京都大学 物質-細胞統合システム拠点

WPI-iCeMs Kyoto University

Sugiyama Laboratory, Kyoto University

List of publications:


1. Singlet-Oxygen Reactions of 1,4-Cyclohexadiene. A Synthetic Approach to the Benzene-1,4-Endoperoxide. Saito, I.; Tamoto, K.; Katsumura, A.; Sugiyama, H.; Matsuura, T. Chemistry Letters, 1978, 127-130.

2. Photochemical Reaction of 8-Azaxantine with Nucleophiles. Saito, I.; Ito, S.; Sugiyama, H.; Akita, M.; Matsuura, T. Tetrahedron Lett., 1979, 42, 4065-4066.

3. Electroreductive Hydrocoupling of Activated Olefines with Ketones or Aldehydes. Shono, T.; Ohmidzu, H.; Kawakami, S.; Sugiyama, H. Tetrahedron Lett., 1980, 21, 5029-5032.

4. Organic Chemical Approach to Photo-Cross-Links of Nucleic Acids to Proteins. T. Matsuura, T.; Saito, I.; Ito, S.; Sugiyama, H.; Shinmura, T. Pure Appl. Chem., 1980, 52, 2705-2715. (Review)

5. A Novel Photoreaction of Thymidine with Lysine. Photoinduced Migration of Thymine from DNA to Lysine. Saito, I.; Sugiyama, H.; Ito, S.; Furukawa, N.; Matsuura, T. J. Am. Chem. Soc., 1981, 103, 1598-1600.

6. Photochemical Ring Opening of Thymidine and Thymine in the Presence of Primary Amines. Saito, I.; Sugiyama, H.; Furukawa, N.; Matsuura, T. Tetrahedron Lett., 1981, 34, 3265-3268.

7. Photoreaction of Thymidine with Alkylamines. Application to Selective Removal of Thymine from DNA. Saito, I.; Sugiyama, H.; Matsuura, T. J. Am. Chem. Soc., 1983, 105, 956-962.

8. Isolation and Characterization of a Thymine-Lysine Adduct in UV-Irradiated Nuclei. The Role of Thymine-Lysine Photoreaction in Photo-Cross-Linking of Proteins to DNA. Saito, I.; Sugiyama, H.; Matsuura, T. J. Am. Chem. Soc., 1983, 105, 6989-6991.

9. Photochemical Reactions of Nucleic Acids and Their Constituents of Photobiological Relevance. Saito, I.; Sugiyama, H.; Matsuura, T. Photochem. Photobiol., 1983, 38, 735-743.

10. A New Procedure for Determinig Thymine Residues in DNA Sequencing. Photoinduced Cleavage of DNA Fragments in the Presence of Spermine. Saito, I.; Sugiyama, H.; Matsuura, T.; Ueda, K.; Komano, T. Nucleic Acids Res., 1984, 12, 2879-2885.

11. Photochemical Reaction between Tryptophan and Thymine. Saito, I.; Sugiyama, H.; Matsuura, T.; Fukuyama, N.; Katsube, Y. Tetrahedron Lett., 1984, 25, 3243-3246.

12. Photochemical Hydrogen-Deuterium Exchange Reaction of Tryptophan. The Role in Nonradiative Decay of Singlet Tryptophan. Saito, I.; Sugiyama, H.; Yamamoto, A.; Muramatsu, S.; Matsuura, T. J. Am. Chem. Soc., 1984, 106, 4286-4287.

13. Specific Labelling of Biologically Important Indoles. Saito, I.; Nakagawa, H.; Sugiyama, H.; Muramatsu, S.; Matsuura, T. Photomedicine and Photobiology, 1984, 6, 55-56.

14. Stacking Interaction between Tryptophan and Uracil in a Synthetic Model Compound. Saito, I.; Sugiyama, H.; Matsuura, T.; Fukuyama, K. Tetrahedron Lett., 1985, 26, 4467-4470.

15. Regio-Controlled Hydrogen-Deuterium Exchange of Biologically Important Indoles under UV Irradiation. Saito, I.; Muramatsu, S.; Sugiyama, H.; Yamamoto, A.; Matsuura, T. Tetrahedron Lett., 1985, 26, 5891-5894.

16. Analysis of Products Formed during Bleomycin-Mediated DNA Degradation. Murugesan, N.; Xu, C.; Ehrenfeld, G. M.; Sugiyama, H.; Kilkuskie, R. E.; Rodriguets, L. O.; Chang, L-H.; Hecht, S. M. Biochemistry, 1985, 24, 5735-5744.

17. Structure of the Alkali-Labile Product Formed during Iron(II)-Bleomycin-Mediated DNA Strand Scission. Sugiyama, H.; Xu, C.; Murugesan, N.; Hecht, S. M. J. Am. Chem. Soc., 1985, 107, 4104-4105.

18. DNA Strand Scission by Bleomycin Group Antibiotics. Sugiyama, H.; Ehrenfeld, G. M.; Shipley, J. B.; Kilkuskie, R. E.; Chang, L-H.; Hecht, S. M. J. Nat. Prod., 1985, 48, 869-877.

19. An Efficient, Site-Specific DNA Target for Bleomycin. Sugiyama, H.; Kilkuskie, R. E.; Hecht, S. M.; van der Marel, G. A.; van Boom, J. H. J. Am. Chem. Soc., 1985, 108, 7765-7767.

20. DNA Strand Scission by Bleomycin: Catalytic Cleavage and Strand Selectivity. Sugiyama, H.; Kilkuskie, R. E.; Chang, L-H.; Ma, L-T.; Hecht, S. M.; van der Marel G. A.; van Boom, J. H. J. Am. Chem. Soc., 1986, 108, 3852-3854.

21. Copper-Dependent Cleavage of DNA by Bleomycin. Ehrenfeld, G. M.; Shiply, J. B.; Heimbrook, D. C.; Sugiyama, H.; Long, E. C.; van Boom, J. H.; van der Marel, G. A.; Oppenheimer, N. J.; Hecht, S. M. Biochemistry, 1987, 26, 931-942.

22. Excited-State Behavior of Tryptamine and Related Indoles. Remarkably Efficient Intramolecular Proton-Induced Quenching. Shizuka, H.; Serizawa, M.; Kobayashi, H.; Kameta, K.; Sugiyama, H.; Matsuura, T.; Saito, I. J. Am. Chem. Soc., 1988, 110, 1726-1732.

23. Chemistry of the Alkali-Labile Lesion Formed by Iron(II) Bleomycin and d(CGCTTTAAAGCG). Sugiyama, H.; Xu, C.; Murugesan, N.; Hecht, S. M.; van der Marel, G. A.; van Boom, J. H. Biochemistry, 1988, 27, 58-67.

24. Photoinduced DNA Strand Scission by Cobalt Bleomycin Green Complex. Saito, I.; Morii, T.; Sugiyama, H.; Matsuura, T.; Meares, C. F.; Hecht, S. M. J. Am. Chem. Soc., 1989, 111, 2307-2308.

25. Chemistry of Neocarzinostatin-Mediated Degradation of d(GCATGC). Mechanism of Spontaneous Thymine Release. Kawabata, H.; Takeshita, H.; Fujiwara, T.; Sugiyama, H.; Matsuura, T.; Saito, I. Tetrahedron Lett., 1989, 30, 4263-4266.

26. A Novel Ribose C-4' Hydroxylation Pathway in Neocarzinostatin-Mediated Degradation of Oligonulceotides. Saito, I.; Kawabata, H.; Fujiwara, T.; Sugiyama, H.; Matsuura, T. J. Am. Chem. Soc., 1989, 111, 8302-8303.

27. Synthetic Cobalt Bleomycin Models as a Photochemical DNA Cleaver. Saito, I.; Morii, T.; Obayashi, T.; Sera, T.; Sugiyama, H.; Matsuura, T. J. Chem. Soc., Chem. Commun., 1989, 6, 360-361.

28. Metallo-Bleomycin-Mediated Degradation of Deoxytetranucleotides. Unusual C-4' Hydroxylation at Terminal Cytidine. Sugiyama, H.; Tashiro, T.; Dannoue, Y.; Miwa, T.; Matsuura, T.; Saito, I. Tetrahedron Lett., 1989, 30, 7213-7216.

29. Oxidative Strand Scission of DNA. Matsuura, T.; Saito, I.; Sugiyama, H.; Morii, T.; Kawabata, H. Pure Appl. Chem., 1989, 61, 473-476. (Review)

30. Specific Detection of C-4' Hydroxylated Abasic Sites Generated by Bleomycin and Neocarzinostatin in DNA. Sugiyama, H.; Kawabata, H.; Fujiwara, T.; Dannoue,Y.; Matsuura, T. J. Am. Chem. Soc., 1990, 112, 5253-5257.

31. Highly Sequence Selective Photoreaction of 5-Bromouracil-Containing Deoxyhexanucleotides. Sugiyama, H.; Tsutsumi, Y.; Saito, I. J. Am. Chem. Soc., 1990, 112, 6720-6721.

32. Covalent Alkylation of DNA with Duocarmycin A. Identification of Abasic Site Structure. Sugiyama, H.; Hosoda, M.; Saito, I.; Asai, A.; Saito, H. Tetrahedron Lett., 1990, 31, 7179-7200.

33. Bleomycin-Mediated Degradation of Aristeromycin-Containing DNA. Novel Dehydrogenation Activity of Iron(II)-Bleomycin. Sugiyama, H.; Sera, T.; Dannoue, Y.; Saito, I. J. Am. Chem. Soc., 1991, 113, 2290-2295.

34. Bis-Hydroperoxy Naphthaldiimide as "Photo-Fenton Reagent": Sequence-Specific Photocheavage of DNA. Matsugo, S.; Kawanishi, S.; Yamamoto, K.; Sugiyama, H.; Matsuura, T.; Saito, I. Ang. Chem. Int. Ed. Engl., 1991, 30, 1351-1353.

35. DNA Cleavage Reaction of Antitumour Antibiotic, Kapurimycin A3, with Deoxytetranucleotide d(CGCG)2. Chan, K. L.; Sugiyama, H.; Saito, I. Tetrahedron Lett., 1991, 32, 7719-7722.

36. A Novel Cyclization Pathway in Activation of Neocarzinostatin Chromophore by Thiol under Physiological Conditions. Sugiyama, H.; Yamashita, K.; Saito, I.; Nishi, M. Tetrahedron Lett., 1992, 33, 515-518.

37. Chemistry of Neocarzinostatin-Mediated Cleavage of Oligonucleotides. Competitive Ribose C5' and C4' Hydroxylation. Sugiyama, H.; Fujiwara, T.; Kawabata, H.; Saito, I.; Hirayama, N.; Yoda, N. J. Am. Chem. Soc., 1992, 114, 5573-5578.

38. 6α-Hydroxyeurycomalactone, A Quassinoid from Eurycoma Longifolia. Chan, K. L.; Iitaka, Y.; Noguchi, H.; Sugiyama, H.; Saito, I.; Sankawa, U. Phytochemistry, 1992, 31, 4295-4298.

39. Concerted DNA Recognition and Novel Site-Specific Alkylation by Duocarmycin A with Distamycin A. Yamamoto, K.; Sugiyama, H.; Kawanishi, S. Biochemistry, 1993, 32, 1059-1066.

40. A Novel Guanine N3 Alkylation by Antitumor Antibiotic Duocarmycin A. Sugiyama, H.; Ohmori, K.; Chan, K. L.; Hosoda, M.;Asai, A.; Saito, H.; Saito, I. Tetrahedron Lett., 1993, 34, 2179-2182.

41. Photoinduced Deoxyribose C2' Oxidation in DNA. Alkali-Dependent Cleavage of Erythrose-Containing Sites via a Retroaldol Reaction. Sugiyama, H.; Tsutsumi, Y.; Fujimoto, K.; Saito, I. J. Am. Chem. Soc., 1993, 115, 4443-4448.

42. Apoprotein-Assisted Unusual Cyclization of Neocarzinostatin Chromophore. Sugiyama, H.; Yamshita, K.; Fujiwara, T.; Saito, I. Tetrahedron, 1994, 50, 1311-1325.

43. Chemistry of Thermal Degradation of Abasic Sites in DNA. Mechanistic Investigation on Thermal DNA Strand Cleavage of Alkylated DNA. Sugiyama, H.; Fujiwara, T.; Ura, A.; Tashiro, T.; Yamamoto, K.; Kawanishi, S.; Saito, I. Chem. Res. Toxicology, 1994, 7, 673-683.

44. Oligonucleotides Containing a Radical Trap: The Trapping of Deoxyribose C4' Radical in Bleomycin-Mediated Reactions. Sugiyama, H.; Ohmori, K.; Saito, I. J. Am. Chem. Soc., 1994, 116, 10326-10327.

45. Activation of Neocarzionstatin-Chromophore by 4-Hydroxythiophenol: Intermolecular Radical Trapping of Biradical Intermediate. Sugiyama, H.; Fujimoto, K.; Saito, I. Tetrahendron Lett., 1994, 35, 8825-8828.

46. Stereospecific 1,2-Hydride Shift in Ribonolactone Formation in the Photoreaction of 2'-Iododeoxyuridine. Sugiyama, H.; Fujimoto, K.; Saito, I. J. Am. Chem. Soc., 1995, 117, 2945-2946.

47. Photoinduced DNA Cleavage via Electron Transfer: Demonstration that Guanine Residues Loacated 5' to Guanine Are the Most Electron-Donating Sites. Saito, I.; Takayama, M.; Sugiyama, H.; Nakatani, K.; Tsuchida, A.; Yamamoto, M. J. Am. Chem. Soc., 1995, 117, 6406-6407.

48. NMR Characterization of Guanine and DNA Site Alkylated by Kapurimycin A3, An Antitumour Antibiotic from Streptomyces sp. Chan, K. L.; Sugiyama, H.; Saito, I.; Hara, M. Phytochemistry, 1995, 40, 1373-1374.

49. Evidence for Intrastrand C2' Hydrogen Abstraction in Photoirradiation of 5-Halouracil-Containing Oligonucleotides by Using Stereospecifically C2'-Deuterated Deoxyadenosine. Sugiyama, H.; Fujimoto, K.; Saito, I.; Kawashima, E.; Sekine, T.; Ishido, Y. Tetrahedron Lett., 1996, 37, 1805-1808.

50. Synthesis, Structure and Thermodynamic Properties of 8-Methylguanine-Containing Oligonucleotides: Z-DNA under Physiological Salt Conditions. Sugiyama, H.; Kawai, K.; Matsunaga, A.; Fujimoto, K.; Saito, I.; Robinson, H.; Wang, A. H.-J. Nucleic Acids Res., 1996, 24, 1272-1278.

51. Theoretical Studies of GG-Specific Photocleavage of DNA via Electron Transfer: Significant Lowering of Ionization Potential and 5'-Localization of HOMO of Stacked GG Bases in B-Form DNA. Sugiyama, H.; Saito, I. J. Am. Chem. Soc., 1996, 118, 7063-7068.

52. Catalytic Activities of Hammerhead Ribozymes with a Triterpenoid Linker Instead of Stem/Loop II. Sugiyama, H.; Hatano, K.; Saito, I.; Amontov, S.; Taira, K. FEBS Letters., 1996, 392, 215-219.

53. Remarkably Stable Parallel-Stranded Oligonucleotides Containing 5-Methylisocytosine and Isoguanine. Sugiyama, H.; Ikeda, S.; Saito, I. J. Am. Chem. Soc., 1996, 118, 9994-9995.

54. Distamycin A Modulates the Sequence Specificity of DNA Alkylation by Duocarmycin A. Sugiyama, H.; Lian, C.; Isomura, M.; Saito, I.; Wang, A. H.-J. Proc. Natl. Acad. Sci. USA., 1996, 93, 14405-14410.

55. New Synthetic Method of 5-Formyluracil-Containing Oligodeoxynucleotides and Their Melting Behavior. Sugiyama, H.; Matsuda, S.; Kino, K.; Zhang, Q.-M.; Yonei, S.; Saito, I. Tetrahedron Lett., 1996, 37, 9067-9070.

56. Structures of Cobalt(III)-Pepleomycin and Cobalt(III)-Deglycopepleomycin (green forms) Determined by NMR Studies. Caceres-Cortes, J.; Sugiyama, H.; Ikudome, K.; Saito, I.; Wang, A. H.-J. Eur. J. Biochem., 1997, 244, 818-828.

57. Interactions of Deglycosylated Cobalt (III)-Pepleomycin (Green Form) with DNA Based on NMR Structural Studies. Caceres-Cortes, J.; Sugiyama, H.; Ikudome, K.; Saito, I.; Wang, A. H.-J. Biochemistry, 1997, 36, 9995-10005.

58. Preferential C1' Hydrogen Abstraction by a Uracilyl Radical in a DNA-RNA Hybrid. Sugiyama, H.; Fujimoto, K.; Saito, I. Tetrahedron Lett., 1997, 38, 8057-8060.

59. Replication of DNA Templates Containing 5-Formyluracil, a Major Oxidative Lesion of Thymine in DNA. Zhang, Q.-M.; Sugiyama, H.; Matsuda, S.; Saito, I. Nucleic Acids Res., 1997, 25, 3969-3973.

60. Design of Photochemical DNA-Cleaving Molecules via Electron Transfer. Saito, I.; Takayama, M.; Sugiyama, H.; Nakamura. T. J. Photochem. Phobiol. A: Chemistry, 1997, 106, 141-144.

61. Sequence Dependent Photoreduction of 5-Bromouracil-Containing Oligonucleotides via Electron Transfer. Fujimoto, K.; Sugiyama, H.; Saito, I. Tetrahedron Lett., 1998, 39, 2137-2140.

62. Stabilization of Hoogsteen Base Pairing by Introduction of NH2 Group at the C8 Position of Adenine. Kawai, K.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 1998, 39, 5221-5224.

63. Structural Studies of a Stable Paralle-Stranded DNA Duplex Incorporating Isoguanine:Cytosine and Isocytosine:Guanine Basepairs by Nuclear Magnetic Resonance Spectroscopy. Yang, X.-L.; Sugiyama, H.; Ikeda, S.; Saito, I.; Wang, A. H.-J. Biophys. J., 1998, 75, 1163-1171.

64. Facile Synthesis of Puromycin-Tethered Oligonucleotides at the 3'-End. Ikeda, S.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 1998, 39, 5975-5978.

65. Product Analysis of GG-Specific Photooxidation of DNA via Electron Transfer: 2-Aminoimidazolone as a Major Guanine Oxidation Product. Kino, K.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 1998, 120, 7373-7374.

66. Mapping of the Hot Spots for DNA Damage by One-Electron Oxidation: Efficacy of GG Doublets and GGG Triplets as a Trap in Long-Range Hole Migration. Saito, I.; Nakamura, T.; Nakatani, K.; Yoshioka, Y.; Yamaguchi, K.; Sugiyama, H. J. Am. Chem. Soc., 1998, 120, 12686-12687.

67. Conformation-Dependent Photochemistry of 5-Halouracil-Containing DNA: Stereospecific 2’α-Hydroxylation of Deoxyribose in Z-form DNA. Kawai, K.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 1999, 121, 1391-1392.

68. Highly Efficient DNA Interstrand Crosslinking Induced by an Antitumor Antibiotic, Carzinophilin. Fujiwara, T.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 1999, 40, 315-318.

69. Sequence-Specific DNA Alkylation by Hybrid Molecules between Segment A of Duocarmycin A and Pyrrole/Imidazole Diamide. Tao, Z.-F.; Fujiwara, T.; Saito, I.; Sugiyama, H. Angew. Chem. Int. Ed., 1999, 38, 650-653.

70. Replication in vitro and Cleavage by Restriction Endonuclease of 5-Formyluracil- and 5-Hydroxymethyluracil-Containing Oligonucleotides. Zhang, Q-M.; Sugiyama, H.; Miyabe, I.; Matuda, S.; Kino, K.; Saito, I.; Yonei, S. Int. J. Radiat. Biol., 1999, 75, 59-65.

71. Rational Design of Sequence-Specific DNA Alkylating Agents Based on Duocarmycin A and Pyrrole-Imidazole Hairpin Polyamides. Tao, Z.-F.; Fujiwara, T.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 1999, 121, 4961-4967.

72. Intrastrand 2'β Hydrogen Abstraction of 5-Adjacent Deoxyguanosine by Deoxyuridin-5-yl in Z-form DNA. Kawai, K.; Saito, I.; Kawashima, E.; Ishido, Y.; Sugiyama, H. Tetrahedron Lett., 1999, 40, 2589-2592.

73. Photochemical Halogen-Exchange Reaction of 5-Iodouracil-Containing Oligonucleotides. Kawai, K.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 1999, 40, 5721-5724.

74. Modulation of Sequence Specificity of Duocarmycin-Dependent DNA Alkylation by Pyrrole-Imidazole Triamides. Fujiwara, T.; Tao, Z.-F.; Ozeki, Y.; Saito, I.; Wang, A. H.-J.; Lee, M.; Sugiyama, H. J. Am. Chem. Soc., 1999, 121, 7706-7707.

75. Substrate Recognition by Escherichia coli MutY using Substrate Analogs. Chepanoske, C. L.; Porello, S. L.; Fujiwara, T.; Sugiyama, H.; David, S. S. Nucleic Acids Res., 1999, 27, 3197-3204.

76. Imidazole-imidazole Pair as a Minor Groove Recognition Motif for T:G Mismatched Base Pairs. Yang, X.-L.; Hubbard IV, R. B.; Lee, M.; Tao, Z.-F.; Sugiyama, H.; Wang, H.-J. Nucleic Acids Res., 1999, 27, 4183-4190.

77. State Transtitions by Molecules. Sakamoto, K.; Kiga, D.; Ken, K.; Gouzu. H.; Yokoyama, S.; Ikeda, S.; Sugiyama, H.; Hagiya, M. Biosystems, 1999, 52, 81-91.

78. Highly Cooperative DNA Dialkylation by the Homodimer of Imidazole-Pyrrole Diamide-CPI Conjugate with Vinyl Linker. Tao, Z.-F.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 2000, 122, 1602-1608.

79. Enhanced Cytotoxicity in a Z-Photoisomer of a Benzopyrane Derivative of Propolis. Hirota, M.; Matsuno, T.; Fujiwara, T.; Sugiyama, H.; Mineshita, S. J. Nat. Prod., 2000, 63, 366-370.

80. Metallo-Bleomycin Cleaves Parallel-Stranded DNA Similarly to B-DNA. Ikeda, S.; Saito, I.; Sugiyama, H. Tetrahedron Lett., 2000, 41, 3919-3922.

81. Mechanism of DNA Strand Scission Induced by (1,10-Phenanthroline) Copper Complex: Major Direct DNA Cleavage Is Not through 1', 2'-Dehydronucleotide Intermediate nor β-Elimination of Forming Ribonolactone. Oyoshi, T.; Sugiyama, H. J. Am. Chem. Soc., 2000, 122, 6313-6314.

82. Identification of Repair Enzymes for 5-Formyluracil in DNA: Nth, Nei and MutM Proteins of Escherichia coli. Zhang, Q.-M.; Miyabe, I.; Matsumoto, Y.; Kino, K.; Sugiyama, H.; Yonei, S. J. Biol. Chem., 2000, 275, 35471-35477.

83. Amplification of Pepleomycin-Mediated DNA Cleavage and Apoptosis by Unfused Aromatic Cations. Kawanishi, S.; Oikawa, S.; Kawanishi, M.; Sugiyama, H.; Saito, I.; Stredowski, L.; Wilson, W. D. Biochemistry, 2000, 39, 13210-13215.

84. Mutagenic Effects of 5-Formyluracil on a Plasmid Vector during Replication in Escherichia coli. Miyabe, I.; Zhang, Q.-M.; Kino, K.; Sugiyama, H.; Yonei, S. Int. J. Radiat. Biol., 2001, 77, 53-58.

85. Amplification of Bleomycin-Induced DNA Cleavage at Cytosine Residues 3' to GGG Sequences by Pyrrole Triamide. Hiraku,Y.; Oikawa, K.; Sugiyama, H.; Saito, I.; Kawanishi, S. Biochemical Pharmacology, 2001, 61, 351-356.

86. Possible Cause of G・C->C・G Transversion Mutation by Guanine Oxidation Product, Imidazolone. Kino, K.; Sugiyama, H. Chem. & Biol., 2001, 8, 369-378.

87. Sequence-Specific DNA Interstrand Cross-Linking by Imidazole-Pyrrole CPI Conjugate. Bando, T.; Iida, H.; Saito, I.; Sugiyama, H. J. Am. Chem. Soc., 2001, 123, 5158-5159.

88. Design, Synthesis, DNA Binding, and Biological Evaluation of Water-Soluble Hybrid Molecules Containing Two Pyrazole Analogues of the Alkylating Cyclopropylpyrroloindole (CPI) Subunit of the Antitumor Agent CC-1065 and Polypyrrole Minor Groove Binders. Baraldi, G.; Balbone, G.; Pabani, M. G.; Spalluto, G.; Clercq, E.; Balzarini, J.; Bando, T.; Sugiyama, H.; Romagnoli, R. J. Med. Chem., 2001, 44, 2536-2543.

89. Synthesis of 6-(2-Thienyl)Purine Nucleoside Derivatives That Form Unnatural Base Pairs with Pyridin-2-one Nucleosides. Fujiwara, T.; Kimoto, M.; Sugiyama, H.; Hirao, I.; Yokoyama, S. Bioorg. Med. Chem. Lett., 2001, 11, 2221-2223.

90. Photoreactivity of 5-Iodouracil-Containing DNA-Sso7d Complex in Solution: Protein-Induced DNA Kink Causes Intrastrand Hydrogen Abstraction from 5-Methyl of Thymine at the 5' Side. Oyoshi, T.; Wang, A. H.-J.; Sugiyama, H. J. Am. Chem. Soc., 2002, 124, 2086-2087.

91. Identification of 5-Formyluracil DNA Glycosylase Activity of Human hNTH1 Protein. Miyabe, I.; Zhang, Q.-M.; Kino, K.; Sugiyama, H.; Kakao, M.; Yasui , A.; Yonei, S. Nucleic Acids Res., 2002, 30, 3443-3448.

92. Characterization of 2-Hydroxyadenine DNA Glycosylase Activity of Escherichia coli MutY Protein. Hashiguchi, K.; Zhang, Q. M.; Sugiyama, H.; Ikeda, S.; Yonei, S. Int. J. Radiat. Biol., 2002, 78, 585-592.

93. Sequence-Specific Protection of Plasmid DNA from Restriction Endonuclease Hydrolysis by Pyrrole-Imidazole-Cyclopropapyrroloindole Conjugates. Fujimoto, K.; Iida, H.; Bando, T.; Tao, Z.-F.; Sugiyama, H. Nucleic Acids Res., 2002, 30, 3748-3753.

94. Molecular Design of a Pyrrole-Imidazole Hairpin Polyamides for Effective DNA Alkylation. Bando, T.; Narita, A.; Saito, I.; Sugiyama, H. Chem. Eur. J., 2002, 8, 4781-4790.

95. The Conformational Study of Two Carbocyclic Nucleosides: Why Carbocyclic Nucleic Acids (CarNAs) Form more Stable Duplexes with RNA than DNA Does. Xu, Y.; Kino, K.; Sugiyama, H. J. Biol. Struct. Dyn., 2002, 20, 437-446.

96. Deglyco-Peplomycin Metal Complexes on DNA Fibers: A Role of the Sugar Moiety for the Stability and the Orientation on the Complexes. Iiyama,T.; Chikira, M.; Oyoshi, T.; Sugiyama, H. J. Bioinorg. Chem., 2003, 8, 135-140.

97. Efficient C2'α-Hydroxylation of Deoxyribose in Protein-Induced Z-Form DNA. Oyoshi, T.; Kawai, K.; Sugiyama H. J. Am. Chem. Soc., 2003, 125, 1526-1531.

98. Identification of High Excision Capacity for 5-Hydroxymethyluracil Mispaired with Guanine in DNA of Eschericha coli MutM, Nei and Nth DNA Glydosylases. Hori, M.; Yonei, S.; Sugiyama, H.; Kino, K; Yamamoto, K.; Zhang, Q. M. Nucleic Acids Res., 2003, 31, 1191-1196.

99. Highly Efficient Sequence-Specific DNA Interstrand Cross-linking by Pyrrole/Imidazole CPI Conjugates. Bando, T.; Narita, A.; Sugiyama, H. J. Am. Chem. Soc., 2003, 125, 3471-3485.

100. Inhibition of Transcription at a Coding Sequence by Alkylating Polyamide. Oyoshi, T.; Kawakami, W.; Narita, A.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2003, 125, 4752-4753.

101. Specific Alkylation of Human Telomere Repeats by Hairpin Pyrrole-Imidazole Polyamide. Takahashi R,; Bando T,; Sugiyama H. Bioorg. Med. Chem., 2003, 11, 2503-2509.

102. Sequence Specificity, Reactivity, and Antitumor Activity of DNA-Alkylating Pyrrole-Imidazole Diamides. Bando, T.; Iida, T.; Tao, Z.-F.; Narita, A.; Fukuda, N.; Yamori, T.; Sugiyama, H. Chem. Biol., 2003, 10, 751-758.

103. 8-Methylguanosine: A Powerful Z-DNA Stabilizer. Xu, Y.; Ikeda, R.; Sugiyama, H. J. Am. Chem. Soc., 2003, 125, 13519-13524.

104. A Nanothermometer Based on the Different π-Stacking of B- and Z-DNA. Tashiro, R.; Sugiyama, H. Angew. Chem. Int. Ed., 2003, 42, 6018-6020.

105. Unique Charge Transfer Properties of the Four-Base π-Stacks in Z-DNA. Tashiro, R.; Sugiyama, H. J. Am. Chem. Soc., 2003, 125, 15282-15283.

106. Biology of N-Methylpyrrole-N-Methylimidazole Hairpin Polyamide. Murthy, M.S.R.C.; Sugiyama, H. Biol. Pharm. Bull., 2004, 27, 468-474. (Review)

107. Nucleotide Excision Repair of 5-Formyluracil in Vitro Is Enhanced by the Presence of Mismatched Bases. Kino, K.; Shimizu, Y.; Sugasawa, K.; Sugiyama, H.; Hanaoka, F. Biochemistry, 2004, 43, 2682-2687.

108. C-H to N Substitution Dramatically Alters the Sequence-Specific DNA Alkylation, Cytotoxicity, and Expression of Human Cancer Cell Lines. Bando, T.; Narita, A.; Iwai, A.; Kihara, K.; Sugiyama, H. J. Am. Chem. Soc., 2004, 126, 3406-3407.

109. Sequence-Specific Gene Silencing in Mammalian Cells by Alkylating Pyrrole-Imidazole Polyamides. Shinohara, K.; Narita, A.; Oyoshi, T.; Bando, T.; Teraoka, H.; Sugiyama, H. J. Am. Chem. Soc., 2004 , 126, 5113-5118.

110. Highly Efficient Photochemical 2'-Deoxyribonolactone Formation at the Diagonal Loop of a 5-Iodouracil-Containing Antiparallel G-Quartet. Xu, Y.; Sugiyama, H. J. Am. Chem. Soc., 2004, 126, 6274-6279.

111. (P)-Helicene Displays Chiral Selection in Binding to Z-DNA. Xu, Y.; Zhang Y. X.; Sugiyama, H. ; Umano, T.; Osuga, H.; Tanaka, K. J. Am. Chem. Soc., 2004, 126, 6566-6567.

112. Enantioselective DNA Alkylation by a Pyrrole-Imidazole S-CBI Conjugate. Bando, T.; Narita, A.; Asada, K.; Ayame, H.; Sugiyama, H. J. Am. Chem. Soc., 2004, 126, 8948-8955.

113. Binding of Distamycin A to UV-Damaged DNA. Inase, A.; Kodama, T.S.; Sharif, J.; Xu, Y.; Ayame, H.; Sugiyama, H.; Iwai S. J. Am. Chem. Soc., 2004, 126, 11017-11023.

114. DNA Glycosylase Activities for Thymine Residues Oxidized in the Methyl Group are Functions of the hNEIL1 and hHTH1 Enzymes in Human Cells. Zhang, Q.-M.; Yonekura, S.; Takao, M.; Yasui, A.; Sugiyama, H.; Yonei, S. DNA Repair, 2005, 4, 71-79.

115. Efficient Generation of 2'-Deoxyuridin-5-yl at 5'-(G/C)AAXUXU-3' (X=Br, I) Sequences in Duplex DNA under UV Irradiation. Watanabe, T.; Bando, T.; Xu, Y.; Tashiro, R.; Sugiyama, H. J. Am. Chem. Soc., 2005, 127, 44-45.

116. Biomolecule-Based Switching Devices that Respond Inversely to Thermal Stimuli. Tashiro, R.; Sugiyama, H. J. Am. Chem. Soc., 2005, 127, 2094-2097.

117. 5-Exo versus 6-Endo Cyclization of Nucleoside 2-Sila-5-hexenyl Radicals: Reaction of 6-(Bromomethyl)dimethylsilyl 1', 2'-Unsaturated Uridines. Ogamino, J.; Mizunuma, H.; Kumamoto, H.; Takeda, S.; Haraguchi, K.; Nakamura, K. T.; Sugiyama, H.; Tanaka, H. J. Org. Chem., 2005, 70, 1684-1690.

118. UVR-Induced G-C to C-G Transversions from Oxidative DNA Damage. Kino, K.; Sugiyama, H. Mutat. Res., 2005, 571, 33-42.

119. Synthetic Pyrrole-Imidazole Polyamide Inhibits Expression of the Human Transforming Growth Factor-β1 Gene. Lai, Y.-M.; Fukuda, N.; Ueno, T.; Kishioka, H.; Matsuda, H.; Saito, S.; Matsumoto, K.; Ayame, H.; Bando, T.; Sugiyama, H.; Mugishima, H.; Kim, S.-J. J. Pharmacol. Exp. Ther., 2005, 315, 571-575.

120. Specific Adenine Alkylation by Pyrrole-Imidazole CBI Conjugates. Bando, T.; Narita, A.; Sasaki, S.; Sugiyama, H. J. Am. Chem. Soc., 2005, 127, 13890-13895.

121. Development of Gene Silencing Pyrrole-Imidazole Polyamide Targeting the TGF-β1 Promoter for Treatment of Progressive Renal Diseases. Matsuda, H.; Fukuda, N.; Ueno, T.; Tahira, Y.; Ayame, H.; Zhang, W.; Bando, T.; Sugiyama, H.; Saito, S.; Matsumoto, K.; Mugishima, H.; Serie, K. J. Am. Soc. Nephrol., 2006, 17, 422-432.

122. Photochemical Approach to Probing Different DNA Structures. Xu, Y.; Sugiyama, H. Angew. Chem. Int. Ed., 2006, 45, 1354-1362.

123. Antitumor Activity of Sequence-Specific Alkylating Agents: Pyrolle-Imidazole CBI Conjugates with Indole Linker. Shinohara, K.; Bando, T.; Sasaki, S.; Sakakibara, Y.; Minoshima, M.; Sugiyama, H. Cancer Sci., 2006, 97, 219-225.

124. Efficient DNA Alkylation by a Pyrrole-Imidazole CBI Conjugate with an Indole Lnker: Sequence-Specific Alkylation with Nine-Base-Pair Recognition. Bando, T.; Sasaki, S.; Minoshima, M.; Dohno, C.; Shinohara, K.; Narita, A.; Sugiyama, H. Bioconjug. Chem., 2006, 17, 715-720.

125. Formation of the G-quadruplex and I-motif Structures in Retinoblastoma Susceptibility Genes (Rb). Xu, Y.; Sugiyama, H. Nucleic Acids Res., 2006, 34, 949-954.

126. Alkylation of Template Strand of Coding Region Causes Effective Gene Silencing. Shinohara, K.; Sasaki, S.; Minoshima, M.; Bando, T.; Sugiyama, H. Nucleic Acids Res., 2006, 34, 1189-1195.

127. The New Models of the Human Telomere d[AGGG(TTAGGG)3] in K+ Solution. Xu, Y.; Noguchi, Y.; Sugiyama, H. Bioorg. Med. Chem., 2006, 14, 5584-5591.

128. Suppression of VEGF Transcription in Renal Cell Carcinoma Cells by Pyrrole-Imidazole Hairpin Polyamides Targeting the Hypoxia Responsive Element. Kageyama, Y.; Sugiyama, H.; Ayame, H.; Iwai, A.; Fujii, Y.; Huang, L. E.; Kizaka-Kondoh, S.; Hiraoka, M.; Kihara, K. Acta. Oncol., 2006, 45, 317-324.

129. Discrimination of Hairpin Polyamides with an α-Substituted-γ-Aminobutyric Acid as a 5'-TG-3' Reader in DNA Minor Groove. Zhang, W.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2006, 128, 8766-8776.

130. Synthesis and Biological Properties of Sequence-Specific DNA-Alkylating Pyrrole-Imidazole Polyamides. Bando, T.; Sugiyama, H. Acc. Chem. Res., 2006, 39, 935-944. (Review)

131. Sequence-Specific Alkylation of Double-Strand Human Telomere Repeat Sequence by Pyrrole-Imidazole Polyamides with Indole Linkers. Sasaki, S.; Bando, T.; Minoshima, M.; Shimizu, T.; Shinohara, K.; Takaoka, T.; Sugiyama, H. J. Am. Chem. Soc., 2006, 128, 12162-12168.

132. Photoreactivation of DNA by an Archaeal Nucleoprotein Sso7d. Tashiro, R.; Wang A. H. -J.; Sugiyama, H. Proc. Natl. Acad. Sci. USA., 2006, 103, 16655-16659.

133. Base Pair Recognition of the Stereochemically α-Substituted γ-Turn of Pyrrole/Imidazole Hairpin Polyamides. Zhang, W.; Minoshima, M.; Sugiyama, H. J. Am. Chem. Soc., 2006, 128, 14905-14912.

134. I-motif and Quadruplex-Based Device that can Control a Protein Release or Bind Release Small Molecule to Influence Biological Processes. Xu, Y.; Hirao, Y.; Nishimura, Y.; Sugiyama, H. Bioorg. Med. Chem., 2007, 15, 1275-1279.

135. Photochemical Determination of Different DNA Structures. Xu, Y.; Tashiro, Ryu.; Sugiyama, H. Nat. Protoc., 2007, 2, 78-87.

136. Chemical Biology that Controls DNA Structure and Function: Lessons in Organic Chemistry from Nature. Sugiyama, H. Bull. Chem. Soc. Jpn., 2007, 80, 823-841. (Review)

137. User-friendly Synthesis and Photoirradiation of a Flavin-Linked Oligomer. Kino, K.; Miyazawa, H.; Sugiyama, H. Genes and Environment, 2007, 29, 23-28.

138. Distamycin A Enhances the Cytotoxicity of Duocarmycin A and Suppresses Duocarmycin A-induced Apoptosis in Human Lung Carcinoma Cells. Hirota, M.; Fujiwara, T.; Mineshita, S.; Sugiyama, H.; Teraoka H. Int. J. Biochem. Cell. Biol., 2007, 39, 988-996.

139. DNA Alkylation by Pyrrole-Imidazole seco-CBI Conjugates with an Indole Linker: Sequence-Specific DNA Alkylation with 10-Base-Pair Recognition through Hetelodimer Formation. Minoshima, M.; Bando, T.; Sasaki, S.; Shinohara, K.; Shimizu, T.; Fujimoto, J.; Sugiyama, H. J. Am. Chem. Soc., 2007, 129, 5384-5390.

140. Efficient and Erroneous Incorporation of Oxidized DNA Precursors by Human DNA Polymerase η. Shimizu, M.; Gruz, P.; Kamiya, H.; Masutani, C.; Xu, Y.; Usui, Y.; Sugiyama, H.; Harashima, H.; Hanaoka, F.; Nohmi, T. Biochemistry, 2007, 46, 5515-5522.

141. Photoreaction at 5'-(G/C)AABrUT-3' Sequence in Duplex DNA: Efficient Generation of Uracil-5-yl Radical by Charge Transfer. Watanabe, T.; Tashiro, R.; Sugiyama, H. J. Am. Chem. Soc., 2007, 129, 8163-8168.

142. Structure of a Human Telomeric DNA Sequence Stabilized by 8-Bromoguanosines Substitutions, as Determined by NMR in a K+ Solution. Matsugami, A.; Xu, Y.; Noguchi, Y.; Sugiyama, H.; Katahira, M. FEBS J., 2007, 274, 3545-3556.

143. Detection of CAG Repeat DNA Sequences by Pyrene-Functionalized Pyrrole-Imidazole Polyamides. Bando, T.; Fujimoto, J.; Minoshima, M.; Shinohara, K.; Sasaki, S.; Kashiwazaki, G.; Mizumura, M.; Sugiyama, H. Bioorg. Med. Chem., 2007, 15, 6937-6942.

144. Recombinant Schizosaccharomyces pombe Nth1 Protein Exhibits DNA Glycosylase Activities for 8-oxo-7,8-dihydroguanine and Thymine Residues Oxidized in the Methyl Group. Yonekura, S.; Nakamura, N.; Doi, T.; Sugiyama, H.; Yamamoto, K.; Yonei, S.; Zhang, Q.-M. J. Radiat. Res., 2007, 48, 417-424.

145. Meeting Review: First International Meeting on Quadruplex DNA. Wilson, W. D.; Sugiyama, H. ACS Chem. Biol., 2007, 2 , 589-594.

146. Optimization and Validation of a High-Performance Liquid Chromatographic Method with UV Detection for the Determination of Pyrrole-Imidazole Polyamides in Rat Plasma. Fukasawa, A.; Nagashima, T.; Aoyama, T.; Fukuda, N.; Matusda, H.; Ueno, T.; Sugiyama, H.; Nagase, H.; Matsumono, Y. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2007, 859, 272-275.

147. The Androgen Receptor as Putative Therapeutic Target in Hormonone-Refractory Prostate Cancer. Kageyama, Y.; Hyochi, N.; Kihara, K.; Sugiyama, H. Recent Pat. Anticancer Drug Discov., 2007, 2, 203-211.

148. Sequence-Specific Alkylation by Y-Shaped and Tandem Hairpin Pyrrole-Imidazole Polyamides. Sasaki, S.; Bando, T.; Minoshima, M.; Shinohara, K.; Sugiyama, H. Chem. Eur. J., 2008, 18, 864-870.

149. Photoreaction of Iodouracil in DNA duplex; C-I bond is Cleaved via Two Different Pathways "Homolysis and Heterolysis". Tashiro, R.; Nakamura, K.; Sugiyama, H. Tetrahedron Lett., 2008, 49, 428-431.

150. Requirement of β-Alanine Components in Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Conjugates with Seven-Base Pair Recognition. Bando, T.; Minoshima, M.; Kashiwazaki, G.; Shinohara, K.; Sasaki, S.; Fujimoto, J.; Ohtsuki, A.; Murakami, M.; Nakazono, S.; Sugiyama, H. Bioorg. Med. Chem., 2008, 16, 2286-2291.

151. Pyrrole-Imidazole Hairpin Polyamides with High Affinity at 5'-CGCG-3' DNA Sequence; Influence of Cytosine Methylation on Binding. Minoshima, M.; Bando, T.; Sasaki, S.; Fujimoto, J.; Sugiyama, H. Nucleic Acids Res., 2008, 36, 2889-2894.

152. Detection of Triplet Repeat Sequences in the Double-Stranded DNA using Pyrene-Functionalized Pyrrole-Imidazole Polyamides with Rigid Linkers. Fujimoto, J.; Bando, T.; Minoshima, M.; Uchida, S.; Iwasaki, M.; Shinohara, K.; Sugiyama, H. Bioorg. Med. Chem., 2008, 16, 5899-5907.

153. Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Attenuates Restenosis of the Artery after Injury. Yao, E-H; Fukuda, N.; Ueno,T.; Matsuda, M.; Matsumoto, M.; Nagase, H.; Matsumoto, Y.; Takasaka, A.; Serie, K.; Sugiyama, H.; Sawamura, T. Hypertension, 2008, 52, 86-92.

154. G-Quadruplex Structures of Human Telomere DNA examined by Single Molecule FRET and BrG-Substitution. Okamoto, K.; Sannohe, Y.; Mashimo, T.; Sugiyama, H.; and Terazima, M. Bioorg. Med. Chem., 2008, 16, 6873-6879.

155. Development of Pyrrole-Imidazole Polyamide for Specific Regulation of Human Aurora Kinase-A and -B Gene Expression. Takahashi, T.; Asami, Y.; Kitamura, E.; Suzuki, T.; Wang, X.; Igarashi, J.; Morohashi, A.; Shinojima, Y.; Kanou, H.; Saito, K.; Takasu, T.; Nagase, H.; Harada, Y.; Kuroda, K.; Watanabe, T.; Kumamoto, S.; Aoyama, T.; Matsumoto, Y.; Bando, T.; Sugiyama, H.; Yoshida-Noro, C.; Fukuda, N.; Hayashi N. Chem. Biol., 2008, 15, 829-841.

156. Perylene-Conjugated Pyrrole Polyamide as a Sequence-Specific Fluorescent Probe. Fujimoto, J.; Bando, T.; Minoshima, M.; Kashiwazaki, G.; Nishijima, S.; Shinohara, K.; Sugiyama, H. Bioorg. Med. Chem., 2008, 16, 9741-9744.

157. Stable Lariat Formation Based on a G-Quadruplex Scaffold. Xu, Y.; Sato, H.; Sannohe, Y.; Shinohara, K.; Sugiyama, H. J. Am. Chem. Soc., 2008, 130, 16470-16471.

158. A Pyrrole-Imidazole Polyamide Targeting Transforming Growth Factor-β1 Inhibits Restenosis and Preserves Endothelialization in the Injured Artery. Yao, E-H.; Fukuda, N.; Ueno, T.; Matsuda, H.; Nagase, N.; Matsumoto, Y.; Sugiyama, H.; Matsumoto, K. Cardiovasc. Res., 2009, 81, 797-804.

159. Cooperative Alkylation of Double-Strand Human Telomere Repeat Sequences by PI Polyamides with 11-Base-Pair Recognition Based on a Heterotrimeric Design. Kashiwazaki, G.; Bando, T.; Shinohara, K.; Minoshima, M.; Nishijima, S.; Sugiyama, H. Bioorg. Med. Chem., 2009, 17, 1393-1397.

160. The Orientation of the Ends of G-Quadruplex Structures Investigated using End-Extended Oligonucleotides. Sannohe, Y.; Sato, K.; Matsugami, A.; Shinohara, K.; Mashimo, T.; Katahira, M.; Sugiyama, H. Bioorg. Med. Chem., 2009, 17, 1870-1875.

161. Pharmacokinetic Modeling and Prediction of Plasma Pyrrole-Imidazole Polyamide Concentration in Rats using Simultaneous Urinary and Biliary Excretion Data. Nagashima, T.; Aoyama, T.; Yokoe, T.; Fukasawa, A.; Fukuda, N.; Ueno, T.; Sugiyama, H.; Nagase, H. Bio. Pharm. Bull., 2009, 32, 921-927.

162. Pharmacokinetics of Pyrrole-Imidazole Polyamides after Intravenous Administration in Rat. Fukasawa, A.; Aoyama, T.; Nagashima, T.; Fukuda, N.; Ueno, T.; Sugiyama, H.; Nagase, H.; Matsumoto, H. Biopharm. Drug Dispos., 2009, 30, 81-89.

163. KsgA, a 16S rRNA Adenine Methyltransferase, Has a Novel DNA Glycosylase/AP lyase Activity to Prevent Mutations in Escherichia coli. Zhang-Akiyama, Q. M.; Morinaga, H.; Kikuchi, M.; Yonekura, S.; Sugiyama, H.; Yamamoto, K.; Yonei, S.; Nucleic Acids Res., 2009, 37, 2116-2125.

164. A Novel Gene Silencer, Pyrrole-Imidazole Polyamide Targeting Human Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Gene Improves Endothelial Cell Function. Ueno, T.; Fukuda, N.; Tsunemi, A.; Yao, E. H.; Matsuda, H.; Tahira, K.; Matsumoto, T.; Matsumoto, Y.; Nagase, H.; Sugiyama, H.; Sawamura, T. J. Hypertens., 2009, 27, 508-516.

165. Determination of Pyrrole-Imidazole Polyamide in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Nagashima, T.; Aoyama, T.; Fukasawa, A.; Watabe, S.; Fukuda, N.; Ueno, T.; Sugiyama, H.; Nagase, H.; Matsumoto, Y. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2009, 877, 1070-1076.

166. Purification and Characterization of Caenorhabditis Elegans NTH, a Homolog of Human Endonuclease III: Essential Role of N-Terminal Region. Morinaga, H.; Yonekura, S.; Nakamura, N.; Yonei, S.; Zhang-Akiyama, Q. M. DNA Repair, 2009, 8, 844-851.

167. Development of a Molecule-Recognized Promoter DNA Sequence for Inhibition of HER2 Expression. Suzuki, T.; Asami, Y.; Takahashi, T.; Wang, X.; Watanabe, T.; Bando, T.; Sugiyama, H.; Fukuda, N.; Nagase, H. J. Antibiot., 2009, 62, 339-341.

168. Chemical Approaches to DNA Nanotechnology. Endo, M.; Sugiyama, H. ChemBioChem, 2009, 10, 2420-2443. (Review)

169. Synthesis and Properties of PI Polyamide-SAHA Conjugate. Ohtsuki, A.; Kimura, M. T.; Minoshima, M.; Suzuki, T.; Ikeda, M.; Bando, T.; Nagase, H.; Shinohara, K.; Sugiyama, H. Tetrahedron Lett., 2009, 50, 7288-7292.

170. Eukaryotic DNA Polymerases α, β and ε Incorporate Guanine Opposite 2,2,4-Triamino-5(2H) -oxazolone. Kino, K.; Sugasawa, K.; Mizuno, T.; Bando, T.; Sugiyama, H.; Akita, M.; Miyazawa, H.; Hanaoka, F. ChemBioChem, 2009, 10, 2613-2616.

171. DNA Prism Structures Constructed by Folding of Multiple Rectangular Arms. Endo, M.; Hidaka, K.; Kato, T.; Namba, K.; Sugiyama, H. J. Am. Chem. Soc., 2009, 131, 15570-15571.

172. Design of a G-quadruplex Topology through Glycosidic Bond Angles. Webba da Silva, M.; Trajkovsiki, M.; Sannohe, Y.; Ma'ami Hessari, N.; Sugiyama, H.; Plavec, J. Angew. Chem. Int. Ed., 2009, 48, 9167-9170.

173. Potent Activity Against K562 Cells by Polyamide-seco-CBI Conjugates Targeting Histone H4 Genes. Minoshima, M.; Chou, J. C.; Lefebvre, S.; Bando, T.; Shinohara, K.; Gottesfeld, J. M.; Sugiyama, H. Bioorg. Med. Chem., 2010, 18, 168-174.

174. Cell Permeability of Py-Im-Polyamide-Fluorescein Conjugates: Influence of Molecular Size and Py/Im Content. Nishijima, S.; Shinohara, K.; Bando,T.; Minoshima, M.; Kashiwazaki, G.; Sugiyama, H. Bioorg. Med. Chem., 2010, 18, 978-983.

175. Comparative Analysis of DNA Alkylation by Conjugates between Pyrrole-Imidazole Hairpin Polyamides and Chlorambucil or seco-CBI. Minoshima, M.; Bando, T.; Shinohara, K.; Kashiwazaki, K.; Nishijima, S.; Sugiyama, H. Bioorg. Med. Chem., 2010, 18, 1236-1243.

176. Anticancer Activities of Alkylating Pyrrole-Imidazole Polyamides with Specific Sequence Recognition. Shinohara, K.; Bando, T.; Sugiyama, H. Anticancer Drugs, 2010, 21, 228-242. (Review)

177. Regulation of DNA Methylation using Different Tensions of Double Strands Constructed in a Defined DNA Nanostructure. Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132 , 1592-1597.

178. A Chiral Wedge Molecule Inhibits Telomerase Activity. Shinohara, K.; Sannohe, Y.; Kaieda, S.; Tanaka, K.; Osuga, H.; Xu, Y.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132, 3778-3782.

179. Overview of Formation of G-Quadruplex Structures. Sannohe, Y.; Sugiyama, H. Curr. Protoc. Nucleic Acid Chem., 2010, 17.2.1-17.2.17. (Review)

180. DNA-Based Hybrid Catalysts for Asymmertic Organic Synthesis. Park, S.; Sugiyama, H. Angew. Chem. Int. Ed., 2010, 49, 3870-3878. (Review)

181. Inhibition of MMP-9 Transcription and Suppression of Tumor Metastasis by Pyrrole-Imidazole Polyamide. Wang, X.; Nagase, H.; Watanabe, T.; Nobusue, H.; Suzuki, T.; Kimura, M.; Mishra, R.; Shinojima, Y.; Kawashima, H.; Takagi, K.; Igarashi, J.; Takayama, T.; Fukuda, N.; Sugiyama, H. Cancer Sci., 2010, 101, 759-766.

182. Alkylation of a Human Telomere Sequence by Heterotrimeric Chlorambucil PI Polyamide Conjugates. Kashiwazaki, G.; Bando, T.; Shinohara, K.; Minoshima, M.; Kumamoto, H.; Nishijima, S.; Sugiyama, H. Bioorg. Med. Chem., 2010, 18, 2887-2893.

183. Programmed-Assembly System Using DNA Jigsaw Pieces. Endo, M.; Sugita, T.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. Chem. Eur. J., 2010, 16, 5362-5368.

184. Synthesis of Bicyclic Enediynes That Possess a Photosensitive Triggering Device and Exhibit strong DNA Cleaving Activity. Tanaka, H.; Tanaka, Y.; Minoshima, M.; Yamaguchi, S.; Takahashi, H.; Fuse, S.; Doi, T.; Kusumi, T.; Kawauchi, S.; Sugiyama, H.; Takahashi, T. Chem. Commum., 2010, 46, 5942-5944.

185. Folding Pathways of Human Telomeric Type-1 and Type-2 G-Quadruplex Structures. Mashimo, T.; Yagi, H.; Sannohe, Y.; Rajendran, A.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132, 14910-14918.

186. The Distance between Donor and Acceptor Affects the Proportion of C1' and C2' Oxidation Products of DNA in a BrU-containing Excess Electron Transfer System. Tashiro, R.; Ohtsuki, A.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132, 14361-14363.

187. Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine. Hori, M.; Yonekura, S.I.; Nohmi, T.; Gruz, P.; Sugiyama, H.;Yonei, S.; Zhang Akiyama, Q. M. J. Nucleic Acids, 2010, 807579-807588.

188. Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure. Sannohe, Y.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2010, 132, 16311-16313.

189. A Versatile DNA Nanochip for Direct Analysis of DNA Base-Excision Repair. Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. Angew. Chem. Int. Ed., 2010, 49, 9412-9416.

190. Transcriptional Inhibition of Progressive Renal Disease by the Gene Silencing Pyrrole-Imidazole polyamide Targeted to the TGF-β1Promoter. Matsuda, H.; Fukuda, N.; Ueno, T.; Katakawa, M.; Wang, X.; Watanabe, T.; Matsui, S.; Aoyama, T.; Saito, K.; Bando, T.; Matsumoto, Y.; Nagase, H.; Matsumoto, K.; Sugiyama, H. Kidney Int., 2011, 79, 46-56.

191. Programmed Two-Dimensional Self-Assembly of Multiple sDNA Origami Jigsaw Pieces. Rajendran, A.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. ACS Nano, 2011, 5, 665-671.

192. Direct AFM Observation of an Opening Event of a DNA Cuboid Constructed via a Prism Structure. Endo, M.; Hidaka, K.; Sugiyama, H. Org. Biomol. Chem., 2011, 9, 2075-2077.

193. Photo Controllable Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Polyamide seco-CBI Conjugate. Park, S.; Bando, T.; Shinohara, K.; Sugiyama, H. Biocojugate Chem., 2011, 22, 120-124.

194. Two-Dimensional DNA Origami Assemblies Using a Four-Way Connector. Endo, M.; Sugita, T.; Rajendran, A.; Katsuda, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2011, 47, 3213-3215.

195. Direct Observation of Stepwise Movement of a Synthetic Molecular Transporter. Wickham, S. F. J.; Endo, M.; Katsuda, Y.; Hidaka, K.; Bath, J.; Sugiyama, H.; Turberfield, A. J. Nature Nanotechnol., 2011, 6, 166-169.

196. Recent Progress in DNA Origami Technology. Endo, M.; Sugiyama, H. Curr. Protoc. Nucleic Acid Chem., 2011, 45, 12.8.1-12.8.19. (Review)

197. Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly. Rajendran, A.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2011, 133, 14488-14491.

198. Programmed Placement of Gold Nanoparticles Onto a Slit-Type DNA Origami Scaffold. Endo, M.; Yang, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2011, 47, 10743-10745.

199. Evaluation of PI polyamide Conjugates With Eight-Base Pair Recognition and Improvement of The Aqueous Solubility by PEGylation. Takagaki, T.; Bando, T.; Kitano, M.; Hashiya, K.; Kashiwazaki, G.; Sugiyama, H. Bioorg. Med. Chem., 2011, 19, 5896-5902.

200. Cysteine Cyclic Pyrrole-Imidazole Polyamide for Sequence-Specific Recognition In the DNA Minor Groove. Morinaga, H.; Bando, T.; Takagaki, T.; Yamamoto, M.; Hashiya, K.; Sugiyama, H. J. Am. Chem. Soc., 2011, 133, 18924-18930.

201. DNA Ligand Designed to Antagonize EBNA1 Represses Epstein-Barr Virus-Induced Immortalization. Noguchi, K.; Yasuda, A.; Minoshima, M.; Kashiwazaki, G.; Kanda, T.; Katayama, K.; Mitsuhashi, J.; Bando, T.; Sugiyama, H.; Sugimoto, Y. Cancer Sci., 2011, 102, 2221-2230.

202. Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes In Mouse Embryonic Fibroblasts. Pandian, G. N.; Shinohara, K.; Ohtsuki, A.; Nakano, Y.; Minoshima, M.; Bando, T.; Nagase, H.; Yamada, Y.; Watanabe, A.; Terada, N.; Sato, S.; Morinaga, H.; Sugiyama, H. ChemBioChem, 2011, 12, 2822-2828.

203. A Single-Molecule Platform for Investigation of Interactions between G-Quadruplexes and Small-Molecule Ligands. Koirala, D.; Dhakal, S.; Ashbridge, B.; Sannohe, Y.; Rodriguez, R.; Sugiyama, H.; Balasubramanian, S.; Mao, H. Nature Chemistry, 2011, 3, 782-787.

204. Discrimination between T/A and A/T Base Pairs of Pyrrole-Imidazole Polyamides Substituted with Chiral β-Hyroxy-γ-Aminobutyric Acid/β-Alanine Pairs. Zhang, W.; Jiang, S.K.; Wu, Y.L.; Guo, C.X.; Zhang, H.F.; Sugiyama, H.; Chen, X.L. ChemBioChem, 2012, 13, 47-50.

205. Single-Molecule Analysis Using DNA Origami. Rajendran, A.; Endo, M.; Sugiyama, H. Angew. Chem. Int. Ed., 2012, 51, 874-890. (Review)

206. Intramolecular Folding in Three Tandem Guanine Repeats of Human Telomeric DNA. Koirala, D.; Mashimo, T.; Sannohe, Y.; Yu, Z.; Mao, H.; Sugiyama, H. Chem. Commun., 2012, 48, 2006-2008.

207. Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure. Endo, M.; Miyazaki, R.; Emura, T.; Hidaka, K.; H.; Sugiyama, H. J. Am. Chem. Soc., 2012, 134, 2852-2855.

208. Zinc-Finger Proteins for Site-Specific Protein Positioning on DNA-Origami Structures. Nakata, E.; Fong, L.W.; Uwatoko, C.; Kiyonaka, S.; Mori, Y.; Katsuda, Y.; Endo, M.; Sugiyama, H.; Morii, T. Angew Chem. Int. Ed., 2012, 51, 2421-2424.

209. SWI/SNF-Mediated Chromatin Remodeling Induces Z-DNA Formation on a Nucleosome. Mulholland, N.; Xu, Y.; Sugiyama, H.; Zhao, K. Cell and Bioscience, 2012 , 2:3.

210. Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N- Methylpyrrole- N- Methylimidazole Polyamide Conjugates. Kashiwazaki, G.; Bando, T.; Yoshidome, T.; Masui, S.; Takagaki, T.; Hashiya, K.; Pandian, G.N.; Yasuoka, J.; Akiyoshi, K.; Sugiyama, H. J. Med. Chem., 2012, 55, 2057-2066.

211. Single Strand DNA Catenane Synthesis Using the Formation of G-Quadruplex Structure. Sannohe, Y.; Sugiyama, H. Bioorg. Med. Chem., 2012, 20, 2030-2034.

212. DNA Origami: Synthesis and Self-Assembly. Rajendran, A.; Endo, M.; Sugiyama, H. Curr. Protoc. Nucleic Acid Chem., 2012, 48, 12.9.1-12.9.18.

213. A DNA-Based Molecular Motor that can Navigate a Network of Tracks. Wickham, S. F. J; Bath, J.; Katsuda, Y.; Endo, M.; Hidaka, K.; Sugiyama, H.; Tuberfield , A. J. Nature Nanotechnol., 2012, 7, 169-173.

214. Sequence-Selective Single-Molecule Alkylation with a Pyrrole-Imidazole Polyamide Visualized in a DNA Nanoscaffold. Yoshidome, T.; Endo, M.; Kashiwazaki, G.; Hidaka, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2012, 134, 4654-4660.

215. Development of Programmable Small DNA-Binding Molecules with Epigenetic Activity for Induction of Core Pluripotency Genes. Pandian, G. N.; Ohtsuki, A.; Bando, T.; Sato, S.; Hashiya, K.; Sugiyama, H. Bioorg. Med. Chem., 2012, 20, 2656-2660.

216. Structural and Functional Analysis of Proteins by High-Speed Atomic Force Microscopy. Rajendran, A.; Endo, M.; Sugiyama, H. Adv. Protein Chem. Struct. Biol., 2012, 87, 5-55. (Review)

217. Programmable Genetic Switiches to Control Transcrpitional Machinery of Pluripotency. Pandian, G. N.; Sugiyama, H. Biotechnol. J., 2012, 7, 798-809. (Review)

218. Recognition by Nonaromatic and Stereochemical Subunit- Containing Polyamides of the Four Watson-Crick Base Pairs in the DNA Minor Groove. Zhang, H. F.; Wu, Y. L.; Jiang, S. K.; Wang, P.; Sugiyama, H.; Chen, X. L.; Zhang, W.; Ji, Y. J.; Guo, C. X. ChemBioChem, 2012, 13, 1366-1374.

219. Direct Visualization of the Movement of a Single T7 RNA Polymerase and Transcription on a DNA Nanostructure. Endo, M.; Tatsumi, K.; Terushima, K.; Katsuda, Y.; Hidaka, K.; Harada, Y.; Sugiyama, H. Angew. Chem. Int. Ed., 2012, 51, 8778-8782.

220. Design and Development of Nanosized DNA Assemblies in Polypod-Like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells. Mohri, K.; Nishikawa, M.; Takahashi, N.; Shiomi, T.; Matsuoka, N.; Ogawa, K.; Endo, M.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y. ACS Nano, 2012, 6, 5931-5940.

221. A Synthetic Small Molecule for Rapid Induction of Multiple Pluripotency Genes in Mouse Embryonic Fibroblasts. Pandian, G. N.; Nakano, Y.; Sato, S.; Morinaga, H.; Bando, T.; Nagase, H.; Sugiyama, H. Sci. Rep., 2012, 2, 544.

222. Synthesis of Pyrrole-Imidazole Polyamide seco-1-Chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole Conjugates with a Vinyl Linker Recognizing a 7 bp DNA Sequence. Takagaki, T.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2012, 134, 13074-13081.

223. Single-Molecule Visualization of the Hybridization and Dissociation of Photoresponsive Oligonucleotides and Their Reversible Switching Behavior in a DNA Nanostructure. Endo, M.; Yang, Y.; Hidaka, K.; Sugiyama, H. Angew. Chem. Int. Ed., 2012, 51, 10518-10522.

224. Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes. Vaijayanthi, T.; Bando, T.; Pandian, G. N.; Sugiyama, H. ChemBioChem, 2012, 13, 2170-2185. (Review)

225. Binding of Hairpin Pyrrole and Imidazole Polyamides to DNA: Relationship between Torsion Angle and Association Rate Constants. Han, Y-W.; Matsumoto, T.; Yokota, H.; Kashiwazaki, G.; Morinaga, H.; Hashiya, k.; Bando, T.; Harada, Y.; Sugiyama, H. Nucleic Acids Res., 2012, 40, 11510-11517.

226. Deciphering DNA-Based Asymmetric Catalysis through Intramolecular Friedel-Crafts Alkylations. Park, S.; Watabe, R.; Ikehata, K.; Hidaka, Y.; Rajendran, A.; Sugiyama, H. Chem. Commun., 2012, 48, 10398-10400.

227. DNA as a Chiral Scaffold for Asymmetric Synthesis. Park, S.; Sugiyama, H. Molecules, 2012, 17, 12792-12803. (Review)

228. Immunotherapies: The Blockade of Inhibitory Signals . Wu, Y.; Liang, J.; Zhang, W.; Tanaka, Y.; Sugiyama, H. Intl. J. Biol. Sci., 2012, 8, 1420-1430. (Review)

229. Photo-Controllable DNA Origami Nanostructures Assembling into Predesigned Multiorientational Patterns. Yang, Y.; Endo, M.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2012, 134, 20645-20653.

230. G-Quadruplex Nanostructures Probed at the Single Molecular Level by Force-Based Methods. Dhakal, S.; Mao, H.; Rajendran, A.; Endo, M.; Sugiyama, H. Guanine Quartets: Structure and Application (Royal Society of Chemistry) , 2013, 73-85.

231. Photoreactivities of 5-Bromouracil-containing RNAs. Morinaga, H.; Kizaki, S.; Takenaka, T.; Kanesato, S.; Sannohe, Y.; Tashiro, R.; Sugiyama, H. Bioorg. Med. Chem., 2013, 21, 466-469.

232. Strategies to Modulate Heritable Epigenetic Defects in Cellular Machinery: Lessons from Nature . Pandian, G. N.; Sugiyama, H. Pharmaceuticals, 2013, 6, 1-24.

233. DNA Origami Technology for Biomaterials Applications. Endo, M.; Yang, Y.; Sugiyama, H. Biomater. Sci., 2013, 1, 347-360. (Review)

234. Control of the Two-dimensional Crystallization of DNA Origami with Various Loop Arrangements. Rajendran, A.; Endo, M.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2013, 49, 686-688.

235. Helical Structure and Circular Dichroism Spectra of DNA: A Theoretical Study. Miyahara, T.; Nakatsuji, H.; Sugiyama, H. J. Phys. Chem. A., 2013, 117, 42-55.

236. Design of a New Fluorescent Probe: Pyrrole/Imidazole Hairpin Polyamides with Pyrene Conjugation at Their γ-Turn. Vaijayanthi, T.; Bando, T.; Hashiya, K.; Pandian, G. N.; Sugiyama, H. Bioorg. Med. Chem., 2013, 21, 852-855.

237. Direct and Real-Time Observation of Rotary Movement of a DNA Nanomechanical Device. Rajendran, A.; Endo, M.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2013, 135, 1117-1123.

238. Long-Loop G-Quadruplexes Are Misfolded Population Minorities with Fast Transition Kinetics in Human Telomeric Sequences. Koirala, D.; Ghimire, C.; Bohrer, C.; Sannohe, Y.; Sugiyama, H.; Mao, H. J. Am. Chem. Soc., 2013, 135, 2235-2241.

239. Hydrochlorothiazide Enhances UVA-induced DNA Damage . Kunisada, M.; Masaki, T.; Ono, R.; Morinaga, H.; Nakano, E.; Yogianti, F.; Okunishi, K.; Sugiyama, H.; Nishigori, C. Photochemistry and Photobiology, 2013, 39, 649-652.

240. Sequence-Specific Electron Injection into DNA from an Intermolecular Electron Donor. Morinaga, H.; Takenaka, T.; Hashiya, F.; Kizaki, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Nucleic Acids Res., 2013, 41, 4724-4728.

241. RNA-templated DNA Origami Structures. Endo, M.; Yamamoto, S.; Tatsumi, K.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2013, 49, 2879-2881.

242. RNA Binding Properties of Novel Gene Silencing Pyrrole-Imidazole Polyamides . Iguchi, A.; Fukuda, N.; Takahashi, T.; Watanabe, T.; Matsuda, H.; Nagase, H.; Bando, T.; Sugiyama, H.; Shimizu, K. Biol. Pharm. Bull., 2013, 36, 1152-1158.

243. Synthesis and Biological Evaluation of a Targeted DNA-binding Transcriptional Activator with HDAC8 Inhibitory Activity . Saha, A.; Pandian, G. N.; Sato, S.; Taniguchi, J.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2013, 21, 4201-4209.

244. The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases. Liang, J.; Wu, Y.; Chen, B.; Zhang, W.; Tanaka, Y.; Sugiyama, H. Int. J. Biol., Sci. 2013, 9, 435-443. (Review)

245. Effect of Single Pyrrole Replacement with β-Alanine on DNA Binding Affinity and Sequence Specificity of Hairpin Pyrrole/Imidazole Polyamides Targeting 5'-GCGC-3' Han, Y-W.; Kashiwazaki, G. ; Morinaga, H.; Matsumoto, T.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2013, 21, 5436-5441.

246. Solid-Supported DNA for Asymmetric Synthesis: a Stepping-Stone toward Practical Applications. Park, S.; Ikehata, K.; Sugiyama, H. Biomater. Sci., 2013, 1, 1034-1036.

247. Controlling the Stoichiometry and Strand Polarity of a Tetramolecular G-Quadruplex Structure by Using a DNA Origami Frame. Rajendran, A.; Endo, M.; Hidaka, K.; Thao, P. L. T.; Mergny, J-L.; Sugiyama, H. Nucleic Acids Res., 2013, 41, 8738-8747.

248. Guided Assembly of Tetramolecular G-Quadruplexes. Yatsunyk, L. A.; Pietrement, O.; Albrecht, D.; Tran, P. L. T., Renciiuk, D.; Sugiyama, H.; Arbona, J-M.; Aime, J-P.; Mergny, J-L. ACS Nano, 2013, 7, 5701-5710.

249. Chemically Induced Pluripotent Stem Cells (CiPSCs): A Transgene-Free Approach. Masuda, S.; Wu, J.; Hishida, T.; Pandian, G. N.; Sugiyama, H.; Belmonte, J. C. I. J. Mol. Cell Biol., 2013, 5, 354-355.

250. A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell . Han, L.; Pandian, G. N.; Junetha, S.; Sato, S.; Anandhkumar, C.; Taniguchi, J.; Saha, A.; Bando, T.; Nagase, H.; Sugiyama, H. Angew. Chem. Int. Ed., 2013, 52, 13410-13413. (Hot Paper)

251. Development of a New Method for Synthesis of Tandem Hairpin Pyrrole-Imidazole Polyamide Probes Targeting Human Telomeres. Kawamoto, Y.; Bando, T.; Kamada, F.; Li, Y.; Hashiya, K.; Maeshima, K.; Sugiyama, H. J. Am. Chem. Soc., 2013, 135, 16468-16477.

252. Conjugation of Peptide Nucleic Acid with a Pyrrole/Imidazole Polyamide to Specifically Recognize and Cleave DNA. Kameshima, W.; Ishizuka, T.; Minoshima, M.; Yamamoto, M.; Sugiyama, H.; Xu, Y.; Komiyama, M. Angew. Chem. Int. Ed., 2013, 52, 13681-13684.

253. Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources. Wu, Y-L.; Pandian, G. N.; Ding, Y-P.; Zhang, W.; Tanaka, Y.; Sugiyama, H. Chem. Biol., 2013, 20, 1311-1322. (Review)

254. Regulation of B-Z Conformational Transition and Complex Formation with a Z-form Binding Protein by Introduction of Constraint to Double-Stranded DNA by using a DNA Nanoscaffold. Endo, M.; Inoue, M.; Suzuki, Y.; Masui, C.; Morinaga, H.; Hidaka, K.; Sugiyama, H. Chem. Eur. J., 2013, 19, 16887-16890.

255. HIV-1 Nucleocapsid Proteins as Molecular Chaperones for Tetramolecular Antiparallel G-Quadruplex Formation. Rajendran, A.; Endo, M.; Hidaka, K.; Tran, P. L. T.; Mergny, J-L.; Gorelick, R. J.; Sugiyama, H. J. Am. Chem. Soc., 2013, 135, 18575-18585.

256. CGmCGCG is a Versatile Substrate with which to Evaluate Tet Protein Activity . Kizaki, S.; Sugiyama, H. Org. Biomol. Chem., 2014, 12, 104-107.

257. State-of-the-Art High-Speed Atomic Force Microscopy for Investigation of Single-Molecular Dynamics of Proteins . Rajendran, A.; Endo, M.; Sugiyama, H. Chem. Rev., 2014, 114, 1493-1520. (Review)

258. Construction and Characterization of Cy3- or Cy5-Conjugated Hairpin Pyrrole-Imidazole Polyamides Binding to DNA in the Nucleosome. Han, Y-W.; Tsunaka, Y.; Yokota, H.; Matsumoto, T.; Kashiwazaki, G.; Morinaga, H.; Hashiya, K.; Bando, T.; Sugiyama, H.; Harada, Y. Biomater. Sci., 2014, 2, 297-307.

259. Sequence-Specific DNA Recognition by Cyclic Pyrrole-Imidazole Cysteine-Derived Polyamide Dimers. Yamamoto, M.; Bando, T.; Morinaga, H.; Kawamoto, Y.; Hashiya, K.; Sugiyama, H. Chem. Eur. J., 2014, 20, 752-759.

260. Controlling Electron Rebound within Four-Base π-Stacks in Z-DNA by Changing the Sugar Moiety from Deoxy- to Ribonucleotide . Sannohe, Y.; Kizaki, S.; Kanesato, S.; Fujiwara, A.; Morinaga, H.; Tashiro, R.; Sugiyama, H. Chem. Eur. J., 2014, 20, 1223-1225.

261. Sequence-Specific DNA Alkylation Targeting for Kras Codon 13 Mutation by Pyrrole-Imidazole Polyamide seco-CBI Conjugates . Taylor, R. D.; Asamitsu, S.; Takenaka, T.; Yamamoto, M.; Hashiya, K.; Kawamoto, Y.; Bando, T.; Nagase, H.; Sugiyama, H. Chem. Eur. J., 2014, 20, 1310-1317.

262. Highly Emissive Deoxyguanosine Analogue Capable of Direct Visualization of B-Z Transition. Park, S.; Otomo, H.; Zheng, L.; Sugiyama, H. Chem. Commun., 2014, 50, 1573-1575.

263. DNA Origami Based Visualization System for Studying Site-Specific Recombination Events . Suzuki, Y.; Endo, M.; Katsuda, Y.; Ou, K.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2014, 136, 211-218.

264. G-quadruplex-binding Ligand-induced DNA Synapsis Inside a DNA Origami Frame. Rajendran, A.; Endo, M.; Hidaka, K.; Tran, P. L. T.; Teulade-Fichou, M-P.; Mergny, J-L.; Sugiyama, H. RSC Adv., 2014, 4, 6346-6355.

265. Distinct DNA-based Epigenetic Switches Trigger Transcriptional Activation of Silent Genes in Human Dermal Fibroblasts. Pandian, G. N.; Taniguchi, J.; Junetha, S.; Sato, S.; Han, L.; Saha, A.; Anandhkumar, C.; Bando, T.; Nagase, H.; Thangavel, V.; Taylor, R. D.; Sugiyama, H. Sci. Rep., 2014, 4, 3843.

266. Dynamic Assembly/Disassembly Processes of Photoresponsive DNA Origami Nanostructures Directly Visualized on a Lipid Membrane Surface . Suzuki, Y.; Endo, M.; Yang, Y.; Sugiyama, H. J. Am. Chem. Soc., 2014, 136, 1714-1717.

267. Specific Alkylation of Human Telomere Repeat Sequences by a Tandem-Hairpin Motif of Pyrrole-Imidazole Polyamides with Indole-Seco-CBI. Yamamoto, M.; Bando, T.; Kawamoto, Y.; Taylor, R. D.; Hashiya, K.; Sugiyama, H. Bioconjugate Chem., 2014, 25, 552-559.

268. Single-Molecule Imaging of Dynamic Motions of Biomolecules in DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy. Endo, M.; Sugiyama, H. Acc. Chem. Res., 2014, 47, 1645-1653. (Review)

269. Direct and Single-Molecule Visualization of the Solution-State Structures of G-Hairpin and G-Triplex Intermediates . Rajendran, A.; Endo, M.; Hidaka, K.; Sugiyama, H. Angew. Chem. Int. Ed., 2014, 126, 4191-4196.

270. Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges . Pandian, G. N.; Sugiyama, H. Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications (Springer Book), 2014 , 347-365. (Review)

271. Direct Observation of the Dual-Switching Behaviors Corresponding to the State Transition in a DNA Nanoframe. Yang, Y.; Endo, M.; Suzuki, Y.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2014, 50, 4211-4213.

272. Investigation of B-Z Transitions with DNA Oligonucleotides Containing 8-Methylguanine. Chen, Y-H.; Park, S.; Otomo, H.; Sakashita, S.; Sugiyama, H. Artificial DNA: PNA & XNA, 2014, 5, e28226-1-e28226-7.

273. Cellular Reprogramming for Pancreatic β-Cell Regeneration: Clinical Potential of Small Molecule Control . Pandian, G. N.; Taniguchi, J.; Sugiyama, H. Clin. Transl. Med., 2014, 3: 6.

274. The Origin of Enantioselectivity for Intramolecular Friedel-Crafts Reaction Catalyzed by Supramolecular Cu/DNA catalyst Complex. Petrova, G. P.; Ke, Z.; Park, S.; Sugiyama, H.; Morokuma, K. Chem. Phys. Lett., 2014, 600, 87-95.

275. Single Molecule Visualization and Characterization of Sox2-Pax6 Complex Formation on a Regulatory DNA Element Using a DNA Origami Frame. Yamamoto, S.; De, D.; Hidaka, K.; Kim, K. K.; Endo, M.; Sugiyama, H. Nano Lett., 2014, 14, 2286-2292.

276. Direct Analysis of Holliday Junction Resolving Enzyme in a DNA Origami Nanostructure. Suzuki, Y.; Endo, M.; Canas, C.; Ayora, S.; Alonso, J. C.; Sugiyama, H.; Takeyasu, K. Nucleic Acids Res., 2014, 42, 7421-7428.

277. Alteration of Epigenetic Program to Recover Memory and Alleviate Neurodegeneration: Prospects of Multi-target Molecules. Pandian, G. N.; Taylor, R. D.; Junetha, S.; Saha, A.; Anandhakumar, C.; Vaijayanthi, T.; Sugiyama, H. Biomater. Sci., 2014, 2, 1043-1056.

278. A Lock-and-Key Mechanism for the Controllable Fabrication of DNA Origami Structures. Rajendran, A.; Endo, M.; Hidaka, K.; Shimada, N.; Maruyama, A.; Sugiyama, H. Chem. Commun., 2014, 50, 8743-8746.

279. Sequence-Specific DNA Alkylation by Tandem Py-Im Polyamide Conjugates . Taylor, R, D.; Kawamoto, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Asian J., 2014, 9, 2527-2533.

280. Helical DNA Origami Tubular Structures with Various Sizes and Arrangements . Endo, M.; Yamamoto, S.; Emura, T; Hidaka, K.; Morone, N.; Heuser, J, E.; Sugiyama, H. Angew. Chem. Int. Ed., 2014, 53, 7484-7490.

281. Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures. Koirala, D.; Shrestha, P.; Emura, T; Hidaka, K.; Mandal, S.; Endo, M.; Sugiyama, H.; Mao, H. Angew. Chem. Int. Ed., 2014, 126, 8275-8279.

282. Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast s. Saha, A.; Pandian, G. N.; Sato, S.; Taniguchi, J.; Kawamoto, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemMedChem, 2014, 9, 2374-2380.

283. AFM Analysis of Changes in Nucleosome Wrapping Induced by DNA Epigenetic Modification. Kizaki, S.; Suzuki, Y.; Takenaka, T.; Endo, M.; Sugiyama, H. Biomater. Sci., 2014, 2, 1399-1403.

284. Sequence-Specific DNA Alkylation and Transcriptional Inhibition by Long-Chain Hairpin Pyrrole-Imidazole Polyamide-Chlorambucil Conjugates Targeting CAG/CTG Trinucleotide Repeats. Asamitsu, S.; Kawamoto, Y.; Hashiya, F.; Hashiya, K.; Yamamoto, M.; Kizaki, S.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2014, 22, 4646-4657.

285. Amplification of Fluorescent DNA through Enzymatic Incorporation of a Highly Emissive Deoxyguanosine Analogue. Otomo, H.; Park, S.; Yamamoto, S.; Sugiyama, H. RSC Adv., 2014, 4, 31341-31344.

286. Targeted Suppression of EVI1 Oncogene Expression by Sequence-specific Pyrrole-imidazole Polyamide. Junetha, S.; Pandian, G, N.; Sato, S.; Taniguchi, J.; Anandhakumar, C.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Biol., 2014, 23, 1370-1380.

287. Structural Evaluation of Tandem Hairpin Pyrrole-Imidazole Polyamides Recognizing Human Telomeres. Hirata, A.; Nokihara, K.; Kawamoto, Y.; Bando, T.; Sasaki, A.; Ide, S.; Maeshima, K.; Kasama, T.; Sugiyama, H. J. Am. Chem. Soc., 2014, 136, 11546-11554.

288. Engineering RNA-Protein Complexes with Different Shapes for Imaging and Therapeutic Applications. Osada, E.; Suzuki, Y.; Hidaka, K.; Ohno, H.; Sugiyama, H.; Endo, M.; Saito, H. ACS Nano, 2014, 8, 8130-8140.

289. NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation. Patel, S.; Jung, D.; Yin, P.; Carlton, P.; Yamamoto, M.; Bando, T.; Sugiyama, H.; Lee, K. B. ACS Nano, 2014, 8, 8959-8967.

290. Photoresponsive DNA Nanocapsule Having an Open/Close System for Capture and Release of Nanomaterials. Takenaka, T.; Endo, M.; Suzuki, Y.; Yang, Y.; Emura, T.; Hidaka, K.; Kato, T.; Mitata, T.; Namba, K.; Sugiyama, H. Chem. Eur. J., 2014, 20, 14951-14954.

291. Next-Generation Sequencing Studies Guide the Design of Pyrrole-Imidazole Polyamides with Improved Binding Specifictiy by the Addition of β-Alanine. Anandhakumar, C.; Li, Y.; Kizaki, S.; Pandian, G. N.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemBioChem, 2014, 15, 2647-2651.

292. Development of DNA-Based Hybrid Catalysts through Direct Ligand Incorporation: Toward Understanding of DNA-Based Asymmetric Catalysis. Park, S.; Zheng, L. J.; Kumakiri, S.; Sakashita, S.; Otomo, H.; Ikehata, K.; Sugiyama, H. ACS Catalysis, 2014, 4, 4070-4073.

293. Preparation of Chemically Modified RNA Origami Nanostructures. Endo, M.; Takeuchi, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Eur. J., 2014, 20, 15330-15333.

294. Direct Quantification of Loop Interaction and π-π Stacking for G-Quadruplex Stability at the Submolecular Level. Ghimire, C.; Park, S.; Iida, K.; Yangyuoru, P.; Otomo, H.; Yu, Z.; Nagasawa, K.; Sugiyama, H.; Mao, H. J. Am. Chem. Soc., 2014, 136, 15537-15544.

295. Identification of a Small Molecule That Turns ON the Pluripotency Gene Circuitry in Human Fibroblasts . Pandian, G. N.; Sato, S.; Anandhakumar, C.; Taniguchi, J.; Takashima, K.; Syed, J.; Han, L.; Saha, A.; Bando, T.; Nagase, H.; Sugiyama, H. ACS Chem. Biol., 2014, 9, 2729-2736.

296. Direct Observation of G-Quadruplexes using DNA Origami Nanoscaffold. Rajendran, A.; Li, Y.; Endo, M. ; Sugiyama, H. E. Book Chapter:DNA G-quadruplexes as new anticancer targets, (Ed. Ryan De Vooght-Johnson), Future Science Ltd, London, 2015 , 38-54. (Review)

297. Locating the uracil-5-yl Radical Formed Upon Photoirradiation of 5-bromouracil-substituted DNA. Hashiya, F.; Saha, A.; Kizaki, S.; Li, Y.; Sugiyama, H. Nucleic Acids Res., 2014, 42, 13469-13473.

298. Synthetic Strategies to Identify and Regulate Noncoding RNAs. Pandian, G. N.; Syed, J.; Sugiyama, H. Long Noncoding RNAs: Structure and Function, 23-43 (Review)

299. Advancing Small-Molecule-Based Chemical Biology with Next-Generation Sequencing Technologies. Anandhakumar, C.; Kizaki, S.; Bando, T.; Pandian, G. N.; Sugiyama, H. ChemBioChem, 2015, 16, 20-38.

300. Rational Design of Specific Binding Hairpin Py-Im Polyamides Targeting Human Telomere Sequences. Guo, C. X .; Kawamoto, Y.; Asamitsu, S.; Sawatani, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2015, 23, 855-860.

301. Tandem Trimer Pyrrole-Imidazole Polyamide Probes Targeting 18 Base Pairs in Human Telomere Sequence. Kawamoto, Y.; Sasaki, A.; Hashiya, K.; Ide, S; Bando, T.; Maeshima, K; Sugiyama, H. Chem. Sci ., 2015, 6, 2307-2312.

302. Inhibition of KRAS Codon 12 Mutants Using a Novel DNA-alkylating Pyrrole-imidazole Polyamide Conjugate. Hiraoka, K.; Inoue, T.; Taylor, R. D.; Watanabe, T.; Koshikawa, N.; Yoda, H.; Shinohara, K.; Takatori, A.; Sugimoto, K.; Maru, Y.; Denda, T.; Fujiwara, K.; Balmain, A.; Ozaki, T.; Bando, T.; Sugiyama, H.; Nagase, H. Nature Commun., 2015, 6, 6706.

303. Self-Assembling DNA Dendrimer for Effective Delivery of Immunostimulatory CpG DNA to Immune Cells. Mohri, K.; Kusuki, Eri.; Ohtsuki, S.; Takahashi, N.; Endo, M.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Biomacromolecules, 2015, 16, 1095-1101.

304. Integrating Epigenetic Modulators into NanoScript for Enhances Chondrogenesis of Stem Cells. Patel, S.; Pongkulapa, T.; Yin, P.; Pandian, G, N.; Rathnam, C.; Bando, T.; Vaijayanthi, T.; Sugiyama, H.; Lee, K, B. J. Am. Chem. Soc., 2015, 137, 4598-4601.

305. Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model. Igarashi, J.; Fukuda, N.; Inoue, T.; Nakai, S.; Saito, K.; Fujiwara, K.; Matsuda, H.; Ueno, T.; Matsumoto, Y.; Watanabe, T.; Nagase, H.; Bando, T.; Sugiyama, H.; Itoh, T.; Soma, M. PLOS ONE, 2015, 10, e0125295.

306. Small Molecule Binding to a G-hairpin and a G-riplex: A New Insight in Anticancer Drug Design Targeting G-rich Regions. Rajendran, A.; Endo, M.; Hidaka, K.; Teulade-Fichou, M.; Mergny, J, L.; Sugiyama, H. Chem. Commun., 2015, 9, 3418-3420.

307. Mimicking Membrane-Related Biological Events by DNA Origami Nanotechnology. Suzuki, Y.; Endo, M.; Sugiyama, H. ACS Nano, 2015, 9, 3418-3420.

308. Photoreactivity of the Linker Region of Two Consecutive G-quadruplexes Formed by Human Telomeric DNA. Li, Y; Sugiyama, H. Chem. Commun., 2015, 51, 8861-8864.

309. A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts. Syed, J.; Chandran, A.; Pandian, G, N.; Taniguchi, J.; Sato, S.; Hashiya, K.; Kashiwazaki, G.; Bando, T.; Sugiyama, H. ChemBioChem, 2015, 16, 1497-1501.

310. A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network. Han, L.; Pandian, G, N.; Chandran, A.; Sato, S.; Taniguchi, J.; Kashiwazaki, G.; Sawatani, Y.; Hashiya, K.; Bando, T.; Xu, Y.; Qian, X,; Sugiyama, H. Angew. Chem. Int. Ed., 2015, 54, 8700-8703.

311. Studying RNAP-promoter Interactions Using Atomic Force Microscopy. Suzuki, Y.; Endo, M.; Sugiyama, H. Methods, 2015, 86, 4-9.

312. Detection of UV-induced Cyclobutane Pyrimidine Dimers by Near-infared Spectroscopy and Aquaphotomics. Goto, N.; Bazar, G.; Kovacs, Z.; Kunisada, M.; Morita, H.; Kizaki, S.; Sugiyam, H.; Tesenkova, R.; Nishigori, C. Sci. Rep., 2015, 5, 11808.

313. Single-Molecule Visualization of the Activity of a Zn2+ -Dependent DNAzyme. Endo, M.; Takeuchi, Y.; Suzuki, Y.; Emura, T.; Hidaka, K.; Wang, F.; Willner, I.; Sugiyama, H. Angew. Chem. Int. Ed., 2015, 54, 10550-10554.

314. Folding RNA-Protein Complex into Designed Nanostructures. Shibata, T.; Suzuki, Y.; Sugiyama, H.; Endo, M.; Saito, H. Springer Book. Methods in Molecular Biology. 2015 , 1316, 169-179. (Review)

315. Linking Two DNA Duplexes with a Rigid Linker for DNA Nanotechnology. Tashiro, R.; Iwamoto, M.; Morinaga, H.; Emura, T.; Hidaka, K.; Endo, M.; Sugiyama, H. Nucleic Acids Res., 2015, 43, 6692-6700.

316. Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells. Ohtsuki, S.; Matsuzaki, N.; Mohri, K.; Endo, M.; Emura, T.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Ishiyama, K.; Kadowaki, N.; Takakura, Y.; Nishikawa, M. Nucleic Acid Therapeutics, 2015, 25, 245-253.

317. Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole-Imidazole Polyamide seco-CBI Conjugates. Taylor, R, D.; Chandran, A.; Kashiwazaki, G.; Hashiya, K.; Bando, T.; Nagase, H.; Sugiyama, H. Chem. Eur. J., 2015, 21, 14996-15003.

318. Development of DNA Metalloenzymes Using a Rational Design Approach and Application in the Asymmetric Diels-Alder Reaction. Park, S.; Okamura, I.; Sakashita, S.; Yum, J, H.; Chiranjit, A.; Gao, L.; Sugiyama, H. ACS Catal., 2015, 5, 4708-4712.

319. Lipid-bilayer-assisted Two-dimensional Self-assembly of DNA Origami Nanostructures. Suzuki, Y.; Endo, M.; Sugiyama, H. Nature Commun., 2015, 6, 8052.

320. Measuring Chloride in Live Cells. Endo, M.; Sugiyama, H . Nature Nanotechnol., 2015, 10, 569-570. (Review)

321. A Novel Detection Technique of Polyamide Binding Sites by Photo-Induced Electron Transfer in BrU Substituted DNA. Saha, A.; Hashiya, F.; Kizaki, S.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Commun., 2015, 51, 14485-14488.

322. Atomic Force Microscopy Analysis of Orientation and Bending of Oligodeoxynucleotides in Polypod-like Structured DNA. Shiomi, T.; Tan, M. M.; Takahashi, N.; Endo, M.; Emura, T.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Nano. Research, 2015, 8, 3764-3771.

323. Inducing Stem Cell Myogenesis Using NanoScript. Patel, S.; Yin, T.; Sugiyama, H.; Lee, K. B. ACS Nano, 2015, 9, 6909-6917.

324. Direct Visualization of Walking Motions of Photocontrolled DNA Nanomachine on the DNA Nanostructure. Yang, Y.; Goetzfied, M. A.; Hidaka, K.; You, M. X.; Tan, W. H.; Sugiyama, H.; Endo, M. Nano Lett., 2015, 15, 6672-6676.

325. Single-Molecule Manipulation of the Duplex Formation and Dissociation at the G-Quadruplex/i-Motif Site in the DNA Nanostructure. Endo, M.; Xing, X. W.; Zhou, X.; Emura, T.; Hidaka, K.; Tuesuwan, B.; Sugiyama, H. ACS Nano, 2015, 9, 9922-9929.

326. Water Revealed as Molecular Mirror When Measuring Low Concentrations of Sugar With Near Infrared Light. Bazar, G.; Kovacs, G.; Tanaka, M.; Furukawa, A.; Nagai, A.; Osawa, M.; Itakura, Y.; Sugiyama, H.; Tsenkova, R. Analytica Chimica Acta., 2015, 896, 52-62.

327. Efficient Amplification of Self-gelling Polypod-like Structured DNA by Rolling Circle Amplification and Enzymatic Digestion. Yata, T.; Takahashi, Y.; Hidaka, K.; Endo, M.; Sugiyama, H.; Tan, M. M.; Takakura, Y.; Nishikawa, M. Sci. Rep., 2015, 5, 14979.

328. Development of a Visible Nanothermometer with a Highly Emissive 2'-O-Methylated Guanosine Analogue. Yamamoto, S.; Park, S.; Sugiyama, H. RSC Adv., 2015, 5, 104601-104605.

329. Induction of Stem-Cell-Derived Functional Neurons by NanoScript-Based Gene Repression. Patel, S.; Chueng, S. T. D.; Yin, P. T.; Dardir, K.; Song, Z. C.; Pasquale, N.; Kwan, K.; Sugiyama, H.; Lee, K. B. Angew. Chem. Int. Ed., 2015, 54, 11983-11988.

330. Single-molecule Observations of RNA-RNA Kissing Interactions in a DNA Nanostructure. Takeuchi, Y.; Endo, M.; Suzuki, Y.; Hidaka, K.; Durand, G.; Dausse, E; Toulme, J. J; Sugiyama, H. Biomater. Sci., 2016, 4, 130-135.

331. A Light-Driven Three-Dimensional Plasmonic Nanosystem that Translates Molecular Motion into Reversible Chiroptical Function. Kuzyk, A.; Yang, Y, Y.; Duan, X, Y.; Stoll, S.; Govorov, A, O.; Sugiyama, H.; Endo, M.; Liu, N. Nature Commun., 2015, 7, 10591.

332. Identification of Sequence Specificity of 5-Methylcytosine Oxidation by Tet1 Protein with High-Throughput Sequencing. Kizaki, S.; Chandranan, A.; Sugiyama, H. ChemBioChem. Sci., 2016, 17, 403-406.

333. The Application of Fluorescence-Conjugated Pyrrole/Imidazole Polyamides in the Characterization of Protein-DNA Complex Formation. Han, Y, W.; Sugiyama, H.; Harada, Y. Biomater. Sci., 2016 , 4, 391-399. (Review)

334. Self-Assembling DNA Hydrogel-Based Delivery of Immunoinhibitory Nucleic Acids to Immune Cells. Nishida, Y.; Ohtsuki, S.; Araie, Y.; Umeki, Y.; Endo, M.; Tomoko, E.; Hidaka, K.; Sugiyama, H.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Nanomedicine, 2016, 12, 123-130.

335. Triple Helix Formation in a Topologically Controlled DNA Nanosystem. Yamagata, Y.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M. Chem. Eur. J., 2016, 22, 5494-5498.

336. Effect of ATRX and G-Quadruplex Formation by the VNTR Sequence on α-Globin Gene Expression. Li, Y.; Syed, J.; Suzuki, Y.; Asamitsu, S.; Shioda, N.; Wada, T.; Sugiyama, H. ChemBioChem, 2016 , 17, 928-935.

337. Nature-Inspired Design of Smart Biomaterials Using the Chemical Biology of Nucleic Acids. Pandian, G. N.; Sugiyama, H.Bull. Chem. Soc. J., 2016, 89, 843-868. (Review)

338. Deciphering the Genomic Targets of Alkylating Polyamide Conjugates Using High-Throughput Sequencing. Chandran, A.; Syed, J.; Taylor, R. D.; Kashiwazaki, G.; Sato, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Nucleic Acids Res., 2016, 44, 4014-4024.

339. Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B2 to Duplex DNA. Zou, T. T.; Kizaki, S.; Pandian, G. N.; Sugiyama, H. Chem. Eur. J., 2016, 22, 8756-8758.

340. Double β-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole Polyamides for Lengthened DNA Minor Groove Recognition. Watanabe, T.; Shinohara, K.; Shinozaki, Y.; Uekusa, S.; Wang, X. F.; Koshikawa, N.; Hiraoka, K.; Inoue, T.; Lin, J.; Bando, T.; Sugiyama, H.; Nagase, H. Adv Tech Biol Med., 2016, 4, 175.

341. Ligand-Mediated G-Quadruplex Induction in a Double-Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide. Asamitsu, S.; Li, Y.; Bando, T.; Sugiyama, H. ChemBioChem, 2016, 17, 1317-1322.

342. Examining Cooperative Binding of Sox2 on DC5 Regulatory Element upon Complex Formation with Pax6 through Excess Electron Transfer Assay. Saha, A.; Kizaki, S.; De D.; Endo, M.; Kim, K.; Sugiyama, H. Nucleic Acids Res., 2016, 44, e125.

343. Sequence-Specific DNA Binding by Long Hairpin Pyrrole-Imidazole Polyamides Containing an 8-Amino-3,6-Dioxaoctanoic Acid Unit. Sawatani, Y.; Kashiwazaki, G.; Chandran, A.; Asamitsu, S.; Guo, C.; Sato, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2016, 24, 3603-3611.

344. Telomere Visualization in Tissue Sections using Pyrrole-Imidazole Polyamide Probes. Sasaki, A.; Ide, S.; Kawamoto, Y.; Bando, T.; Murata, Y.; Shimura, M.; Yamada, K.; Hirata, A.; Nokihara, K.; Hirata, T.; Sugiyama, H.; Maeshima, K. Sci. Rep., 2016, 6, 29261.

345. Mechanical Properties of DNA Origami Nanoassemblies are Determined by Holliday Junction Mechanophores. Shrestha, P.; Emura, T.; Koirala, D.; Cui, Y.; Hidaka, K.; Maximuck, W.; Endo, M.; Sugiyama, H.; Mao, H. Nucleic Acids Res., 2016, 44, 6574-6582.

346. Comparative Analysis of DNA-Binding Selectivity of Hairpin and Cyclic Pyrrole-Imidazole Polyamides Based on Next-Generation Sequencing. Kashiwazaki, G.; Chandran, A.; Asamitsu, S.; Kawase, T.; Kawamoto, Y.; Sawatani, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. ChemBioChem, 2016, 17, 1752-1758.

347. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. Katsuda, Y.; Sato, S.; Asano, L.; Morimura, Y.; Furuta, T.; Sugiyama, H.; Hagihara, M.; Uesugi, M. J. Am. Chem. Soc., 2016 , 138, 9037-9040.

348. Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by Utilizing the Power of High-Throughput Sequencing. Chandran, A.; Syed, J.; Li, Y.; Sato, S.; Bando, T.; Sugiyama, H. ChemBioChem, 2016, 17, 1905-1910.

349. Preferential 5-Methylcytocine Oxidation in the Linker Region of Reconstituted Positioned Nucleosome by Tet1 Protein. Kizaki, S.; Zou, T.; Li, Y.; Han, Y. -W.; Suzuki, Y.; Harada, Y.; Sugiyama, H. Chem. Eur. J., 2016, 22, 16498-16601.

350. RNA-DNA Triplex Formation by Long Noncoding RNAs. Li, Y.; Syed, J.; Sugiyama, H. Cell. Chem. Biol., 2016, 23, 1325-1333. (Review)

351. Targeting 24 bp within Telomere Repeat Sequences with Tandem Tetramer Pyrrole-Imidazole Polyamide Probes. Kawamoto, Y.; Sasaki, A.; Chandran, A.; Hashiya, K.; Ide, S.; Bando, T.; Maeshima, K.; Sugiyama, H. J. Am. Chem. Soc., 2016, 138, 14100-14107.

352. Torsional Constraints of DNA Substrates Impact Cas9 Cleavage. Räz, M.; Hidaka, K.; Sturla, S.; Sugiyama, H.; Endo, M. J. Am. Chem. Soc., 2016, 138, 13842-13845.

353. Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Genome. Lin, J.; Hiraoka, K.; Watanabe, T.: Kuo, T.; Shinozuka, Y.: Takatori, A.; Koshikawa N.; Chandran, A.; Otsuki, J.; Sugiyama, H.; Horton, P.; Nagase, H. PLOS ONE, 2016, 11(10): e0165581.

354. A Multi-target Small Molecule for Targeted Transcriptional Activation of Therapeutically Significant Nervous System Genes. Wei, Y.; Pandian, G. N.; Zou, T.; Taniguchi, J.; Sato, S.; Kashiwazaki, G.; Vaijayanthi, T.; Hidaka, T.; Bando, T.; Sugiyama, H. ChemistryOpen, 2016, 5, 517-521.

355. Similarities and Differences between RNA and DNA Double-Helical Structures in Circular Dichroism Spectroscopy: A SAC-CI Study. Miyahara, T.; Nakatsuji, H.; Sugiyama, H. J. Phys. Chem. A., 2016, 120, 9008-9018.

356. Characterization of the Releasing Profile of MicroRNA from RISC Using Anti-miRNA Oligonucleotides. Ariyoshi, J.; Eimori, N.; Kobori, A.; Murakami, A.; Sugiyama, H.; Yamayoshi, A. Chem. Lett., 2017, 46, 143-145.

357. DNA Interstrand Crosslinks by H-pin Polyamide (S)-seco-CBI Conjugates. Guo, C.; Asamitsu, S.; Kashiwazaki, G.; Sato, S.; Bando, T.; Sugiyama, H. ChemBioChem, 2017, 18, 166-170.

358. Programmable Formation of Catalytic RNA Triangles and Squares by Assembling Modular RNA Enzymes. Oi, H.; Fujita, D.; Suzuki, Y.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. J. Biochem., 2017, 161(5), 451-462.

359. Synthesis, Photophysical Properties, and Enzymatic Incorporation of an Emissive Thymidine Analogue. Okamura, I.; Park, S.; Hiraga, R.; Yamamoto, S.; Sugiyama, H. Chemistry Letters, 2017, 46, 245-248.

360. The Chemical Compound Bubblin Induces Stomatal Mispatterning in Arabidopsis by Disrupting the Intrinsic Polarity of Stomatal Lineage Cells. Sakai, Y.; Sugano, S. S.; Kawase, T.; Shirakawa, M.; Imai, Y.; Kawamoto, Y.; Sugiyama, H.; Nakagawa, T.; Hara-Nishimura, I.; Shimada, T. Development, 2017, 144, 499-506.

361. A Photoregulated DNA-Based Rotary System And Direct Observation of Its Rotational Movement. Yang, Y.; Tashiro, R.; Suzuki, Y.; Emura, T.: Hidaka, K.; Sugiyama, H.; Endo, M. Chem. Eur. J., 2017, 23, 3979-3985.

362. Confined Space Facilitates G-quadruplex Formation. Shrestha, P.; Jonchhe, S.; Emura, T.; Hidaka, K.; Endo, M.; Sugiyama, H.; Mao, H. Nature Nanotech., 2017, 12, 582-588.

363. Unusual Topological RNA Architecture with an Eight-Stranded Helical Fragment Containing A-, G- and U-Tetrads. Xiao, C.; Ishizuka, T.; Zhu, X.; Li, Y.; Sugiyama, H.; Xu, Y. J. Am. Chem. Soc., 2017, 139, 2565-2568.

364. Genetic Regulation of the RUNX Transcription Factor Family Has Antitumor Effects. Morita, K.; Suzuki, K.; Maeda, S.; Matsuo, A.; Mitsuda, Y.; Tokushige, C.; Kashiwazaki, G.; Taniguchi, J.; Maeda, R.; Noura, M.; Hirata, M.; Kataoka, T.; Yano, A.; Yamada, Y.; Kiyose, H.; Tokumasu, M.; Matsuo, H.; Tanaka, S.; Okuno, Y.; Muto, M.; Naka, K.; Ito, K.; Kitamura, T.; Kaneda, Y.;Liu, P.P.; Bando, T.; Adachi, S.; Sugiyama, H.; Kamikubo, Y. J. Clin. Invest., 2017, 127, 2815-2828.

365. Development of a Vivid FRET System Based on a Highly Emissive dG-dC Analogue Pair. Han, J.; Yamamoto, S.; Park, S.; Sugiyama, H. Chem. Eur. J., 2017, 23, 7607-7613.

366. Holliday Junction Resolvases Mediate Chloroplast Nucleoid Segregation. Kobayashi, Y.; Misumi, O.; Odahara, M.; Ishibashi, K.; Hirono, M.; Hidaka, K.; Endo, M.; Sugiyama, H.; Iwasaki, H.; Kuroiwa, T.; Shikanai, T.; Nishimura, Y. Science, 2017, 356, 631-634.

367. Copper-containing DNA-Silica Mineral Complexes for the Asymmetric Diels-Alder Reaction. Sakashita, S.; Park, S.; Sugiyama, H. Chemistry Letters, 2017, 46, 1165-1168.

368. Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression. Hidaka, T.; Pandian, G. N.; Taniguchi, J.; Nobeyama, T.; Hashiya, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2017, 139, 8444-8447.

369. Antiproliferative and Apoptotic Activities of Sequence-Specific Histone Acetyltransferase Inhibitors. Yu, Z.; Taniguchi, J.; Wei, Y.; Pandian, G. N.; Hashiya, K.; Bando, T.; Sugiyama, H. Eur. J. Med. Chem., 2017, 138, 320-327.

370. Protein-driven RNA Nanostructured Devices that Function in Vitro and Control Mammalian Cell Fate. Shibata, T.; Fujita, Y.; Ohno, H.; Suzuki, Y.; Hayashi, K.; Komatsu, K.; Kawasaki, S.; Hidaka, K.; Yonehara, S.; Sugiyama, H.; Endo, M.; Saito, H. Nature Commun., 2017, 8, 540.

371. Paradoxical Enhancement of Leukemogenesis in Acute Myeloid Leukemia with Moderately-attenuated RUNX1 Expressions. Morita, K.; Maeda, S.; Suzuki, K.; Kiyose, H.; Taniguchi, J.; Liu, P. P.; Sugiyama, H.; Adachi, S.; Kamikubo, Y. Blood Adv., 2017, 1, 1440-1451.

372. A Synthetic DNA-binding Inhibitor of SOX2 Guides Human Induced Pluripotent Stem Cells to Differentiate into Mesoderm. Taniguchi, J.; Pandian, G.; Hidaka, T.; Hashiya, K.; Bando, T.; Kim, K. K.; Sugiyama, H. Nucleic Acids, 2017, 45, 9219-9228.

373. Effective Anti-miRNA Oligonucleotides Show High Releasing Rate of MicroRNA from RNA-Induced Silencing Complex. Ariyoshi, J.; Matsuyama, Y.; Kobori, A.; Murakami, A; Sugiyama, H.; Yamayoshi, A. Nucleic Acid Ther., 2017, 27, 303-308.

374. A Combination of Visible-Light Photoredox and Metal Catalysis for the Mannich-Type Reaction of N-Aryl Glycine Esters. Okamura, I.; Park, S.; Han, J.; Notsu, S.; Sugiyama, H. Chem. Lett., 2017, 46, 1597-1600.

375. Single-Molecule Observation of The Photo Regulated Conformational Dynamics of DNA Origami Nanoscissors. Willner, E.; Kamada, Y.; Suzuki, Y.; Emura, T.; Hidaka, K.; Dietz, H.; Sugiyama, H.; Endo, M. Angew. Chem. Int., 2017, 56, 15324-15328.

376. Autonomous Feedback Loop of RUNX1-p53-CBFB in Acute Myeloid Leukemia Cells. Morita, K.; Noura, M.; Tokushige, C.; Maeda, S.; Kiyose, H.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Yoshida, K.; Ozaki, T.; Matsuo, H.; Ogawa, S.; Liu, P. P.; Nakahata, T.; Sugiyama, H.; Adachi, S.; Kamikubo, Y. Sci. Reports, 2017, 7, 16604.

377. Evaluation of Alkylating Pyrrole-Imidazole Polyamide Conjugates by a Novel Method for High-Throughput Sequencer. Kashiwaszaki, G.; Maeda, R.; Kawase, T.; Hashiya, K.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2018, 26, 1-7.

378. UVA Irradiation of BrU-Substituted DNA in The Presence of Hoechst 33258. Saha, A.; Kizaki, S.; Han, J. H.; Yu, Z.; Sugiyama, H. Bioorg. Med. Chem., 2018, 26, 37-40.

379. G-Quadruplex Induction by the Hairpin Pyrrole–Imidazole Polyamide Dimer. Obata, S.; Asamitsu, S.; Hashiya, K.; Bando, T.; Sugiyama, H. Biochem., 2018, 57, 498-502.

380. Investigating Nucleosome Accessibility for MNase, FeII Peplomycin, and Duocarmycin B2 by Using Capillary Electrophoresis. Zou, T.; Kizaki, S.; Sugiyama, H. ChemBioChem, 2018, 19, 664-668.

381. DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K + Channels. Kurokawa, T.; Kiyonaka, S.; Nakata, E.; Endo, M.; Koyama, S.; Mori, E.; Tran, N. H.; Dinh, H.; Suzuki, Y.; Hidaka, K.; Kawata, M.; Sato, C.; Sugiyama, H.; Morii, T.; Mori, Y. Angew. Chem., 2018, 57, 2586-2591.

382. Targeting G-quadruplex DNA as Cognitive Function Therapy for ATR-X Syndrome. Shioda, N.; Yabuki, Y.; Yamaguchi, K.; Onozato, M.; Li, Y.; Kurosawa, K.; Tanabe, H.; Okamoto, N.; Era, T.; Sugiyama, H.; Wada, T.; Fukunaga, K. Nature Medicine, 2018, 24, 802-813.

383. RUNX Transcription Factors Potentially Control E-Selectin Expressions in the Bone Marrow Vascular Niche in Mice. Morita, K.; Tokushige, C.; Maeda, S.; Kiyose, H.; Noura, M.; Iwai, A.; Yamada, M.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Hirata, M.; Kataoka, T. R.; Nakahata, T.; Adachi, S.; Sugiyama, H.; Kamikubo, Y. Blood Advances, 2018 , 5, 509-515.

384. Sequence-specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications, Kawamoto, Y.; Bando, T.; Sugiyama, H. Bioorg. Med., 2018, 26, 1393-1411. (Review)

385. Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-binding Components to a G-quadruplex and its Proximal Duplex. Asamitsu, S.; Obata, S.; Phan, A. T.; Hashiya, K.; Bando, T.; Sugiyama, H. Chem. Eur., 2018, 24, 4428-4435.

386. Triggering Nucleic Acid Nanostructure Assembly by Conditional Kissing Interactions. Azéma, L.; Bonnet-Salomon, S.; Endo, M.; Takeuchi, Y.; Durand, G.; Emura, T.; Hidaka, K.; Dausse, E.; Sugiyama, H.; Toulmé, JJ. Nucleic Acids Res., 2018, 46, 1052-1058.

387. Pip-HoGu: an Artificial Assembly with Cooperative DNA Recognition Capable of Mimicking Transcription Factor Pairs. Yu, Z.; Guo, C.; Wei, Y.; Hashiya, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2018 , 140, 2426-2429.

388. A Synthetic DNA-binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation. Wei, Y.; Pandian, G.; Yu, Z.; Zou, T.; Li, Y.; Darokar, J.; Hashiya, K.; Bando, T.; Sugiyama, H. ACS Omega, 2018, 3, 3608-3616.

389. Complexing DNA Origami Frameworks through Sequential Self-Assembly Based on Directed Docking. Suzuki, Y.; Sugiyama, H.; Endo, M. Angew. Chem. Int. Ed., 2018, 57, 7061-7065.

390. RUNX1 Positively Regulates the ErbB2/HER2 Signaling Pathway through Modulating SOS1 Expression in Gastric Cancer Cells. Mitsuda, Y.; Morita, K.; Kashiwazaki, G.; Taniguchi, J.; Bando, T.; Obara, M.; Hirata, M.; Kataoka, R. T.; Muto, M.; Kaneda, Y.; Nakahata, T.; Liu, P. P.; Adachi, S.; Sugiyama, H.; Kamikubo, Y. Scientific Reports, 2018 , 8:6423.

391. Environment-Dependent Self-Assembly of DNA Origami Lattices on Phase-Separated Lipid Membranes. Sato, Y.; Endo, M.; Morita, M.; Takinoue, M.; Sugiyama, H.; Murata, S.; Nomura, S.; Suzuki, Y. Adv. Mater. Interfaces, 2018, 1800437.

392. Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones. Taniguchi, J.; Feng, Y.; Pandian, G.; Hashiya, F.; Hidaka, T.; Hashiya, K.; Park, S.; Bando, T.; Ito, S.; Sugiyama, H. J. Am. Chem. Soc., 2018, 140, 7108-7115.

393. TAMRA-Polypyrrole for A/T Sequence Visualization on DNA Molecules. Lee, S.; Kawamoto, Y.; Thangavel, V.; Park, J.; Bae, J.; Kim-Ha, J.; Sugiyama, H.; Jo, K. Nucleic Acids Research, 2018 , 46, e108.

394. Construction of Integrated Gene Logic-chip. Masubuchi, T.; Endo, M.; Iizuka, R.; Iguchi, A.; Yoron, D. H.; Sekiguchi, T.; Qi, H.; Iinuma, R.; Miyazono, Y.; Shoji, S.; Funatsu, T.; Sugiyama, H.; Harada, Y.; Ueda, T.; Tadakuma, H. Nature Nanotechnology, 2018, 13, 933-940.

395. Orthogonal γPNA Dimerization Domains Empower DNA Binders with Cooperativity and Versatility Mimicking that of Transcription Factor Pairs. Yu, Z.; Hsieh, W-C.; Asamitsu, S.; Hashiya, K.; Bando, T.; Ly, H. D.; Sugiyama, H. Chem. Eur. J., 2018, 24, 14183-14188.

396. DNA Origami Nanomachines. Endo, M.; Sugiyama, H. Molecules, 2018, 23, E1766. (Review)

397. Colloidal Stability of Lipid/Protein-Coated Nanomaterials in Salt and Sucrose Solutions. Nobeyama, T.; Mori, M.: Shigyou, K.; Takata, K.; Pandian, G. N.; Sugiyama, H.; Murakami T. ChemistrySelect, 2018, 3, 8325-8331.

398. Decreased Water Activity in Nanoconfinement Contributes to the Folding of G-quadruplex and i-motif Structures. Jonchhe, S.; Pander, S.; Emura, T.; Hidaka, K.; Hossain, M. A.; Shrestha, P.; Sugiyama, H. Endo, M.; Mao, H. PNAS, 2018, 115, 9539-9544.

399. Direct Observation of H3-H4 Octasome by High-Speed AFM. Zou, T.; Hashiya, F.; Wei, Y.; Yu, Z.; Ganesh, N. P.; Sugiyama, H. Chem. Eur. J., 2018, 24, 15998-16002.

400. Direct Observation of Dynamic Movement of DNA Molecules in DNA Origami Imaged Using High-speed AFM. Endo, M.; Sugiyama, H. Springer Book. Methods in Molecular Biology, Nanoscale Imaging Lyubchenko Y. L. ed., 2018 , Chapter 13, 213-224. (Review)

401. Sequence Preference and Structural Heterogeneity of BZ junctions. Kim, D.; Hur, J.; Han, J. H.; Ha, S. C.; Shin, D.; Lee, S.; Park, S.; Sugiyama, H.; Kim, K. K. Springer Book. Methods in Molecular Biology, Nucleic Acids Research, 2018 , 46, 10504-10513.

402. Approach to the Investigation of Nucleosome Structure by Using the Highly Emissive Nucleobase thdG-tC FRET Pair. Han, J. H.; Park, S.; Hashiya, F.; Sugiyama, H. Chem. Eur. J., 2018 , 24, 17091-17095.

403. Chemical Control System of Epigenetics. Vaijayanthi, T.; Pandian G. N.; Sugiyama, H. Chem. Rec., 2018, 18, 1833-1853. (Review)

404. Ligand Design to Acquire Specificity to Intended G-quadruplex Structure. Asamitsu, S.; Bando, T.; Sugiyama, H. Chem. Eur. J., 2019, 25, 417-430. (Review)

405. Nanochannel-confined TAMRA-polypyrrole Stained DNA Stretching by Varying the Ionic Strength from Micromolar to Millimolar Concentrations. Jo, K.; Lee, S.; Lee, Y.; Kim, Y.; Wang, C.; Park, J.; Jung, G. Y.; Chen, Y. L.; Chang, R.; Ikeda, S.; Sugiyama, H. Polymers, 2019 , 11, 15.

406. Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-quadruplex. Jonchhe, S.; Chimire, C.; Cui, Y.; Park, S.; Iida, K.; Nagasawa, K.; Sugiyama, H.; Mao, H. Angew. Chem., 2019, 131, 887-891.

407. Electron Injection from Mitochondrial Transcription Factor A to DNA Associated with Thymine Dimer Photo Repair. Hashiya, F.; Ito, S.; Sugiyama, H. Bioorg. Med. Chem., 2019, 27, 278-284.

408. Direct Observation of the Double‐Stranded DNA Formation through Metal Ion‐Mediated Base Pairing in the Nanoscale Structure. Xing, X.; Feng, Y.; Yu, Z.; Hidaka, K.; Liu F.; Ono, A.; Sugiyama, H.; Endo, M. Chem. E. J., 2019, 25, 1446-1450.

409. Chemical and photobiological study of the structures and functions of DNA. Sugiyama, H. Photomedicine and Photobiology, 2018 , 40, 1-6. (Review)

410. Molecular Characteristics of DNA-alkylating PI Polyamides Targeting RUNX Transcription Factors. Maeda, R.; Sato, S.; Ohno, T.; Kashiwazaki, G.; Obata, S.; Hashiya, K.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2019, 141, 4257-4263.

411. Recent Progress of Specific G-quadruplex-preferred Ligands Toward Cancer Therapy. Asamitsu, S.; Obata, S.; Yu, Z.; Bando, T.; Sugiyama, H. Molecules, 2019, 24, 429; doi:10.3390/molecules24030429. (Review)

412. Therapeutic Gene Regulation using Pyrrole-Imidazole Polyamides. Yu, Z.; Pandian, G. N.; Hidaka, T.; Sugiyama, H. Adv. Drug Deliv. Rev., 2019, 147, 66-85. (Review)

413. Modular DNA-based Hybrid Catalysts as a Toolbox for Enantioselective Hydration of α,β-Unsaturated Ketones. Yum, J. H.; Park, S.; Hiraga, R.; Okamura, I.; Notsu, S.; Sugiyama, H. Org. and Biomol. Chem., 2019, 17, 2548-2553.

414. Submolecular Dissection Reveals Strong and Specific Binding of Polyamide-Pyridostatin Conjugates to Human Telomere Interface. Mandel, S.; Kawamoto, Y.; Yue, Z.; Hashiya, K.; Cui Y.; Bando, T.; Sugiyama, H.; Mao, H. Nucleic Acids Res., 2019, 47, 3295-3305.

415. A Photocaged DNA Nanocapsule for Controlled Unlocking and Opening inside the Cell. Tohgasaki, T.; Shitomi, Y. Feng, Y.; Honna, S.; Emura, T.; Hidaka, K.; Sugiyama, H.; Endo, M. Bioconjugate Chem., 2019, 30, 1860-1863.

416. Direct Observation and Analysis of the Dynamics of the Photoresponsive Transcription Factor GAL4. Raghavan, G.; Hidaka, K.; Sugiyama, H.; Endo, M. Angew. Chem. Int. Ed., 2019, 58, 7626-7630.

417. Oligomerization of a Modular Ribozyme Assembly of which is Controlled by a Programmable RNA-RNA Interface between Two Structural Modules. Tsuruga, R.; Uehara, N.; Suzuki, Y.; Furuta, H.; Sugiyama, H.; Endo, M.; Matsumura, S.; Ikawa, Y. J. Biosci. & Bioeng., 2019, 128, 410-415.

418. Orientation Preferences of Hairpin Pyrrole-Imidazole Polyamides toward mCGG Site. Sato, S.; Asamitsu, S.; Bando, T.; Sugiyama, H. Bioorg. Med. Chem., 2019, 27, 2167-2171.

419. New Size-expanded Fluorescent Thymine Analogue: Synthesis. Characterization, and Application. Hirashima, S.; Han, J.; Tsuno, H.; Tanigaki, Y.; Park, S.; Sugiyama, H. Chem. Eur. J., 2019, 25, 9913-9919.

420. Direct Observation of the Formation and Dissociation of Double-Stranded DNA Containing G-Quadruplex/i-Motif Sequences in the DNA Origami Frame Using High-Speed AFM. Endo, M.; Xing, X.; Sugiyama, H.Methods Molecular Biology, Vol. 2035,: G-Quadruplex Nucleic Acids, 2019, 299-308. (Review)

421. Translation-dependent Unwinding of Stem-loops by UPF1 Licenses Regnase-1 to Degrade Inflammatory mRNAs. Mino, T.; Iwai, N.; Endo, M.; Inoue, K.; Akaki, K.; Hia, F.; Uehata, T.; Emura, T.; Hidaka, K.; Suzuki, Y.; Standley, D.M.; Okada-Hatakeyama, M.; Ohno, S.; Sugiyama, H.; Yamashita, A.; Takeuchi, O. Nucleic Acids Research, 2019, 47, 8838-8859.

422. Highly Sensitive and Selective Mercury Sensor based on Mismatched Base Pairing with dioxT. Han, J. H.; Hirashima, S.; Park, S.; Sugiyama, H. Chem. Commun., 2019, 55, 10245-10248.

423. Control of Forward/Reverse Orientation Preference of Cyclic Pyrrole-Imidazole Polyamides. Hirose, Y.; Asamitsu, S.; Bando, T.; Sugiyama, H. J. Am. Chem. Soc., 2019, 141, 13165-13170.

424. Switching Off Cancer-Causing Telomerase Using Small Molecules. Asamitsu, S.; Shioda, N.; Sugiyama, H. Cell Chemical Biology, 2019, 26, 1045-1047. (Review)

425. Effects of Physical Damage in the Intermediate Phase on the Progression of Amyloid β Fibrillation. Tashiro, R.; Taguchi, H.; Kidaka, K.; Endo, M.; Sugiyama, H. Chem. Asian J., 2019, 14, 4140-4145.

426. G-quadruplexes as Versatile Scaffolds for Catalysis. Yum, J. H.; Park, S.; Sugiyama, H. Org. Biomol. Chem., 2019, 17, 9547-9561.

427. Folding of Single-stranded Circular DNA into Rigid Rectangular DNA Accelerates its Cellular Uptake. Otsuki, S.; Shiba, Y.; Maezawa, T.; Hidaka, K.; Sugiyama, H.; Endo, M.; Takahashi, Y.; Takakura, Y.; Nishikawa, M. Nanoscale, 2019, 11, 23416-23422.

428. Sequence-specific PI Polyamides Make It Possible to Regulate DNA Structure and Function. Bando, T.; Sugiyama, H. Bull. Chem. Soc. J., 2020, 93, 205-215.

429. Advances in DNA Origami-Cell Interfaces. Mishra, S.; Feng, Y.; Endo, M.; Sugiyama, H. ChemBioChem., 2020, 21, 33-44.

430. Targeted Suppression of Metastasis Regulatory Transcription Factor SOX2 in Various Cancer Cell Lines using a Sequence-specific Designer Pyrrole-imidazole Polyamide. Malinee, M.; Kumar, A.; Hidaka, T.; Hirose, M.; Hasegawa, K.; Namasivayam, P. G.; Sugiyama, H., Bioorg. Med. Chem., in press

431. A Synthetic Transcription Factor Pair Mimic for Precise Recruitment of an Epigenetic Modifier to the Targeted DNA Locus. Yu, Z.; Ai, M; Samanta, S. K.; Hashiya, F.; Taniguchi, J.; Asamitsu, S.; Ikeda, S.; Hashiya, K.; Bando, T.; Pandian, G. N.; Isaacs, L.; Sugiyama, H.Chem. Comm., 2020, 56, 2296-2299.

432. N1-Methylpseudouridine Substitution Enhances the Performance of Synthetic mRNA Switches in Cells. Parr, C.; Wada, S.; Kotake, K.; Kameda, S.; Matsuura, S.; Sakashita, S.; Park, S.; Sugiyama, H.; Kuang, Y.; Saito, H. Nucleic Acids Research. in press

433. Direct Observation and Analysis of TET-mediated Oxidation Processes in a DNA Origami Nanochip. Xing, X.; Sato, S., Wong, N-K.; Hidaka, K.; S.; Sugiyama, H.; Endo, M. Nucleic Acids Research. in press

434. Histidine-conjugated DNA as a Biomolecular Depot for Metal Ions. Park, S.; Matsui, H.; Fukumoto, K.; Yum, Ji Hye.; Sugiyama, H. RSC Advances. in press