京都大学 物質−細胞統合システム拠点

WPI-iCeMs Kyoto University

Sugiyama Laboratory, Kyoto University

Professor :Hiroshi Sugiyama

Professor

CEO

(b. 1956) Professor of Chemistry; B.S., 1979, Kyoto University; Ph.D., 1984, Kyoto University; Postdoctoral Fellow, 1984-1986, University of Virginia; Assistant Professor, 1986-1993, Kyoto University; Associate Professor, 1993-1996, Kyoto University; Professor, 1996-2003, Tokyo Medical and Dental University; Professor, 2003-, Kyoto University.

Professor Sugiyama's research interests involve the bioorganic chemistry of nucleic acids. Using the tools of synthetic physical organic chemistry and molecular biology, the Sugiyama group is defining the chemical principles underlying the recognition, reactivity and structure of nucleic acids. There are no other research groups on such a general and fundamental aspect of nucleic acids as a substance.The group utilizes a chemical approach in following areas: Molecular mechanism of DNA modification by DNA base alkylation, hydrogen abstraction and charge transfer. Design of highly efficient sequence-specific DNA acting agents based on understanding of the action mechanism of antitumor antibiotics. Design of unnatural nucleic acid for understanding of nucleic acid structure and function. Development of a method probing DNA local conformation in vivo. The long-range goal is creation of artificial genetic switches for targeted cell differentiation and treatment of many diseases.


1999
IBM Japan Science Award
2005
The CSJ Award for Creative Work
2005
Editorial Advisory Board of ChemBioChem
2009-2014
Editorial Advisory Board of J. Am. Chem. Soc.
2009
Editorial Advisory Board of J. Nucleic Acids
2011
Editorial Advisory Board of J. Med. Chem.
2011-2014
Editorial Board of The Chemical Record
2012-2016
Associate Editor of Biomaterials Science
2014
Editorial Board of Scientific Reports
2016
Editorial Advisory Board of Cell, Chemical Biology
2017
The Chemical Society of Japan (CSJ) Award