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Bioarchitecture Chemistry Labratory

DNA nanotechnology

In the DNA nanotechnology group, we are creating DNA molecular nanodevices and functional materials,
and developing single-molecule imaging and analysis system for understanding biological phenomena
.

Research

All existing things in nature, for example, cells in animals and plants are built up by assembly and organization of the predefined molecules, and their functions are expressed by the reaction of the molecules in a highly ordered fashion. We are learning the nature’s system and mimicking it to create a new system in a small scale. So if we artificially design nanoscale structures and precisely incorporate molecules there, it could be an ultimate technology not only for studying basic science but also for creation of new materials and devices for physical and biological applications. Using a DNA molecule as a basic component, we are working on developing novel technologies applicable for imaging, sensing, creation of nanosystem and nanodevice, and delivery system by combining designable DNA nanoscale structure & space (bioarchitecture) and chemistry.

DNA is one of the most promising molecules for preparing various nanoscale structures and spaces. This allows us to integrate multiple functional molecules and nanomaterials onto a designed nanostructure and also to produce a large-scale complicated architecture. Using an innovative DNA self-assembly system “DNA origami”, our group focuses on the following research topics. (1) Design and construction of the novel 2D and 3D DNA nanostructures and spaces; (2) Programmed assembly of nanostructures into the 2D and 3D architectures; (3) Regulation of chemical and enzymatic reactions in a designed nanospace; (4) Visualization and analysis of biomolecules in a designed nanostructure; (5) Analysis of physical properties of biomolecules in a designed nanospace; (6) Development of novel DNA crystals; (7) Development of molecular nanodevices; (8) Applications for photonic nanomaterials; (9) Applications for molecular machines and robots; (10) Development of novel delivery system for cellular applications; (11) Diagnosis and medical applications. We are using the high-speed AFM imaging system for visualizing the dynamics of molecules and nanostructures.

NEWS新着情報

  
4/1/2020
New undergrad and graduate students joined our group.
3/18/2020
Our research reseults were introduced in JSPS research topics.
12/3/2019
Endo visted College of Chemistry and Molecular Sciences, Wuhan University (Prof. Xiang Zhou) and gave a talk.
12/2/2019
Endo visted College of Life Science and Technology, Jinan University (Dr. Xiwen Xing) and gave a talk.
Endo visted School of Chemistry, Sun Yat-sen University (Prof. Liang Xu) and gave a talk.
11/22/2019
Prof. Bodin Tuesuwan (Chulalongkorn University) joined our group.
11/5/2019
Dr. Ioanna Mela (University of Cambridge) visted our graoup.
10/29/2019
We joined the 46th International Symposium on Nucleic Acid Chemistry (ISNAC2019), Tokyo (10/29-31).
9/26/2019
We joined The 57th Annual Meeting of the Biophysical Society of Japan, Miyazaki (9/24-26).
9/18/2019         
The collaborative research with Prof. Masahiro Takinoue was press released from Tokyo Institute of Technology.
9/15/2019
We joined Kyoto University Academic Day 2019.
8/28/2019
Dr. Xiwen Xing (Jinan Univ.) visited our group. (June-August)
7/22/2019
We joined Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry 2019 (CISNAC) (Konan Univ. Kobe). (7/22-24)
7/3/2019
Endo stayed Hanbin Mao Lab and visited Thorsten Schmidt Lab in Kent Stat University (Kent, OH, USA). (7/3-19)        
6/28/2019
Endo talked in symposium on molecular motor (National Genetic Research, Mishima). (6/27-28)
6/25/2019
Endo talked in 10th International Conference on Materials for Advanced Technologies (ICMAT2019) (Marina Bay Sands, Singapore). (6/23-26)
6/13/2019
Endo talked in Young Scientist Salon (Kyoto University).
5/28/2019
Endo talked in NANTECH2019 (Aalto University, Helsinki, Finland). (5/26-29)
4/15/2019
We joined FNANO19(Snowbird, UT, USA). (4/15-18)
3/19/2019
We joined the 99th Annual Meeting of the Chemical Society Japan (Konan University). (3/16-19)
3/14/2019
We joined Molecular Robotics annual meeting (Tokyo Institute of Technology).(3/14-15)
12/3/2018
Prof. Bodin Tuesuwan (Chulalongkorn University) joined our group.
11/12/2018
Dr. Sébastien Lyonnais (Centre d'étude des maladies infectieuses et pharmacologie anti-infectieuse CEMIPAI, France) joined our group.
11/7/2018
We held the 45th International Symposium on Nucleic Acid Chemistry (ISNAC), Kyoto University. (11/7-9)
10/3/2018
Mr. Shubham Mishra (Indian Institute of Science) joined our group.
9/7/2018
We joined the 12th Symposium on Biorelevant Chemistry (Osaka University). (9/9-11)
9/6/2018
The collaborative research with Prof. Hanbin Mao (Kent State University) was press-released from Kyoto University.
8/26/2018
We attended the International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (IRT2018) (UC San Diego). (8/26-30)
8/9/2018        
High school students visited our lab and did DNA origami experiment.
8/1/2018        
The collaborative research with Prof. Hanbin Mao (Kent State University) on physical properties of G-quadruplex and i-motif in a confined space was accepted to PNAS.        
7/24/2018        
The collaborative research with Prof. Hisashi Tadakuma was press released from Osaka University.        
6/25/2018
We joined the 10th iCeMS retreat (Hikone). (6/25-26)
6/15/2018
Collaborative research with Prof. Hisashi Tadakuma (Osaka University) on Gene Logic Chip was accepted to Nature Nanotechnology.
4/2/2018
New undergrad and graduate students joined our group.
3/20/2018
We joined the 98th Annual Meeting of the Chemical Society Japan (Nihon University). (3/20-23)
3/5/2018
We joined Molecular Robotics annual meeting (Tohoku University). (3/5-6)
3/4/2018
Endo talked in Shizuoka Life Science Symposium (Shizuoka University).
2/27/2018
Endo talked in SPIRITS symposium (kyoto University).
1/15/2018
Prof. Hiroshi Sugiyama won the CSJ Awards 2017.
1/9/2018
Prof. Bodin Tuesuwan (Chulalongkorn University) joined our group.
11/14/2017
We joined the 44th International Symposium on Nucleic Acid Chemistry (ISNAC), Tokyo (11/14-16).
10/27/2017
We joined the 9th iCeMS retreat (Hikone). (10/27-28)
10/3/2017
Prof. Kiat Ruxrungtham (Vice President, Chulalongkorn University) visited our group.
9/25/2017
We joined DNA23 (University of Texas, Austin). (9/25-28)
9/15/2017
The collaborative research with Prof. Hirohide Saito was press released from CiRA, Kyoto University.        
9/7/2017
We joined the 11th Symposium on Biorelevant Chemistry (University of Tokyo). (9/7-9)
7/14/2017
We joined the Molecular Robotics Symposium (University of Tokyo).
6/22/2017
Ms. Caroline Rossi-Gendron (Ecole Normale Supérieure) joined our group (JSPS Summer Program).
6/12/2017
Endo visited Kent State University, Hanbin Mao Lab(Kent, OH, USA). (June 12-14).
6/5/2017
Endo joined Unconventional Computation and Natural Computation 2017 (UCNC 2017) conference (University of Arkansas. Fayetteville, AR, USA). (June 5-9).
5/15/2017
Ms. Djamouna Sihou (University of Bordeaux) joined our group.
5/15/2017
Kyoto University Press Release, tiltled "Disentangling chloroplast genetics. Kyoto University isolates a critical gene for plant health." collaborative research with Prof. Yoshiki Nishimura.
4/14/2017
Collaborative research with Prof. Yoshiki Nishimura (Kyoto University) on Holliday junction resolvase in chloroplast was accepted to Science.
4/11/2017
We joined FNANO17 (Snowbird, UT, USA). (4/11-14)
4/4/2017
We joined the 253rd American Chemical Society National Meeting (San Francisco, CA). (4/4-7)       
4/3/2017
New undergrad and graduate students joined our group.
4/1/2017
Dr. Yosuke Katsuda moved to Department Applied Chemistry and Biology, Kumamoto University as an assistant professor.
3/28/2017        
Kyoto University Press Release, tiltled "Nanocages dramatically facilitate structure formation of biomolecules."  
3/21/2017
Dr. Xiwen Xing joined our group.
3/16/2017
We joined the 97th Annual Meeting of the Chemical Society Japan (Keio University). (3/16-19)
3/11/2017
We joined the Molecular Robotics annual meeting (University of Tokyo). (3/11-13)
2/6/2017
Collaborative research with Prof. Hanbin Mao (Kent State University) on G-quadruplex in confined nanospaces was accepted to Nature Nanotechnology.
2/2/2017
We joined The 3rd SPIRITS international symposium (Kyoto University).
1/16/2017
We joined Chemical Biology Mini-sumposium at KIT.
11/26/2016
We joined The 54th Annual Meeting of the Biophysical Society of Japan, Tsukuba (11/26-27).
11/16/2016
Prof. Ilko Bald (Universität Potsdam) visited our group.
9/27/2016
We joined the 43rd International Symposium on Nucleic Acid Chemistry (ISNAC), Kumamoto (9/27-29).
9/13/2016
Endo visited Sturla Lab, ETH Zürich (Switzerland).
9/4/2016
We joined DNA22(Ludwig-Maximilians-Universität München, Germany).(9/4-9)
7/22/2016
We joined The 38th Annual Meeting of the Japanese Society for Photomedicine and Photobiology (Kyoto). (7/22-23)
7/13/2016
Ms. Tracy Guo (Tufts University) worked in our group (Amgen Scholar Programs).
6/29/2016
Endo visited Hanbin Mao Lab, Kent State University (Kent, OH, USA). (6/29-7/9)
6/15/2016
We joined the 11th Annual Meeting of the Japanese Society for Chemical Biology (Kyoto). (6/15-17)
5/30/2016
We joined the 8th iCeMS retreat (Hikone). (5/30-31)
5/24/2016
Prof. Shana Sturla (ETH Zürich) visited our group.
4/19/2016
Prof. Peter Beal (UC Davis) visited our group.
4/11/2016
We joined FNANO16 (Snowbird, UT, USA). (4/11-14)
4/1/2016
New undergrad and graduate students joined our group.
4/1/2016
Dr. Yuki Suzuki moved to Frontier Research Institute for Interdisciplinary Sciences, Tohoku University as an assistant professor.
4/1/2016
Dr. Seigi Yamamoto moved to Department of Biomedical Science and Engineering, The University of Tokushima as an assistant professor.
3/24/2016
We joined the 96th Annual Meeting of the Chemical Society Japan (Doshisha University). (3/24-27)
3/16/2016
We joined the 251st American Chemical Society National Meeting (San Diego, CA). (3/16-17)
3/15/2016
Endo joined and talked in Ten Years of DNA Origami symposium, California Institute of Technology (Pasadena, CA). (3/14-15)
2/20/2016
Molecular Robotics Young Researcher's meeting was held in iCeMS, Kyoto University. (organizer Yuki Suzuki)        
2/10/2016
Mr. Michael Heinrich Räz (ETH Zürich) joined our group and worked for five months (Swiss-JSPS exchange program).
2/4/2016
Endo joined and talked in the 2nd SPIRITS international symposium (Kyoto University).
1/28/2016
We joined nano tech 2016 (Tokyo Big Sight). (1/28-29)
1/25/2016
We held the University of Bordeaux-Kyoto University Mini-Symposium on Biomolecular Science (Kyoto University).
1/23/2016
We held the annual meeting of Molecular Robotics (Kyoto University).
12/16/2015
Endo joined and talked in the 1st SPIRITS international symposium (Honolulu, HI). We invited Prof. Tim Liedl (Ludwig-Maximilians University) and Prof. Stephan Link (Rice University).
12/15/2015
We joined 2015 International Chemical Congress of Pacific Basin Societies (PacifiChem 2015) (Honolulu, HI). (12/15-19)
12/7/2015
Endo joined and talked in 601. Wilhelm und Else Heraeus-Seminar, DNA Nanotechnology Meets Plasmonics, Physikzentrum Bad Honnef, Germany. (12/7-11)
11/14/2015
We joined the SIG-MBI meeting 2015. Keio University, Yokohama.
11/12/2015
We joined the Eighth Annual Meeting of the Japanese Society for Cell Synthesis Research. Osaka University, Suita (11/12-13).
11/5/2015
Endo talked in the 2nd Kobe mini-symposium on functionalized organic molecules, Kobe University, Kobe.
10/27/2015
We joined the Chem-Bio Informatics Society (CBI) annual meeting 2015, Tokyo (10/27-28).
10/14/2015
We joined the Sekisu Chemical Forum, Tokyo.
10/13/2015
Ms. Elena Willner (Technische Universität München) joined to our group and carried out research for six months (interunversity exchange program).        
9/28/2015
Prof. Hanbin Mao (Kent State University) visited our group and gave a lecture.
9/23/2015
We joined the 42nd International Symposium on Nucleic Acid Chemistry (ISNAC), Himeji (9/23-25).
9/15/2015
We joined the 64th Polymer meeting, Sendai (9/15-16).
9/10/2015
We joined the 9th Symposium on Biorelevant Chemistry, Kumamoto (9/10-12).
9/9/2015
Dr. Ioanna Mela (University of Cambridge) stayed and worked in our group.
Mr. Prakash Shrestha (Kent State University) stayed and worked in our group as an internship graduate student.
9/7/2015
We joined the 7th iCeMS retreat (Minamiyamashiro)(9/7-8).
8/28/2015
Dr. Yangyang Yang moved to East China University of Science and Technology as a reseach associate.
8/27/2015
Kyoto University Press Release, tiltled "Micrometer sized two-dimentional assembly of DNA origami on the lipid bilayer."  
8/17/2015
We joined the DNA 21 (Harvard University, Cambridge, MA) (8/17-21).
7/16/2015
Endo talked in the 52nd Phermaceutics meeting (Kaga) (7/15-16).
6/4/2015
We joined kick-off symposium of SPIRITS (Instute of Chemistry, Kyoto University).
5/9/2015
We joined Molecular Robotics meeting for new researchers (Tokyo Institute of Technology).
5/4/2015
Endo talked in the 5th International Conference on Nucleic Acid-Protein Chemical and Structural Biology for Drug Discovery, Sichuan University (Chengdu, China)(5/3-4).
4/13/2015
We joined FNANO14 (Snowbird, UT, USA)(4/13-14).
3/27/2015
We joined the 95th Annual Meeting of the Chemical Society Japan (Funabashi). (3/26-29).
3/10/2015
We joined the Molecular Robotics annual meeting (Ito).
3/6/2015
Endo talked in the 8th symposium of Molecular Nanotechnology Center, University of Hyogo (Himeji).
2/5/2015
Endo was introduced in Angewandte Chemie Author Profile. Author Profile Masayuki Endo, Angewandte Chemie International Edition Vol. 54, page 2002 (2015).
11/13/2014
We joined the annual meeting 7.0 of the Japanese Society for Cell Synthesis Research (Tokyo).
11/5/2014
We joined the 41st International Symposium on Nucleic Acid Chemistry (ISNAC), Kokura (11/5-7).
10/2/2014
We joined the 6th iCeMS retreat (Miyazu).
9/24/2014
Ms. Xiwen Xing (Wuhan Univ.) stayed and worked in our group as an internship graduate student for six months.
9/23/2014
Prof. Ned Seeman (New York Univ.) visited out group.
9/22/2014
DNA20 was held at Shiran-Kaikan at Kyoto University (9/22-25).
9/11/2014
We joined the 8th Symposium on Biorelevant Chemistry, Okayama.
8/19/2014
The collaborative research with Prof. Hirohide Saito was press released from CiRA, Kyoto University.
7/22/2014
Prof. Bodin Tuesuwan (Chulalongkorn Univ.) visited our group and carried out the research.
7/5/2014
Endo gave a talk in a seminar of Department of Chemistry and Biotechnology, University of Tokyo (Tokyo).
5/26/2014
Mr. Guruprasad Raghavan (Indian Institute of Technology, Madras) stayed our group as an internship student and conducted research.
4/14/2014
We joined FNANO14 (Snowbird, UT, USA).
3/27/2014
We joined the 94th Annual Meeting of the Chemical Society Japan, Nagoya.
3/14/2014
We joined the Molecular Robotic meeting (Iwanuma).
3/13/2014
Dr. Ioanna Mela (Univ. Cambridge) visited our group and carried out the research.
2/3/2014
Prof. Jean-Jacques Toulmé (Univ. Bordeaux) visited our group and gave lecture.
1/9/2014
We joined the 2nd Kyoto-Bristol symposium (Kyoto).
11/13/2013
We joined the 40th International Symposium on Nucleic Acid Chemistry (ISNAC), Yokohama. Yuki Suzuki (Postdoctoral Fellow) won the Outstanding Poster Presentation Award,"Dynamic assembly/disassembly processes of photoresponsive DNA origami nanostructures captured by high-speed atomic force microscopy".
11/9/2013
Endo gave a talk in Japan Society for Bioscience, Biotechnology, and Agrochemistry, Chubu branch 169th annual symposium (Gifu)
11/6/2013
We joined the 7th Annual Symposium on Nanobiotechnology (Bristol, UK).
11/1/2013
Endo joined and talked in the 10th Japanese-German Frontiers of Science (JGFoS) Symposium (Kyoto).
10/29/2013
Prof. Peng Yin (Harvard Medical School) visited our group and gave lecture.
10/29/2013
We joined the 51st Annual Meeting of the Biophysical Society of Japan, Kyoto.
10/10/2013
We joined UK-Japan Workshop on Organic-Inorganic Framework Materilas, Kyoto.
9/27/2013
We joined the 7th Symposium on Biorelevant Chemistry, Nagoya.
9/26/2013
Ms. Marisa Götzfried (Technische Universität München) joined our group (interunversity exchange program) and conducted research.        
8/20/2013
Dr. Laura Na Liu (Max Planck Institute) visited our group.
7/20/2013
We joined the reunion party of Sugiyama Lab.
6/24/2013
Yangyang Yang won The 3rd Takegoshi Prize from Graduate School of Science, Kyoto University.
6/21/2012
We joined the 8th Annual Meeting of Japanese Society for Chemical Biology, Tokyo.
6/10/2013
Yangyang Yang visited Baoquan Ding Lab. (National Center for Nano Science and Technology of China, Beijing).
6/1/2013
Dr. Rajendran moved to Komiyama Lab. Tsukuba Advanced Research Alliance, The University of Tsukuba, as a Project Assistant Professor.
4/15/2013
We joined FNANO13 (Snowbird, UT, USA).
3/22/2013
We joined the 93th Annual Meeting of the Chemical Society Japan, Shiga.
3/18/2013
We joined RSC Publishing-iCeMS Joint International Symposium, Kyoto.
2/22/2013
Endo gave a talk in a seminar at Department of Material Sciences, JAIST (Ishikawa).
2/7/2013
Seigi Yamamoto visited Hanbin Mao Lab. (Kent State University, Ohio).
11/28/2012
Prof. Itamar Willner (The Hebrew University of Jerusalem) visited our group and gave lecture.
11/17/2012
We joined the 39th International Symposium on Nucleic Acid Chemistry (ISNAC), Nagoya.
Yuki Suzuki (Postdoctoral Fellow) won the Outstanding Poster Presentation Award, "Direct visualization of Cre-mediated site-specific recombination in the DNA origami scaffold".
11/17/2012
We joined the 6th Annual Symposium on Nanobiotechnology Kyoto Cell Material Integration (Kyoto).
10/19/2012
Yangyang Yang (graduate student) got JSPS pre-doctoral fellowship.
10/1/2012
Mr. Deepak Koirala (Kent State University) visited for collaborative reserach.
9/6/2012
We joined the 6th Symposium on Biorelevant Chemistry, Sapporo.
8/13/2012
We joined dnatec2012 & dna18 (Aarhus, Denmark).
7/13/2012
Endo gave a talk in a seminar at Department of Pharmaceutical Sciences, Osaka University (Suita).
7/9/2012
ACS Chemical & Engineering News (Volume 90, Issue 28, July 9, 2012, pp.30-31),"More Than Just A Smiley Face".
6/9/2012
We joined the 7th Annual Meeting of Japanese Society for Chemical Biology, Kyoto.
4/20/2012
We joined CLS-iCeMS Joint Symposium (Peking University, Tsinghua University, Beijing).
4/18/2012
We joined FNANO12 (Snowbird, UT, USA).
3/28/2012
We joined the 92th Annual Meeting of the Chemical Society Japan, Yokohama. Yousuke Katsuda got the Outstanding Presentation, titled "To reveal the Cre recombinase reaction mechanism using a defined DNA nanostructure".
2/6/2012
ACS Chemical & Engineering News (Volume 90, Issue 6, February 6, 2012, pp.31), "DNA Nanostructure Controls Transcription".
1/13/2012
Kyoto University Press Release, tilttled "Regulation of the movement of DNA motor in nanoscale space".
11/17/2011
We joined the 5th Anual Symposium on Nanobiotechnology, Seoul NanoHealth 2011 (Yonsei University, Seoul, Korea).
11/16/2011
We joined POSTECH AMS Symposium on Nanotechnology (Pohang University of Science and Technology, Pohang, Korea).
11/9/2011
We joined the 38th International Symposium on Nucleic Acid Chemistry (ISNAC), Sapporo.
Arivazhagan Rajendran (Postdoctoral Fellow) won the Outstanding Poster Presentation Award, "Programmed Self-Assembly and Thermal-Stabilization of DNA Origami Nanostructures".
9/12/2011
We joined the 5th Symposium on Biorelevant Chemistry, Tsukuba.
5/16/2011
We joined the 6th Annual Meeting of Japanese Society for Chmical Biology, Tokyo.
4/18/2011
Yousuke Katsuda visited Barry Gold Lab. (University of Pittsburgh).
4/11/2011
We joined FNANO11 (Snowbird, UT, USA).
2/7/2011
Kyoto University Press Release, tilttled "Real-time observation of DNA motor for development of molecular robot in nano- and mesoscale".  
12/10/2010
We joined the International Chemical Congress of Pacific Basin Societies, (Honolulu, Hawaii, USA)
11/12/2010
We joined the 37th International Symposium on Nucleic Acid Chemistry (ISNAC), Yokohama. Yuta Sannohe got the Outstanding Poster Presentation Award, "Dynamic conformational switching via G-quadruplex formation observed in the DNA nanostructure".
11/9/2010
We held the 8th iCeMS International Symposium and invited Prof. William Shih and Prof. Kurt Gothelf.
5/19/2010
We joined the 5th Annual Meeting of Japanese Society for Chmical Biology, Yokohama.
4/13/2010
We joined FNANO10 (Snowbird, UT, USA).
3/29/2010
We joined the 90th Annual Meeting of the Chemical Society Japan, Osaka.Yousuke Katsuda got the Outstanding Presentation, tittled "Regulation of DNA modifying and repair enzymes in a nanostructure".
2/13/2010
We held the 7th iCeMS Cafe "Weave DNA like an origami".
1/15/2010
Kyoto University Press Release, tilttled "Control of the eyzyme reactions and the direct observation in the DNA nano-space".
10/1/2009
We joined the 36th International Symposium on Nucleic Acid Chemistry(ISNAC), Takayama.
アクセスカウンター

バナースペース

DNA Nanotechnology Group
Bioarchitecture Chemistry Laboratory
Graduate School of Science
Kyoto University

Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501

TEL 075-753-9765
FAX 075-753-9761