.; Sugiyama, H.; Turberfield, A. J. Nature Nanotechnol., 2011, 6, 166-169.
196. Recent Progress in DNA Origami Technology. Endo, M.; Sugiyama, H. Curr. Protoc. Nucleic Acid Chem., 2011, 45, 12.8.1-12.8.19. (Review)
197. Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly. Rajendran, A.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2011, 133, 14488-14491.
198. Programmed Placement of Gold Nanoparticles Onto a Slit-Type DNA Origami Scaffold. Endo, M.; Yang, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2011, 47, 10743-10745.
199. Evaluation of PI polyamide Conjugates With Eight-Base Pair Recognition and Improvement of The Aqueous Solubility by PEGylation. Takagaki, T.; Bando, T.; Kitano, M.; Hashiya, K.; Kashiwazaki, G.; Sugiyama, H. Bioorg. Med. Chem., 2011, 19, 5896-5902.
200. Cysteine Cyclic Pyrrole-Imidazole Polyamide for Sequence-Specific Recognition In the DNA Minor Groove. Morinaga, H.; Bando, T.; Takagaki, T.; Yamamoto, M.; Hashiya, K.; Sugiyama, H. J. Am. Chem. Soc., 2011, 133, 18924-18930.
201. DNA Ligand Designed to Antagonize EBNA1 Represses Epstein-Barr Virus-Induced Immortalization. Noguchi, K.; Yasuda, A.; Minoshima, M.; Kashiwazaki, G.; Kanda, T.; Katayama, K.; Mitsuhashi, J.; Bando, T.; Sugiyama, H.; Sugimoto, Y. Cancer Sci., 2011, 102, 2221-2230.
202. Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes In Mouse Embryonic Fibroblasts. Pandian, G. N.; Shinohara, K.; Ohtsuki, A.; Nakano, Y.; Minoshima, M.; Bando, T.; Nagase, H.; Yamada, Y.; Watanabe, A.; Terada, N.; Sato, S.; Morinaga, H.; Sugiyama, H. ChemBioChem, 2011, 12, 2822-2828.
203. A Single-Molecule Platform for Investigation of Interactions between G-Quadruplexes and Small-Molecule Ligands. Koirala, D.; Dhakal, S.; Ashbridge, B.; Sannohe, Y.; Rodriguez, R.; Sugiyama, H.; Balasubramanian, S.; Mao, H. Nature Chemistry, 2011, 3, 782-787.
204. Discrimination between T/A and A/T Base Pairs of Pyrrole-Imidazole Polyamides Substituted with Chiral β-Hyroxy-γ-Aminobutyric Acid/β-Alanine Pairs. Zhang, W.; Jiang, S.K.; Wu, Y.L.; Guo, C.X.; Zhang, H.F.; Sugiyama, H.; Chen, X.L. ChemBioChem, 2012, 13, 47-50.
205. Single-Molecule Analysis Using DNA Origami. Rajendran, A.; Endo, M.; Sugiyama, H. Angew. Chem. Int. Ed., 2012, 51, 874-890. (Review)
206. Intramolecular Folding in Three Tandem Guanine Repeats of Human Telomeric DNA. Koirala, D.; Mashimo, T.; Sannohe, Y.; Yu, Z.; Mao, H.; Sugiyama, H. Chem. Commun., 2012, 48, 2006-2008.
207. Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure. Endo, M.; Miyazaki, R.; Emura, T.; Hidaka, K.; H.; Sugiyama, H. J. Am. Chem. Soc., 2012, 134, 2852-2855.
208. Zinc-Finger Proteins for Site-Specific Protein Positioning on DNA-Origami Structures. Nakata, E.; Fong, L.W.; Uwatoko, C.; Kiyonaka, S.; Mori, Y.; Katsuda, Y.; Endo, M.; Sugiyama, H.; Morii, T. Angew Chem. Int. Ed., 2012, 51, 2421-2424.
209. SWI/SNF-Mediated Chromatin Remodeling Induces Z-DNA Formation on a Nucleosome. Mulholland, N.; Xu, Y.; Sugiyama, H.; Zhao, K. Cell and Bioscience, 2012 , 2:3.
210. Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N- Methylpyrrole- N- Methylimidazole Polyamide Conjugates. Kashiwazaki, G.; Bando, T.; Yoshidome, T.; Masui, S.; Takagaki, T.; Hashiya, K.; Pandian, G.N.; Yasuoka, J.; Akiyoshi, K.; Sugiyama, H. J. Med. Chem., 2012, 55, 2057-2066.
211. Single Strand DNA Catenane Synthesis Using the Formation of G-Quadruplex Structure. Sannohe, Y.; Sugiyama, H. Bioorg. Med. Chem., 2012, 20, 2030-2034.
212. DNA Origami: Synthesis and Self-Assembly. Rajendran, A.; Endo, M.; Sugiyama, H. Curr. Protoc. Nucleic Acid Chem., 2012, 48, 12.9.1-12.9.18.
213. A DNA-Based Molecular Motor that can Navigate a Network of Tracks. Wickham, S. F. J; Bath, J.; Katsuda, Y.; Endo, M.; Hidaka, K.; Sugiyama, H.; Tuberfield , A. J. Nature Nanotechnol., 2012, 7, 169-173.
214. Sequence-Selective Single-Molecule Alkylation with a Pyrrole-Imidazole Polyamide Visualized in a DNA Nanoscaffold. Yoshidome, T.; Endo, M.; Kashiwazaki, G.; Hidaka, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2012, 134, 4654-4660.
215. Development of Programmable Small DNA-Binding Molecules with Epigenetic Activity for Induction of Core Pluripotency Genes. Pandian, G. N.; Ohtsuki, A.; Bando, T.; Sato, S.; Hashiya, K.; Sugiyama, H. Bioorg. Med. Chem., 2012, 20, 2656-2660.
216. Structural and Functional Analysis of Proteins by High-Speed Atomic Force Microscopy. Rajendran, A.; Endo, M.; Sugiyama, H. Adv. Protein Chem. Struct. Biol., 2012, 87, 5-55. (Review)
217. Programmable Genetic Switiches to Control Transcrpitional Machinery of Pluripotency. Pandian, G. N.; Sugiyama, H. Biotechnol. J., 2012, 7, 798-809. (Review)
218. Recognition by Nonaromatic and Stereochemical Subunit- Containing Polyamides of the Four Watson-Crick Base Pairs in the DNA Minor Groove. Zhang, H. F.; Wu, Y. L.; Jiang, S. K.; Wang, P.; Sugiyama, H.; Chen, X. L.; Zhang, W.; Ji, Y. J.; Guo, C. X. ChemBioChem, 2012, 13, 1366-1374.
219. Direct Visualization of the Movement of a Single T7 RNA Polymerase and Transcription on a DNA Nanostructure. Endo, M.; Tatsumi, K.; Terushima, K.; Katsuda, Y.; Hidaka, K.; Harada, Y.; Sugiyama, H. Angew. Chem. Int. Ed., 2012, 51, 8778-8782.
220. Design and Development of Nanosized DNA Assemblies in Polypod-Like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells. Mohri, K.; Nishikawa, M.; Takahashi, N.; Shiomi, T.; Matsuoka, N.; Ogawa, K.; Endo, M.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y. ACS Nano, 2012, 6, 5931-5940.
221. A Synthetic Small Molecule for Rapid Induction of Multiple Pluripotency Genes in Mouse Embryonic Fibroblasts. Pandian, G. N.; Nakano, Y.; Sato, S.; Morinaga, H.; Bando, T.; Nagase, H.; Sugiyama, H. Sci. Rep., 2012, 2, 544.
222. Synthesis of Pyrrole-Imidazole Polyamide seco-1-Chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole Conjugates with a Vinyl Linker Recognizing a 7 bp DNA Sequence. Takagaki, T.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2012, 134, 13074-13081.
223. Single-Molecule Visualization of the Hybridization and Dissociation of Photoresponsive Oligonucleotides and Their Reversible Switching Behavior in a DNA Nanostructure. Endo, M.; Yang, Y.; Hidaka, K.; Sugiyama, H. Angew. Chem. Int. Ed., 2012, 51, 10518-10522.
224. Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes. Vaijayanthi, T.; Bando, T.; Pandian, G. N.; Sugiyama, H. ChemBioChem, 2012, 13, 2170-2185. (Review)
225. Binding of Hairpin Pyrrole and Imidazole Polyamides to DNA: Relationship between Torsion Angle and Association Rate Constants. Han, Y-W.; Matsumoto, T.; Yokota, H.; Kashiwazaki, G.; Morinaga, H.; Hashiya, k.; Bando, T.; Harada, Y.; Sugiyama, H. Nucleic Acids Res., 2012, 40, 11510-11517.
226. Deciphering DNA-Based Asymmetric Catalysis through Intramolecular Friedel-Crafts Alkylations. Park, S.; Watabe, R.; Ikehata, K.; Hidaka, Y.; Rajendran, A.; Sugiyama, H. Chem. Commun., 2012, 48, 10398-10400.
227. DNA as a Chiral Scaffold for Asymmetric Synthesis. Park, S.; Sugiyama, H. Molecules, 2012, 17, 12792-12803. (Review)
228. Immunotherapies: The Blockade of Inhibitory Signals . Wu, Y.; Liang, J.; Zhang, W.; Tanaka, Y.; Sugiyama, H. Intl. J. Biol. Sci., 2012, 8, 1420-1430. (Review)
229. Photo-Controllable DNA Origami Nanostructures Assembling into Predesigned Multiorientational Patterns. Yang, Y.; Endo, M.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2012, 134, 20645-20653.
230. G-Quadruplex Nanostructures Probed at the Single Molecular Level by Force-Based Methods. Dhakal, S.; Mao, H.; Rajendran, A.; Endo, M.; Sugiyama, H. Guanine Quartets: Structure and Application (Royal Society of Chemistry) , 2013, 73-85.
231. Photoreactivities of 5-Bromouracil-containing RNAs. Morinaga, H.; Kizaki, S.; Takenaka, T.; Kanesato, S.; Sannohe, Y.; Tashiro, R.; Sugiyama, H. Bioorg. Med. Chem., 2013, 21, 466-469.
232. Strategies to Modulate Heritable Epigenetic Defects in Cellular Machinery: Lessons from Nature . Pandian, G. N.; Sugiyama, H. Pharmaceuticals, 2013, 6, 1-24.
233. DNA Origami Technology for Biomaterials Applications. Endo, M.; Yang, Y.; Sugiyama, H. Biomater. Sci., 2013, 1, 347-360. (Review)
234. Control of the Two-dimensional Crystallization of DNA Origami with Various Loop Arrangements. Rajendran, A.; Endo, M.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2013, 49, 686-688.
235. Helical Structure and Circular Dichroism Spectra of DNA: A Theoretical Study. Miyahara, T.; Nakatsuji, H.; Sugiyama, H. J. Phys. Chem. A., 2013, 117, 42-55.
236. Design of a New Fluorescent Probe: Pyrrole/Imidazole Hairpin Polyamides with Pyrene Conjugation at Their γ-Turn. Vaijayanthi, T.; Bando, T.; Hashiya, K.; Pandian, G. N.; Sugiyama, H. Bioorg. Med. Chem., 2013, 21, 852-855.
237. Direct and Real-Time Observation of Rotary Movement of a DNA Nanomechanical Device. Rajendran, A.; Endo, M.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2013, 135, 1117-1123.
238. Long-Loop G-Quadruplexes Are Misfolded Population Minorities with Fast Transition Kinetics in Human Telomeric Sequences. Koirala, D.; Ghimire, C.; Bohrer, C.; Sannohe, Y.; Sugiyama, H.; Mao, H. J. Am. Chem. Soc., 2013, 135, 2235-2241.
239. Hydrochlorothiazide Enhances UVA-induced DNA Damage . Kunisada, M.; Masaki, T.; Ono, R.; Morinaga, H.; Nakano, E.; Yogianti, F.; Okunishi, K.; Sugiyama, H.; Nishigori, C. Photochemistry and Photobiology, 2013, 39, 649-652.
240. Sequence-Specific Electron Injection into DNA from an Intermolecular Electron Donor. Morinaga, H.; Takenaka, T.; Hashiya, F.; Kizaki, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Nucleic Acids Res., 2013, 41, 4724-4728.
241. RNA-templated DNA Origami Structures. Endo, M.; Yamamoto, S.; Tatsumi, K.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2013, 49, 2879-2881.
243. Synthesis and Biological Evaluation of a Targeted DNA-binding Transcriptional Activator with HDAC8 Inhibitory Activity . Saha, A.; Pandian, G. N.; Sato, S.; Taniguchi, J.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2013, 21, 4201-4209.
244. The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases. Liang, J.; Wu, Y.; Chen, B.; Zhang, W.; Tanaka, Y.; Sugiyama, H. Int. J. Biol., Sci. 2013, 9, 435-443. (Review)
245. Effect of Single Pyrrole Replacement with β-Alanine on DNA Binding Affinity and Sequence Specificity of Hairpin Pyrrole/Imidazole Polyamides Targeting 5'-GCGC-3' Han, Y-W.; Kashiwazaki, G. ; Morinaga, H.; Matsumoto, T.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2013, 21, 5436-5441.
246. Solid-Supported DNA for Asymmetric Synthesis: a Stepping-Stone toward Practical Applications. Park, S.; Ikehata, K.; Sugiyama, H. Biomater. Sci., 2013, 1, 1034-1036.
247. Controlling the Stoichiometry and Strand Polarity of a Tetramolecular G-Quadruplex Structure by Using a DNA Origami Frame. Rajendran, A.; Endo, M.; Hidaka, K.; Thao, P. L. T.; Mergny, J-L.; Sugiyama, H. Nucleic Acids Res., 2013, 41, 8738-8747.
248. Guided Assembly of Tetramolecular G-Quadruplexes. Yatsunyk, L. A.; Pietrement, O.; Albrecht, D.; Tran, P. L. T., Renciiuk, D.; Sugiyama, H.; Arbona, J-M.; Aime, J-P.; Mergny, J-L. ACS Nano, 2013, 7, 5701-5710.
249. Chemically Induced Pluripotent Stem Cells (CiPSCs): A Transgene-Free Approach. Masuda, S.; Wu, J.; Hishida, T.; Pandian, G. N.; Sugiyama, H.; Belmonte, J. C. I. J. Mol. Cell Biol., 2013, 5, 354-355.
250. A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell . Han, L.; Pandian, G. N.; Junetha, S.; Sato, S.; Anandhkumar, C.; Taniguchi, J.; Saha, A.; Bando, T.; Nagase, H.; Sugiyama, H. Angew. Chem. Int. Ed., 2013, 52, 13410-13413. (Hot Paper)
251. Development of a New Method for Synthesis of Tandem Hairpin Pyrrole-Imidazole Polyamide Probes Targeting Human Telomeres. Kawamoto, Y.; Bando, T.; Kamada, F.; Li, Y.; Hashiya, K.; Maeshima, K.; Sugiyama, H. J. Am. Chem. Soc., 2013, 135, 16468-16477.
252. Conjugation of Peptide Nucleic Acid with a Pyrrole/Imidazole Polyamide to Specifically Recognize and Cleave DNA. Kameshima, W.; Ishizuka, T.; Minoshima, M.; Yamamoto, M.; Sugiyama, H.; Xu, Y.; Komiyama, M. Angew. Chem. Int. Ed., 2013, 52, 13681-13684.
253. Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources. Wu, Y-L.; Pandian, G. N.; Ding, Y-P.; Zhang, W.; Tanaka, Y.; Sugiyama, H. Chem. Biol., 2013, 20, 1311-1322. (Review)
254. Regulation of B-Z Conformational Transition and Complex Formation with a Z-form Binding Protein by Introduction of Constraint to Double-Stranded DNA by using a DNA Nanoscaffold. Endo, M.; Inoue, M.; Suzuki, Y.; Masui, C.; Morinaga, H.; Hidaka, K.; Sugiyama, H. Chem. Eur. J., 2013, 19, 16887-16890.
255. HIV-1 Nucleocapsid Proteins as Molecular Chaperones for Tetramolecular Antiparallel G-Quadruplex Formation. Rajendran, A.; Endo, M.; Hidaka, K.; Tran, P. L. T.; Mergny, J-L.; Gorelick, R. J.; Sugiyama, H. J. Am. Chem. Soc., 2013, 135, 18575-18585.
256. CGmCGCG is a Versatile Substrate with which to Evaluate Tet Protein Activity . Kizaki, S.; Sugiyama, H. Org. Biomol. Chem., 2014, 12, 104-107.
257. State-of-the-Art High-Speed Atomic Force Microscopy for Investigation of Single-Molecular Dynamics of Proteins . Rajendran, A.; Endo, M.; Sugiyama, H. Chem. Rev., 2014, 114, 1493-1520. (Review)
259. Sequence-Specific DNA Recognition by Cyclic Pyrrole-Imidazole Cysteine-Derived Polyamide Dimers. Yamamoto, M.; Bando, T.; Morinaga, H.; Kawamoto, Y.; Hashiya, K.; Sugiyama, H. Chem. Eur. J., 2014, 20, 752-759.
260. Controlling Electron Rebound within Four-Base π-Stacks in Z-DNA by Changing the Sugar Moiety from Deoxy- to Ribonucleotide . Sannohe, Y.; Kizaki, S.; Kanesato, S.; Fujiwara, A.; Morinaga, H.; Tashiro, R.; Sugiyama, H. Chem. Eur. J., 2014, 20, 1223-1225.
261. Sequence-Specific DNA Alkylation Targeting for Kras Codon 13 Mutation by Pyrrole-Imidazole Polyamide seco-CBI Conjugates . Taylor, R. D.; Asamitsu, S.; Takenaka, T.; Yamamoto, M.; Hashiya, K.; Kawamoto, Y.; Bando, T.; Nagase, H.; Sugiyama, H. Chem. Eur. J., 2014, 20, 1310-1317.
262. Highly Emissive Deoxyguanosine Analogue Capable of Direct Visualization of B-Z Transition. Park, S.; Otomo, H.; Zheng, L.; Sugiyama, H. Chem. Commun., 2014, 50, 1573-1575.
263. DNA Origami Based Visualization System for Studying Site-Specific Recombination Events . Suzuki, Y.; Endo, M.; Katsuda, Y.; Ou, K.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2014, 136, 211-218.
264. G-quadruplex-binding Ligand-induced DNA Synapsis Inside a DNA Origami Frame. Rajendran, A.; Endo, M.; Hidaka, K.; Tran, P. L. T.; Teulade-Fichou, M-P.; Mergny, J-L.; Sugiyama, H. RSC Adv., 2014, 4, 6346-6355.
265. Distinct DNA-based Epigenetic Switches Trigger Transcriptional Activation of Silent Genes in Human Dermal Fibroblasts. Pandian, G. N.; Taniguchi, J.; Junetha, S.; Sato, S.; Han, L.; Saha, A.; Anandhkumar, C.; Bando, T.; Nagase, H.; Thangavel, V.; Taylor, R. D.; Sugiyama, H. Sci. Rep., 2014, 4, 3843.
266. Dynamic Assembly/Disassembly Processes of Photoresponsive DNA Origami Nanostructures Directly Visualized on a Lipid Membrane Surface . Suzuki, Y.; Endo, M.; Yang, Y.; Sugiyama, H. J. Am. Chem. Soc., 2014, 136, 1714-1717.
267. Specific Alkylation of Human Telomere Repeat Sequences by a Tandem-Hairpin Motif of Pyrrole-Imidazole Polyamides with Indole-Seco-CBI. Yamamoto, M.; Bando, T.; Kawamoto, Y.; Taylor, R. D.; Hashiya, K.; Sugiyama, H. Bioconjugate Chem., 2014, 25, 552-559.
268. Single-Molecule Imaging of Dynamic Motions of Biomolecules in DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy. Endo, M.; Sugiyama, H. Acc. Chem. Res., 2014, 47, 1645-1653. (Review)
269. Direct and Single-Molecule Visualization of the Solution-State Structures of G-Hairpin and G-Triplex Intermediates . Rajendran, A.; Endo, M.; Hidaka, K.; Sugiyama, H. Angew. Chem. Int. Ed., 2014, 126, 4191-4196.
270. Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges . Pandian, G. N.; Sugiyama, H. Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications (Springer Book), 2014 , 347-365. (Review)
271. Direct Observation of the Dual-Switching Behaviors Corresponding to the State Transition in a DNA Nanoframe. Yang, Y.; Endo, M.; Suzuki, Y.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2014, 50, 4211-4213.
272. Investigation of B-Z Transitions with DNA Oligonucleotides Containing 8-Methylguanine. Chen, Y-H.; Park, S.; Otomo, H.; Sakashita, S.; Sugiyama, H. Artificial DNA: PNA & XNA, 2014, 5, e28226-1-e28226-7.
273. Cellular Reprogramming for Pancreatic β-Cell Regeneration: Clinical Potential of Small Molecule Control . Pandian, G. N.; Taniguchi, J.; Sugiyama, H. Clin. Transl. Med., 2014, 3: 6.
274. The Origin of Enantioselectivity for Intramolecular Friedel-Crafts Reaction Catalyzed by Supramolecular Cu/DNA catalyst Complex. Petrova, G. P.; Ke, Z.; Park, S.; Sugiyama, H.; Morokuma, K. Chem. Phys. Lett., 2014, 600, 87-95.
275. Single Molecule Visualization and Characterization of Sox2-Pax6 Complex Formation on a Regulatory DNA Element Using a DNA Origami Frame. Yamamoto, S.; De, D.; Hidaka, K.; Kim, K. K.; Endo, M.; Sugiyama, H. Nano Lett., 2014, 14, 2286-2292.
276. Direct Analysis of Holliday Junction Resolving Enzyme in a DNA Origami Nanostructure. Suzuki, Y.; Endo, M.; Canas, C.; Ayora, S.; Alonso, J. C.; Sugiyama, H.; Takeyasu, K. Nucleic Acids Res., 2014, 42, 7421-7428.
277. Alteration of Epigenetic Program to Recover Memory and Alleviate Neurodegeneration: Prospects of Multi-target Molecules. Pandian, G. N.; Taylor, R. D.; Junetha, S.; Saha, A.; Anandhakumar, C.; Vaijayanthi, T.; Sugiyama, H. Biomater. Sci., 2014, 2, 1043-1056.
278. A Lock-and-Key Mechanism for the Controllable Fabrication of DNA Origami Structures. Rajendran, A.; Endo, M.; Hidaka, K.; Shimada, N.; Maruyama, A.; Sugiyama, H. Chem. Commun., 2014, 50, 8743-8746.
279. Sequence-Specific DNA Alkylation by Tandem Py-Im Polyamide Conjugates . Taylor, R, D.; Kawamoto, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Asian J., 2014, 9, 2527-2533.
280. Helical DNA Origami Tubular Structures with Various Sizes and Arrangements . Endo, M.; Yamamoto, S.; Emura, T; Hidaka, K.; Morone, N.; Heuser, J, E.; Sugiyama, H. Angew. Chem. Int. Ed., 2014, 53, 7484-7490.
281. Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures. Koirala, D.; Shrestha, P.; Emura, T; Hidaka, K.; Mandal, S.; Endo, M.; Sugiyama, H.; Mao, H. Angew. Chem. Int. Ed., 2014, 126, 8275-8279.
282. Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast s. Saha, A.; Pandian, G. N.; Sato, S.; Taniguchi, J.; Kawamoto, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemMedChem, 2014, 9, 2374-2380.
283. AFM Analysis of Changes in Nucleosome Wrapping Induced by DNA Epigenetic Modification. Kizaki, S.; Suzuki, Y.; Takenaka, T.; Endo, M.; Sugiyama, H. Biomater. Sci., 2014, 2, 1399-1403.
284. Sequence-Specific DNA Alkylation and Transcriptional Inhibition by Long-Chain Hairpin Pyrrole-Imidazole Polyamide-Chlorambucil Conjugates Targeting CAG/CTG Trinucleotide Repeats. Asamitsu, S.; Kawamoto, Y.; Hashiya, F.; Hashiya, K.; Yamamoto, M.; Kizaki, S.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2014, 22, 4646-4657.
285. Amplification of Fluorescent DNA through Enzymatic Incorporation of a Highly Emissive Deoxyguanosine Analogue. Otomo, H.; Park, S.; Yamamoto, S.; Sugiyama, H. RSC Adv., 2014, 4, 31341-31344.
286. Targeted Suppression of EVI1 Oncogene Expression by Sequence-specific Pyrrole-imidazole Polyamide. Junetha, S.; Pandian, G, N.; Sato, S.; Taniguchi, J.; Anandhakumar, C.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Biol., 2014, 23, 1370-1380.
287. Structural Evaluation of Tandem Hairpin Pyrrole-Imidazole Polyamides Recognizing Human Telomeres. Hirata, A.; Nokihara, K.; Kawamoto, Y.; Bando, T.; Sasaki, A.; Ide, S.; Maeshima, K.; Kasama, T.; Sugiyama, H. J. Am. Chem. Soc., 2014, 136, 11546-11554.
288. Engineering RNA-Protein Complexes with Different Shapes for Imaging and Therapeutic Applications. Osada, E.; Suzuki, Y.; Hidaka, K.; Ohno, H.; Sugiyama, H.; Endo, M.; Saito, H. ACS Nano, 2014, 8, 8130-8140.
289. NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation. Patel, S.; Jung, D.; Yin, P.; Carlton, P.; Yamamoto, M.; Bando, T.; Sugiyama, H.; Lee, K. B. ACS Nano, 2014, 8, 8959-8967.
290. Photoresponsive DNA Nanocapsule Having an Open/Close System for Capture and Release of Nanomaterials. Takenaka, T.; Endo, M.; Suzuki, Y.; Yang, Y.; Emura, T.; Hidaka, K.; Kato, T.; Mitata, T.; Namba, K.; Sugiyama, H. Chem. Eur. J., 2014, 20, 14951-14954.
291. Next-Generation Sequencing Studies Guide the Design of Pyrrole-Imidazole Polyamides with Improved Binding Specifictiy by the Addition of β-Alanine. Anandhakumar, C.; Li, Y.; Kizaki, S.; Pandian, G. N.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemBioChem, 2014, 15, 2647-2651.
292. Development of DNA-Based Hybrid Catalysts through Direct Ligand Incorporation: Toward Understanding of DNA-Based Asymmetric Catalysis. Park, S.; Zheng, L. J.; Kumakiri, S.; Sakashita, S.; Otomo, H.; Ikehata, K.; Sugiyama, H. ACS Catalysis, 2014, 4, 4070-4073.
293. Preparation of Chemically Modified RNA Origami Nanostructures. Endo, M.; Takeuchi, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Eur. J., 2014, 20, 15330-15333.
294. Direct Quantification of Loop Interaction and π-π Stacking for G-Quadruplex Stability at the Submolecular Level. Ghimire, C.; Park, S.; Iida, K.; Yangyuoru, P.; Otomo, H.; Yu, Z.; Nagasawa, K.; Sugiyama, H.; Mao, H. J. Am. Chem. Soc., 2014, 136, 15537-15544.
295. Identification of a Small Molecule That Turns ON the Pluripotency Gene Circuitry in Human Fibroblasts . Pandian, G. N.; Sato, S.; Anandhakumar, C.; Taniguchi, J.; Takashima, K.; Syed, J.; Han, L.; Saha, A.; Bando, T.; Nagase, H.; Sugiyama, H. ACS Chem. Biol., 2014, 9, 2729-2736.
296. Direct Observation of G-Quadruplexes using DNA Origami Nanoscaffold. Rajendran, A.; Li, Y.; Endo, M. ; Sugiyama, H. E. Book Chapter:DNA G-quadruplexes as new anticancer targets, (Ed. Ryan De Vooght-Johnson), Future Science Ltd, London, 2015 , 38-54. (Review)
297. Locating the uracil-5-yl Radical Formed Upon Photoirradiation of 5-bromouracil-substituted DNA. Hashiya, F.; Saha, A.; Kizaki, S.; Li, Y.; Sugiyama, H. Nucleic Acids Res., 2014, 42, 13469-13473.
298. Synthetic Strategies to Identify and Regulate Noncoding RNAs. Pandian, G. N.; Syed, J.; Sugiyama, H. Long Noncoding RNAs: Structure and Function, 23-43 (Review)
299. Advancing Small-Molecule-Based Chemical Biology with Next-Generation Sequencing Technologies. Anandhakumar, C.; Kizaki, S.; Bando, T.; Pandian, G. N.; Sugiyama, H. ChemBioChem, 2015, 16, 20-38.
300. Rational Design of Specific Binding Hairpin Py-Im Polyamides Targeting Human Telomere Sequences. Guo, C. X .; Kawamoto, Y.; Asamitsu, S.; Sawatani, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2015, 23, 855-860.
301. Tandem Trimer Pyrrole-Imidazole Polyamide Probes Targeting 18 Base Pairs in Human Telomere Sequence. Kawamoto, Y.; Sasaki, A.; Hashiya, K.; Ide, S; Bando, T.; Maeshima, K; Sugiyama, H. Chem. Sci ., 2015, 6, 2307-2312.
302. Inhibition of KRAS Codon 12 Mutants Using a Novel DNA-alkylating Pyrrole-imidazole Polyamide Conjugate. Hiraoka, K.; Inoue, T.; Taylor, R. D.; Watanabe, T.; Koshikawa, N.; Yoda, H.; Shinohara, K.; Takatori, A.; Sugimoto, K.; Maru, Y.; Denda, T.; Fujiwara, K.; Balmain, A.; Ozaki, T.; Bando, T.; Sugiyama, H.; Nagase, H. Nature Commun., 2015, 6, 6706.
303. Self-Assembling DNA Dendrimer for Effective Delivery of Immunostimulatory CpG DNA to Immune Cells. Mohri, K.; Kusuki, Eri.; Ohtsuki, S.; Takahashi, N.; Endo, M.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Biomacromolecules, 2015, 16, 1095-1101.
304. Integrating Epigenetic Modulators into NanoScript for Enhances Chondrogenesis of Stem Cells. Patel, S.; Pongkulapa, T.; Yin, P.; Pandian, G, N.; Rathnam, C.; Bando, T.; Vaijayanthi, T.; Sugiyama, H.; Lee, K, B. J. Am. Chem. Soc., 2015, 137, 4598-4601.
305. Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model. Igarashi, J.; Fukuda, N.; Inoue, T.; Nakai, S.; Saito, K.; Fujiwara, K.; Matsuda, H.; Ueno, T.; Matsumoto, Y.; Watanabe, T.; Nagase, H.; Bando, T.; Sugiyama, H.; Itoh, T.; Soma, M. PLOS ONE, 2015, 10, e0125295.
306. Small Molecule Binding to a G-hairpin and a G-riplex: A New Insight in Anticancer Drug Design Targeting G-rich Regions. Rajendran, A.; Endo, M.; Hidaka, K.; Teulade-Fichou, M.; Mergny, J, L.; Sugiyama, H. Chem. Commun., 2015, 9, 3418-3420.
307. Mimicking Membrane-Related Biological Events by DNA Origami Nanotechnology. Suzuki, Y.; Endo, M.; Sugiyama, H. ACS Nano, 2015, 9, 3418-3420.
308. Photoreactivity of the Linker Region of Two Consecutive G-quadruplexes Formed by Human Telomeric DNA. Li, Y; Sugiyama, H. Chem. Commun., 2015, 51, 8861-8864.
309. A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts. Syed, J.; Chandran, A.; Pandian, G, N.; Taniguchi, J.; Sato, S.; Hashiya, K.; Kashiwazaki, G.; Bando, T.; Sugiyama, H. ChemBioChem, 2015, 16, 1497-1501.
310. A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network. Han, L.; Pandian, G, N.; Chandran, A.; Sato, S.; Taniguchi, J.; Kashiwazaki, G.; Sawatani, Y.; Hashiya, K.; Bando, T.; Xu, Y.; Qian, X,; Sugiyama, H. Angew. Chem. Int. Ed., 2015, 54, 8700-8703.
311. Studying RNAP-promoter Interactions Using Atomic Force Microscopy. Suzuki, Y.; Endo, M.; Sugiyama, H. Methods, 2015, 86, 4-9.
312. Detection of UV-induced Cyclobutane Pyrimidine Dimers by Near-infared Spectroscopy and Aquaphotomics. Goto, N.; Bazar, G.; Kovacs, Z.; Kunisada, M.; Morita, H.; Kizaki, S.; Sugiyam, H.; Tesenkova, R.; Nishigori, C. Sci. Rep., 2015, 5, 11808.
313. Single-Molecule Visualization of the Activity of a Zn2+ -Dependent DNAzyme. Endo, M.; Takeuchi, Y.; Suzuki, Y.; Emura, T.; Hidaka, K.; Wang, F.; Willner, I.; Sugiyama, H. Angew. Chem. Int. Ed., 2015, 54, 10550-10554.
314. Folding RNA-Protein Complex into Designed Nanostructures. Shibata, T.; Suzuki, Y.; Sugiyama, H.; Endo, M.; Saito, H. Springer Book. Methods in Molecular Biology. 2015 , 1316, 169-179. (Review)
315. Linking Two DNA Duplexes with a Rigid Linker for DNA Nanotechnology. Tashiro, R.; Iwamoto, M.; Morinaga, H.; Emura, T.; Hidaka, K.; Endo, M.; Sugiyama, H. Nucleic Acids Res., 2015, 43, 6692-6700.
316. Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells. Ohtsuki, S.; Matsuzaki, N.; Mohri, K.; Endo, M.; Emura, T.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Ishiyama, K.; Kadowaki, N.; Takakura, Y.; Nishikawa, M. Nucleic Acid Therapeutics, 2015, 25, 245-253.
317. Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole-Imidazole Polyamide seco-CBI Conjugates. Taylor, R, D.; Chandran, A.; Kashiwazaki, G.; Hashiya, K.; Bando, T.; Nagase, H.; Sugiyama, H. Chem. Eur. J., 2015, 21, 14996-15003.
318. Development of DNA Metalloenzymes Using a Rational Design Approach and Application in the Asymmetric Diels-Alder Reaction. Park, S.; Okamura, I.; Sakashita, S.; Yum, J, H.; Chiranjit, A.; Gao, L.; Sugiyama, H. ACS Catal., 2015, 5, 4708-4712.
319. Lipid-bilayer-assisted Two-dimensional Self-assembly of DNA Origami Nanostructures. Suzuki, Y.; Endo, M.; Sugiyama, H. Nature Commun., 2015, 6, 8052.
320. Measuring Chloride in Live Cells. Endo, M.; Sugiyama, H . Nature Nanotechnol., 2015, 10, 569-570. (Review)
321. A Novel Detection Technique of Polyamide Binding Sites by Photo-Induced Electron Transfer in BrU Substituted DNA. Saha, A.; Hashiya, F.; Kizaki, S.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Commun., 2015, 51, 14485-14488.
322. Atomic Force Microscopy Analysis of Orientation and Bending of Oligodeoxynucleotides in Polypod-like Structured DNA. Shiomi, T.; Tan, M. M.; Takahashi, N.; Endo, M.; Emura, T.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Nano. Research, 2015, 8, 3764-3771.
323. Inducing Stem Cell Myogenesis Using NanoScript. Patel, S.; Yin, T.; Sugiyama, H.; Lee, K. B. ACS Nano, 2015, 9, 6909-6917.
324. Direct Visualization of Walking Motions of Photocontrolled DNA Nanomachine on the DNA Nanostructure. Yang, Y.; Goetzfied, M. A.; Hidaka, K.; You, M. X.; Tan, W. H.; Sugiyama, H.; Endo, M. Nano Lett., 2015, 15, 6672-6676.
325. Single-Molecule Manipulation of the Duplex Formation and Dissociation at the G-Quadruplex/i-Motif Site in the DNA Nanostructure. Endo, M.; Xing, X. W.; Zhou, X.; Emura, T.; Hidaka, K.; Tuesuwan, B.; Sugiyama, H. ACS Nano, 2015, 9, 9922-9929.
326. Water Revealed as Molecular Mirror When Measuring Low Concentrations of Sugar With Near Infrared Light. Bazar, G.; Kovacs, G.; Tanaka, M.; Furukawa, A.; Nagai, A.; Osawa, M.; Itakura, Y.; Sugiyama, H.; Tsenkova, R. Analytica Chimica Acta., 2015, 896, 52-62.
327. Efficient Amplification of Self-gelling Polypod-like Structured DNA by Rolling Circle Amplification and Enzymatic Digestion. Yata, T.; Takahashi, Y.; Hidaka, K.; Endo, M.; Sugiyama, H.; Tan, M. M.; Takakura, Y.; Nishikawa, M. Sci. Rep., 2015, 5, 14979.
328. Development of a Visible Nanothermometer with a Highly Emissive 2'-O-Methylated Guanosine Analogue. Yamamoto, S.; Park, S.; Sugiyama, H. RSC Adv., 2015, 5, 104601-104605.
329. Induction of Stem-Cell-Derived Functional Neurons by NanoScript-Based Gene Repression. Patel, S.; Chueng, S. T. D.; Yin, P. T.; Dardir, K.; Song, Z. C.; Pasquale, N.; Kwan, K.; Sugiyama, H.; Lee, K. B. Angew. Chem. Int. Ed., 2015, 54, 11983-11988.
330. Single-molecule Observations of RNA-RNA Kissing Interactions in a DNA Nanostructure. Takeuchi, Y.; Endo, M.; Suzuki, Y.; Hidaka, K.; Durand, G.; Dausse, E; Toulme, J. J; Sugiyama, H. Biomater. Sci., 2016, 4, 130-135.
331. A Light-Driven Three-Dimensional Plasmonic Nanosystem that Translates Molecular Motion into Reversible Chiroptical Function. Kuzyk, A.; Yang, Y, Y.; Duan, X, Y.; Stoll, S.; Govorov, A, O.; Sugiyama, H.; Endo, M.; Liu, N. Nature Commun., 2015, 7, 10591.
332. Identification of Sequence Specificity of 5-Methylcytosine Oxidation by Tet1 Protein with High-Throughput Sequencing. Kizaki, S.; Chandranan, A.; Sugiyama, H. ChemBioChem. Sci., 2016, 17, 403-406.
333. The Application of Fluorescence-Conjugated Pyrrole/Imidazole Polyamides in the Characterization of Protein-DNA Complex Formation. Han, Y, W.; Sugiyama, H.; Harada, Y. Biomater. Sci., 2016 , 4, 391-399. (Review)
334. Self-Assembling DNA Hydrogel-Based Delivery of Immunoinhibitory Nucleic Acids to Immune Cells. Nishida, Y.; Ohtsuki, S.; Araie, Y.; Umeki, Y.; Endo, M.; Tomoko, E.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Nanomedicine, 2016, 12, 123-130.
335. Triple Helix Formation in a Topologically Controlled DNA Nanosystem. Yamagata, Y.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M. Chem. Eur. J., 2016, 22, 5494-5498.
336. Effect of ATRX and G-Quadruplex Formation by the VNTR Sequence on α-Globin Gene Expression. Li, Y.; Syed, J.; Suzuki, Y.; Asamitsu, S.; Shioda, N.; Wada, T.; Sugiyama, H. ChemBioChem, 2016 , 17, 928-935.
337. Nature-Inspired Design of Smart Biomaterials Using the Chemical Biology of Nucleic Acids. Pandian, G. N.; Sugiyama, H.Bull. Chem. Soc. J., 2016, 89, 843-868. (Review)
338. Deciphering the Genomic Targets of Alkylating Polyamide Conjugates Using High-Throughput Sequencing. Chandran, A.; Syed, J.; Taylor, R. D.; Kashiwazaki, G.; Sato, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Nucleic Acids Res., 2016, 44, 4014-4024.
339. Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B2 to Duplex DNA. Zou, T. T.; Kizaki, S.; Pandian, G. N.; Sugiyama, H. Chem. Eur. J., 2016, 22, 8756-8758.
340. Double β-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole Polyamides for Lengthened DNA Minor Groove Recognition. Watanabe, T.; Shinohara, K.; Shinozaki, Y.; Uekusa, S.; Wang, X. F.; Koshikawa, N.; Hiraoka, K.; Inoue, T.; Lin, J.; Bando, T.; Sugiyama, H.; Nagase, H. Adv Tech Biol Med., 2016, 4, 175.
341. Ligand-Mediated G-Quadruplex Induction in a Double-Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide. Asamitsu, S.; Li, Y.; Bando, T.; Sugiyama, H. ChemBioChem, 2016, 17, 1317-1322.
342. Examining Cooperative Binding of Sox2 on DC5 Regulatory Element upon Complex Formation with Pax6 through Excess Electron Transfer Assay. Saha, A.; Kizaki, S.; De D.; Endo, M.; Kim, K.; Sugiyama, H. Nucleic Acids Res., 2016, 44, e125.
343. Sequence-Specific DNA Binding by Long Hairpin Pyrrole-Imidazole Polyamides Containing an 8-Amino-3,6-Dioxaoctanoic Acid Unit. Sawatani, Y.; Kashiwazaki, G.; Chandran, A.; Asamitsu, S.; Guo, C.; Sato, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2016, 24, 3603-3611.
344. Telomere Visualization in Tissue Sections using Pyrrole-Imidazole Polyamide Probes. Sasaki, A.; Ide, S.; Kawamoto, Y.; Bando, T.; Murata, Y.; Shimura, M.; Yamada, K.; Hirata, A.; Nokihara, K.; Hirata, T.; Sugiyama, H.; Maeshima, K. Sci. Rep., 2016, 6, 29261.
345. Mechanical Properties of DNA Origami Nanoassemblies are Determined by Holliday Junction Mechanophores. Shrestha, P.; Emura, T.; Koirala, D.; Cui, Y.; Hidaka, K.; Maximuck, W.; Endo, M.; Sugiyama, H.; Mao, H. Nucleic Acids Res., 2016, 44, 6574-6582.
346. Comparative Analysis of DNA-Binding Selectivity of Hairpin and Cyclic Pyrrole-Imidazole Polyamides Based on Next-Generation Sequencing. Kashiwazaki, G.; Chandran, A.; Asamitsu, S.; Kawase, T.; Kawamoto, Y.; Sawatani, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemBioChem, 2016, 17, 1752-1758.
347. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. Katsuda, Y.; Sato, S.; Asano, L.; Morimura, Y.; Furuta, T.; Sugiyama, H.; Hagihara, M.; Uesugi, M. J. Am. Chem. Soc., 2016 , 138, 9037-9040.
348. Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by Utilizing the Power of High-Throughput Sequencing. Chandran, A.; Syed, J.; Li, Y.; Sato, S.; Bando, T.; Sugiyama, H. ChemBioChem, 2016, 17, 1905-1910.
349. Preferential 5-Methylcytocine Oxidation in the Linker Region of Reconstituted Positioned Nucleosome by Tet1 Protein. Kizaki, S.; Zou, T.; Li, Y.; Han, Y. -W.; Suzuki, Y.; Harada, Y.; Sugiyama, H. Chem. Eur. J., 2016, 22, 16498-16601.
350. RNA-DNA Triplex Formation by Long Noncoding RNAs. Li, Y.; Syed, J.; Sugiyama, H. Cell. Chem. Biol., 2016, 23, 1325-1333. (Review)
351. Targeting 24 bp within Telomere Repeat Sequences with Tandem Tetramer Pyrrole-Imidazole Polyamide Probes. Kawamoto, Y.; Sasaki, A.; Chandran, A.; Hashiya, K.; Ide, S.; Bando, T.; Maeshima, K.; Sugiyama, H. J. Am. Chem. Soc., 2016, 138, 14100-14107.
352. Torsional Constraints of DNA Substrates Impact Cas9 Cleavage. Räz, M.; Hidaka, K.; Sturla, S.; Sugiyama, H.; Endo, M. J. Am. Chem. Soc., 2016, 138, 13842-13845.
353. Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Genome. Lin, J.; Hiraoka, K.; Watanabe, T.: Kuo, T.; Shinozuka, Y.: Takatori, A.; Koshikawa N.; Chandran, A.; Otsuki, J.; Sugiyama, H.; Horton, P.; Nagase, H. PLOS ONE, 2016, 11(10): e0165581.
354. A Multi-target Small Molecule for Targeted Transcriptional Activation of Therapeutically Significant Nervous System Genes. Wei, Y.; Pandian, G. N.; Zou, T.; Taniguchi, J.; Sato, S.; Kashiwazaki, G.; Vaijayanthi, T.; Hidaka, T.; Bando, T.; Sugiyama, H. ChemistryOpen, 2016, 5, 517-521.
355. Similarities and Differences between RNA and DNA Double-Helical Structures in Circular Dichroism Spectroscopy: A SAC-CI Study. Miyahara, T.; Nakatsuji, H.; Sugiyama, H. J. Phys. Chem. A., 2016, 120, 9008-9018.
356. Characterization of the Releasing Profile of MicroRNA from RISC Using Anti-miRNA Oligonucleotides. Ariyoshi, J.; Eimori, N.; Kobori, A.; Murakami, A.; Sugiyama, H.; Yamayoshi, A. Chem. Lett., 2017, 46, 143-145.
357. DNA Interstrand Crosslinks by H-pin Polyamide (S)-seco-CBI Conjugates. Guo, C.; Asamitsu, S.; Kashiwazaki, G.; Sato, S.; Bando, T.; Sugiyama, H. ChemBioChem, 2017, 18, 166-170.
358. Programmable Formation of Catalytic RNA Triangles and Squares by Assembling Modular RNA Enzymes. Oi, H.; Fujita, D.; Suzuki, Y.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. J. Biochem., 2017, 161(5), 451-462.
359. Synthesis, Photophysical Properties, and Enzymatic Incorporation of an Emissive Thymidine Analogue. Okamura, I.; Park, S.; Hiraga, R.; Yamamoto, S.; Sugiyama, H. Chemistry Letters, 2017, 46, 245-248.
360. The Chemical Compound Bubblin Induces Stomatal Mispatterning in Arabidopsis by Disrupting the Intrinsic Polarity of Stomatal Lineage Cells. Sakai, Y.; Sugano, S. S.; Kawase, T.; Shirakawa, M.; Imai, Y.; Kawamoto, Y.; Sugiyama, H.; Nakagawa, T.; Hara-Nishimura, I.; Shimada, T. Development, 2017, 144, 499-506.
361. A Photoregulated DNA-Based Rotary System And Direct Observation of Its Rotational Movement. Yang, Y.; Tashiro, R.; Suzuki, Y.; Emura, T.: Hidaka, K.; Sugiyama, H.; Endo, M. Chem. Eur. J., 2017, 23, 3979-3985.
362. Confined Space Facilitates G-quadruplex Formation. Shrestha, P.; Jonchhe, S.; Emura, T.; Hidaka, K.; Endo, M.; Sugiyama, H.; Mao, H. Nature Nanotech., 2017, 12, 582-588.
363. Unusual Topological RNA Architecture with an Eight-Stranded Helical Fragment Containing A-, G- and U-Tetrads. Xiao, C.; Ishizuka, T.; Zhu, X.; Li, Y.; Sugiyama, H.; Xu, Y. J. Am. Chem. Soc., 2017, 139, 2565-2568.
364. Genetic Regulation of the RUNX Transcription Factor Family Has Antitumor Effects. Morita, K.; Suzuki, K.; Maeda, S.; Matsuo, A.; Mitsuda, Y.; Tokushige, C.; Kashiwazaki, G.; Taniguchi, J.; Maeda, R.; Noura, M.; Hirata, M.; Kataoka, T.; Yano, A.; Yamada, Y.; Kiyose, H.; Tokumasu, M.; Matsuo, H.; Tanaka, S.; Okuno, Y.; Muto, M.; Naka, K.; Ito, K.; Kitamura, T.; Kaneda, Y.;Liu, P.P.; Bando, T.; Adachi, S.; Sugiyama, H.; Kamikubo, Y. J. Clin. Invest., 2017, 127, 2815-2828.
365. Development of a Vivid FRET System Based on a Highly Emissive dG-dC Analogue Pair. Han, J.; Yamamoto, S.; Park, S.; Sugiyama, H. Chem. Eur. J., 2017, 23, 7607-7613.
366. Holliday Junction Resolvases Mediate Chloroplast Nucleoid Segregation. Kobayashi, Y.; Misumi, O.; Odahara, M.; Ishibashi, K.; Hirono, M.; Hidaka, K.; Endo, M.; Sugiyama, H.; Iwasaki, H.; Kuroiwa, T.; Shikanai, T.; Nishimura, Y. Science, 2017, 356, 631-634.
367. Copper-containing DNA-Silica Mineral Complexes for the Asymmetric Diels-Alder Reaction. Sakashita, S.; Park, S.; Sugiyama, H. Chemistry Letters, 2017, 46, 1165-1168.
368. Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression. Hidaka, T.; Pandian, G. N.; Taniguchi, J.; Nobeyama, T.; Hashiya, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2017, 139, 8444-8447.
369. Antiproliferative and Apoptotic Activities of Sequence-Specific Histone Acetyltransferase Inhibitors. Yu, Z.; Taniguchi, J.; Wei, Y.; Pandian, G. N.; Hashiya, K.; Bando, T.; Sugiyama, H. Eur. J. Med. Chem., 2017, 138, 320-327.
370. Protein-driven RNA Nanostructured Devices that Function in Vitro and Control Mammalian Cell Fate. Shibata, T.; Fujita, Y.; Ohno, H.; Suzuki, Y.; Hayashi, K.; Komatsu, K.; Kawasaki, S.; Hidaka, K.; Yonehara, S.; Sugiyama, H.; Endo, M.; Saito, H. Nature Commun., 2017, 8, 540.
371. Paradoxical Enhancement of Leukemogenesis in Acute Myeloid Leukemia with Moderately-attenuated RUNX1 Expressions. Morita, K.; Maeda, S.; Suzuki, K.; Kiyose, H.; Taniguchi, J.; Liu, P. P.; Sugiyama, H.; Adachi, S.; Kamikubo, Y. Blood Adv., 2017, 1, 1440-1451.
372. A Synthetic DNA-binding Inhibitor of SOX2 Guides Human Induced Pluripotent Stem Cells to Differentiate into Mesoderm. Taniguchi, J.; Pandian, G.; Hidaka, T.; Hashiya, K.; Bando, T.; Kim, K. K.; Sugiyama, H. Nucleic Acids, 2017, 45, 9219-9228.
373. Effective Anti-miRNA Oligonucleotides Show High Releasing Rate of MicroRNA from RNA-Induced Silencing Complex. Ariyoshi, J.; Matsuyama, Y.; Kobori, A.; Murakami, A; Sugiyama, H.; Yamayoshi, A. Nucleic Acid Ther., 2017, 27, 303-308.
374. A Combination of Visible-Light Photoredox and Metal Catalysis for the Mannich-Type Reaction of N-Aryl Glycine Esters. Okamura, I.; Park, S.; Han, J.; Notsu, S.; Sugiyama, H. Chem. Lett., 2017, 46, 1597-1600.
375. Single-Molecule Observation of The Photo Regulated Conformational Dynamics of DNA Origami Nanoscissors. Willner, E.; Kamada, Y.; Suzuki, Y.; Emura, T.; Hidaka, K.; Dietz, H.; Sugiyama, H.; Endo, M. Angew. Chem. Int., 2017, 56, 15324-15328.
376. Autonomous Feedback Loop of RUNX1-p53-CBFB in Acute Myeloid Leukemia Cells. Morita, K.; Noura, M.; Tokushige, C.; Maeda, S.; Kiyose, H.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Yoshida, K.; Ozaki, T.; Matsuo, H.; Ogawa, S.; Liu, P. P.; Nakahata, T.; Sugiyama, H.; Adachi, S.; Kamikubo, Y. Sci. Reports, 2017, 7, 16604.
377. Evaluation of Alkylating Pyrrole-Imidazole Polyamide Conjugates by a Novel Method for High-Throughput Sequencer. Kashiwaszaki, G.; Maeda, R.; Kawase, T.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2018, 26, 1-7.
378. UVA Irradiation of BrU-Substituted DNA in The Presence of Hoechst 33258. Saha, A.; Kizaki, S.; Han, J. H.; Yu, Z.; Sugiyama, H. Bioorg. Med. Chem., 2018, 26, 37-40.
379. G-Quadruplex Induction by the Hairpin Pyrrole–Imidazole Polyamide Dimer. Obata, S.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Biochem., 2018, 57, 498-502.
380. Investigating Nucleosome Accessibility for MNase, FeII Peplomycin, and Duocarmycin B2 by Using Capillary Electrophoresis. Zou, T.; Kizaki, S.; Sugiyama, H. ChemBioChem, 2018, 19, 664-668.
381. DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K + Channels. Kurokawa, T.; Kiyonaka, S.; Nakata, E.; Endo, M.; Koyama, S.; Mori, E.; Tran, N. H.; Dinh, H.; Suzuki, Y.; Hidaka, K.; Kawata, M.; Sato, C.; Sugiyama, H.; Morii, T.; Mori, Y. Angew. Chem., 2018, 57, 2586-2591.
382. Targeting G-quadruplex DNA as Cognitive Function Therapy for ATR-X Syndrome. Shioda, N.; Yabuki, Y.; Yamaguchi, K.; Onozato, M.; Li, Y.; Kurosawa, K.; Tanabe, H.; Okamoto, N.; Era, T.; Sugiyama, H.; Wada, T.; Fukunaga, K. Nature Medicine, 2018, 24, 802-813.
383. RUNX Transcription Factors Potentially Control E-Selectin Expressions in the Bone Marrow Vascular Niche in Mice. Morita, K.; Tokushige, C.; Maeda, S.; Kiyose, H.; Noura, M.; Iwai, A.; Yamada, M.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Adachi, S.; Sugiyama, H.; Kamikubo, Y. Blood Advances, 2018 , 5, 509-515.
384. Sequence-specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications, Kawamoto, Y.; Bando, T.; Sugiyama, H. Bioorg. Med., 2018, 26, 1393-1411. (Review)
385. Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-binding Components to a G-quadruplex and its Proximal Duplex. Asamitsu, S.; Obata, S.; Phan, A. T.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Eur., 2018, 24, 4428-4435.
386. Triggering Nucleic Acid Nanostructure Assembly by Conditional Kissing Interactions. Azéma, L.; Bonnet-Salomon, S.; Endo, M.; Takeuchi, Y.; Durand, G.; Emura, T.; Hidaka, K.; Dausse, E.; Sugiyama, H.; Toulmé, JJ. Nucleic Acids Res., 2018, 46, 1052-1058.
387. Pip-HoGu: an Artificial Assembly with Cooperative DNA Recognition Capable of Mimicking Transcription Factor Pairs. Yu, Z.; Guo, C.; Wei, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2018 , 140, 2426-2429.
388. A Synthetic DNA-binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation. Wei, Y.; Pandian, G.; Yu, Z.; Zou, T.; Li, Y.; Darokar, J.; Hashiya, K.; Bando, T.; Sugiyama, H. ACS Omega, 2018, 3, 3608-3616.
389. Complexing DNA Origami Frameworks through Sequential Self-Assembly Based on Directed Docking. Suzuki, Y.; Sugiyama, H.; Endo, M. Angew. Chem. Int. Ed., 2018, 57, 7061-7065.
390. RUNX1 Positively Regulates the ErbB2/HER2 Signaling Pathway through Modulating SOS1 Expression in Gastric Cancer Cells. Mitsuda, Y.; Morita, K.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Obara, M.; Hirata, M.; Kataoka, R. T.; Muto, M.; Kaneda, Y.; Nakahata, T.; Liu, P. P.; Adachi, S.; Sugiyama, H.; Kamikubo, Y. Scientific Reports, 2018 , 8:6423.
391. Environment-Dependent Self-Assembly of DNA Origami Lattices on Phase-Separated Lipid Membranes. Sato, Y.; Endo, M.; Morita, M.; Takinoue, M.; Sugiyama, H.; Murata, S.; Nomura, S.; Suzuki, Y. Adv. Mater. Interfaces, 2018, 1800437.
392. Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones. Taniguchi, J.; Feng, Y.; Pandian, G.; Hashiya, F.; Hidaka, T.; Hashiya, K.; Park, S.; Bando, T.; Ito, S.; Sugiyama, H. J. Am. Chem. Soc., 2018, 140, 7108-7115.
393. TAMRA-Polypyrrole for A/T Sequence Visualization on DNA Molecules. Lee, S.; Kawamoto, Y.; Thangavel, V.; Park, J.; Bae, J.; Kim-Ha, J.; Sugiyama, H.; Jo, K. Nucleic Acids Research, 2018 , 46, e108.
394. Construction of Integrated Gene Logic-chip. Masubuchi, T.; Endo, M.; Iizuka, R.; Iguchi, A.; Yoron, D. H.; Sekiguchi, T.; Qi, H.; Iinuma, R.; Miyazono, Y.; Shoji, S.; Funatsu, T.; Sugiyama, H.; Harada, Y.; Ueda, T.; Tadakuma, H. Nature Nanotechnology, 2018, 13, 933-940.
395. Orthogonal γPNA Dimerization Domains Empower DNA Binders with Cooperativity and Versatility Mimicking that of Transcription Factor Pairs. Yu, Z.; Hsieh, W-C.; Asamitsu, S.; Hashiya, K.; Bando, T.; Ly, H. D.; Sugiyama, H. Chem. Eur. J., 2018, 24, 14183-14188.
396. DNA Origami Nanomachines. Endo, M.; Sugiyama, H. Molecules, 2018, 23, E1766. (Review)
397. Colloidal Stability of Lipid/Protein-Coated Nanomaterials in Salt and Sucrose Solutions. Nobeyama, T.; Mori, M.: Shigyou, K.; Takata, K.; Pandian, G. N.; Sugiyama, H.; Murakami T. ChemistrySelect, 2018, 3, 8325-8331.
398. Decreased Water Activity in Nanoconfinement Contributes to the Folding of G-quadruplex and i-motif Structures. Jonchhe, S.; Pander, S.; Emura, T.; Hidaka, K.; Hossain, M. A.; Shrestha, P.; Sugiyama, H. Endo, M.; Mao, H. PNAS, 2018, 115, 9539-9544.
399. Direct Observation of H3-H4 Octasome by High-Speed AFM. Zou, T.; Hashiya, F.; Wei, Y.; Yu, Z.; Ganesh, N. P.; Sugiyama, H. Chem. Eur. J., 2018, 24, 15998-16002.
400. Direct Observation of Dynamic Movement of DNA Molecules in DNA Origami Imaged Using High-speed AFM. Endo, M.; Sugiyama, H. Springer Book. Methods in Molecular Biology, Nanoscale Imaging Lyubchenko Y. L. ed., 2018 , Chapter 13, 213-224. (Review)
401. Sequence Preference and Structural Heterogeneity of BZ junctions. Kim, D.; Hur, J.; Han, J. H.; Ha, S. C.; Shin, D.; Lee, S.; Park, S.; Sugiyama, H.; Kim, K. K. Springer Book. Methods in Molecular Biology, Nucleic Acids Research, 2018 , 46, 10504-10513.
402. Approach to the Investigation of Nucleosome Structure by Using the Highly Emissive Nucleobase thdG-tC FRET Pair. Han, J. H.; Park, S.; Hashiya, F.; Sugiyama, H. Chem. Eur. J., 2018 , 24, 17091-17095.
403. Chemical Control System of Epigenetics. Vaijayanthi, T.; Pandian G. N.; Sugiyama, H. Chem. Rec., 2018, 18, 1833-1853. (Review)
404. Ligand Design to Acquire Specificity to Intended G-quadruplex Structure. Asamitsu, S.; Bando, T.; Sugiyama, H. Chem. Eur. J., 2019, 25, 417-430. (Review)
405. Nanochannel-confined TAMRA-polypyrrole Stained DNA Stretching by Varying the Ionic Strength from Micromolar to Millimolar Concentrations. Jo, K.; Lee, S.; Lee, Y.; Kim, Y.; Wang, C.; Park, J.; Jung, G. Y.; Chen, Y. L.; Chang, R.; Ikeda, S.; Sugiyama, H. Polymers, 2019 , 11, 15.
406. Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-quadruplex. Jonchhe, S.; Chimire, C.; Cui, Y.; Park, S.; Iida, K.; Nagasawa, K.; Sugiyama, H.; Mao, H. Angew. Chem., 2019, 131, 887-891.
407. Electron Injection from Mitochondrial Transcription Factor A to DNA Associated with Thymine Dimer Photo Repair. Hashiya, F.; Ito, S.; Sugiyama, H. Bioorg. Med. Chem., 2019, 27, 278-284.
408. Direct Observation of the Double‐Stranded DNA Formation through Metal Ion‐Mediated Base Pairing in the Nanoscale Structure. Xing, X.; Feng, Y.; Yu, Z.; Hidaka, K.; Liu F.; Ono, A.; Sugiyama, H.; Endo, M. Chem. E. J., 2019, 25, 1446-1450.
409. Chemical and photobiological study of the structures and functions of DNA. Sugiyama, H. Photomedicine and Photobiology, 2018 , 40, 1-6. (Review)
410. Molecular Characteristics of DNA-alkylating PI Polyamides Targeting RUNX Transcription Factors. Maeda, R.; Sato, S.; Ohno, T.; Kashiwazaki, G.; Obata, S.; Hashiya, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2019, 141, 4257-4263.
411. Recent Progress of Specific G-quadruplex-preferred Ligands Toward Cancer Therapy. Asamitsu, S.; Obata, S.; Yu, Z.; Bando, T.; Sugiyama, H. Molecules, 2019, 24, 429; doi:10.3390/molecules24030429. (Review)
412. Therapeutic Gene Regulation using Pyrrole-Imidazole Polyamides. Yu, Z.; Pandian, G. N.; Hidaka, T.; Sugiyama, H. Adv. Drug Deliv. Rev., 2019, 147, 66-85. (Review)
413. Modular DNA-based Hybrid Catalysts as a Toolbox for Enantioselective Hydration of α,β-Unsaturated Ketones. Yum, J. H.; Park, S.; Hiraga, R.; Okamura, I.; Notsu, S.; Sugiyama, H. Org. and Biomol. Chem., 2019, 17, 2548-2553.
414. Submolecular Dissection Reveals Strong and Specific Binding of Polyamide-Pyridostatin Conjugates to Human Telomere Interface. Mandel, S.; Kawamoto, Y.; Yue, Z.; Hashiya, K.; Cui Y.; Bando, T.; Sugiyama, H.; Mao, H. Nucleic Acids Res., 2019, 47, 3295-3305.
415. A Photocaged DNA Nanocapsule for Controlled Unlocking and Opening inside the Cell. Tohgasaki, T.; Shitomi, Y. Feng, Y.; Honna, S.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M. Bioconjugate Chem., 2019, 30, 1860-1863.
416. Direct Observation and Analysis of the Dynamics of the Photoresponsive Transcription Factor GAL4. Raghavan, G.; Hidaka, K.; Sugiyama, H.; Endo, M. Angew. Chem. Int. Ed., 2019, 58, 7626-7630.
417. Oligomerization of a Modular Ribozyme Assembly of which is Controlled by a Programmable RNA-RNA Interface between Two Structural Modules. Tsuruga, R.; Uehara, N.; Suzuki, Y.; Furuta, H.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. J. Biosci. & Bioeng., 2019, 128, 410-415.
418. Orientation Preferences of Hairpin Pyrrole-Imidazole Polyamides toward mCGG Site. Sato, S.; Asamitsu, S.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2019, 27, 2167-2171.
419. New Size-expanded Fluorescent Thymine Analogue: Synthesis. Characterization, and Application. Hirashima, S.; Han, J.; Tsuno, H.; Tanigaki, Y.; Park, S.; Sugiyama, H. Chem. Eur. J., 2019, 25, 9913-9919.
420. Direct Observation of the Formation and Dissociation of Double-Stranded DNA Containing G-Quadruplex/i-Motif Sequences in the DNA Origami Frame Using High-Speed AFM. Endo, M.; Xing, X.; Sugiyama, H.Methods Molecular Biology, Vol. 2035,: G-Quadruplex Nucleic Acids, 2019, 299-308. (Review)
421. Translation-dependent Unwinding of Stem-loops by UPF1 Licenses Regnase-1 to Degrade Inflammatory mRNAs. Mino, T.; Iwai, N.; Endo, M.; Inoue, K.; Akaki, K.; Hia, F.; Uehata, T.; Emura, T.; Hidaka, K.; Suzuki, Y.; Standley, D.M.; Okada-Hatakeyama, M.; Ohno, S.; Sugiyama, H.; Yamashita, A.; Takeuchi, O. Nucleic Acids Research, 2019, 47, 8838-8859.
422. Highly Sensitive and Selective Mercury Sensor based on Mismatched Base Pairing with dioxT. Han, J. H.; Hirashima, S.; Park, S.; Sugiyama, H. Chem. Commun., 2019, 55, 10245-10248.
423. Control of Forward/Reverse Orientation Preference of Cyclic Pyrrole-Imidazole Polyamides. Hirose, Y.; Asamitsu, S.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2019, 141, 13165-13170.
424. Switching Off Cancer-Causing Telomerase Using Small Molecules. Asamitsu, S.; Shioda, N.; Sugiyama, H. Cell Chemical Biology, 2019, 26, 1045-1047. (Review)
425. Effects of Physical Damage in the Intermediate Phase on the Progression of Amyloid β Fibrillation. Tashiro, R.; Taguchi, H.; Kidaka, K.; Endo, M.; Sugiyama, H. Chem. Asian J., 2019, 14, 4140-4145.
426. G-quadruplexes as Versatile Scaffolds for Catalysis. Yum, J. H.; Park, S.; Sugiyama, H. Org. Biomol. Chem., 2019, 17, 9547-9561.
427. Folding of Single-stranded Circular DNA into Rigid Rectangular DNA Accelerates its Cellular Uptake. Otsuki, S.; Shiba, Y.; Maezawa, T.; Hidaka, K.; Sugiyama, H.; Endo, M.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Nanoscale, 2019, 11, 23416-23422.
428. Sequence-specific PI Polyamides Make It Possible to Regulate DNA Structure and Function. Bando, T.; Sugiyama, H. Bull. Chem. Soc. J., 2020, 93, 205-215.
429. Advances in DNA Origami-Cell Interfaces. Mishra, S.; Feng, Y.; Endo, M.; Sugiyama, H. ChemBioChem., 2020, 21, 33-44.
430. Targeted Suppression of Metastasis Regulatory Transcription Factor SOX2 in Various Cancer Cell Lines using a Sequence-specific Designer Pyrrole-imidazole Polyamide. Malinee, M.; Kumar, A.; Hidaka, T.; Hirose, M.; Hasegawa, K.; Namasivayam, P. G.; Sugiyama, H. Bioorg. Med. Chem., 2020, 28, 115248.
431. A Synthetic Transcription Factor Pair Mimic for Precise Recruitment of an Epigenetic Modifier to the Targeted DNA Locus. Yu, Z.; Ai, M; Samanta, S. K.; Hashiya, F.; Taniguchi, J.; Asamitsu, S.; Ikeda, S.; Hashiya, K.; Bando, T.; Pandian, G. N.; Isaacs, L.; Sugiyama, H.Chem. Comm., 2020, 56, 2296-2299.
432. N1-Methylpseudouridine Substitution Enhances the Performance of Synthetic mRNA Switches in Cells. Parr, C.; Wada, S.; Kotake, K.; Kameda, S.; Matsuura, S.; Sakashita, S.; Park, S.; Sugiyama, H.; Kuang, Y.; Saito, H. Nucleic Acids Research. 2020, 48, e35.
433. Direct Observation and Analysis of TET-mediated Oxidation Processes in a DNA Origami Nanochip. Xing, X.; Sato, S., Wong, N-K.; Hidaka, K.; S.; Sugiyama, H.; Endo, M. Nucleic Acids Research. 2020, 48, 4041-4051.
434. Histidine-conjugated DNA as a Biomolecular Depot for Metal Ions. Park, S.; Matsui, H.; Fukumoto, K.; Yum, J. H.; Sugiyama, H. RSC Advances, 2020, 10, 9717-9722.
435. Telomeric Quadruplexes as Therapeutic Target. Asamitsu, S.; Shioda, N.; Sugiyama, H. Stephen Needle (eds.), Quadruplex nucleic acids as targets for medicinal chemistry, Part 2 Quadruplex Targets in human and other organisms. Elsevier, 2020, 54, 77-99.
436. DNA Nanostructures for Targeted Antimicrobial Delivery. Mela, I.; Vallejo-Raminez, P. P.; Makarchuk, S.; Christie, G.; Bailey D.; Henderson, R. M.; Sugiyama, H, Endo, M.; Kaminski, C. F. Angew. Chem. Int. Ed., 2020, 59, 12698-12702.
437. Catalytic RNA Nano-objects Formed by Self-assembly of Group I Ribozyme Dimers Serving as Unit Structures. Kiyooka, R.; Akagi, J.; Sugiyama, H.; Endo, M. Matsumura, S.; Ikawa, Y. J. Bioscience & Bioengineering, 2020, 130, 253-259.
438. Duplex DNA is Weakened in Nanoconfinement. Jonchhe, S.; Pandey, S.; Karna, D.; Pokhrel, P.; Cui, Y.; Mishra, S.; Sugiyama, H.; Endo, M.; Mao, H. J. Am. Chem. Soc., 2020, 142, 10042-10049.
439. A Photocaged DNA Nanocapsule for Delivery and Manipulation in Cells. Feng, Y.; Tohgasaki, T.; Shitomi, Y.; Sugiyama, H. Endo, M. Methods in Enzymology, 2020, 641, 329-342.
440. X-ray Crystal Structure of a Cyclic-PIP–DNA Complex in the Reverse-binding Orientation. Abe, K.; Hirose, Y.; Eki, H.; Takeda, K.; Bando, T.; Endo, M.; Sugiyama, H. J. Am. Chem. Soc., 2020, 142, 10544-10549.
441. Dynamic Stabilization of DNA Assembly by Using Pyrrole-Imidazole Polyamide. Ang, Y. S.; Bando, T.; Sugiyama, H.; Yung, L. Y. L. ChemBioChem., 2020, 21, 2912-2915.
442. Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles. Nobeyama, T.; Shigyou, K.; Nakatsuji, H.; Sugiyama, H.; Komura, N.; Ando, H.; Hamada, T.; Murakami, T. Langmuir. 2020, 36, 7741-7746.
443. Development of Antibody-Oligonucleotide Complexes for Targeting Exosomal MicroRNA. Yamayoshi, A.; Oyama, S.; Kishimoto, Y.; Konishi, R.; Yamamoto, T.; Kobori, A.; Harada, H.; Ashihara, E.; Sugiyama, H.; Murakami, A. Pharmaceutics, 2020, 12, 545.
444. DNA Density-dependent Uptake of DNA Origami-based Two-or Three-dimensional Nanostructures by Immune Cells. Maezawa, T.; Ohtsuki, S.; Hidaka, K.; Sugiyama, H.; Endo, Takahashi, Y.; Takakura, Y.; Nishikawa, M. Nanoscale, 2020, 12, 14818-14824.
445. DNA Alkylation of the RUNX-binding Sequence by CBI-PI Polyamides Conjugates. Maeda, R.; Ito, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Eur. J. 2020, 26, 14639-14644.
446. Design, Synthesis and Anti-cancer Activity of Pyrrole-Imidazole Polyamides through Target-downregulation of c-Kit Gene Expression. Zhang, M.; Liang, J.; Jiang, S-K.; Xu, L.; Wu, Y-L.; Awadasseid, A.; Zhao, X-Y.; Xiong, X-Q.; Sugiyama, H.; Zhang, W. Eur. J. Med. Chem., 2020, 207, 112704.
447. Direct Observation of Dynamic Interactions between Orientation-Controlled Nucleosomes in a DNA Origami Frame. Feng, Y.; Hashiya, F.; Hidaka, K.; Sugiyama, H.; Endo, M. Chem. Eur. J. 2020, 26, 15282-15289.
448. Modular Quadruplex-Duplex Hybrids as Biomolecular Scaffolds for Asymmetric Michael Addition Reactions. Yum, J. H.; Sugiyama, H.; Park, S. Org. Biomol. Chem., 2020, 18, 6812-6817.
449. Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of the Tri-arginine Vector. Hidaka, T.; Tsubono, Y.; Hashiya, K.; Bando, T.; Pandian, G. N.; Sugiyama, H. Chem. Comm., 2020, 56, 12371-12374.
450. Construction of a FRET System in a Double-Stranded DNA Using Fluorescent Thymidine and Cytidine Analogs. Hirashima, S.; Sugiyama, H.; Park, S. J. Phys. Chem. B, 2020, 124, 8794-8800.
451. Differentially Expressed Goes on the Growth of Mouse Leydig Cells Treated with Standardized Eurycoma Longifolia Extract. Ahmed, N. A. K; Lim, S. K.; Pandian, G. N.; Sugiyama, H.; Lee, C. Y.; Khoo, B. Y.; Chan, K. L. Molecular Medicine Reports 2020, DOI: 10.3892/mmr.2020.11485.
452. A Near-Infrared Fluorogenic Pyrrole-Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres. Tsubono, Y.; Kawamoto, Y.; Hidaka, T.; Pandian, G.; Hashiya, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2020, 142, 17356-17363.
453. Suppression of Malignant Rhabdoid Tumors through Chb-M’-mediated RUNX1 Inhibition. Daifu, T.; Mikami, M.; Hiramatsu, H.; Iwai, A.; Umeda, K.; Noura, M.; Kubota, H.; Matsuda, T.; Furuichi, K.; Takasaki, S.; Noguchi, Y.; Morita, K.; Bando, T.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Kuwahara, Y.; Iehara, T.; Hosoi, H.; Takita, J.; Sugiyama, H.; Adachi, S.; Kamikubo, Y. Pediatric Blood & Cancer 2020, 68, e28789.
454. Targeted Epigenetic Modulation using a DNA-based Histone Deacetylase Inhibitor Enhances Cardiomyogenesis in Mouse Embryonic Stem Cells. Lee, J. A.; An, J.; Taniguchi, J.; Kashiwazaki, G.; Pandian, G. P.; Parveen, N.; Kang, T. M.; Sugiyama, H.; Kim K. K. J. Cell. Phys. 2021, 236, 3946-3962.
455. Nucleosomes and Epigenetics from a Chemical Perspective. Feng, Y.; Endo, M.; Sugiyama, H. ChemBioChem. 2021, 22, 595-612.
456. Photocontrolled DNA Origami Assembly using Two Photoswitches. Mishra, S.; Park, S.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M. Chem. Eur. J. 2021, 27, 778-784.
457. Evaluation of the DNA Alkylation Properties of a Chlorambucil-Conjugated Cyclic Pyrrole–Imidazole Polyamide. Hirose, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Eur. J. 2021, 27, 2782-2788.
458. Combined Use of Chemically Modified Nucleobases and Nanostructured DNA for Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide. Araie, Y.; Ohtsuki, S.; Park, S.; Nagaoka, M.; Umemura, K.; Sugiyama, H.; Kusamori, K.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Bioorg. Med. Chem. 2021, 29, 115864.
459. CGG Repeat RNA G-quadruplexes Interact with FMRpolyG to Cause Neuronal Dysfunction in Fragile X-related Tremor/ataxia Syndrome. Asamitsu, S.; Yabuki, Y.; Ikenoshita, S.; Kawakubo, K.; Kawasaki, M.; Usuki, S.; Nakayama, Y.; Adachi, K.; Kugoh, H.; Ishii, K.; Matsuura, T.; Nanba, E.; Sugiyama, H.; Fukunaga, K.; Shioda, N. Science Advances 2021, 7, eabd9440.
460. Designing Biomimicking Synthetic Transcription Factors for Therapeutic Gene Modulation. Pandian, G. N.; Sugiyama, H. Cell-Inspired Materials and Engineering, Springer Book 2021, 135-161.
461. Chemical Approaches to the Development of Artificial Transcription Factors Based on Pyrrole-Imidazole Polyamides. Hidaka, T.; Sugiyama, H. Chemical Record 2021, 12, 1374-1384.
462. Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment. Maeda, R.; Bando, T.; Sugiyama, H. ChemBioChem 2021, 22, 1538-1545.
463. Nanoscopic Observation of a DNA Crystal Surface and Its Dynamic Formation and Degradation Using Atomic Force Microscopy. Eki, H.; Abe, K.; Sugiyama, H.; Endo, M. Chem. Commun. 2021, 57, 1651-1654.
464. Synthesis and Application of a 19F-labeled Fluorescent Nucleoside as a Dual-mode Probe for i-Motif DNAs. Wee, W. A.; Yum, J. H.; Hirashima, S.; Sugiyama, H.; Park, S. RSC Chem. Biol. 2021, 2, 876-882.
465. An RNA Triangle with Six Ribozyme Units can Promote a Trans-splicing Reaction through Trimerization of Unit Ribozyme Dimers. Akagi, J.; Yamada, T.; Hidaka, K.; Fujita, Y.; Saito, H.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. Applied Sciences 2021, 11, 2583.
466. HBD1 Protein with a Tandem Repeat of Two HMG Box Domains is a DNA Clip to Organize Chloroplast Nucleoids in Chlamydomonas Reinhardtii. Takusagawa, M.; Kobayashi, Y.; Fukao, Y.; Hidaka, K.; Endo, M.; Sugiyama, H.; Yamaji, T.; Kato, Y.; Miyakawa, I.; Misumi, O.; Shikanai, T.; Nishimura, Y. Proc. Natl. Acad. Sci. USA., 2021, 118(20) e2021053118.
467. Landscape of Immune Cell Infiltration in Clear Cell Renal Cell Carcinoma to Aid Immunotherapy. Bai, D.; Feng, H.; Yang, J.; Yin, A.; Qian, A.; Sugiyama, H. Cancer Science 2021, 112, 2126-2139.
468. Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin. Yum, J. H.; Ishizuka, T.; Fukumoto, K.; Hori, D.; Bao, H. L.; Xu, Y.; Sugiyama, H.; Park, S. ACS Biomaterials Science and Engineering 2021, 7, 1338-1343.
469. Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs. Hidaka, T.; Sugiyama, H.; Pandian, G. N. Methods Mol. Biol. 2021, 2275, 217-225.
470. Construction of an Optically Controllable CRISPR-Cas9 System using a DNA Origami Nanostructure. Abe, K.; Sugiyama, H.; Endo, M. Chem. Commun. 2021, 57, 5594-5596.
471. Non-invasive Regulation of Cellular Morphology Using a Photoswitchable Mechanical DNA Polymer. Sethi, S.; Hidaka, K.; Sugiyama, H.; Endo, M. Angew. Chem. Int. Ed. 2021, 60, 20342-20349.
472. Discovery of Pyrrole-imidazole Polyamides as PD-L1 Expression Inhibitors and Their Anticancer Activity via Immune and Nonimmune Pathways. Wang, M.; Ma, X.; Zhou, K.; Mao, H.; Liu, J.; Xiong, X.; Zhao, X.; Narva, S.; Tanaka, Y.; Wu, Y.; Guo, C.; Sugiyama, H.; Zhang, W. J. Med. Chem., 2021, 64, 6021-6036.
473. RUNX Inhibitor Suppresses Graft-versus-host Disease through Targeting RUNX-NFATC2 Axis. Kubota, H.; Masuda, T.; Noura, M.; Furuichi, K.; Matsuo, H.; Hirata, M.; Kataoka, T.; Hiramatsu, H.; Yasumi, T.; Nakahata, T.; Imai, Y.; Takita, J.; Adachi, S.; Sugiyama, H.; Kamikubo, Y. eJHaem., 2021, 2,449-458.
474. Impact of Reactive Oxygen Species and G-Quadruplexes in Telomeres and Mitochondria. Malinee, M.; Sugiyama, H. Creative Complex Systems, Springer Book, Nishimura, K.; Murase, M.; Yoshimura, K. ed. Creative Complex Systems 2021, 249-2746.
475. Tropylium Derivatives as New Entrants that Sence G-quadruplex Structures. Hori, D.; Yum, J. H.; Sugiyama, H.; Park, S. Bull. Chem. Soc. J., 2021, 94, 1948-1953.
476. Short Intrinsically Disordered Polypeptide-Oligonucleotide Conjugates for Programmed Self-assembly of Nanospheres with Temperature-dependent Size Controllability. Wang, B.; Pan, R.; Zhu, W.; Xu, Y.; Tian, Y.; Endo, M.; Sugiyama, H.; Yang, Y.; Qian, X. Soft Matter, 2021, 17, 1184-1188.
477. Flexible Assembly of Engineered Tetrahymena Ribozymes Forming Polygonal RNA Nanostructures with Catalytic Ability. Mori, Y.; Oi, H.; Suzuki, Y.; Hidaka, K.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. ChemBioChem., 2021, 22, 2168-2176.
478. A Novel Method for Locating Nucleosomes by Exploiting 5-Bromouracil, Pyrene-Modified Histone, and Photoirradiation. Hashiya, F., Sugiyama, H. Photomedicine and Photobiology, 2021, 42, 13-16.
479. Genomic Analysis Uncovers Prognostic and Immunogenic Characteristics of Ferroptosis for Clear Cell Renal Cell Carcinoma. Bai, D.; Feng, H.; Yang, J.; Yin, A.; Lin, X.; Qian, A.; Sugiyama, H. Mol. Ther. Nucleic Acids, 2021, 25, 186-197.
480. Integrated Analysis of Immune-related Gene Subtype and Immune Index for Immunotherapy in Clear Cell Renal Cell Carcinoma. Bai, D.; Chen, S.; Feng, H.; Yin, A.; Lu, J.; Ma, Y.; Sugiyama, H. Pathol. Res. Pract., 2021, 225, 153557.
481. Characterization of a Conformation-restricted Amyloid β Peptide and Immunoreactivity of its Antibody in Human AD Brain. Kageyama, Y.; Irie, Y.; Matsushima, Y.; Segawa, T.; Bellier, J.-P.; Hidaka, K.; Sugiyama, H.; Kaneda, D.; Hashizume, Y.; Akatsu, H.; Miki, K.; Kita, A.; Walker, D. ; Irie, K.; Tooyama, I. ACS Chemical Neuroscience, 2021, 12, 3418-3432.
482. Photo-controllable Phase Transition of Arylazopyrazole-conjugated Oligonucleotides. Hidaka,T.; Wee, W. A.; Yum, J. H.; Sugiyama, H.; Park, S. Bioconjugate Chem, 2021, 32, 2129-2133.
483. Telomere-Specific Chromatin Capture using a Pyrrole–Imidazole Polyamide Probe for the Identification of Proteins and Non-Coding RNAs. Ide, S.; Sasaki, A.; Kawamoto, Y.; Bando, T.; Sugiyama, H.; Maeshima, K. Epigenetics & Chromatin, 2021, 14, 46.
484. Photoswitchable Single-Stranded DNA-Peptide Coacervate Formation as a Dynamic System for Reaction Control. Wee, W. A.; Sugiyama, H.; Park, S. iScience, 2021, 24, 103455.
485. Targeted Elimination of Mutated Mitochondrial DNA by a Multi-functional Conjugate Capable of Sequence-specific Adenine Alkylation. Hidaka, T.; Hashiya, K.; Bando, T.; Pandian, G. N.; Sugiyama, H. Cell Chem. Biol., 2022, 29, 1-6.
486. Targeted Epigenetic Induction of Mitochondrial Biogenesis Enhances Antitumor Immunity in Mouse Model. Malinee M.; Pandian, G. N.; Sugiyama, H. Cell Chem. Biol., 2022, 29, 463-475.
487. Photoreaction of DNA Containing 5-Halouracil and its Products. Tashiro, R.; Sugiyama, H. Photochemistry and Photobiology, 2022, 98, 532-545.
488. Single-Molecule Visualization of B-Z Transition in DNA Origami using High-Speed AFM. Endo, M; Sugiyama H. Z-DNA Methods and Protocols. Methods in Molecular Biology K. Kim and V. Subramani Ed., in press
489. Biomimetic DNA Nanotechnology to Understand and Control Cellular Responses. Sethi, S.; Sugiyama, H.; Endo, M. ChemBioChem., 2022, 23, e202100446.
490. Strong and Specific Recognition of CAG/CTG Repeat DNA (5’-dWGCWGCW-3’) by a Cyclic Pyrrole–Imidazole Polyamide. Hirose, Y.; Ohno, T.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemBioChem., 2022, 23, e202100533 (1-5).
491. RUNX1 Transactivates BCR-ABL1 Expression in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia. Masuda, T.; Maeda, S.; Shimada, S. ; Sakuramoto, N.; Morita, K.; Koyama, A.; Suzuki, K.; Mitsuda, Y.; Matsuo, H.; Kubota, H.; Kato, I.; Tanaka, K.; Takita, J.; Hirata, M.; Karaoke, T.; Nakahata, T.; Adachi, S.; Hirai, H.; Mizuta, S.; Naka, K.; Imai, Y.; Kimura, S.; Sugiyama, H.; Kamikubo, Y. Cancer Science, 2022, 113, 529-539.
492. Enhanced Immunostimulatory Activity of Covalent DNA Dendrons. Kawamoto, Y.; Liu, W.; Yum, J. H.; Park, S.; Sugiyama, H.; Takahashi, Y.; Takakura, Y. ChemBioChem., 2022, 23, e202100583.
493. Dissection of Nanoconfinement and Proximity Effects on the Binding Events in DNA Origami Nanocavity. Jonchhe, S.; Pandey, S.; Beneze, C.; Emura, T.; Sugiyama, H.; Endo, M.; Mao, H. Nucleic Acids Res., 2022, 50, 697-703.
494. Single Base-Modification Reports and Locates Z-DNA Conformation on a Z-B-Chimera Formed by Topological Constraint. Liu, M.; Cui, Y.; Zhang, Y.; An, R.; Li, L.; Park, S.; Sugiyama, H.; Liang, X. Bull. Chem. Soc. J., 2022, 95, 433-439.
495. Photo-Cross-Linking between BrU and Pyrene Residues in an RNA/DNA Hybrid. Tashiro, R.; Yum, J. H.; Park, S.; Sugiyama, H. ChemBioChem., 2022, 23, e202100626.
496. A Hexameric Ribozyme Nanostructure Formed by Double-Decker Assembly of a Pair of Triangular Ribozyme Trimers. Yu, K.; Hidaka, K.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. ChemBioChem., 2022, 23, e202100573.
497. Tumor Accumulation of PIP-based KRAS Inhibitor KR12 Evaluated by the Use of a Simple, Versatile Chicken Egg Tumor Model. Higashi, Y.; Ikeda, S.; Matsumoto, K.; Satoh, S.; Komatsu, A.; Sugiyama, H.; Tamanoi, F. Cancers, 2022, 14, 951.
498. Inhibition of GLI-mediated Transcription by Cyclic Pyrrole-Imidazole Polyamide in Cancer Stem Cells. Sahayasheela, V. J.; Yu, Z.; Hirose, Y.; Pandian, G. N.; Bando, T.; Sugiyama, H. Bull. Chem. Soc. J., 2022, 95, 693-699.
499. Harnessing DNA as a Designable Scaffold for Asymmetric Catalysis: Recent Advances and Future Perspectives. Yum, J. H.; Sugiyama, H.; Park, S. Chemical Record, 2022, 22, e202100333.
500. Targeting Chemoresistance in Xp11.2 Translocation Renal Cell Carcinoma using a Novel Polyamide-chlorambucil Conjugate. Funasaki, S.; Mehanna, S.; Ma, W.; Nishizawa, H.; Kamikubo, Y.; Sugiyama, H.; Ikeda, S.; Motoshima, T.; Hasumi, H.; Linehan, W. M.; Schmit, L.S.; Ricketts, C.; Suda, T.; Oike, Y. Kamba, T.; Baba, M. Cancer Science, 2022, 113, 2352-2367.
501. An Informatics Approach to Distinguish RNA Modifications in Nanopore Direct RNA Sequencing. Ramasamy, S.; Mishra, S.; Sharma, S.; Parimalam, S. S.; Thangavel, V.; Fujita, Y.; Kovi, B.; Sugiyama, H.; Pandian, G. N. Genomics, 2022, 114, 110372.
502. Characterization of 2-Fluoro-2’-deoxyadenosine in Duplex, G-quadruplex and I-motif. Hirashima, S.; Sugiyama, H.; Park, S. ChemBioChem, 2022, 23, e202200222.
503. N-terminal Cationic Modification of Linear Pyrrole-Imidazole Polyamide Improves its Binding. Hatanaka, J.; Hirose, Y.; Hashiya, K.; Bando, B.; Sugiyama, H. ChemBioChem, 2022, 23, e202200124.
504. Box-shaped ribozyme octamer formed by face-to-face dimerization of a pair of square-shaped ribozyme tetramers. Islam, M. D.; Hidaka, K.; Suzuki, Y.; Sugiyama, H,; Endo, M.; Matsumura, S.; Ikawa, Y. J. Biosci. Bioeng., 2022, 134, 195-202.
505. Chlorambucil-conjugated PI-polyamides (Chb-M’), a Transcription Inhibitor of RUNX Family, Has an Anti-tumor Activity Against SHH-type Medulloblastoma with p53 Mutation. Matsui, Y.; Mineharu, Y.; Noguchi, Y.; Yamamoto-Hattori, E.; Kubota, H.; Hirata, M.; Miyamoto, S.; Sugiyama, H.; Kamikubo, Y. BBRC, 2022, 620, 150-157.
506. RUNX1-Survivin Axis as a Novel Therapeutic Target for Malignant Rhabdoid Tumor. Mikami, M.; Masuda, T.; Kanatani, T.; Noura, M.; Umeda, K.; Hiramatsu, H.; Kubota, H.; Daifu, T.; Iwai, A.; Hattori, E.; Furuichi, K.; Takasaki, S.; Tanaka, S.; Matsui, Y.; Matsuo, H.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Kuwahara, Y.; Iehara, T.; Hosoi, H.; Takita, J.; Sugiyama, H.; Adachi, S.; Kamikubo, Y. Molecules and Cells, 2022, 45, 886-895.
507. DNA-Based Daisy Chain Rotaxane Nanocomposite Hydrogels as Dual-Programmable Dynamic Scaffolds for Stem Cell Adhesion. Yao, S.; Chang, Y.; Zhai, Z.; Sugiyama, H.; Endo, M.; Zhu, W.; Xu, Y.; Yang, Y.; Qian, X. ACS Appl. Mater. Interfaces, 2022, 14, 20739-20748.
508. Artificial Intelligence in Microbial Natural Product Drug Discovery: Current and Emerging Role. Sahayasheela, V. J.; Lankadasari, M. B.; Dan, V. M.; Dastager, S. G.; Pandian, G. N.; Sugiyama, H. Natural Product Reports, 2022, 39, 2215-2230.
509. A RUNX-targeted Gene Switch-off Approach Modulates the BIRC5/PIF1-p21 Pathway and Reduces Glioblastoma Growth in Mice. Hattori, E. Y.; Arakawa, Y.; Mineharu, Y.; Mikami, M.; Terada, Y.; Matsui, Y.; Masuda, T.; Kubota, H.; Hidemasa Matsuo, H.; Masahiro Hirata, M.; Kataoka, T. R.; Nakahata, T.; Ikeda, S.; Sugiyama, H.; Souichi Adachi, S.; Miyamoto, S.; Kamikubo, Y. Communication Biology, 2022, 5, 939.
510. Chemical Probe-based Nanopore Sequencing to Selectively Assess the RNA Modifications. Ramasamy, S.; Sahayasheela, V. J.; Sharma, S.; Yu, Z.; Hidaka, T.; Cai, L.; Thangavel, V.; Sugiyama, H.; Pandian, G. N. ACS Chem. Biol., 2022, 17, 2704-2709.
511. Twelve Colors of Streptavidin-Fluorescent Proteins (SA-FPs): A Versatile Tool to Visualize Genetic Information in Single-Molecule DNA. Jin, Y.; Bae, J.; Kim, T.; Hwang, H.; Kim, T.; Yu, M.; Oh, H.; Hashiya, K.; Bando, T.; Sugiyama, H.; Jo, K. Analytical Chemistry, 2022, 94, 16927-16935.
512. Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes. Siddika, M. A.; Yamada, T.; Aoyama, R.; Hidaka, K.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. Molecules, 2022, 27, 8298.
513. Zeptoliter DNA Origami Reactor to Reveal Cosolute Effects on Nanoconfined G‐Quadruplexes. Pandey, S.; Jonchhe, S.; Mishra, S.; Emura, T.; Sugiyama, H.; Endo, M.; Mao, H. Phys. Chem. Lett., 2022, 13, 8692-8698.
514. Mitochondria and G-quadruplex Evolution: An Intertwined Relationship. Sahayasheela, V. J.; Yu, Z.; Hidaka, T.; Pandian, G. N.; Sugiyama, H. Trends in Genetics, 2023, 39, 15–30.
515. Sequece-Specific Chromosomal DNA Binders: An Unfulfilled Promise? Yu, Z.; Pandian, G. N.; Sugiyama, H. Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, 2023, Chapter 5, 132-156.
516. RNA G-quadruplex Organizes Stress Granule Assembly through DNAPTP6 in Neurons. Asamitsu, S.; Yabuki, Y.; Matsuo, K.; Kawasaki, M.; Hirose, Y.; Kashiwazaki, G.; Chandran, A.; Bando, T.; Wang, D. O.; Sugiyama, H.; Shioda, N. Science Advances, 2023, 9, eade2035 (1-15).
517. Photocontrolled DNA Nanotubes as Stiffness Tunable Matrices for Controlling Cellular Behavior. Sethi, S.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M. Nanoscale, 2023, 15, 2904-2910.
518. Evaluation by Experimentation and Simulation of a FRET Pair Comprising Fluorescent Nucleobase Analogs in Nucleosomes. Hirashima, S.; Park, S.; Sugiyama, H. Chem. Eur. J, 2023, e20220396 (1-8).
519. Thiophene-extended Fluorescent Nucleosides as Molecular Rotor-Type Fluorogenic Sensors for Biomolecular Interactions. Kumagai, T.; Kinoshita, B.; Hirashima, S.; Sugiyama, H.; Park, S. ACS Sensors, 2023, 8, 923-932.
520. Nanoparticle-Based Artificial Mitochondrial DNA Transcription Regulator: MitoScript. Yang, L.; Rathnam, C.; Hidaka, T.; Hou, Y.; Conklin, B.; Pandian, G. N.; Sugiyama, H.; Lee, K. B. Nano Letter, 2023, 23, 2046-2055.
521. Substitution to Hydrophobic Linker and Formation of Host–guest Complex Enhanced the Effect of Synthetic Transcription Factor. Hatanaka, J.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2023, 81, 117208.
522. Pyrrole-Imidazole Polyamides- A Frontrunner in Nucleic Acid-Based Small Molecule Drugs. Vaijayanthi, T.; Pandian, G. N.; Sugiyama, H. Advanced Therapeutics, 2023, 2300022 (1-8).
523. Artificial Genetic Switches and DNA Origami: Current Landscape and Prospects as Designer Therapeutics and Visualization Tools. Pandian, G. N.; Mishra, S.; Sugiyama, H. in Handbook of Chemical Biology of Nucleic Acids, Eriks Rozners, Naoki Sugimoto, Ed. Springer Nature., in press
524. Identification of Genes Responsible for the Social Skill in the Earthworm, Eudrilus Eugeniae. Lathakumari, S.; Seenipandian, S.; Balakrishnan, S.; Raj, A. P. M. S.; Sugiyama, H.; Pandian, G. N.; Sivasubramaniam, S. Gene Reports, 2023, 31, 101774 (1-19).
525. Highly Fluorescent Isomorphic Nucleobase Analogs Based on the Thieno[3,4-d]-pyrimidine. Park, S.; Sugiyama, H. Photomed. Photobiol.,, 2023, 43-44, 29-43.
526. Histidine-DNA Nanoarchitecture as Laccase Mimetic DNAzymes. Yum, J.; Kumagai, T.; Hori, D.; Suigyama, H.; Park, S. Nanoscale, 2023, https://doi.org/10.1039/D3NR01625K.
527. AT-specific DNA Visualization Revisits the Directionality of Bacteriophage λ DNA Ejection. Bong S.; Park C. B.; Cho S.-G.; Bae, J.; Hapsari, N. D.; Jin, X.; Heo, S.; Lee, J.; Hashiya, K.; Bando, T.; Sugiyama, H.; Jung, K.-H.; Sung, B. J.; Jo, K. Nucleic Acids Research, 2023, 51, 5634-5646.
528. Isothermal Self-assembly of Multicomponent and Evolutive DNA Nanostructures. Rossi-Gendron, C.; Fakih, F. E.; Bourdon, L.; Nakazawa, K.; Finkel, J.; Triomphe, N.; Chocron, L.; Endo, M.; Sugiyama, H.; Bellot, G.; Morel, M.; Rudiuk, S.; Baigl, D. Nature Nanotechnology, 2023, 18, 1311-1318.
529. Two-Dimensional DNA Origami Lattices Assembled on Lipid Bilayer Membranes. Suzuki, Y.; Sugiyama, H.; Endo, M. in: DNA and RNA Origami. Methods in Molecular Biology, vol 2639. 2023 Humana, New York, NY, https://doi.org/10.1007/978-1-0716-3028-0_5
530. Anticancer Activities of DNA-Alkylating Pyrrole−Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53 Mutated Pancreatic Cancer PANC-1 Cells. Hirose, Y.; Sato, S.; Hashiya, K.; Bando, T.; Sugiyama, H. J. Med. Chem., 2023, 66, 12059-12068
531. Structural Expansion of Catalytic RNA Nanostructures Through Oligomerization of a Cyclic Trimer of Engineered Ribozymes. Siddika, M. A.; Oi, H.; Hidaka, K.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. Molecules, 2023, 28, 6465
532. DNA methylation modification patterns identify prognosis responses to immunotherapy and targeted therapy. Bai, D.; Yang, Z.; Cheng, Y.; Pandian, G. N.; Sugiyama, H. Frontiers in Bioscience-Landmark, 2023, 28, 224
533. Targeting Cis-regulatory Elements of FOXO Family is a Novel Therapeutic Strategy for Induction of Leukemia Cell Differentiation. Hirao, A.; Kurayoshi, K.; Takase, Y.; Ueno, M.; Ohta, K.; Fuse, K.; Ikeda, S.; Watanabe, T.; Nishida, Y.; Horike, S.; Hosomichi, K.; Tadokoro, Y.; Kobayashi, M.; Kasahara, A.; Jing, Y.; Shoulkamy, M.; Meguro-Horike, M.; Kojima, K.; Sugiyama, H.; Hiroki, N.; Tajima, A.; Ishikawa, Y.; Kiyoi, H.; Hirao, A. Cell Death & Disease, 2023, 14, 642
534. A Cyclic Pyrrole-imidazole Polyamide Reduces Pathogenic RNA in CAG/CTG Triplet Repeat Neurological Disease Models. Ikenoshita, S.; Matsuo, K.; Yabuki, Y.; Kawakubo, K.; Asamitsu, S.; Hori, K.; Usuki, S.; Hirose, Y.; Bando, T.; Araki, K.; Ueda, M.; Sugiyama, H.; Shioda, N. J. Clin. Invest, 2023, 133, e164792
535. Novel Auger-Electron emitting 191Pt-labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma. Bai, D.; Zhao, W.; Feng, H.; Sugiyama, H. APL Mater. 2023, 11, 100601
536. Nucleic Acid Assembled Semiconducting Materials: Rational Design, Structure-property Modulation and Performance Evaluations. Obata, H.; Atsushi B. Tsuji, B. A.; Sudo, H.; Sugyo A.; Hashiya K.; Ikeda, H.; Minegishi, K.; Nagatsu, K.; Ogawa, M.; Bando, T.; Sugiyama, H.; Zhang, M.-R. Pharmaceuticals (Basel) 2023, 16, 1526
537. Modulation of Excimer Formation and Photoexcitation Behaviour through DNA-Surfactant-dye Supramolecular Assembly. Bai, D.; Zhao, W.; Feng, H.; Sugiyama, H. Macromol. Mater. Eng., 2023, 2300329
538. Nucleic Acid-based Small Molecules as Targeted Transcription Therapeutics for Immunoregulation. Bai, R.; Ziadlou, R.; Vaijayanthi, T.; Karthikeyan, S.; Chinnathambi, S.; Parthasarathy, A.; Cai, L.; Bruggen, M-C., Sugiyama, H.; Pandian, G. N. Allergy, in press
539. RNA G-quadruplex in the Functional Regulation of Non-coding RNA: Challenges and Emerging Opportunities. Sahayasheela, V. J.; Sugiyama H. Cell, Chem. Biol., 2024, 31, 53-70.
540. Structural Studies of a Complex of a CAG/CTG Repeat Sequence-specific Binding Molecule and A-A-mismatch-containing DNA. Abe, K.; Hirose, Y.; Kumagai, T.; Hashiya, K.; Hidaka, K.; Emura, T.; Bando, T.; Kazuki Takeda, K.; Sugiyama, H. JACS Au, in press